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Biochemistry 3G03

Biochemistry of Macromolecules
Term I (2010-2011)
Course Outline
Dr. Daniel Yang. Office: HSC-4H31a, yang@mcmaster.ca
Dr. Russell Bishop. Office: HSC-4H19, bishopr@mcmaster.ca

Teaching Assistants:
Kondratyev, Maria, mashlo88@gmail.com
Mulder, David, mulderdt@mcmaster.ca

Introduction: Chemical and conformational properties of proteins and relationships to their function including regulation
of enzyme activity. Chemical and physical structure of DNA and RNA relevant to biological function.

Evaluation: It will be based on five tests and a final examination (all multiple choices). Students are responsible for
materials covered in the textbook and lectures. The final grade will be calculated using the following two schemes and the
higher of the two will be used: Scheme A - Five tests only (20% each); Scheme B - The best four of the five tests (15% each)
+ final examination (40%). No make-up tests will be offered. If you miss a test without an ‘approved’ note from the Dean
of your program, the test will receive a grade of ZERO. If you miss one test (with the exception of the fifth test) and have an
‘approved’ note from the Dean, your grade will be calculated as: Scheme A - Four tests only (25% each); Scheme B - The
best three of the four tests (20% each) + final examination (40%). If you miss the fifth test and have an ‘approved’ note
from the Dean, your grade will be calculated based on Scheme B - The best three of the four tests (20% each) + final
examination (40%). If you miss more than one test and have ‘approved’ notes from the Dean, your grade will be calculated
based on Scheme C – All tests that you wrote (60%) + final examination (40%). Deferred examination will be evaluated
based on Scheme B or C. “Discretionary notes from the Dean’s office will not be accommodated.” Percentage grade will
be converted to a final letter (see Table below).

% Letter % Letter % Letter % Letter % Letter

100-90 A+ 79 - 77 B+ 69 – 67 C+ 59-57 D+ 49-0 F
89 – 85 A 76 - 73 B 66 – 63 C 56-53 D
84 – 80 A- 72 - 70 B- 60-62 C- 52-50 D-
All percentage grades within 0.5% of the next letter grade will be reviewed.

Questions: Students are encouraged to ask questions in class and use Learnlink for discussion.

Textbook: Fundamentals of Biochemistry, 3rd edition. D.Voet, J.G.Voet, and C.W.Pratt. Wiley & Sons Inc. 2008.

Academic ethics: Students are asked to reread two documents provided on registration, the Senate Statement on
Academic Ethics and the Senate Resolutions on Academic Dishonesty. Students should be sure that they understand the
expectations the University has of its scholars, and the possible consequences when these expectations are not met.

Academic dishonesty consists of misrepresentation by deception or by other fraudulent means and can result in serious
consequences, e.g. the grade of zero on an assignment, loss of credit with a notation on the transcript (notation reads: “Grade
of F assigned for academic dishonesty”), and/or suspension or expulsion from the university. It is your responsibility to
understand what constitutes academic dishonesty. For information on the various kinds of academic dishonesty please refer
to the Academic Integrity Policy, specifically Appendix 3, located at:

Additional notes: The instructor and university reserve the right to modify elements of the course during the term. The
university may change the dates and deadlines for any or all courses in extreme circumstances. If either type of modification
becomes necessary, reasonable notice and communication with the students will be given with explanation and the
opportunity to comment on changes. It is the responsibility of the student to check their McMaster email and course
websites weekly during the term and to note any changes.
Schedule of Lectures, Office hours & Tests. Place: BSB/147
Lectures: Mo We (8:30-9:20), Fr (10:30-11:20); Office hours: Mo Wed (9:30-10:20)
Date Lecture # Topics – remarks Chapter
10-Sep Friday 10:30 1 Organization
13-Sep Monday 8:30 2 Introduction, Chemistry of Life 1
15-Sep Wednesday 8:30 3 Thermodynamics, Water, Acid-Base 1, 2
17-Sep Friday 10:30 4 Acid-Base, Buffer 2
20-Sep Monday 8:30 5 Nucleotides and Nucleic Acids 3
22-Sep Wednesday 8:30 6 Genetic Information 3
24-Sep Friday 10:30 T1 Evaluation One (ch 1, 2, 3)
27-Sep Monday 8:30 7 Nucleic Acid Structure 24
29-Sep Wednesday 8:30 8 Nucleic Acid Structure 24
1-Oct Friday 10:30 9 DNA Replication, Repair & Recombination 25
4-Oct Monday 8:30 10 DNA Replication, Repair & Recombination 25
6-Oct Wednesday 8:30 11 Transcription & RNA processing 26
8-Oct Friday 10:30 T2 Evaluation Two (+ ch 24, 25)
11-Oct Monday 8:30 Thanksgiving - no class
13-Oct Wednesday 8:30 12 Transcription & RNA processing 26
15-Oct Friday 10:30 13 Protein Synthesis 27
18-Oct Monday 8:30 14 Protein Synthesis 27
20-Oct Wednesday 8:30 15 Protein Synthesis 27
22-Oct Friday 10:30 T3 Evaluation Three (+ ch 26, 27)
25-Oct Monday 8:30 16 Amino Acids 4
27-Oct Wednesday 8:30 17 Amino Acids 4
29-Oct Friday 10:30 18 Proteins: Primary Structure 5
1-Nov Monday 8:30 19 Proteins: Primary Structure 5
3-Nov Wednesday 8:30 20 Proteins: 3-D Structure 6
5-Nov Friday 10:30 21 Proteins: 3-D Structure 6
8-Nov Monday 8:30 22 Proteins: 3-D Structure 6
10-Nov Wednesday 8:30 23 Protein Functions 7
12-Nov Friday 10:30 T4 Evaluation Four (+ ch 4, 5, 6)
15-Nov Monday 8:30 24 Protein Functions 7
17-Nov Wednesday 8:30 25 Protein Functions 7
19-Nov Friday 10:30 26 Enzymatic Catalysis 11
22-Nov Monday 8:30 27 Enzymatic Catalysis 11
24-Nov Wednesday 8:30 28 Enzymatic Catalysis 11
26-Nov Friday 10:30 T5 Evaluation Five (+ ch 7,11)
29-Nov Monday 8:30 29 Enzyme Kinetics etc. 12
1-Dec Wednesday 8:30 30 Enzyme Kinetics etc. 12
3-Dec Friday 10:30 31 Enzyme Kinetics etc. 12
6-Dec Monday 32 Review
To be announced Final Exam (+ ch 12)

List of sections to be omitted will be posted on Learnlink. Location of Tutorials will be posted on Learnlink. Tutorials
are scheduled for Tue, Wed and Thur evenings (4:00-5:00 pm and 5:00 – 6:00 pm) before each Test.