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CLASA EXEMPLE ORIGINE SPECTRU MOD DE ACTIUNE

Beta-
Penicillium Inhiba etape in sinteza
lactamine- Penicilina G,
notatum si Gram pozitive peretelui(peptidoglican)
peniciline si Cephalothin
Cephalosporium si asamblarea mureinei
cefalosporine
Inhiba etape in sinteza
Beta-lactamine Ampicilina, Gram-pozitive
peretelui(peptidoglican)
semisintetice Amoxicilina Gram-negative
si asamblarea mureinei
Augmentin - Gram-pozitive
Streptomyces Inhibitor de bacterial
Acid Clavulanic clavulanic acid si Gram-
clavuligerus beta-lactamaze
plus Amoxicillin negative
Inhiba etape in sinteza
Gram-pozitive
Chromobacterium peretelui
Monobactami Aztreonam si Gram-
violaceum (peptidoglican) si
negative
asamblarea mureinei
Gram-positive
Inhiba etape in sinteza
Streptomyces si Gram-
Carbapenemi Imipenem peretelui(peptidoglican)
cattleya negative
si asamblarea mureinei
bacteria
Gram-pozitive
Streptomyces Inhibits traducerea
Aminoglicozide Streptomicina si Gram-
griseus (sinteza proteica
negative
Gram-pozitive
si Gram-
Micromonospora Inhiba traducerea
Gentamicina negative
kjjj (sinteza proteica)
Pseudomonas
aeruginosa
Amycolatopsis Bacterii G+ Inhiba etape in sinteza
Glicopeptide Vancomicina orientalisNocardia Staphylococcus peretelui(peptidoglican)
orientalis aureus si asamblarea mureinei
Gram-pozitive
and Gram- Inhiba traducerea la
Streptomyces
Lincomicine Clindamicin negative esp. nivel ribozomal (sinteza
lincolnensis
anaerobic proteica)
Bacteroides
Gram-positive
bacteria, Gram-
negative
Erythromycin, Streptomyces bacteria not Inhiba traducerea
Macrolide
Azithromycin erythreus enterics, (sinteza proteica
Neisseria,
Legionella,
Mycoplasma
Distruge membrana
Polipeptide Polymyxin Bacillus polymyxa Gram-negative
citoplasmatica
Inhiba etape in sinteza
Bacitracin Bacillus subtilis Gram-pozitive peretelui(peptidoglican)
si asamblarea mureinei
Streptomyces Fungi Inactiveaza membrane
Polienes Amphotericin
nodosus Histoplasma cu steroli
Streptomyces Inactiveaza membrane
Nistatin Fungi Candida
noursei cu steroli
Gram-pozitive
and Gram- Inhiba transcrierea
Streptomyces
Rifamicine Rifampicin negative, (bacterial ARN
mediterranei
Mycobacterium polimeraza bacteriana)
tuberculosis
Gram-pozitive Inhiba traducerea
Streptomyces and Gram- traducerea la nivel
Tetracicline Tetraciclina
species negative ribozomal (sinteza
Rickettsia proteica
Gram-pozitive
and Gram- Inhiba traducerea
Tetracicline negative traducerea la nivel
Doxycycline
Semisintetice Rickettsia ribozomal (sinteza
Ehrlichia, proteica
Borrelia
Inhiba traducerea
Gram-pozitive
Streptomyces traducerea la nivel
Cloramfenicol Chloramphenicol and Gram-
venezuelae ribozomal (sinteza
negative
proteica)
Quinolone Nalidixic acid sintetic Gram-negativ Inhiba replicarea ADN
Fluoroquinone Ciprofloxacin sintetic Gram-negativ Inhiba replicarea ADN
si unele Gram-
pozitive
(Bacillus
anthracis)
Analogi de Sulfanilamide, sintetic Gram-pozitive Inhiba metabolismul
factori de Gantrisin, si Gram- acidului folic (anti-folat)
crestere Trimethoprim negative
Isoniazid (INH) sintetic Mycobacterium Inhiba sinteza acidului
tuberculosis micolic analog al
pyridoxin (Vit B6)
para- sintetic Mycobacterium
aminosalicylic tuberculosis
acid (PAS)