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Is Smoking Associated with Depression

and Anxiety in Teenagers?

George C. Patton, MD, Marienne Hibbert, PhD, Malcolm J. Rosier, PhD,


John B. Carlin, PhD, Joanna Caust, BSc, and Glenn Bowes, PhD

Introduction transition to regular use, and the process


of quitting. The aim of this study was to
High levels of depressive and anxiety examine and quantify associations be-
symptoms reported by adult smokers, as tween the common psychiatric symptoms
well as high lifetime rates of major of depression and anxiety and teenage
depression, indicate a substantial relation- smoking at each transition point.
ship between tobacco use and mental
health.1-4 Surveys of psychiatric patients Methods
have similarly demonstrated high rates of
smoking by comparison with community Procedure and Sample
norms.5 The link has often been taken to Data were collected from subjects in
reflect a causal relationship, with poor a statewide survey of adolescent health in
mental health predisposing to regular Victoria, Australia, between August and
tobacco use. Recent studies of cessation November 1992. This state has a popula-
of and relapse in tobacco use in adults tion of 4.4 million, of whom 63% live in
have supported this hypothesis. Smokers the capital city, Melbourne.'6 A two-stage
with self-reported depressive symptoms cluster sampling procedure was used to
are, for example, less likely to quit if define the study population. At stage 1, 60
negative affect is identified as the reason schools were chosen at random from a
for continuing.3'6 Dysphoric mood is simi- stratified frame of government, Catholic,
larly a common antecedent of smoking and independent schools with a probabil-
relapse.7'8 ity proportional to the number of year 7,
The influence of depressive and 9, and 11 students in the schools in each
anxiety symptoms on initial experimenta- stratum in the state (total numbers were
tion and progression to regular smoking 59 746, 60 905, and 59 133, respectively).
during the teen years has attracted less These correspond to the 8th, 10th, and
attention.9 Earlier surveys of adolescents 12th years of full-time education, respec-
reported links between smoking and neu- tively. Five schools declined participation,
roticism, 0 neurotic symptoms,11 poor cop- and each was replaced by a previously
ing skills,'2 and low self-esteem.13 A defined school from the equivalent stra-
10-year follow-up of an adolescent cohort tum. At stage 2, a single intact class was
found that self-report of minor depressive selected at random from each of years 7,
symptoms in nonsmokers at 15 years 9, and 11 in selected schools. The sample
significantly predicted smoking at 25
years.'4 Despite this evidence, there re-
mains uncertainty as to whether the George C. Patton is with the Department of
findings reflect a link with psychiatric Psychiatry, and Marienne Hibbert, Malcolm J.
symptoms or associated personality char- Rosier, John B. Carlin, Joanna Caust, and
Glenn Bowes are with the Department of
acteristics. Possible mechanisms of influ- Paediatrics, University of Melbourne, Mel-
ence also remain unclear. Adolescent bourne, Australia.
smoking is a dynamic process, with many Requests for reprints should be sent to
experimenting but fewer going on to George C. Patton, MD, Centre for Adoles-
cent Health, 2 Gatehouse St, Parkville 3052,
regular use.15 Mental health might influ- Australia.
ence the process of becoming a smoker at This paper was accepted September 7,
various points: initiation of smoking, 1995.

American Journal of Public Health 225


Patton et al.

Ease 78.5, Flesch Grade Level 7.1).


= =

TABLE 1-Characteristics of Survey Population of Victorian Secondary School The CIS generates scores (1-4) on 14
Students (n = 2525), by School Year Level and Sex subscales covering the common psychiat-
ric symptoms found in nonclinical popula-
Year 7 Year 9 Year 11 tions. These were summarized into a total
Female Male Female score and stratified into four levels of
Male Female Male
(n = 479) (n = 477) (n = 437) (n = 474) (n = 301) (n = 357) psychiatric morbidity: level 1 (0-5), level 2
(6-11), level 3 (12-17), and level 4 ( 2 18).
Mean age (SD), y 12.5 (0.6) 12.5 (0.6) 14.5 (0.6) 14.5 (0.5) 16.6 (0.8) 16.4 (0.6) The stratification incorporates a sug-
Smoking status, % gested threshold of 12 or higher for
Never smoked 85 82 68 69 64 54 caseness, corresponding to the point where
Ex-smokers(>1 mo) 4 5 7 6 3 5
10 10 11 14 17 17 a general practitioner might be concerned
Occasional (<2
days/week) about a subject's mental health.202123
Regular (> 3 1 3 13 11 15b 24b Alcohol consumption was assessed
days/week)a with self-evaluation of current drinking
Psychiatric morbidity, %c status and a 7-day retrospective drinking
CIS score of 0-5 64 55 60 43 51 32
CIS score of 6-11 21 22 23 23 16 22 diary. The alcohol diary used a beverage-
CIS score of 12-17d 9 8 8 16 17 20 specific approach and detailed types of
ClSscoreof .18d 6 15 9 18 17 25 drink (e.g., low-alcohol beer, normal-
Alcohol consumption, %e alcohol beer, wine, spirits, mixed drinks)
Nondrinkers 85 87 59 63 34 34 as well as the quantities consumed accord-
Light 15 12 37 32 49 49
Heaviere 0 1 4 5 17 17 ing to a range of relevant measures (e.g.,
small bottles [375 mL], large bottles [750
Parental smoking, % mL], glasses, cans). Nine grams of ethanol
Nonsmokers 62 62 64 60 66 58
Occasional 14 9 10 9 13 14 was taken as a standard unit.
Regular 24 29 25 31 22 28 Three levels of consumption were
defined on the basis of reported consump-
Note. Values are weighted prevalence estimates. tion in the previous week: nondrinking,
aSignificant increase in regular smoking across year levels: males X2 = 62, P < .001; females X =
101, P < .001. light drinking, and heavier drinking. Sub-
bSignfficant sex difference in regular smoking at year 11: X2 = 6.5, P < .02. jects consuming in excess of 50% of
cSignfficant increase across year levels in proportion scoring . 12 on CIS: males X = 34, P < .001; National Health and Medical Research
females x2 = 50, P < .001.
dSignificant sex dffference in high psychiatric morbidity (.12 on CIS): MantelHaenszel X = 49, Council recommended guidelines for
P < .001. adults24 were classified as heavier drinkers
eSignificant increase in any alcohol use across year levels: males X2 = 206, P < .001; females X2 =
223, P < .001. (i.e., males consuming at least 14 units/
'Significant increase across year levels: males X2 - 165, P < .001; females X2 = 14.5, P < .001. week and females consuming at least 7
units/week).
Parental smoking was assessed with
two questions dealing with current mater-
was designed to have a standard error of the diary. Smoking was categorized on the nal and paternal smoking patterns, respec-
0.02 after adjustment for the effects of basis of frequency, so that a subject who tively. Parental smoking was defined on
clustering. reported smoking on 3 or more days in the three levels: at least one parent smok-
The survey was presented as dealing past week was defined as a regular ing daily, at least one parent smoking
with important health issues for adoles- smoker.18,19 Those smoking on 2 or fewer less than daily, and both parents not
cents and included questions on a broad days in the past week were categorized as smoking.
range of health-related issues. Active occasional smokers. Self-defined ex- Analysis. Prevalences were weighted
consent for participation, including writ- smokers, who reported not smoking in the by geographic area to allow for chance
ten parental permission, was sought. month before the survey, were catego- undersampling in particular areas of the
Laptop computers were used to adminis- rized as ex-smokers. Those who reported state. We adjusted confidence intervals
ter the questionnaire to each class. Com- giving up smoking in the last 4 weeks were (CIs) for prevalence estimates using ran-
puter administration has been shown to categorized as occasional smokers. dom-effects procedures in ML3E soft-
enhance disclosure of health risk behav- Mental health status was evaluated ware25 to take into account the effect of
iors in adolescents.17 with a computerized form of the Clinical
the two-stage survey design on effective
Interview Schedule (CIS)-R,2022 a struc-
tured interview designed for the assess- sample size. Prevalence estimates and
Measures ment of symptoms of anxiety and depres-
odds ratios (ORs) are presented with
Tobacco use was categorized by sion in nonclinical populations. The CIS 95% confidence intervals. Analysis was
using a 7-day retrospective diary. To has been used as a criterion measure for conducted with the Epi Info26 and SAS
reduce exposure to unnecessary ques- the definition of psychiatric "caseness" in programs27 and logistic regression analy-
teenage groups23 and has an ease of ses exploring the interrelationships be-
tions, never-smokers and self-defined ex-
smokers who had not smoked a cigarette reading consistent with its suitability for tween smoking and psychiatric morbidity
in the previous month did not complete the younger group (Flesch Reading in GLIM.28

226 American Journal of Public Health February 1996, Vol. 86, No. 2
Teenage Smokers

Results
TABLE 2-Percentages of Regular Smokers among Subjects Reporting High and
Sample Charactenstics Low Levels of Psychiatric Symptoms, by School Year Level and Sex
Time limitations restricted school
numbers to 46 in year 7, 45 in year 9, and Males (n = 1217) Females (n = 1308)
36 in year 11. Twenty-six participating Low High Low High
schools were government, 11 were Catho- Levels,% Levels,% ORa Levels, % Levels, % ORa
lic, and 9 were independent and private. Year (n = 965) (n = 252) (95% Cl) (n = 886) (n = 442) (95% Cl)
Stratum weights for the overall estimation
of prevalence rates were less than 1.5 for 7 (n = 956) 1 7 8.5 (2.3, 32) 2 10 4.7 (1.8,12)
9 (n = 911) 15 19 1.3 (0.6,2.7) 8 25 3.5 (2.0,6.2)
all but two of the 12 geographic regions of 11 (n = 658) 17 24 1.5 (0.8,3.1) 18 46 3.8 (2.3,6.5)
Victoria (2.3 in metropolitan west Mel- Mantel-Haenszel 1.7 (1.03, 2.8) 3.8 (2.6, 5.6)
bourne, 2.1 in rural north Victoria). weighted OR
A total of 2525 students completed
the survey: 956 in year 7, 911 in year 9, and Note. A high level of psychiatric symptoms was defined as a score above a cutoff point of . 12 on
658 in year 11. The overall response rate the CIS. OR = odds ratio; Cl = confidence interval.
was 83%. However, the response rate for
aSignificant interaction between year level and psychiatric morbidity for males (X2 = 7.05, P < .05).
year 11 (79%) was significantly lower than
it was for year 7 (85%) and year 9 (84%)
(x2= 12.9, P < .001). Reasons for non- high-morbidity group, compared with 29% variables were included in these models:
participation were as follows: nonreturn
of others. An examination of the homoge- year level, sex, alcohol consumption, and
of consent form (10.2%), absence on
survey day (3.5%), and parental refusal
neity of odds ratios with logistic regression parental smoking. Both alcohol consump-
demonstrated a significant interaction tion and parental smoking are known to
(3.3%). Higher nonresponse rates in year between year level and psychiatric morbid-
11 resulted from a higher rate (13.7%) of be associated with higher rates of teenage
nonreturn of consent forms. The sex ratio
ity for males (X21 = 7.05, P < .05) but not smoking and psychiatric morbidity.32
females (X2 = 0.54). This result supports Cuwrent smokers compared with non-
(males year 7: 50.0%; year 9: 47.0%; year the impression given by the stratum- smokers. Subjects in the higher CIS groups
11: 43.8%) was similar to that in Victorian
schools.29 Table 1 presents characteristics specific odds ratios that there may be little had a twofold increased risk for smoking.
of the survey population.
association of regular smoking with psychi- There was a significant linear trend of
Both smoking participation and regu- atric morbidity for males in the two higher increasing risk with CIS level (likelihood
lar smoking rates rose across year levels year levels. ratio x2 = 35.5, P < .001), with the great-
Associations between regular smok- est difference between those scoring 12-17
for males and females. Within the smok-
ing and dimensions of psychopathology and those scoring 6-11. A modest associa-
ing group, the proportion of regular were examined with logistic regression to
smokers rose across year levels for both tion with school year level persisted, but
estimate odds ratios per unit step on the the association with sex disappeared when
males (X2 = 6.8, P < .01) and females
ordinal scale 0-4 for the 14 subscales of psychiatric morbidity was added to the
(x2= 10.4,P < .005). the CIS. All subscales other than Worry model. A strong relationship between
With a cutoff point of 12 and above about Physical Health (OR = 1.05, 95%
for CIS scores, psychiatric morbidity rates drinking and smoking was evident, particu-
CI = 0.87, 1.26) had a significant associa- larly for those in the heavy-drinking
rose substantially across year levels, with
tion with regular smoking. The highest category, who had an over 15-fold associ-
significantly higher scores for females. associations were with panic (OR = 1.5, ated risk. Students who reported that at
Alcohol use also rose across year levels, 95% CI = 1.3,1.7), depression (OR = 1.4, least one parent smoked on a daily basis
with nondrinkers in the minority in the
95% CI = 1.3, 1.6), irritability (OR = 1.4, had a twofold increased risk. No signifi-
year 11 group. The likelihood of a drinker
95% CI = 1.3, 1.6), impaired concentra- cant two-way interactions between CIS
falling into the heavier-consumption cat- tion (OR = 1.4, 95% CI = 1.2, 1.6), and scores and year level, sex, alcohol use, or
egory was higher in the upper-year levels
for both sexes. Overall rates of smoking in
sleep disturbance (OR = 1.4, 95% CI= parental smoking were found, although
1.2, 1.6). this analysis did not attempt to incorpo-
one parent were 27% for reported daily
rate the three-way interaction of age, sex,
smoking and 11% for less-than-daily MultivariableAnalyses and CIS suggested by Table 2.
smoking, with no significant difference Regular smokers compared with occa-
across year levels.
Three separate logistic regression
analyses examined the association of sional smokers. Subjects in the high-
psychiatric morbidity with current smok- psychiatric-morbidity group were almost
Regular Smoking and Psychiatic ing (current smokers vs nonsmokers), twice as likely to fall into the regular-
Morbidity byAge and Sex current regular smoking (regular vs occa- smoking group, but this association was
The association between psychiatric sional smokers), and continuing smoking significant only for those scoring 18 or
morbidity and regular smoking was mod- (current smokers vs ex-smokers) (Table higher on the CIS. There was a significant
est for teenage males but substantial for 3). These correspond to the transition linear trend for increasing risk with CIS
teenage females (Table 2). Across year points of smoking initiation, development level (likelihood ratio x2 = 8.5, P < .01).
levels, 38% of male regular smokers fell of regular smoking, and smoking cessa- Parental smoking and year level had the
into the high-morbidity group, compared tion. It should be noted that the first and strongest associations with regular smok-
with 19% of others. Fifty-nine percent of third comparisons are not statistically ing status, confirming that regular smok-
regular female smokers fell into the independent. Four potential confounding ing was more likely in the later years of

February 1996, Vol. 86, No. 2 American Journal of Public Health 227
Patton et al.

though evident for young males, was most


TABLE 3-Adjusted Odds Ratios from Multiple Logistic Regression Models of pronounced in young females.
Smoking Outcomes in Victorian Teenagers This study population, although
drawn from a representative sample of
Adjusted ORs (95% Cl) secondary schools in Victoria, is open to
three potential sources of selection bias.
Regular Smokers Five of the 60 originally sampled schools
Current Smokersa (n = 221) Current Smokersa
(n = 551) vs Occasional (n = 551) declined participation and were replaced.
vs Nonsmokers Smokers vs Ex-Smokers Survey time constraints further reduced
Smoking Groups (n = 1974) (n = 330) (n = 114) school numbers, particularly at the year
11 level. Although findings for expected
School year level age and geographic distribution of partici-
7 (n = 956) 1.0b 1.0 1.0
9 (n = 911) 1.4 (1.05,1.9) 3.6 (1.9, 6.6) 1.03 (0.62,1.7) pants suggest that minimal bias resulted,
11 (n = 658) 1.4 (1.02, 1.9) 4.2 (2.2, 7.9) 1.8 (0.96, 3.3) this possibility cannot be totally excluded.
Sex Second, there is evidence that early school
Male(n = 1217) 1.0 1.0 1.0 leavers, not included in the sampling
Female (n = 1308) 1.1 (0.87,1.3) 1.1 (0.73,1.6) 1.1 (0.7,2.3) frame, have high levels both of substance
Psychiatric morbidityc use and of psychiatric morbidity.37 A high
CISscoreof0-5(n= 1312) 1.0 1.0 1.0 school-retention rate to year 11 of 93.3%
CIS score of 6-11 (n = 539) 1.2 (0.93,1.8) 1.5 (0.89, 2.6) 1.0 (0.6,1.8) for Victoria in the year of the survey29
CIS score of 12-17 (n = 319) 1.9 (1.4, 2.7) 1.7 (0.99, 2.9) 1.1 (0.6, 3.4)
CIS score of 18+ (n = 355) 2.3 (1.7, 3.1) 2.1 (1.3, 3.4) 1.3 (0.7, 2.4) should have minimized this bias. Neverthe-
less, it is possible that the observed
Alcohol consumption prevalence rates of smoking and psychiat-
Nondrinkers (n = 1598) 1.0 1.0 1.0
Light (n = 771) 5.1 (4.0, 6.5) 1.8 (1.1, 2.8) 1.7 (1.06, 2.6) ric morbidity underestimate true popula-
Heavier (n = 156) 16 (11, 25) 2.9 (1.6, 5.4) 4.8 (1.9, 19) tion rates, with further potential for
Parental smoking misspecification of the association be-
Nonsmokers (n = 1632) 1.0 1.0 1.0 tween tobacco use and psychiatric morbid-
Occasional (n = 2271) 0.92 (0.63,1.3) 2.4 (1.2, 4.6) 0.9 (0.4, 1.8) ity. The evidence that absentees have high
Regular (n = 622) 2.0 (1.5, 2.5) 3.8 (2.5, 5.8) 1.7 (1.05, 2.7) rates of smoking by comparison with
aCurrent smoking combines occasional and regular smoking.
school attenders30 raises a possible third
bl.0 indicates the reference category for a subsequent odds ratio. source of bias. However, satisfactory
cSignificant linear trend in relationship with smoking for current smokers vs nonsmokers response rates at all year levels, with low
(X2 = 35.5, P < .001) and for regular smokers vs occasional smokers (X2 = 85, P < .01). rates of absenteeism ( < 4%), should have
minimized nonparticipation bias.
The computerized administration of
the questionnaire permitted the collec-
secondary school. The association with males to fall into a high-psychiatric- tion of detailed information on psychiatric
parental smoking held whether a parent morbidity group. symptoms and teenage smoking.38 The
was reported to smoke on an occasional An association between symptoms of cutoff point of 3 days per week for regular
or a daily basis. depression and anxiety, observed in stud- smoking was chosen to reflect a degree of
Continuing smokers. Little difference ies of adult smokers,' 4also characterized nicotine dependence and was supported
was found between continuing and ex- teenage smokers at an early point in their by the probability that most regular users
smokers in psychiatric morbidity. Heavier smoking careers. The link was particularly at year 11 smoked an average of more
use of alcohol was the strongest factor evident in the youngest teenage group. than five cigarettes per day. The stratifica-
associated with continuing smoking. There Earlier studies of teenagers have consis- tion of psychiatric morbidity was designed
was a weaker association with reported tently demonstrated differences in the to define a level of anxiety and depressive
parental daily smoking. mental health of teenage smokers but symptoms likely to cause a general practi-
have largely relied on indirect measures tioner concern and used a lower threshold
such as low self-esteem, poor coping for caseness than for major depression or
Discussion strategies, and neuroticism.10,12,13 One the specific anxiety disorders outlined in
Tobacco use rose across the teenage Australian' and two American surveys35,36 The Diagnostic and Statistical Manual of
years both in frequency and in quantity, so demonstrated an association between Mental Disorders, 4th edition.
that by late secondary school one in five symptoms of depression and anxiety and The association between smoking
teenagers fell into a regular-smoking smoking in teenage groups. The current and psychiatric morbidity has most com-
category. The rise in smoking for females study has confirmed the link in a large, monly been interpreted as mental health
was more marked, with older teenage representative teenage population and influencing the uptake and course of
females having a higher likelihood of demonstrated a twofold rise in the risk for tobacco use.32'39 An alternative interpreta-
smoking regularly. Self-reported depres- smoking in the high-psychiatric-morbidity tion is that smoking has a negative impact
sion and anxiety were more evident in group. Within the smoking group, teenag- on mental health.33 Nicotine's influence
later secondary school, a pattern consis- ers with a high level of psychiatric symp- on neurotransmission pathways impli-
tent with reported higher rates of depres- toms had a further twofold increase in the cated in affective disorders provides a
sion and anxiety disorders in older adoles- risk for regular smoking. The link of potential mechanism for such a causal
cents.33 34Females were twice as likely as smoking with psychiatric morbidity, al- influence.A02 A survey of adult smok-

228 American Journal of Public Health February 1996, Vol. 86, Nc. 2
Teenage Smokers

ers,4344 which reported that heightened mistaken, with perceived benefits in func-
dysphoria persisted only as long as smok- tioning possibly arising from alleviation of Acknowledgment
We thank the Victorian Health Promotion
ing continued, lent support to this view. In withdrawal symptoms.44"49'50 Foundation for their support of this study.
the current study, however, the mental Smoking in young women is a source
health of ex-smokers was similar to that of of concern because of both its high
continuing smokers rather than to that of prevalence and the particular health risks References
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