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Roseroot is best absorbed when taken on an empty stomach, 20 minutes before breakfast/lunch

or 2 hours after a meal (Cuerrier & Ampong-Nyarko, 2015).  It is dosed starting at 100-150
mg/day and increased every 3-7 days by 100-150 mg to a max dose of 600 mg/day (Cuerrier &
Ampong-Nyarko, 2015). When used for depression as monotherapy individuals may need to
utilize 750 mg/day (Cuerrier & Ampong-Nyarko, 2015).  This herbal supplement can be utilized
as long as needed as a maintenance treatment for depression. There may be people who find an
increase in sensitivity and experience anxiety, jitteriness, or agitation (Cuerrier & Ampong-
Nyarko, 2015).
Roseroot is known to have a mildly stimulating effect. It does not cause addiction, habituation, or
withdrawal symptoms unlike prescription stimulants (Cuerrier & Ampong-Nyarko, 2015).  Due
to the stimulating effect, it is reasonable to reduce caffeine intake. There is some thought that
roseroot can increase fertility in childbearing age women (Cuerrier & Ampong-Nyarko, 2015).
Currently, there are no reported adverse interactions with pharmacological medications.
Individuals utilizing roseroot at high doses may experience adverse reactions just like
prescription medications. At high doses, individuals may experience insomnia, irritability,
vivid/lucid dreams, platelet aggregation and headaches (Aswathi, Venkateswaramurthy, &
Kumar, 2019). Increased platelet aggregation may increase bruising in susceptible individuals. It
has also been found that roseroot extract can bind to estrogen receptors in the body and should
not be used in individuals with a family history of breast cancer (Aswathi, Venkateswaramurthy,
& Kumar, 2019).
Side effects can be a reason individuals decide to discontinue medications.  
Reference
Aswathi, T., Venkateswaramurthy, N., & Kumar, R. S. (2019). A Review on Relevance of
Herbal Medications for Psychiatric Patients. Research Journal of Pharmacy and
Technology, 12(7), 3151. doi: 10.5958/0974-360x.2019.00531.6

Cuerrier, A. (Ed.), Ampong-Nyarko, K. (Ed.). (2015). Rhodiola rosea. Boca Raton: CRC
Press, https://doi-org.proxy.libraries.uc.edu/10.1201/b17903 (Links to an external site.)
Ravindran, A. V., Balneaves, L. G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R. L.,
Ravindran, L., Yatham, L. N., Kennedy, S. H., Lam, R. W., MacQueen, G. M., Milev, R. V.,
Parikh, S. V., & CANMAT Depression Work Group (2016). Canadian Network for Mood and
Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with
Major Depressive Disorder: Section 5. Complementary and Alternative Medicine
Treatments. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 61(9), 576–587.
https://doi.org/10.1177/0706743716660290