Complete

Brain Charge
By Dr. Lynn Toohey
We have always recognized the essential role for choline. Choline is a
necessary element and building block for the structural components of
cell membranes and helps account for fluidity and communication
within those membranes. Choline is essential for phosphatidylcholine
and sphingomyelin, which are the two major phospholipids in cell
walls. Choline is the precursor molecule for the neurotransmitter
acetylcholine, which is involved in many functions of the brain and
muscles.
Choline has many forms, several of which have been called “designer
cholines” because they exhibit properties above and beyond regular
choline. Two of these designer cholines are known as alpha-GPC, or
Alpha Glycerolphosphorylcholine, and CDP choline, or Cytidine 5'-diphosphocholine.

CHOLINE INCREASES ABSORPTION!

Additionally, phosphtidyl choline and phosphatidyl serine have been discovered as nutritional
additions to help boost the absorptive power of other ingredients that are given in conjunction with
them, such as ginkgo and curcumin for instance (Drug Deliv. 2014 Nov 4:1-9. Curcumin-loaded nanostructured lipid carriers
(NLCs) for nasal administration: design, characterization, and in vivo study.Madane RG, Mahajan HS.; Hum Psychopharmacol. 2007
Jun;22(4):199-210. Acute effects of standardized Ginkgo biloba extract complexed with phosphatidylserine.Kennedy DO et al.; Planta Med. 2001
Jun;67(4):326-30. Complexation of Ginkgo biloba extract with phosphatidylcholine improves activity and increases the plasma antioxidant capacity
in the rat.Carini M, et al.; Phytother Res. 2006 Oct;20(10):901-5.Neuropharmacological evaluation of Ginkgo bilobaphytosomes...Naik SR, et al.)

Complete Brain Charge is good support for: Brain function; healthy aging; cognitive function;
acetylcholine, &neurotransmitter production; energy; general well-being.

DESIGNER CHOLINES: Alpha GPC and Cytidine 5'-diphosphocholine (CDP-Choline)

Alpha Glycerolphosphorylcholine (Alpha GPC demonstrated a support benefit for patients in a

number of clinical studies conducted on the brain and maintenance of brain function. In fact, the
researchers, “being impressed not only with results but in lack of side effects, recommended that it is
desirable to reconsider Alpha Glycerolphosphorylcholine in larger carefully controlled studies … for
the maintenance of brain function” (Scapicchio PL. Revisiting choline alphoscerate profile: a new, perspective, role…Int J Neurosci.

“Supplementation with alpha-GPC and CDP choline (Cytidine 5'-diphosphocholine)

has proven to be much superior to supplementation with just basic choline for brain
support and normal neurotransmitter production. It is theorized that these designer
cholines are able to be better incorporated and stored into the phospholipids in the
brain, and therefore make better precursors for acetylcholine”
- Amenta F, Tayebati SK. Pathways of acetylcholine synthesis, transport and release. Curr Med
Chem. 2008;15(5):488-98.
2013 Jul;123(7):444-9.)

More on alpha GPC:

A multicenter, randomized, controlled study compared the efficacy (for
brain support) of alpha-GPC among 126 patients, and found that alpha GPC
provides excellent support (Drugs Aging. 1993 Mar-Apr;3(2):159-64.Multicentre study of l-
alpha-glyceryl-phosphorylcholine. Parnetti L. et al.)

“Alpha-Glycerolphosphorylcholine, (alpha-GPC) is a derivative of phosphatidyl choline known

to support the parasympathetic nervous system. Alpha-GPC demonstrated benefit for patients in
a number of clinical studies conducted on the brain and maintenance of brain function. The
researchers, being impressed not only with results but in lack of side effects, recommended that
“it is desirable to reconsider alpha-GPC in larger carefully controlled studies”, … for the
maintenance of brain function. Scapicchio PL. Revisiting choline alphoscerate profile: a new, perspective, role…?Int J
Neurosci. 2013 Jul;123(7):444-9.

CDP Choline undergoes quick hydrolysis and dephosphorylation after ingestion to yield cytidine and
choline, which then enter the brain separately and are used to resynthesize CDP-choline inside brain
cells. A research paper reviews the roles of choline and of choline-containing phospholipidson brain
metabolism, stating that (CCPLs) are safe, effective compounds developed a long time ago thathave a
place in this support category and should be further investigated by new appropriate clinical studies.
They also report that CDP-choline has displayed interesting effects documented in preclinical studies
and limited clinical trials for its neurotransmission support (ClinChem Lab Med. 2013 Mar 1;51(3):513-21. Choline-
containing phospholipids: relevance to brain functional pathways.Tayebati SK1, Amenta F.) In an open, multicenter trial, CDP
choline supported biosynthesis of phospholipids in neuronal membranes, brain metabolism,
neurotransmitters, and the central nervous system (ClinInterv Aging. 2013;8:131-7. Effectiveness and safety of citicoline…: the
IDEALE study.Cotroneo AM1, et al.)

Brain Power Nutrients:

Curcumin (Turmeric (95% curcuminoids)) is one of the most studied herbs for cognitive support
(Planta Med. 2014 Oct;80(15):1249-58. Mechanisms of action of phytochemicals from medicinal herbs ….Kim MH, et al.) Curcumin
boosts DHA in the brain (BiochimBiophysActa. 2014 Dec 27;1852(5):951-961. Curcumin boosts DHA in the brain: Implications...Wu
A, et al.) DHA is the long chain fatty acid that is essential for brain development and has been found in
numerous clinical trials and observational studies to support cognitive function (Yurko-Mauro K. et al.
Docosahexaenoic Acid …: a systematic review and meta-analysis.PLoS One. 2015 Mar 18;10(3):e0120391.) Curcumin demonstrated
support for both nerve and glial cells (glial cells are non-neuronalcells that maintain homeostasis,
form myelin, and provide support for neurons in the brain and peripheral nervous system) and axonal
microenvironment (J Surg Res. 2015 Jan 7. pii: S0022-4804(15)00006-2. Curcumin…Yuan J, et al.)
One review searched the literature (including PubMed, Science Direct, Scopus, and Cochrane
Library)and found mechanisms of action to explain why the constituents of plants have support
potential for neurotransmitters, including curcumin (Rev Neurosci. 2015 Feb 14. Plant-derived natural medicines for the
management of depression: an overview of mechanisms of action.Farahani MS, et al.) Curcumin from Curcuma longa interact with D1 and D2
receptors as well as elevate the brain dopamine level) On mechanism of support seems to be through Vitamin D
receptors.
Brain Power Nutrients: (cont’d)
Turmeric (95% curcuminoids): Some scientists recognize the huge impact that a dietary component
like curcumin can have: “The development of curcumin for clinical use as a regulator of epigenetic
changes needs further investigation to determine novel and effective strategies, either alone or in
combination with other agents, for improving outcomes”(Simone Reuter et al. Genes Nutr. 2011 May; 6(2): 93–108.)

Ginkgo Biloba Extract (24% ginkgosides, 6% terpene lactones): Clinical trials report outcomes
documenting brain support in patients (J Stroke Cerebrovasc Dis. 2013 Nov;22(8):e557-63. The effect of Ginkgo biloba…: a
double-blind, placebo-controlled, randomized clinical trial.Oskouei DS1, et al.) In an open clinical pilot study, GBE was
administered to 20 children over 3 to 5 weeks. Ginkgo was found to have ideal characteristics to
support the brain and behavior in children (Z Kinder JugendpsychiatrPsychother. 2014 Sep;42(5):337-47. Ginkgo biloba extract in
children with ADHD.Uebel-von Sandersleben H. et al.)

Ginkgo, along with phosphatidyl choline and phosphatidyl serine are the most frequently
recommended nutritional substances for cognitive support, “often in combinations with many other
substances” (J Neuropsychiatry ClinNeurosci. 2010 Summer;22(3):345-7. A study of herbal remedies for memory complaints.Serby MJ, et. al.)

Phosphatidyl Serine or phosphatidyl choline combined with ginkgo biloba appears to potentiate the
effects of a low dose of ginkgo biloba (Hum Psychopharmacol. 2007 Jun;22(4):199-210. Acute cognitive effects of standardized
Ginkgo biloba extract complexed with phosphatidylserine.Kennedy DO et al.) The data suggest that combining standardized
Ginkgo biloba extract (GBE) with soy-derived phospholipids enhances the bioavailability of GBE's
active components. The current study therefore aimed to assess the comparative effects of a low dose
of GBE with either phosphatidyl serine or phosphatidyl choline. The study utilized a placebo-
controlled, multi-dose, double-blind, balanced-crossover design. Twenty-eight healthy young
participants received either GBE, GBE with phosphatidylserine, or GBE with phosphatidylcholine or
placebo. Ginkgo together with phosphatidylserine had the biggest effect, followed by ginkgo with
phosphatidyl choline.
Complete Brain Charge
The new designer cholines are available providing effective synergy for charging the brain with necessary
building blocks and essential nutrients to power brain support, with sufficient lipid mobilizers for
increased absorption (phosphatidyl- serine and choline).

Each Tablet Contains: Choline (as bitartrate) 24 mg, Proprietary blend 143.2
mg* of: Ginkgo Biloba Extract (24% ginkgosides, 6% terpene lactones),
Phosphatidyl Choline (as sunflower lecithin), Phosphatidyl Serine,
Alpha Glycerolphosphorylcholine, Turmeric (95% curcuminoids), Cytidine 5-
diphosphocholine.

60– Tablets per bottle 1540*** – Product Number

Contraindications: Some ingredients in Complete Brain Charge are

derived from soy, but they do not contain the soy protein (amino acid
sequence).

***No Frees with this product

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The above statements have not been evaluated by the FDA. The nutritional information, suggestions, and research
provided are not intended to diagnose, treat, cure, or prevent disease and should not be used as a substitute for sound
medical advice. Please see your health care professional in all matters pertaining to your physical health.