Pharmacology 1 – Case Study 1

General Instructions:
1. The case study will be done by group.
2. The deadline for submission of cases will be on May 24, 2020 for the marks to be encoded.
Students who failed to submit after the said date will merit 150 mark (incomplete) and are
given 1 year to comply.
3. Grading of the work is as follows:
a. Relevance (50%) – ability to answer the questions/items properly.
b. Quality of Information (20%) – depth of scientific language that was used.
c. Organization (10%) – presentation of the submitted work.
d. Neatness (10%) – should have minimal to no erasures.
e. References (10%) – the quality of source like journals or books.
4. Format
Computerized in short bond paper.
Font Style/Size: Book Antiqua/12
First Page - Case Titles
Submitted by: (group members)
Submitted to: Hazel Anne L. Catublas, PhD.
Professor
Succeeding Pages: Case A
Questions immediately followed by the respective answer.
Case B
Questions immediately followed by the respective answer.
Case C
Questions immediately followed by the respective answer.
5. All references used in the case study should be stated as a bibliographic entry on the last part
of the submitted paper. Please follow APA format. Books and journals are preferred
references. No need to attach documentations.

Group 1 – Abayan, Adviento, Atendido

Group 2 - Batnag, Bernardo, Binuya, Calvento
Group 3 -Cañas, Castro, Chee
Group 4 - Comia, Ferrer, Forcadas
Group 5 - Fria, Garcia, Gatchalian
Group 6 - Glang, Gumila, Jamolo
Group 7 - Juan, Macrohon, Malsada
Group 8 -Manalo, Medina, Molina
Group 9 - Nacpil, Napa, Narvaez, Oandasan
Group 10 - Pacis, Perello, Raduban
Group 11 - Rubenecia, Rufin, Salazar
Group 12 - Salvador, Talavera, Undang, Vega
Case A – Peculiar Tablet
Aspirin is considered as an acidic drug given at a dose of 80 mg tablet as an antithrombotic
agent for patients with angina and prevention of myocardial and cerebral infarction. In today’s
market, some preparations of aspirin would be given as 100 mg enteric coated tablet.
1. Rationalize the need to enteric coat the aspirin tablet.
2. Why is the enteric coated tablet given in 100 mg dose as compared to the compressed tab of 80
mg only?
3. In the principle of like dissolves like, aspirin should be dissolved non-ionized in the acidic
medium of the stomach to take effect. Explain why the 100 mg enteric coated tablets dissolved
in the alkaline pH of the stomach still exerts an effect. HINT: It involves three (3) factors in
pharmacokinetics.

Case B – Because I love pomelos.

A 40-year old woman was rushed to the hospital due to a heart attack. She was revived and
was able to live. Upon interview by the pharmacist, the patient is well aware and faithfully takes her
medications as prescribed. She also discussed that she always eat grapefruits, pomelos, and oranges
from her backyard.
1. If the patient is taking her medications as prescribed, why did she suffer from a heart attack?
Rationalize the connection of her diet to the event.
2. In connection with number 1, what are other foods and medications that could have either
caused another heart attack or hypotension? Explain the rationale behind their effect on the
intended action of the medications of the patient.
3. If the patient will take an enzyme inhibitor and an enzyme inducer at the same time, what is
the effect to her blood pressure? Increased or decreased? Rationalize your answers.

Case C – I am suffering from drug addiction

A 25-year old celebrity was diagnosed to have a stage 2 cancer of the bone He was given
100mg morphine prn orally or 10 mg morphine prn IV when admitted to the hospital during
chemotherapy sessions. After a year of battling with his condition, he recovered from the cancer and
was declared cancer free. However, he is still suffering from physiological dependence from the
morphine that he always takes.
1. Why would morphine cause drug addiction to the patient? Rationalize using the effects of
morphine on different receptors for opioids.
2. What would be the effect if the patient will take:
a. Butorphanol
b. Naloxone?
Rationalize using the effects of these drugs to the opioid receptors.
3. If a patient will take a receptor agonist and antagonist at the same time, what are the factors
that will affect the manifestation of the effect of both drugs? Explain each factor.