PHYSICAL PHARMACY

DEFINE – 1 MARK

Micromeritics, Colloids, CMC, Surface tension, Viscosity, Surface active agent, Emulsifying
agent, Complexation, Rheology, Thixotropy, Rheopexy, craft point, cloud point, HLB,
spreading coefficient, Brownian motion, Chelate complex, Micro emulsion, buffer capacity,
and polymorphism.

SHORT NOTE: 5-6 MARKS

1. Method determination of particle size. Explain optical microscopy.

2. Coulters counter method, Capillary rice method
3. Phase rule. Phase diagram of one component system.
4. S.N on Angle of repose, Carr’s index, Hausner ratio
5. Thixotropy. Measurement of thixotropy.
6. Define Newtonian flow. Application of rheology in pharmacy.
7. Write note on aerosol. Describe Ideal & Real solution
8. S.N on Plastic, Pseudoplastic , Dilatant flow. / Non- Newtonian flow
9. Protective colloid
10. Application of Complexation in pharmaceutical.
11. Organic & Inclusion complex.
12. Different method to measurement of surface tension.
13. Electrical double layer & zeta potential.
14. Factor affecting suspension and type of suspension.
15. DLVO Theory. Diff bet lyophilic and lyophobic colloid.
16. Different between flocculated and deflocculated suspension.
17. Physical stability of emulsion.
18. Define associate colloids. Electrical properties of colloids.
19. Define Buffer index. Important of buffer in pharmaceutical.
20. Define isotonicity. Measurement of isotonic calculation and PH adjustment.
21. Type of emulsion. Evaluation test of emulsion.
22. Write law of distribution. SN on solubility of Gases in liquids.
PHARMACEUTICAL CHEMISTRY

DEFINATION 1 MARK

Surface tension, Refractive index, Reverse osmosis, Optical rotation, Particle coefficient,
Adsorption, Thermochemistry, Half life, shelf life, entropy, lattice energy, rate constant,
Parachor, Degree of freedom, Henry’s law, Dipole moment, Stability, Quantum efficiency,
Radio isotopes, Conductance.

SHORT NOTE 5-6 MARKS

1. Short note on colligative properties. Explain any one in detail.

2. Derive equation to determine surface tension. S.N On capillary rise method.
3. Important of specific conductivity. S.N On Debye-Huckel theory.
4. Method determination of refractive index.
5. Explain Raoult’s law.
6. Explain triple point of water. Explain importance in changes of states.
7. Gibb’s adsorption isotherm.
8. Application of adsorption in pharmacy. Explain Langmuir’s Adsorption isotherm.
9. S.N on thermodynamic first law.
10. Method measurement of radioactivity. Complexing agent used in therapy.
11. Draw Jablonski diagram.
12. Beer’s Lambarts law.
13. Phase diagram of phenol water system.
14. Note on types of thermodynamic process. Explain second law of thermodynamic.
15. Factor affecting viscosity.
16. Method used to determination of order of kinetic. Explain second order kinetics.
17. G- M Counter. Scintillation counter.
18. Pharmaceutical application of photochemistry.
PHARMACEUTICAL ANALYSIS

DEFINATION- 1 MARK

Chromatography, Retention time, Accuracy, Resolution, Robustness, Dead volume, Capacity

factor, HETP, Validation, Migration current, band broadening, Equivalent conductance,
Stationary phase, Mobile phase, Indicator electrode, Racemic mixture, Specific conductance,
Extraction.

SHORT NOTE: 5-6 MARKS

1. What is signal to noise ratio. Source of noise in instrumental analysis.

2. Short note on thin layer chromatography.
3. Short note on oxygen combustion flask method.
4. Discuss different methods to locate the end point in potentiometry.
5. Write detail about TGA & DSC. List out Application of Thermal gravimetric analysis.
6. Write note on Gasometric method.
7. What is retention mechanisms involved in chromatography? Explain any 2 in detail.
8. Write note on dropping mercury electrode.
9. Discuss Biamperometric titration in detail.
10. Explain validation. Describe instrument validation method for analysis.
11. Explain Plate & Rate theory of chromatographic separation.
12. Type of Paper chromatography. Write application of Paper chromatography.
13. Explain principle and working of Glass electrode. Write limitation of it.
14. Write principle of column chromatography. Application of it.
15. Factor affecting diffusion current.
16. S.N on Multiple extractors. Explain Soxhlet Apparatus.
17. What is calorimetry? Type of Calorimetry.
18. What is electro analytical technique? Classify electro analytical technique.
19. Instrumentation of Polarimeter. Application of Polarimeter. Write component of
Polarogram.
20. Classify chromatographic techniques. Enlist separation mechanism in
chromatography.