Question Bank

(last 5 years questions)

Bioinformatics-2
(EBT-502)

For
B.Tech Biotechnology III year Students

Dr. Ravindra Kumar Jain

Department of Biotechnology
Anand Engineering College
Agra
Questions based on Unit 1

1 Discuss an inference problem in molecular biology and its 10 Marks 2009,

computational biology perspective. Explain with a suitable 2008
example.
2 Discuss the flow of information stored in DNA to protein 10 Marks 2006
3 Enumerate key inference problems in molecular biology. 10 Marks 2007
Differentiate between orthologous and paralogous sequences 10 Marks 2005
4 Discuss Homology identification in biological sequence 10 Marks 2006
alignment.
5 What do you understand by gene regulatory network? Explain 10 Marks 2009
with a suitable example.
6 Discuss the current methods for genome sequencing and 10 Marks 2009,
importance of genome sequence annotation. Explain with 2008
suitable examples
7 Define Genome annotation? Explain in detail. 10 Marks 2005
8 Briefly discuss the Chou-fasman algorithm for secondary 10 Marks 2009
structure prediction of proteins.
9 Discuss the procedure of microarray data analysis and various 10 Marks 2009
software tools used for the purpose.
10 What is network identification. Explain in detail 10 Marks 2008
11 Briefly enumerate the various methods of protein structure 10 Marks 2008,
prediction. 2007
2005
12 What do you mean by protein function prediction. Explain 10 Marks 2007
with a suitable example. 10 Marks 2006
13 Define any one computational method for 3-D protein 07 Marks 2007
structure modeling. 10 Marks 2005
14 Define pairwise sequence alignment. Differentiate between 07 Marks 2007
local and global alignment. 05 Marks 2005
Questions based on Unit 2

1 Describe the advantage of clustering techniques in 10 Marks 2009,

computational molecular biology (microarray data analysis). 2008
2007
2006
2005
2 Discuss the various applications of regression analysis in 10 Marks 2009
bioinformatics
3 Describe regression and statistical inference methods applied 10 Marks 2008
in bioinformatics analysis 2007
2006
4 Explain the concept of Dimentionality reduction and its utility 10 Marks 2009
in solving the molecular biology problems.
5 What is artificial neural network? Discuss the applications of 10 Marks 2009
feed forward back propagation method in protein structure 09 Marks 2008
prediction. 09 Marks 2007
10 Marks 2006
6 Discuss the applications of Support Vector Machines 05 Marks 2009
05 Marks 2005
7 What is Bayes rules. Explain its theorem in biological system. 10 Marks 2008
2007
2006
2005
8 Explain applications of Statistics in Bioinformatics 10 Marks 2008,
2007
2005
9 Describe the applications and limitations of Machine Learning 09Marks 2008
approach. 10 Marks 2007
05 Marks 2005
10 Explain applications of Genetic algorithm in bioinformatics 09Marks 2008
09 Marks 2007
10 marks 2006
05 Marks 2005
11 Briefly explain parametric test, cross validation and empirical 09 Marks 2008
significance testing. 10 Marks 2005
12 Explain different Data Mining methods 07 Marks 2008
07 Marks 2008
10 Marks 2005
Questions based on Unit 3

1 What is biological bibliographic database. Explain with 10 Marks 2009

examples. 07 Marks 2007
2 Discuss how large biological documents are managed 07 Marks 2008
3 What do you understand by sensitivity analysis of a 10 Marks 2009
bioinformatics software tool.
4 What are differential equation simulators, explain with suitable 07 Marks 2008
example
5 Explain discrete and hybrid simulation applications in 07 Marks 2008
molecular biology
6 Describe the general simulation techniques applicable to 07 Marks 2007
biological problems. 10 Marks 2006
10 Marks 2005
7 Give the name of two most common computational operations 07 Marks 2008
performed in continuous simulation. 07 Marks 2007
8 How management information system is applied in 07 Marks 2007
bioinformatics.
9 Discuss the importance of literature database in bioinformatics 10 Marks 2006
Questions based on Unit 4

1 How bioinformatics can help in novel drug design. What is 10 Marks 2009
QSAR analysis.
2 What is Pharmacogenomics. Mention their applications in drug 10 Marks 2009
discovery.
3 Explain any one method for protein-ligand docking in drug 07 Marks 2008
designing. 07 Marks 2007
05 Marks 2005
4 Discuss recent trends in Computational drug designing 07 Marks 2008
10 Marks 2007
10 Marks 2006
05 Marks 2005
5