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Accession Number: BACD200400010126

Document Type: Article

Title: Tea and cancer prevention: Studies in animals and humans.

Author(s): Chung, Fung-Lung (chungahf@aol.comfchung@ifcp.us); Schwartz, Joel; Herzog,

Christopher R.; Yang, Yang-Ming

Source: Journal of Nutrition 133 (10) : 3268S-3274S October 2003

Language: English Medium: print

Abstract: The role of tea in protection against cancer has been supported by ample evidence
from studies in cell culture and animal models. However, epidemiological studies have generated
inconsistent results, some of which associated tea with reduced risk of cancer, whereas others
found that tea lacks protective activity against certain human cancers. These results raise
questions about the actual role of tea in human cancer that needs to be addressed. This article is
intended to provide a better perspective on this controversy by summarizing the laboratory
studies in animals and humans with emphasis on animal tumor bioassays on skin, lung,
mammary glands and colon, and the molecular and cellular mechanisms affected by tea. Finally,
a recent small pilot intervention study with green tea in smokers is presented.

Address: Chung, Fung-Lung ; American Health Foundation Cancer Center, Institute for Cancer
Prevention, Valhalla, NY, 10595, USA

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Record #5 
Accession Number: BACD200700231253
Document Type: Article Literature Type: Literature Review

Title: Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair

Author(s): Katiyar, Suchitra; Elmets, Craig A.; Katiyar, Santosh K. (skatiyar@uab.edu)

Source: Journal of Nutritional Biochemistry 18 (5) : 287-296 MAY 2007

Language: English

Abstract: Human skin is constantly exposed to numerous noxious physical, chemical and
environmental agents. Some of these agents directly or indirectly adversely affect the skin.
Cutaneous overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) has a
variety of adverse effects on human health, including the development of melanoma and
nonmelanoma skin cancers. Therefore, there is a need to develop measures or strategies, and
nutritional components are increasingly being explored for this purpose. The polyphenols present
in green tea (Camellia sinensis) have been shown to have numerous health benefits, including
protection from UV carcinogenesis. (-)-Epigallocatechin-3-gallate (EGCG) is the major and most
photoprotective polyphenolic component of green tea. In this review article, we have discussed
the most recent investigations and mechanistic studies that define and support the
photoprotective efficacy of green tea polyphenols (GTPs) against UV carcinogenesis. The oral
administration of GTPs in drinking water or the topical application of EGCG prevents UVB-
induced skin tumor development in mice, and this prevention is mediated through: (a) the
induction of immunoregulatory cytokine interleukin (IL) 12; (b) IL-12-dependent DNA repair
following nucleotide excision repair mechanism; (c) the inhibition of UVinduced
immunosuppression through IL-12-dependent DNA repair; (d) the inhibition of angiogenic
factors; and (e) the stimulation of cytotoxic T cells in a tumor microenvironment. New
mechanistic information strongly supports and explains the chemopreventive activity of GTPs
against photocarcinogenesis. (c) 2007 Elsevier Inc. All rights reserved.

Address: Katiyar, Santosh K.; Univ Alabama, Dept Dermatol, Birmingham, AL 35294 USA

Record #8 
Accession Number: BACD200700172410
Document Type: Article

Title: Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast
cancer cells

Author(s): Thyagarajan, Anita; Zhu, Jiashi; Sliva, Daniel (dsliva@clarian.org)

Source: International Journal of Oncology 30 (4) : 963-969 APR 2007

Language: English

Abstract: Epidemiological studies have suggested that consumption of green tea may decrease
the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the
promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the
present study we show that extract from green tea (GTE) increased the anticancer effect of G.
lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony
formation (anchorage-independent growth) of breast cancer cells. This effect was mediated by
the down-regulation of expression of oncogene c-myc in MDA-MB-231 cells. Although
individual GTE and GLE independently inhibited adhesion, migration and invasion of MDA-
MB-231 cells, their combination demonstrated a synergistic effect, which was mediated by the
suppression of secretion of urokinase plasminogen activator (uPA) from breast cancer cells. Our
study suggests the potential use of combined green tea and G. lucidum extracts for the
suppression of growth and invasiveness of metastatic breast cancers.

Address: Sliva, Daniel; Methodist Res Inst, Canc Res Lab, 1800 N Capitol Ave,E504,
Indianapolis, IN 46202 USA

Record #14 
Accession Number: BACD200600455410
Document Type: Article

Title: Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes
in Japan - The Ohsaki Study

Author(s): Kuriyama, Shinichi (kuriyama-thk@umin.ac.jp); Shimazu, Taichi; Ohmori, Kaori;

Kikuchi, Nobutaka; Nakaya, Naoki; Nishino, Yoshikazu; Tsubono, Yoshitaka; Tsuji, Ichiro

Source: JAMA (Journal of the American Medical Association) 296 (10) : 1255-1265 SEP 13

Language: English

Abstract: Context Green tea polyphenols have been extensively studied as cardiovascular disease
and cancer chemopreventive agents in vitro and in animal studies. However, the effects of green
tea consumption in humans remain unclear.Objective To investigate the associations between
green tea consumption and all-cause and cause-specific mortality.Design, Setting, and
Participants The Ohsaki National Health Insurance Cohort Study, a population-based,
prospective cohort study initiated in 1994 among 40 530 Japanese adults aged 40 to 79 years
without history of stroke, coronary heart disease, or cancer at baseline. Participants were
followed up for up to 11 years (1995-2005) for all-cause mortality and for up to 7 years (1995-
2001) for cause-specific mortality.Main Outcome Measures Mortality due to cardiovascular
disease, cancer, and all causes.Results Over 11 years of follow-up (follow-up rate, 86.1%), 4209
participants died, and over 7 years of follow-up (follow-up rate, 89.6%), 892 participants died of
cardiovascular disease and 1134 participants died of cancer. Green tea consumption was
inversely associated with mortality due to all causes and due to cardiovascular disease. The
inverse association with all-cause mortality was stronger in women (P = .03 for interaction with
sex). In men, the multivariate hazard ratios of mortality due to all causes associated with
different green tea consumption frequencies were 1.00 (reference) for less than 1 cup/d, 0.93
(95% confidence interval [CI], 0.83-1.05) for 1 to 2 cups/d, 0.95 (95% CI, 0.85-1.06) for 3 to 4
cups/d, and 0.88 (95% CI, 0.79-0.98) for 5 or more cups/d, respectively (P = .03 for trend). The
corresponding data for women were 1.00, 0.98 (95% CI, 0.84-1.15), 0.82 (95% CI, 0.70-0.95),
and 0.77 (95% CI, 0.67-0.89), respectively (P < .001 for trend). The inverse association with
cardiovascular disease mortality was stronger than that with all-cause mortality. This inverse
association was also stronger in women (P = .08 for interaction with sex). In women, the
multivariate hazard ratios of cardiovascular disease mortality across increasing green tea
consumption categories were 1.00, 0.84 (95% CI, 0.63-1.12), 0.69 (95% CI, 0.52-0.93), and 0.69
( 95% CI, 0.53-0.90), respectively (P = .004 for trend). Among the types of cardiovascular
disease mortality, the strongest inverse association was observed for stroke mortality. In contrast,
the hazard ratios of cancer mortality were not significantly different from 1.00 in all green tea
categories compared with the lowest-consumption category.Conclusion Green tea consumption
is associated with reduced mortality due to all causes and due to cardiovascular disease but not
with reduced mortality due to cancer.
Address: Kuriyama, Shinichi ; Tohoku Univ, Grad Sch Med, Dept Publ Hlth and Forens Med,
Div Epidemiol,Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan