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Isotonic fluid: osmolarity (level of concentration) the fluid approaches the serum (the liquid
part of the blood component), so it continues to be in the blood vessels. Useful for patients
experiencing hypovolemia (lack of body fluids, so blood pressure continues to fall). Have a
risk of overload (excess fluid), especially in congestive heart failure and hypertension.
Examples are Ringer-Lactate fluid (RL), and normal saline / physiological saline solution
(NaCl 0.9%).
Hypertonic fluid: its osmolarity is higher than that of serum, so it "draws" fluids and
electrolytes from tissues and cells into blood vessels. Able to stabilize blood pressure,
increase urine production, and reduce edema (swelling). Its use is contradictory to
hypotonic fluid. For example Dextrose 5%, hypertonic 45% NaCl, Dextrose 5% + Ringer-
Lactate, Dextrose 5% + NaCl 0.9%, blood products (blood), and albumin.