ER/PR+ Her2 -ve Breast Cancer

(ER+ often uses cell lines called MCF7 in some of the articles cited)

Glucose Supplements / Source Comments

Pathways Drugs

Glut-1 (gluts Statin

transport glucose Quercetin
into the cell) Curcumin
Anti parasitic
Insulin Low Glycaemic Diet
Metformin
Berberine
PPP (pentose Proliferating cells use
phosphate this pathway.
pathway)

Oxphos IV Vit C Metabolic targeting of ER+ve prefers this

2 DG breast cancer cells with over glutaminolysis
2DG
*Metformin TNBC
Berberine Oxphos as an emerging
target Cancer stem cells
Atovaquone (being (CSCs) are critically
tested. Anti dependant on OXPHOS
parasitic/anti A mitochondrial based
malarial) platform for eradicating
CSCs
Doxycycline

Niclosamide
Aerobic IV C
Glycolysis Metformin
Glutamine Supplements Source Comments
Pathways

IGF-1 Metformin IGF-1 and Breast cancer Clear association

EGCG (Green Tea) risk between circulating
Cruciferous veg IGF1 and ER+
Curcumin The role of IGF-1 in breast tumours. Plays a key
Ashwaganda cancer role in progression &
metastasis.
Upregulates VEGF
(angiogenesis)
MTOR – tells Berberine Recent advances in the use Metformin has shown
cells to Metformin of Metformin/breast cancer cell cycle arrest in both
grow/proliferate Vit D3 ER+ and ER- cell lines,
TNBC and in fact
pretty much all
subtypes.
Macropinocytosi PI3k inhibitors A mitochondrial based Chloroquine and
s (nutrient (Wortmannin) platform for eradicating Doxycycline have been
scavenging CSCs used in conjunction to
pathway) Chloroquine kill stem cells.
Loratidine

Nucleoside Dipyridamole
Salvage
(autophagy)

Glutaminolysis EGCG(green tea) Particularly TNBC and

Ursolic Acid HER2+ but all
Curcumin advanced breast
cancers
Fatty Acid Supplements Source Comments
Pathways

SREBP-1 Fatty acids seem to be

the primary energy
source for TNBC
SREBP-2 Berberine Regulation of lipid SREBP activity
synthesis in ER+ breast important for hormone
cancer dependant ER+ cells to
proliferate. SREBP
expression regulated
by IGF-1 and
hormones in ER+ cells
Acyle (Atp
citrate lyase)

FAS (fatty acid Aspirin HER2+

synthesis) Metformin
Sea Buckthorn
FAO (fatty acid Doxycline
oxidation) Mildronate
Mevalonate Statins Statins: A role in breast Cholesterol synthesis
Bergamot cancer therapy? upregulated in ER+
cells which are
Could statins prevent resistant to oestrogen
breast cancer returning deprivation.
(ER+)

Anything Else
Genistein and Genistein sensitizes Genistein works to
Tamoxifen inhibitory effect of make Tamoxifen more
Tamoxifen in ER+ Her2- on effective.
breast cancer
Albendazole Albendazole: A potent Not specifically breast
inhibitor of VEGF and cancer but the point
malignant ascites stands for any type I’d
say.
Herbs /Spices for Natural products that Always interesting to
anti angiogenesis inhibit angiogenesis read about natural
products.
Curcumin The effect of Curcumin on *Highly toxic to breast
breast cancer cancer