COMPLEXATION QUESTIONS

BY:
Farhan, Al-Muhalab
Farhan, Lames
Franco, Rhystel Dawn
Gayona, Sarah Joy
Pama, Mariemil Rose
Tacda, Hexangeli

A. Electron Donor
B. Electron Acceptor
C. Ligand
D. Coordination Complex
E. Lewis Base

1. It is an ion/ neutral molecule that bonds to a neutral metal atom/ion. C

2. Lewis bases? A
3. Lewis acids? B
4. It is a product of a Lewis acid-base reaction in which neutral molecules/anion bond to a central
metal atom by coordinate covalent bond. D
5. All ligands function as? E
6. Once complexation occurs, which properties are altered? E
a. Solubility c. Partitioning e. All of the above
b. Stability d. A and B
7. Drug complexation with __________ compound also can enhance excretion. D
a. Ionic c. Hydrophobic e. None of the above
b. Covalent d. Hydrophilic
8. All of the following are true about complexation except: d
a. Product of Lewis acid-base reaction
b. Bond to a central metal atom (Ligand)
c. Coordinate of covalent bond
d. None of the above
9. In some instances, complexation also can lead to poor solubility/decreased absorption of the
drugs into the body. A
a. TRUE b. FALSE
10. Ammonia, which has a single pair of electrons for bonding with metal ion is called:A
a. Unidentate Ligand c. Multidentate e. NOTA
b. Bidentate Ligand d. AOTA
 A. VAN DER WAALS FORCES
B. DIPOLAR FORCES
C. ELECTROSTATIC FORCES
D. HYDROGEN BONDING
E. CHARGE TRANSFER

11. Used to define the attraction of intermolecular forces between molecules. A

12. It is a force between ion and a polar molecule. B
13. Studies of electric charges at rest. C
14. It is a partially electrostatic force of attraction between a hydrogen atom which is bound to
move electronegative atom/group. D
15. Is an association of two or more molecules or of different parts of a large molecule in which a
fraction of electronic charge is transferred between the molecular entities. E
16. Complexation of esters results from __________ between nucleophilic carbonyl oxygen and an
active hydrogen. C
a. Ionic Bonding
b. Covalent Bonding
c. Hydrogen Bonding
d. ALL OF THE ABOVE
17. Natural occurring chelates. D
a. Albumin
b. Insulin
c. Haemoglobin
d. B and C
18. The formation or presence of two or more separate coordinate bonds. D
a. Complexation c. Chelating
b. Chelate d. Chelation
19. What are the two geometric forms of chelation? C
a. Mis and Trans Isomer c. Cis and Trans Isomer
b. Sis and Trans Isomer d. Trans and Trans Isomer
20. Consists of constituents held together by weak forces is called? B
a. Inorganic Molecular Complexes c. Inorganic Molecular Complexation
b. Organic Molecular Complexes d. Organic Molecular Complexation
21. Complexation of benzocaine with salicylates will __________ the bioavailability of benzocaine
while its complexation with PEG will __________ its absorption. B
a. Increase, Decrease c. Increase, Increase
b. Decrease, Increase d. Decrease, Decrease
22. Deoxycholic acid: D
a. Clathrates c. Picric Acid Complexes
b. Layer Type d. Channel Lattice Type
23. Crystallize in a cage-like lattice. A
a. Clathrates c. Picric Acid Complexes
b. Layer Type d. Channel Lattice Type
24. Clay montmorillonite complexes: B
a. Clathrates c. Picric Acid Complexes
b. Layer Type d. Channel Lattice Type
25. Is a clathrate of water, isopropyl alcohol. D
a. Sodium Warfarin
b. Sodium Chloride USP
c. USP Warfarin
d. Warfarin Sodium USP