Title Pattern Recognition: Applied To Medicine Requested Award Elements

PROPOSAL NO* ^0^118
OOJ CLASS i*LlO

TITLE PATTERN RECOGNITION APPLIED TO MEDICINE
REQUESTED AWARD ELEMENTS: AMOUNT 0 013 88000

EFF.OATE Q2G17<*
DATE REC 112373
ST. OATE
ENO DATE
AHO OUR
ACT OUR
INST CODES (SUBMIT) 0018259003
(COLLAB) 0000000000
ORG COOE 03030501
PROG ELE
OEPT NAME SCH OF ELECTRICAL ENGI
CAT OF AWO
SUPPORTEE SSN ANO TITLE 1-2 23<»5671211
OLD NSF PROP NUMBER P<»K0<+95GG0

Purdue Research Foundati
5
DIVISION OF SPONSORED
EXECUTIVE BUILDING
PROGRAMS
WEST LAFAYETTE, INDIANA 47907

74 - 6 4 -s
Ref:DSP#6168 Octobe
Central Processing Section

National Science Foundation
1800 G Street, N.W.
Washington, D. C. 20550
Gentlemen:
Enclosed, for consideration of support by the National Science

Foundation, are ten (10) copies of a research proposal entitled
"Pattern Recognition Applied to Medicine" prepared by Professor
Edward A. Patrick of Purdue University's School of Electrical
Engineering. Support is requested for the period February 1,
1974, through January 31, 1976, at the level of $87,973.
We hereby certify that Purdue Research Foundation-Purdue University

will comply with current National Science Foundation regulations
on cost sharing.
Please refer to the proposal for a description of other research

projects, either current or pending, being conducted by Professor
Patrick.
This proposal is being submitted only to the National Science

Foundation for consideration of support.
Please refer technical questions concerning the proposal to Pro

fessor Patrick at West Lafayette, Indiana, telephone 317+463-7121.
Fiscal matters should be referred to Mr. T. L. Gardner, Project
Administrator, Office of Contract Administration, Purdue Uni
versity, West Lafayette, Indiana, telephone 494-8461. If I can
be of assistance, I can be reached by telephone at 749-2113.
Favorable consideration of this proposal will be appreciated.
ery truvLy yours,
i. Davis, Associate Director

Division of Sponsored Programs
RLDikr
enclosures
cc: E. A. Patrick
C. L. Coates
R. A. Greenkorn
A PROPOSAL FOR RESEARCH
ON
PATTERN RECOGNITION APPLIED TO MEDICINE
Prepared by
School of Electrical Engineering

Purdue University
West Lafayette, Indiana
Submitted to
NATIONAL SCIENCE FOUNDATION
through
Purdue Research Foundation
Lafayette, Indiana
July 30, 1971*
Project Period Oct. 1, 1974 - Sept. 30, 1976 Amount Requested $79,917.00
PRINCIPAL INVESTIGATOR: APPROVED:
Edward A. Patrick C. L. Coates, Head

Professor of Electrical Engineering School of Electrical Engineering
Telephone No. (317) ^93-3027 Telephone No. (317) 7^9-2607
July 1971*
■C
hn C. Hancock \J
/an of Engineering
telephone No. (317)
S. M. Marks, Assistant DirecTfor

:..'r\M•' .
; WASHINGTON, 0. C. 20550 [ { ) MASTER DATA FORM ( ' ( )
. PROPOSAL NUMBER 2. DATE RECEIVE* 3. NSf DIVISION (OFfiCE>7SSCTION
11/23/73 Engineering
S. PROPOSED EFF. DATE 6. PROPOSED O«y Wk Mo
ACTIVITY 7. PROPOSED
88,000 02/01/7^ OURATION
nan DURATION
IESEARCH ON Pattern Recognition Applied to Medicine
E /£«»/. Firtl. HI.) 14. APPLICANT INSTITUTION (NSF Directory Nsmt) HA. CODE
PATRICK, Edward A. Purdue University 0018259-00-

0. STATUS IS. DEPARTMENT
Q
PRINCIPAL I 1 PROJECT
INVESTIGATOR I | DIRECTOR | | ADMINISTRATOR
School of Electrical Engineering;
I. INSTITUTION (If different from 14.) 11 A. CODE 16. BRANCH/CAMPUS
0018259 00
2. ADORES 17. COMPONENT
3. BRANCH/CAMPUS E18. ADDRESS (City. Stilt, end Zip orCountry)
/.Lafayette % Indiana Rgkfig 47907

9. ADDITIONAL PI/PO 19A. S.S.N. 20. ADDITIONAL PI/PD 20A. S.S.N.
1. ADDITIONAL PI/PD 21A. S.S.N. 22. ADDITIONAL PI/PD 22A. S.S.N.
23. ORGANIZATION (Propim Name) Control and Automation Prog ram 23a. code 3351
4. PROGRAM ACCOUNT 24A. COOE
K. OBJECT CLASS
Basic Research Qrants 2SA. COOE
4110
28. FIEIO OF SCIENCE OR ENG. 26A. CODE
AREAS OF SPECIAL INTEREST (S miy bt itUetii) 32. TYPE OF ACTION (Project)
27. 27A. CODE NEW 4 Q REDUCTION

28. 28A. CODE 2 Q SIMPLE RENEWAL 5 ^COMMITTED RENEWAL
29. 29A. CODE 31 | SUPPLEMENT REF. NO.
30. 30A. CODE 33. CONTINUING GRANT
31. 31A. CODE YES t \ | NO
36. WITHDRAWAL 37. DECLINATION 38. REASON FOR DECLINATION^

MO-DAY-VR NUMBER MO-DAY-YR NUMBER
I ) NO FUNOS Q OTHER
39. DATE P.O. RECOMMENDS AWARD 40. SIGNATURE OF PROGRAM DIRECTOR
41. RECOM. EFFECTIVE DATE 42. RECOM. AWARO AMOUNT 43. RECOM. AWARO OURATION 44. RECOM. Diy Wk Mo
ACTIVITY t-\ f—. r—i
$ MONTHS OURATION | | | | |_J.
45. TITLE CHANGE (Use only for chanie to 8.)
46. FORM 469 ATTACHED 47. INCOME POTENTIAL 48. ACADEMIC INST. 49. PERFORMING SITE (If different from IS.)
□ YES □ NO □ YES □ NO n YES □

FOR NEW CONTINUING GRANTS. GIVE FUTURE COMMITMENTS BY FI3CAL YEAR
60. FY 61. FY 52. FY
54. PROGRAM RATING OF PROPOSAL 55. INTERNATIONAL IMPLICATIONS

(for Grin It only)
Y~\ FOREIGN TRAVEL I | FOREIGN PROCUREMENT ^Coorfi <w Senlcet)
Q FOREIGN CITIZENS I I LIAISON WITH OR SUPPORT OF
INTERNATIONAL ORGANIZATIONS
PROJECT AT FOREIGN
a □ >*»TICI>ATION IN INTERNATIONAL PROG

56. FUNOS AVAILABLE AND COMMITTED 57. AMOUNT 58. FISCAL YEAR 69. AWARD TYPE 60. LOT NUMBER
(Sifruture cndDtte)
FOR FMO
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USE ONLY
61. REMARKS
NSF torn 1, Feb. 1970

COPY B—PROGRAM
PROPOSAL INFORMATION
PROQRAM SHEET
2. Block No. 3. AulgnceName '3a. Code 4. Type of Request/Award |4a. cod*
(ENG-7404118) Caplan ■ 0 9 New 0 1

FORIOENTIFICATIONrPURPOSE ONLY
6. Submitting Initiation
Patrick. Edward A. Purdue University

SPECIAL PROQRAM DATA ELEMENTS
c. O. E. F. Q.
I I I J I L J I L
K. L. M. N.
J i i I I I J L_L I I I I 1 I I I I J I L
EDUCATION PROQRAM DATA
Participant!' Plidpllrw!
U.Cooptrttlng School Syit«ms
'Part* Count
I tm\. tiu. wrffft
i ; pwi. couai
D. O*tC0
■ I
C. OHcleMni I<LYft.Rtn«wil Op. 17.L*v.ofObcOI((.

■ ' '
It. PROPOSAL TITLE CHANQE (if
Pattern Recognition Applied to Medicine
19. FIELDS OF SCIENCE
a. ENGELECT 5. 5, Q Q Q Q
B.
C.
D.
E.
20. FIELDS OF APPLICATION
a. HEALTH 0Q2 ,0,3,0. 0, (
c.
o.
PROQRAM DIRECTOR'S PROPOSAL ACTION DATA

21. PO's lit PcoponlStitut{22 .PO I 2nd PropoMl StatK 23.PO'l 3rd PropoialSlatut 24.PO't 4th Proposal Statul 25. Program Director's
Dill Oltl Dili Priority
a : D j □ i
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□ Concurs □ Nonconcurs i—i Concur! i—i Nonconcur!
(Code 26) (Cod* 27) U (cod* 36) U(Cod« 371
26E. FINAL ACTION: 27. WITHDRAWN
(Cod* IS)
□concurs Q Nonconcur!
28. Remark!
NSF Form 779. Dec. 73
•mî-TjtA' * rf/-*\
PROJECT N»P ORANT NO.
SUMMARY
4AME OP INSTITUTION (NSP OIK ADDRESS OP INSTITUTION fcr.ci.uoi • RANCH/CAMPUt «■ COMPONCHT)
Purdue University West Lafayette, Indiana
PRINCIPAL INVESTIGATOR SOCIAL SECURITY NO. DIVISION (OPPICE) AND DIRECTORATE
Patrick, Edward A. Engineering
Electrical Sciences and Analysis

PROPOSAL NUMBER PROGRAM
P4K0495-000 (ENG-7404118) Control and Automation

TITLE OP PROJECT
Pattern Recognition Applied to Medicine
SUMMARY OP PROPOSED WORK (limit TO II PIC
This research is concerned with using pattern recognition to store

information about the features attached to a disease (class) in a
class-feature relationship. The class-feature relationship simply
is a class with a list of significant features attached. More and
more information can be stored in the class-feature relationship to
approximate the class-conditional probability density, the ultimate
if statistical decision making is required. Abnormal feature values
for a patient can be provided to the computer-pattern recognition
system which can extract all classes which have these abnormal feature
values. The computer will not provide the physician with a decision
at this point; rather the computer provides the class-feature relation
ships for the classes indicated. At this point the computer-pattern
system is a consultant; the physician, viewing the material, can then
decide what features to take next or to recheck. Using the class-
feature relationship approach, an approach to training sample collection
is taken which will be consistent with, say, Bayes decision making. Thus,
decision making rules can be studied for a specific subset of diseases and
corresponding significant features.
ENG-74-04118 10/1/74 $79,600 24 Mos.
INSTRUCTIONS FOR USE
1. Program Office will complete all items appearing on the first copy; place Proposal Foldtr copy in the folder;
retain Program Suspense copy; and place other copies inside the folder envelope with carbons intact.
2. Grants and Contracts Office will post grant number, amount granted and inclusive project dates on the S.I.E. copy and
make distribution of remaining copies.
NSF Form 4, Jan. 1970
1. PROPOSAL FOLDER
EXHIBIT 1 > i~i
A PROPOSAL WR^tfESMf 11 ON US
PATTERN RECOGNITION APPLIED TO MEDICINE
Prepared by
PURDUE UNIVERSITY
Lafayette, Indiana 3
m
o
m
Submitted to GO
m
vn
Engineering Division o
en
Through
September, 1973
'roject Period - February 1, 1974 - January 31, 1976 Amount Requested $ 87 > 973
Previous Grant Number GJ1099
■RINCIPAL INVESTIGATOR: APPROVED:
'rof. Edward A. Patrick C. L. Coates, Head -^ Z?>

School of Electrical Engineering c" •"?'
17-463-7121 317-749-2609 • ^ £>
y^j. -Jcfvis, Associate Director John C. Hancock

tivision of Sponsored Programs Dean of Engineering
'urdue Research Foundation 317-749-2174
Organ
ObJ. Class
I. INTRODUCTION
II. INTRODUCTION TO THE THEORY OF MEDICAL CONSULTING AND DIAGNOSIS
III. REVIEW OF PATTERN RECOGNITION IN MEDICAL DIAGNOSIS AND CONSULTING

RELATIVE TO A NEW SYSTEM MODEL
IV. ON THE THEORY OF MEDICAL DIAGNOSIS AND CONSULTING
V. PROPOSED RESEARCH
VI. COMPUTER FACILITY
VII. BUDGET
VIII. RESUME OF PRINCIPAL INVESTIGATOR

RESEARCH FOR PATTERN RECOGNITION APPLIED TO MEDICINE
I. Introduction
1. The Principal Investigation
This is a proposal for two years of support, primarily salary, to investi
gate pattern recognition in medicine. Support is requested to begin February
1, 1974.
The princiapl investigator, Professor Edward A. Patrick, is on a one year
sabbatical until February 1974. During this time he expects to complete require
ments for the M. D. degree, as he now is a senior medical student.
In addition to being on the faculty at Purdue, Patrick is an Associate
Professor in the Indiana University School of Medicine. He also is a member of
the Regenstrief Institute for Health Care Delivery.
Research primarily will involve theory of computer assisted medical diagnosis
and consulting.
After spending several years on research in the 1960's concerned mostly with
statistical pattern recognition, Patrick became interested in introducing specific
a priori knowledge about the problem into the pattern recognizer. Because he
also had interest in medicine, the fact that in medicine there are thousands
of classes and measurements, and because of the potential for improving health
care delivery, Patrick chose the medical area for the problem source.
Research so far has shown that decision making in medical diagnosis requires
more than traditional pattern recognition concepts such as decision rules which
minimize or maximize a criteria. Rather, a "systems approach" is required
because of the large number of classes and measurements and the way a priori
medical knowledge is accumulated in medical textbooks and in physicians' memories.
Patrick has developed an approach which can be called a systems approach, whereby
subsystems are defined which contain subsets of classes and subsets of measurements.
-2-
Any such subsystems can correspond, for example, to a particular disease area
such as bacterial disease, or to an organ such as liver. For each class in a
subsystem there is a class-feature relationship incorporating features which
are defined to be significant for that class along with appropriate statistics.
This is only an introduction to the approach which is described in more detail in
the sections to follow.
2. APPROACH OVERVIEW
An approach to computer assisted medical diagnosis and consulting is in
troduced in reference [1] 'Introduction to the Theory of Medical Consulting and
Diagnosis", included here as Section II. This approach advocates a system with
a Consultant and a Decision Maker. Classes, subclasses, intermediate classes,
complex classes, measurements, features, complex features, class-feature
relationships, and significant features are all defined, and a system is developed.
The resulting system can be, in a simplified manner, described as follows.
The user, a physician, has obtained measurements on a patient by taking a history,
doing a physical exam, and receiving certain preliminary test results. The
physician is concerned about a particular organ subsystem or disease subsystem,
possibly directed there by the patient's chief complaint. Can a physician
be assisted by computer-pattern recognition technology at this point? He might,
if there are diseases, features, etiologies, decision-making strategies, drugs of
choice, or drug interactions which he might forget. For common diseases like
an ear infection, a viral caused upper respiratory track infection, or a sore
"strep" throat caused by B-Hemolytic streptococcus, he may not need such assistance.
On the other hand, the "strep" throat could develop into rheumatic fever, a very
serious disease. And, unless the physician has seen rheumatic fevers in the past
six months, he may not remember the facts.
1/.-. I
-3-
Therefore, continuing with a description of the system, a convenient way
is devised to store information about the features attached to a disease (class);
this way is the class-feature relationship. The class-feature relationship
simply is a class with a list of significant features attached. More and more
information can be stored in the class-feature relationship to approximate the
class-conditional probability density, the ultimate if statistical decision
making is required. If the physician has found some abnormal feature values for
a patient, by giving these to the computer-pattern recognition system he can extract
all classes which have these abnormal feature values. The computer will not
provide the physician with a decision at this point; rather the computer provides
the class-feature relationships for the classes indicated. At this point the com
puter-pattern recognition system is a consultant; the physician, viewing the material,
can then decide what features to take next or to recheck. This is an extension
of what he does when he goes to a medical textbook, asks for consultation, or learns
as a student in medical school.
It is a mistake to think that the computer-pattern recognizer is suitable to
do all decision making done by physicians. Rather, it should concentrate on
recall of class-feature relationships, a differential diagnosis given feature
values, and decision making rules. There are some choice decision making rules in
the medical literature; but physicians seem to try to store most of them in their
heads.
Another aspect is research. Using the class-feature relationship approach,
an approach to training sample collection is taken which will be consistent
with, say, Bayes decision making. Thus, decision making rules can be studied for
a specific subset of diseases and corresponding significant features. We are
particularly interested in several subsystems for which decision making is statistical

-4-
and yet statistics are not available. The first is a subsystem where a class is
pulmonary emboli, a second is a subsystem where the features results from a
tap of a pleural effusion and classes are transudate and exudate, which can be
broken down into important subclasses. A third has the two classes strep, sore
throat and viral sore throat. These three subsystems involve differential
diagnoses'made. The decision made is a feature of another subsystem. For
example, deciding that a pleural effusion is an exudate and further is consistent
with a chronic infection like TB, is a feature to be used in deciding about TB.
3. HIGHLIGHTS OF THE PROPOSED WORK
The author is familiar with statistical pattern recognition techniques
including Bayes, maximum likelihood, stochastic approximation, K-nearest neighbor,
etc., as developed in his book, Fundamentals of Pattern Recognition [2]. The
approach proposed here, however, provides for the incorporation of a priori
medical knowledge. This is accomplished through special kinds of features which
are predetermined functions of measurements, special kinds of classes, and special
kinds of subsystems which are interconnected. A priori medical knowledge is
especially reflected through these facilities, but also^can be reflected in the
way the a posteriori probability density is computed (if it need be) on the final
feature vector. By stressing that training samples be saved, a posteriori
probability density can be computed using many different assumptions. But,,the.
actual final decision rule may be very simple if the right special features and
subsystems are defined.
In Section III, "Review of Pattern Recognition in Medical Diagnosis and
Consulting Relative to a New System Model" , a literature review is provided with
respect to the approach just discussed. This review is published as a regular
paper [3]. An important aspect of the review is provided by discussing previous
studies with respect to properties of the approach which are summarized as
Table I in Section III.

-5-
In Section IV, titled "On the Theory of Medical Diagnosis and Consulting'/'
newer apsects of the approach which are presented at the 1st International
Conference on Pattern Recognition, October 1973, are discussed. In this section
remaining problems also are discussed.
Section V, "Proposed Research", lists specific problems to be solved.

REFERENCES
[1] E. A. Patrick, Leonii-Shen, and Frank -Stelmack., "Introduction to the Theory

of Medical Diagnosis and Consulting", Proceedings of the 1973 National
Computer Conference, June 1973.
[2] E. A. Patrick, Fundamentals of Pattern Recognition, Prentice Hall

May 1972. ~ "
[3] E. A. Patrick, Frank Stelmack', 'and Leon Shen, "Review of Pattern Recognition
in Medical Diagnosis and Consulting Relative to a New System Model,"
IEEE Transactions on Systems, Man, and Cybernetics, Januray 1974.
RESUME OF PRINCIPAL INVESTIGATOR
Name; Edward Alfred Patrick
Personnel; Date of birth; October 7, 1937
Place of birth: Wheeling, West Virginia
Citizenship: U.S.A.
Marital status: Married
Wife's name; Patricia L.
Education;
Decree Date School
B.S. June 1960 Massachusetts Institute of Technology

M.S. January 1962 Massachusetts Institute of Technology
Ph.D. January 1966 Purdue University
M.D. March 1974 Indiana University School of Medicine
Professional Experience
September 1957 - June 1960 Technician, Massachusetts Institute of Technology,

Instrumentation Lab., Cambridge, Massachusetts.
June 1960 - September 1960 Design Engineer, Massachusetts Institute of

Technology, Instrumentation Lab., Cambridge,
Massachusetts.
September 1960 - June 1961 Part-Time Research Engineer, Sylvania Applied

Research Laboratory, Waltham, Massachusetts.
September 1961 - January 1962 Casual Research Engineer, Sylvania Applied Re

search Laboratory, Waltham, Massachusetts.
January 1962 - January 1963 Project Engineer, Sylvania Applied Research

Laboratory, Waltham, Massachusetts.
January 1963 - October 1965 Graduate Student and Instructor, School of

Electrical Engineering, Purdue University.
October 1965 - September 1968 Assistant Professor, School of Electrical Eng

ineering, Purdue University.
September 1968 - Present Associate Professor, School of Electrical Eng

ineering, Purdue University.
1970 - Present Associate Professor, School of Medicine, Indiana

University School of Medicine.
.-■.■ o£cTAsafi£ox;»>«|
(E. A. Patrick)
Research Grants and Contracts Received
"Self Taught Communications System." Wright Patterson AFB, Avionics Division

33(615)3768. U-l-66 to 3-1-68. 375,920.
"Non-Supervised Pattern Recognition." Dept. of Navy NObsr 95285. 5-5-66 to

12-31-66. $20,000.
"Unsupervised Adaptive Systems for Submarine Detection." Naval Ships Systems

Coaimand NOOO2U-67-C-1162 (SECRET). l-U-67 to 1-3-68. 0117,000.
I:Information Processing." Griffiss AFB, Rome Air Development Center.

F-3O-6O2-6e~c-Oie6. 2-16-68 to 2-15-71. #122,'*50.
"Supervised and Unsupervised Learning for Sonar Classification." Naval Ships

NOOC24-68-C-1193 (SECRET). 3-22-68 to 2-22-69. $92,33'+.
"Nonsupervised Communication Systems," Wright Patterson F33-615-68-C-1577

(SECRET). 3-1-68 to 5-I-69. $60,000.
"Detection and Classification Using a Prior-Model for Interactively Estimated

Mappings." Naval Ships Systems Caarand NOOO2U-69-C-1265 (SECRET). 2-2^-69 to
2-23-70. $95,109.
"Computer Aided Detection and Classification Utilizing Supervised and Unsuper

vised Estimators." Kavtl Ships Systems Coor-na'id. 1JOCO2H-7C-C-I2li8 (Gi:CR17r).
2-23-70 to 3-19-71. $92,382.88.
"A Study of Clustering and Model for Passive Sonar Detection pnd Classifyoption."
Naval Air Development Center. K62269-71-C-OO25. 8-18-70 to 8-17-71. £30,683.
Indiana University Medical Center - Marion County General Hospital. Free Grant.
10-21-70 until expended. $3,899. Term. 2-29-72.
"Interactive Supervised and Unsuperviced Pattern Recognition." NSF GJ 1099

(with K. Fukimage). 2-1-71 to 1-31-73. $131,900.
Health arc! Hospi+el Corporation of Msrion County Hospital. Free- Grant. 10-1 71
eo. pI3>7^'-'. P>7,2GO on 1?.-23-7j- a"'i $3,08o on 5-î>~72.
:K-uith and Hospital Corporation of Marion County 0 P.egenstrief. Purchase ports

of r,. computer system. ^'SjCOO until expended.
(E. A. Patrick)
Professional Society Activities
June 1966 Session Chairman, Adaptive Systems Session, IEEE

International Comraunications Conference.
August I968 Organizer and Session Chairman, 1968 WESCON Convention.
1971 - Present Member, Board of Examiners, American Association for

Medical Instrumentation.
1972 - Present. Chairman, Pattern Recognition Cotuuittee, IEEE Systems,

Man, and Cybernetics Society,
July 1968 - July 1969 Secretary, Chicago Joint Section Chapter of IEEE
Transactions on Information Theory.
July 1969 - July 1970 Treasurer, Chicago Joint Section Chapter of IEEE Trans
actions on Information Theory.
July 1969 - July 1970 Acting Chairman, Chicago Joint Section Chapter of IEEE
1969 and 1970 Member U. S. Kaval Technical Evaluation Committee for

Automatic Detection and Classification.
1969 Session Chairman, 19&9 University of Hav.-aii Sycteris
July 1970 - July 1971 Vice Chairman, Chicago Joint Section Chapter of IFKE
September 1971 - Present Member Board of Examiners, National Emergency Board.
October 1971 Editor, 1970 Workshop on Pattern Recognition, IEEE

Transactions on Systems, Man, and Cybernetics.
July 1971 - July 1972. Chairman, Chicago Joint Section Chapter of IEEE
October 1971 Organizer, Pattern Recognition Workshop I and II,

Joint National Conference o~> Major Systems.
April 1972 Sess5.on Chairman, Seventh Symposium of the Associet5.cn

for the Advancement of Medical T
Member, American Medical Association.
Member, Nev York Academy of Sciences.
Member, Arn«."^can Society for Hngir.pering Education.

(E. A. Patrick)
Professional Society Activities, continued
1973, 1974, 1975 Member, Administrative Committee (Ad Com) IEEE

Systems, Man, and Cybernetics Society.
Member, Executive Committee, Department of Community

Health Sciences, Indiana University School of
Medicine.
Associate Editor, Computers in Biology and Medicine,

Pergamon Press.
July 1970 - July 1971 Vice-chairman, Chicago Joint Section Chapter of IEEE
Group on Information Theory.
April 1972 Session Chairman, Seventh Symposium of The Associa

tion for the Advancement of Medical Instrumentation.
1973 Session Chairman (Health Care Delivery), IEEE.
October 1973 Systems, Man, and Cybernetics Conference
Fall 1973 Member, Program Committee, First International Con

ference on Pattern Recognition.
(E. A. Patrick)
Ph.D. Thesis Supervision Completed
Costello, Joseph P. Ph.D. 8/1969

"Unsupervised Estimation and Processing of Unknown
Signals".
Bochtel, Friend K. Ph.D. 8/1969

"A Nonparametric Recognition Procedure with Storage
Constraint".
Liporacc, Louis A. Ph.D. 8/1970

"Unsuperviaed Estimation of Parametric Mixtures".
Fischer, F. Phillip Ph.D. 8/1970

"K-Nearest Neighbor Rules".
Shen, Leon Ph.D. 8/1973

"The Interactive Use of A Priori Knowledge and
Association in Pattern Recognition".
Carayannopoulos, George Ph.D. 8/1973

"Some Practical Aspects of Pattern Recognition",
Stelmack, Frank Ph.D. 1/1974, expected

(E. A. Patrick)
M.S. Thesis Supervision Completed
Agnew* Robert A. M.S. 8/1971

"A Computerized System for Detection and Classification
of SONAR targets." (c)
Shen, Leon Y-L. M.S. 1969

"Waveform Dimensionality Reduction Using Intervalized
Basis Functions Determined by A Priori And Established
Structures."
... -. * ..
(E. A. Patrick)
Books Published and Book Contributions
E. A. Patrick, Fundamentals of Pattern Recognition, Prentice Hall, June 1973,

First Printing, Second Printing in Process.
M. Watanabe, Frontiers of Pattern Recognition, 1973, contribution to: "A Priori

Problem Knowledge and Training Samples."
•' •• •■••!'.,
(E. A. Patrick)
Serial Journal Regular Articles
E. A. Patrick, "Codes for Unsupervised Estimation of Source and Binary Channel

Probabilities," Journal on Information and Control, Vol. 1^, No. k, pp. 358-^76,
April I969. """""
E. A. Patrick, "Concepts of an Estimation System, Adaptive System, and a Network

of Adaptive Estimation System," IEEE Transactions on Systems, Science, and
Cybernetics , Vol. SSC-5, No. 1, pp. 79-U5, January 1968.
E. A. Patrick, "Interactive Use of Problem Knowledge for Clustering and Decision

Making," IEEE Transactions on Computers, Vol. C-20, No. 2, pp. 216-222, Feb. 1971.
E. A. Patrick, "Computer Output Display of Cells and Cell Features," Pattern

Recognition, Vol. k, pp. 211-226, 1972.
E. A. Patrick, "Interactive Pattern Analysis and Classification Utilizing A Priori

Knowledge," Pattern Recognition, Vol. 2, pp. 105-116, September 1970.
E. A. Patrick, "Computer Controlled Picture Scanning v.-ith Applications to Labeled

Biological Cells," Computers in Biology and Medicine, Vol. 2, pp. 5-1^, 3-972.
E. A. Patrick, "Mapping Multidimensional Space to One Dimension for Computer

Output Display," IEEE Transactions on Computers, Vol. C-17, Ko. 10, pp. 9^9-953,
October 1968. * ~
E. A. Patrick, "Interactive Pattern Analysis and Classification Utilizing Problem

Knowledge," Pattern Recognition, Vol. 3, pp. 53-71> April 1971.
E. A. Patrick, Editing, 1971 workshop on Pattern Recognition, IEEE Transactions

on Systems, Han, and Cybernetics, Vol. SMC-2,- No. h, September 1972.
E. A. Patrick with J. C. Hancock, "llonsupervised Sequential Classification and

Recognition of Patterns," IEI:E Transactions on Information Theory, Vol. IT-12,
No. 3, PP. 362-372, July B^
E. A. Patrick with J. P. Costello, "On Unsupervised Estimation Algorithms," IEEE

e.9Z2.> Vol> IT~l6, No- 5> PP. 566-569, September 1970.
E. A. Patrick, J. P. Ccst.?11o, onr\ F. C. Monds, "Decision Directed Estimation of
a Tvo Class Decision Boundary," IEEE Transactions on Computers. Vol. C-19. No. 3,
pp. 197-205, March 1970.
E. A. Fabric!:, S. P.. Ai-.derson, "Mapping Multidimensional Space Onto the Pnal line
for Computer Output Display," IE!?!*: Transactions on Computers, October 1968,
pp. 9^9-953.
E. A. Patrick, F. P. Fischer, "Nonparwuetric Feature Selection," IEEE Transaction?;

on Information Theory, Vol. IT-15, No. 5, PP- 577-5#4, September 19^
(E. A. Patrick)
Serial Journal Regular Articles» continued
E. A. Patrick, F. P. Fischer, III, "A Generalized k-Nearest Neighbor Decision

Rule", Information and Control, Vol. 16, No. 2, pp. 128-152, April 1970.
E. A. Patrick, "Cluster Mapping with Experimental Computer Graphics," IEEE

Transactions on Computers, Vol. C-18, No. 11, pp. 987-991, November 1969.
E. A. Patrick, L. A. Liporace, "Quasi Bayes Averaging of Stochastic Approxi

mation Estimators", Information and Control, Vol. 18, No. 2, pp. 168-182,
March 1971.
E. A. Patrick, "Bearing Estimation Using Intervalized Basis Functions", Journal

American Acoustical Society, 1973.
E. A. Patrick, with R. Jarvis, "Clustering Using a Similarity Measure Based

on Shared Near Neighbors", accepted for publication, 1973, IEEE Transactions
on Computers.
E. A. Patrick, "Review of Pattern Recognition in Medical Diagnosis and Consult

ing Relative to a New System Model", IEEE Transactions on Systems, Man, and
Cybernetics, January 1974.
(E. A. I-atrick)
Serial Journal Correspondence or Letters
E. A. Patrick, Editor, 1971 Workshop on Pattern Recognition, IEEE Transactions

on Systems, Man, and Cybernetics, Vol. SMC-2, No. k, September 1972.
/.-*. I
(E. A. Patrick)
E. A. Patrick, J. G. Hancock, "Interactive Computation of A Posteriori Proba

bility for M-ARY Nonsupervised Adaptation", IEEE Transactions on Information
Theory. Vol. IT-12, No. 4, p. 483, October 1966"! ~~
E. A. Patrick, J. P. Costello, "Asymptotic Probability of Error Using Two

Decision Directed Estimators for Two Unknown Mean Vectors", IEEE Transactions
on Information Theory. Vol. IT-A, No. 1, pp. 160-162, January 1968.
E. A. Patrick, "A System for Computerized Blood Cell Processing", accepted

for publication, IEEE Transactions on Systems, Man, and Cybernetics.
OECUSSFJEOX-'
NATIONAL SCIENCE FOUNDATION RESEARCH GRANT Form Approved
Washington D.C. AJDGET & FISCAL REPORT Budget Bureau No. 99-ROO13
Please read instructions on reverse side carefully before completing this form.
GRANT PERIOD
INSTITUTION AND ADDRESS NSF PROGRAM
AomlO/1/74 to 3/31/77
Purdue Research Foundation Control and
REPORTING PERIOD
Lafayette, Indiana Automation from to
GRANT NUMBER BUDGET OUR. PRINCIPAL INVESTIGATOR(S) GRANTEE
(MOS.I
ACCOUNT
ENG74-04118 24 Patrick NUMBER
NSF Funded Man Months NSF AWARD CUMULATIVE GRANT

A. SALARIES AND WAGES
BUDGET EXPENDITURES
1. Senior Personnel Cil. A cad. Summ.
Do Not Round
*. ]_ (ColPrincipal Investigator(s) 17,218
b. Faculty Associates
Sub-Total 17,218
2. Other Personnel (Non-Faculty)
a. Research Associates-Postdoctoral
b. Non-Faculty Professionals
c. 2 Graduate Students 16,800
d. Pre-Baccalaureate Students
e. ]_ Secretarial-Clerical 2,698
f. 2 Technical. Shop, and Other 6,736
TOTAL SALARIES AND WAGES 43,452
B. STAFF BENEFITS IF CHARGED AS DIRECT COST 2,900
C. TOTAL SALARIES. WAGES. AND STAFF BENEFITS (A + B) 46,352
D. PERMANENT EQUIPMENT
E. EXPENDABLE EQUIPMENT AND SUPPLIES 1,300

F. TRAVEL 1. DOMESTIC (INCLUDING CANADA) 1,200
2. FOREIGN
G. PUBLICATION COSTS 1,000

H. COMPUTER COSTS IF CHARGED AS DIRECT COST
I. OTHER DIRECT COSTS
J. TOTAL DIRECT COSTS (C through I) 49,852

K. INDIRECT COSTS
68.5% of salaries & wages

29.765
L. TOTAL COSTS (J plus K) 79.617
M. AMOUNT OF THIS AWARD (ROUNDED) 79.600
N. CUMULATIVE GRANT AMOUNT
O. UNEXPENDED BALANCE (N. BUOGET MINUS L. EXPENDITURE) I $

REMARKS: Use extra sheet if necessary FOR NSF USE ONLY
Final Fiscal Report Accepted
Orant Closed. _R»maini Open.
By Oat*
Grants Administration Section, Area.
SIGNATURE OF PRINCIPAL INVESTIGATOR TYPED OR PRINTED NAME
1 CERTIFY THAT ALL EXPENDITURES REPORTED ARE FOR APPROPRIATE PURPOSES AND IN ACCORDANCE
WITH THE AGREEMENTS SET FORTH IN THE APPLICA'nON AND AWARD DOCUMENTS
SIGNATURE OF AUTHORIZED OFFICIAL TYPED OR PRINTED NAME & TITLE DATE
FOR NSF USE ONLY Unexpended

Organ. Code F.Y. Fund ID Prog. Code Ob. Class O/Ores. Award No. Amd. Inst. Code Balance Trans. Lot
NSF Form 98, JULY 1971 SUPERSEDES ALL PREVIOUS EDITIONS

NATIONAL SCIENCE FOUNDATION RESEARCH GRANT Form Approved
Washington D.C. 2O5#> AJDGET & FISCAL REPORT Budget Buteau No. 99R0013
Please read instructions on reverse side carefully before completing this form.
NSTITUTION AND ADDRESS NSF PROGRAM
GRANT PERIOD
/n>mlO/l/74 {0 3/31/77
REPORTING PERIOD
Lafayette, Indiana Automation from to

GRANT NUMBER BUDGET OUR. PRINCIPAL INVESTIGATOR(S) GRANTEE
ENG74-04118 (MOS124 Patrick

ACCOUNT
NUMBER
NSF Funded Man Months NSF AWARD CUMULATIVE GRANT

A. SALARIES AND WAGES
BUDGET EXPENDITURES
1. Senior Personnel Cal. Acad. Summ.
Do A'or Round
a. \ (Co)Prineipal Investigatorls) 17,218
Sub-Total 17,218
2. Other Personnel (Non-Faculty)
a. Research Associates-Postdoctoral
b. Non-Faculty Professionals
c 2 Graduate Students 16,800
d. Pre-Baccalaureate Students
' *. 1 Secretarial-Clerical 2,698

f. 2 Technical, Shop, and Other 6,736
TOTAL SALARIES AND WAGES 43,452
B. STAFF BENEFITS IF CHARGED AS DIRECT COST 2,900
C. TOTAL SALARIES. WAGES, AND STAFF BENEFITS (A ♦ B> 46,352
E. EXPENDABLE EQUIPMENT AND SUPPLIES 1,300

F. TRAVEL 1. DOMESTIC (INCLUDING CANADA) 1,200
2. FOREIGN
G. PUBLICATION COSTS 1,000

J, TOTAL DIRECT COSTS (C through I) 49,852

K. INDIRECT COSTS
68.5% of salaries & wages 29.765

L. TOTAL COSTS (J plus K> 79.617
M. AMOUNT OF THIS AWARD (ROUNDED) 79.600

m
O. UNEXPENDED BALANCE (N. BUDGET MINUS L. EXPENDITURE)
Final Fiscal Report Accepted
Grant Closed. .Remains Open.
By Date
Granti Administration Section, Area.
SIGNATURE OF PRINCIPAL INVESTIGATOR TYPED OR PRINTED NAME
I CERTIFY THAT ALL EXPENDITURES REPORTED ARE FOR APPROPRIATE PURPOSES AND IN ACCORDANCE
WITH THE AGREEMENTS SET FORTH IN THE APPLICATION AND AWARD DOCUMENTS
SIGNATURE OF AUTHORIZED OFFICIAL TYPED OR PRINTED NAME & TITLE
FOR NSF USE ONLY Unexpended

Organ. Code F.Y, Fund ID Prog. Code Ob. Class O/Ores. Award No. Amd. Intt. Code Balance Trans. Lot
NSF Form 98, JULY 1971 SUPERSEDES ALL PREVIOUS EDITIONS

Purdue University
11 SCHOOL OF ELECTRICAL ENGINEERING
WEST LAFAYETTE. INDIANA 47907
July 26, 197*1
Mr. Norm Kaplan /

National Science Foundation , // ,.A
1800 G Street - Northwest / J>'//.-
Washington, D.C. 20550 //
Reference: Statement of current support
Dear Norm:
This is to inform you that currently I am receiving no

federal or state government funding for any research or other
projects.
I currently am the receipiant of a small amount of non

government support, all less than $10,000.
With reference to my proposal, "A proposal for Research

on Pattern Recognition Applied to Medicine," a starting date
of October 1, 197^» is acceptable.
Sincerely,
Edward A. Patrick, M.D., Ph.D.
EAP/gb
cc: Dr. C.L. Coates, Department Head

PROPOSAL NUMBER
P4K0495-000
PROGRAM AWARD RECOMMENDATION (ENG-7404118)
This research concerns the application of pattern recognition tech

niques to assist the. physician in performing medical diagnosis and
consultation. It represents an excellent example of the possibilities
that exist in improving medical care by utilizing biomedical engineering
et£actively. The pattern recognition system will aid the physician by
employing statistical techniques to evaluate>r.he abnormal features,
predicting diseases, and consulting with the physician on what features
to take next or to recheck.
Th«i Principal Investigator is outstanding in the area of pattern pro

cessing. He has recently been awarded a medical degree which will
considerably strengthen this research effort. A grant award is
recommended.
PROGRAM OFFICER DATE
(1/JL
NSF FORM 9 APR. 72 /
WHITE COPY (GCO)
YELLOW COPY (PROGRAM)

PROPOSAL NUM3ER
P4KO'»95-OOO I Ivoukg
PROPOSAL REVIEW WORKSHEET (ENO71O1118)

NSF DIVISION SEC TION ' PFIOCRAfc
PRINCIPAL INVESTIGATOR'S NAME
Engineering PATRICK, Edward A.

PREVIOUS GRANT(S) ANO/OR PROPOSAL(S) OF P. | . OTHER AGENCIES SUBMITTED TO
CRAM T EFFEC Tl VE
PROPOSAL NO. OURATION OA TE
0076-C 00
REVIEWS
MAIL » PANEL REVIEW RECOMMENDATIONS (and any rematkl)

-> A I C /
/,/lvj. Jyvrfiî^s*'' ST>v>T~viS^vi-, /'XAsi^csUkÂS A"
J. I . i a
|P«c|[notlon I (Sel«ntlflc quality {ud^d to b« b«low Uvtl at which projtct can b« tupporttd with ovalloblt or anllclpaltd
(4tplaln any allnltleanl dtvletlon btlwten ravlatrtf, tlall and panel tatlnf In ttmarkt).
|"~lSupp«t nt«l»«d fremi

<af*ncy)
i iChanglng inilitullen f(oni_

To!
For Grant LnOlh«f (iiplaln In firatkt, tlvlnf ettenllal tacit).
site vi$i T: □ V«» If ft, •«• th« Sit* Vlilt Rtpott Dat«d
SISNATURE OF PROC DATE
Form 7, February 1971

NATIONAL SCIENCE FOUN' TION
PROPOSAL RATING SHEET
Reviewer Proposal No.:

P4K0495
Investigator:
PATRICK, Ed.
Institution:
Purdue Univ.
Please return to:
N. CapIan
If possible by:
12/21/73
Comments {Continue on additional sheet if necessary)
I recommend approval of this grant. Dr. Patrick is seriously

pursuing the automation of medical diagnosis in pattern recogni
tion techniques. He is a capable research worker in pattern re
cognition, and his recent M.D. should help in giving him access
to much medical data. The approach he is proposing is a flexible
and general approach, which needs to be tried out on real data.
This proposal, in fact, proposes to work with real data. I do
hope Professor Patrick is a little more modest in the future re
garding the claims he makes for his own work.
OVERALL RATING Signature of Reviewer:

DEXCELLENT
ffi'vERY GOOD Other suggested reviewers {optional):
□ good
□ fair
□ poor
"Reviewers' comments are solicited and received in confidence by the National Science Founda
NSF Form 173, January 1968 tion, an agency of the U.S. Government, and will be given maximum protection from disclosure
permitted under applicable laws, including 5 U.S.C. 522 (The Freedom of Information Act)."
NATIONAL SCIENCE FOUN TION
Reviewer Proposal No.: P4K0495t-.QQQ

Investigator: PATRICK, Edward A.
Institution: U.C.L.A.:
Please return to: N. Caplan
If possible by: 7/24/74
Comments [Continue on additional sheet if necessary)
This proposal contains a reasonable statistical pattern recognition
formulation of the medical diagnosis problem, three specific medical appli
cations, and a fundamental theoretical problem: definition of complex
features. Most of the text consists of the review material, references [1]
and [3] to Section I. Little is presented regarding the proposed research

other than the formulation [1, 3) and it seems that applying this pattern
recognition approach to the specified medical cases vill be the main result
from funding the proposal. This seems worthwhile as an engineering

objective and further theoretical development may result as well.

□ EXCELLENT
fj^VERY GOOD Other suggested reviewers [optional)
Dgood
Dfair
Dpoor
NATIONAL SCIENCE FOUN TION
Reviewer Proposal No.: P4R049S

Investigator: PATRICK, Ed,
Institution: Putxluft. Univ.
Please return to: H« Cttplflu
Comments (Continue on additional sheet if necessary)
During the past several years, the investigator studied and proposed a model of
unified "systems" approach for computer assisted medical diagnosis and consulting.
He incorporated various existing concepts in an organized fashion and structured the
whole system as networking subsystems, corresponding to either organ categories or
disease categories, each of which contains a set of class- (significant) feature rela
tionship. He emphasized on the utilization of a prior/'medical knowledge in establishing
the class-feature relationship and included the disease management as the physicians1
interactive system. Thus his system is compatible with physicians' thought processes
in either consulting mode or diagnosis mode.
Under the heading of Statistical Decision Making in the proposed research, it is

apparent that he intends to apply the conceptual framework which he developed to
study in depth three subsystems: (1) pulmonary embo$li, (2) pleural effusion, and (3)
strep versus viral sore throat. In each case, the statistical pattern recognition problem
is involved which includes the work of collecting training samples, extracting significant
features, estimating the class conditional probability distribution for subclasses, and
decision making for the eventual diagnosis. This part of the proposal is clearly de
fined. With his excellent background and collaboration of his medical colleagues, the
investigator can make a significant contribution to this problem. Hence, this reviewer
recommends the approval of support to this phase of the proposed work.
The other phase of the proposed work under the heading of System Theory is only
vaguely written, no new idea is presented. Perhaps it would be more fruitful if the
investigator would focus on the first part of the proposed work at the present time.

dexcellent
5>very good Other suggested reviewers (optional):
Dgood
Dfair
Dpoor
"Reviewers' comment* are solicited and received in confidence by the National Science Founda
permitted under applicable laws, Including 5 U.S.C. 522 (The Freedom of Information Act)."
NATIONAL SCIENCE FOUr TION
Reviewer Proposal No.: P4K0495

Investigator: PATRICK, Ed.
Institution: Purdue .Univ.
Please return to: n. Caplan
Comments [Continue on additional sheet if necessary)
This application is a loosely-structured proposal to apply Patrick's

own method of structuring medical information to the study of pulmonary
emboli, pleural effusion, and strep vs. viral sore throat.
Patrick is a young, energetic researcher who has been for several years
strongly interested in applying his engineering training to medical problems;
he is now about to complete his M.D. degree, apparently while still conducting
active research, a remarkable achievement. He is well versed in the statistical
and pattern-recognition techniques he proposes to employ..
Included in the application are an extensive literature survey of efforts

to computerize medical information and to automate diagnosis, and a description
of Patrick's approach to these problems. Unfortunately he is vague on the
precise research he intends to do; while he states the problems he wishes to
work on, he is very unclear as to the source of the data. (Apparently his
patient data will come from the Regenstrieff Institute; this information is
found under Patrick's section on "Computer Facilities I") There is no indication
as to how many patients he will use, no documentation of collaborative arrante-
ments, no hint as to the method of collecting the data and putting them into
computer-readable form. In short, what Patrick needs is a research plan.
This could be a very interesting application, if Patrick would do his home

work. As it is, I cannot rate it highly. Patrick is an up-and-coming young
man, probably deserving of support, but right now he does not write as good an
application as he should.

dexcellent
dvery good Other suggested reviewers (optional):
Bgood
Dfair
Dpoor
NATIONAL SCIENCE FOUN' TION
Reviewer
Proposal No.: P4K0495-000
Investigator: PATRICK, Edward A.
Institution: Purdue U.
Please return to: N. Caplan
Comments (Continue on additional sheet if necessary)
This is a generally veil-prepared proposal for pattern recognition
studies related to health-care problems (i.e., medical diagnosis).
The problem is important, and there is a reasonable chance that
the investigator, who is exceptionally veil qualified for this vork,
vill be able to make a significant contribution here.
Their request for some additional equipment is reasonable. -Their
facilities are adequate.
Very good - deserves support.

dexcellent
x0very good Other suggested reviewers [optional]
Dgooo
Dfaifi
Dpoor
"Reviewers' comments are solicited and received In confidence by the National Science Founda
International Business Machines Corporation Thomas J. Watson Research Center
P.O. Box 218
Yorktown Heights, New York 10598
914/945-3000
December 18, 1973
Dr. Norman Caplan

Program Director for
Control and Automation Program
Engineering Division
Washington, D. C. 20550
Dear Dr. Caplan:
Thank you for asking me to evaluate the enclosed proposal NO. P4K0495
by Professor E. Patrick. I regret that I am not able to evaluate it.
However, I do appreciate the opportunity given me. The proposal is
returned herewith.
With best regards,
Sincerely,
RECOMMEND AND AWARD
DATA FORM
NSF Form 780 Dec. 1973

PROGRAM COPY (FROM GCO)
;rtt 3-2
NATIO. aL SCIENCE FOUNDATI
WASHINGTON, D. C. 20550
OCT 1 1974
Dr. Arthur 0, Hansen, President

Purdue Research Foundation Proposal/Grant Ho.
Lafayette, XndliHt* 47907 RHO74-04118
Dear Dr« Banaom
It is a pleasure to Inform you that $79,600 is granted to Purdue

Research foundation for support of tho project entitled "Pattern
Recognition Applied to Medicine" as outlined in the abova-nu»ber<&d
proposal* This project is uader the direction of Edward A. Patrick,
School of Electrical Engineering.
the funds provided by this grant Are Intended to assist in the support
of the project at the agreed level of effort for approximately twenty-
four Months. The 86? share of such support is «ua«arlKcd in the
attached budget. The grant is effective October 1, 1974 and, osleaa
otherwise amended, will expire on March 31, 1977. The grant period
include* the flexibility period described in Section 120 of mt
73-26» "ftSF Grant Advlnietration Manual."
The provision* of VL 25, "Administration of HSf Project Award," attached,

are applicable to this grant*
Appropriate provisions of NSF 73-12, "Grama for Scientific Research,"

Are applicable to the scientific or technical direction of the proj
ect and the preparation of technical reports*
Sincerely yours,
Oaylord L.
Acting fop
Wilbur W. Bolton, Jr.

Grants Officer
Attachments
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our award numbering system has been revised. The old two digit
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and NSF shall have the right to determine whether or not
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Supersedes Enclosure R-12 (FL 6-32) and replaces FL 25 ()an. 1974)
NATIONAL SCIENCE FOUNDATION RESEARCH GRANT
Washington, D.C. 2O5AP BUDGET & FISCAL REPORT
Please read instructions on reverse aide carefully before completing thn form.
NSTITUTION AMO ADDRESS NSF <-HOGRAM
/wiilO/1/74 to 3/31/77
REPORTING PERIOD
Lafayette, Indiana Automation from 10/1/74 to 9/30/76

RANT NUMBER DUOGET OUR. PRINCIPAL IHVESTIGATOn(S) GRANTEE
ENG74-04118 |MOi-'24 Patrick

ACCOUNT
number 8375-50-1285
CUMULATIVE GRANT
A. SALARIES AND WAGES NSF Funded Man Months NSF AWARD
BUDGET EXPENDITURES
1. Senior Personnel Do Mot Round
*. ]_ (Co)Principal Investigator!*)
Sub-Total
2. Other Personnel (Non-Fic^lYy
•. Research Associate
c. 2 Graduate Students
d. Pie-Bjccaljui<
' «. \ Secretarial-Clerical
f. 2 Technical. Shop.
TOTAL SALARIES AND V/AGES 43,452 S 39,691.10
B. STAFF BENEFITS IF CHARGEO AS DIRECT COST 2,900 2,971.30
C. TOTAL SALARIES. WAGES. AND STAFF BENEFITS (A ♦ B) 46,352 S 42,662.60
E. EXPENDABLE EQUIPMENT AND SUPPLIES 1,300 4,358.37

F. TRAVEL 1. OOMESTIC (INCLUDING CANADA) 1,200 1,563.20
2. FOREIGN
G. PUBLICATION COSTS 1,000 1.683.16

Consultants 185.00
Communications 1,959.25 2,144.25
J. TOTAL DIRECT COSTS (C through I) 49,852 $52,411.58
K. INDIRECT COSTS
68.5% of salaries & wages X 39,691.10 29.765 i 27,188.42

L. TOTAL COSTS (J plus K) 79.617 S 79,600.00
M. AMOUNT OF THIS AWARD (ROUNOEO) 79.600
O. UNEXPENDED BALANCE (N. BUDGGT MINUS L. EXPENDITURE!

Final Fiic.il Raport Accepted
Rebudget Requested and approved by
N. Caplan of NSF on 10/7/75. Grant Closed. _n«ma!ni Op«n_
By _Oat«
Grants Admlnlitntlon Section. Ar*3_
SIGNATURE OF PRINCIPAL INVESTIGATOR TYPED OR PRINTED NAME DATE
E. A. Patrick
!£RTII Y TMAXAUL FXPI Nnil URTS
..IS Rl mRTin AR1" FOR APPROPRIATF. I'liRPOSl S AND IN ACCORDANCl.
/^) \viTirriu:
wiTiriiu: agrekmi-nts
AGRi:KMi:Nrs sir
si i ortii in the aitlk -at ion and award uocumi nts
tlGNATi/fl THQrtllEO OFDCIAL TYPED OR PRINTED NAME & TITLE DATE
K. D, Bertram Project Administrator /A

V FOR NSF USE ONLY Unexpended
Organ. Code F.V. Fund ID Pro). Code Ot>. Class O/Dres. Award No. Ami). Inst. Code fkilance Trant. Lot
NSF rwm 98. JULY 1971 SUPERSEDES ALL PREVIOUS EDITIOSS

YEARLY IDENTIFICATION OF NSF NEEDS FOR THE PERIOD 2/1/74-1/31/76
A. Salaries and Wages

1. Senior Personnel
a. Principal Investigator
E. A. Patrick
SUBTOTAL
2. Other Personnel
a. Graduate Research Assistants (2)
b. Computer Programmer
c. Clerical
TOTAL SALARIES & WAGES
B. Fringe Benefits
TIAA
Workmen's Compensation
Insurance
Unemployment Insurance
SUBTOTAL
C. TOTAL SALARIES, WAGES, & FRINGE BENEFITS

D. Permanent Equipment
1. Computer Core 16K MF 11-L
2. 9 Track Magnetic Tape
E-. Expendable Supplies and Equipment
G. Travel - Domestic
H. Report Preparation and Publication Cost
I. TOTAL DIRECT COST
J. INDIRECT COST 68.5% of A

81
I K. TOTAL COST
F.T.E. Man Months Requested From NSF
Principal Investigators
The difference between the senior personnel effort listed and the totals included
in the FTE summary represents a portion of the University's contribution to this
project."
YEARLY IDENTIFICATION OF NSF NEEDS FOR THE PERIOD 10/1/74-9/30/76
% Effort 10/1/74-9/30/75 10/1/75-9/30/76 Total
A. Salaries and Wages

1. Senior Personnel
Principal Investigator
Edward A. Patrick
SUBTOTAL
2. Other Personnel
Bo Technician
b. Graduate Student (2)

c. Computer Programmer
d. Secretarial - Clerical
TOTAL SALARIES 6- WAGES
B» Fringe Benefits
TIAA-SS
Social Security
Insurance
Workmen's Compensation
Unemployment Insurance
SUBTOTAL $ 1,416 $ 1,484 $ 2,900

Si
10/1/7^-9/30/75 10/1/75-9/30/76 Total
C. Total Salaries, Wages, & Fringes
D. Expendable Supplies Equip s§

E. Travel
F. Publicatton Cost
G. Total Direct Cost
H. Indirect Cost .685 of Salary

$ 39,417 $ 40,500 $ 79,917
Principal Investigator
"The difference between the senior personnel

effort listed and the totals included in the
FTE summary represents a portion of the
University's contribution to this project."
COPY TO
1 « APR 1975
Dr. UmtA A.
fttt&tt
V««fc
ikmv &*
Be, Stftwr h«* s«fem4 yae* i#tt«¥ of Api'U 2, tft?5 t^ »9 tot
tot
gf imd 3a4lci»$, it wovH b»
you to dS»oj«t«i |«ac i,4*»« 4iir*^t;ly with w« eaaeerotog tbt
lt9 of «tf twearch pro^t^tt in tit id aron. I l*
to hav« Ot* U«t»*y Bowtot, fd>etl««t H*sd for
An«ly»t»» A«d Hr. Hi-mmi Gftpltia, Piftfiw
Control nod Awtoaation, p^rtlcl|H»c« In th«M 41««tti«to«o.
t vtlt look fo«v«tr4 to ho wring f*«K« you
cet 0/0 (2)

lHryuty Dlteetor
AD/R Wcy «
DAD/R (without e y of tncora.)
BUG
U. Caplau
EH6UtCBottm«)i* 4/16/75
Purdue University
SCHOOL OF ELECTRICAL ENGINEERING
WEST LAFAYETTE, INDIANA 47907
September 16, 1975
Mr. Norman Caplan

1800 G Street, N.W.
Washington, D.C. 20550
Dear Norm,
This is to request a transfer of funds from the salary category to

travel. The amount Is $650.00.
The travel funds will be used for myself and graduate students to
travel to scientific conferences where we have had papers accepted:
Second Illinois Conference on Medical Information

System
University of 111inois
Champaign, Illinois
Systems, Man and Cybernetics Conference (1975)

San Francisco, California
Sincerely,
Edward A. Patrick, M.D., Ph.DV

Professor of Electrical
Engineering, Purdue University,
School of Medicine, Indiana
University
EAP/gb
cc: Mr. Randy Stoll

EE Business Office
■i* ^
October 7, 1975
Professor Edward A. Patrick

Purdue University
West Lafayette, Indiana 47907
Ref: ENG-7404118
Dear Professor Patrick:
In response to your letter of September 16, 1975, permission

is granted to transfer $650 from the category of "Salaries
and Wages" to the category of "Domestic Travel". It is
understood that no additional coat will accrue to the
Foundation as a result of this change.
Sincerely yours,
Norman Caplan
Program Director for
Control and Automation
Engineering Division
Sopy to: Hr. Randy Stoll
bcc: Grants Office w/cy of incora. ltr.
NC:slm**"
nsf form 264 apr. 1968 CORRESPONDENCE APPROVAL SHEET (Official File Copy)
*»..
NATIONAL SCIENCE I OUNDATION I'orni Approved

Washington, D.C 20550
SUMMARY OF COMPLETED PROJECT OMU No. 99RIMU3
Please read instructions on reverse carefully before completing this form.

1. INSTITUTION AND ADDRESS 2. NSF PROGRAM 3. GRANT PERIOD
School of Electrical Engrg.

Purdue University
Control and Automation
W. Lafayette, Indiana A7907 from 10/1/74'° 3/31/77
4. GRANT NUMBER 5. BUDGET DUR. 6. PRINCIPAL INVESTIGATOR(S) 7. GRANTEE ACCOUNT NUMBER
(MOSI
MSF EHG7'»-OJ»118 2't mos. Dr. E.A. PatrIck 8375-50-1285
8. SUMMARY (Attach list of publications to form)
Methods v/ere developed to model the outcome of treatment and diagnosis -j
for a multiclass statistical pattern recognition problem In medicine. (Section

II). This work presumed that diagnosis and treatment took place at a fixed state
for the patient. It was extended (Section III) for a patient progressing through
multiple states. For each state, subsystems, classes, complex classes, class-
feature relationships are defined consistent with previous work by Patrick et al.
The Important problem of early diagnosis of heart attacks was taken as an
example and results are reported in Section IV. It Is shown that the approach
results in decision performance signl ficantly better than physician performance
for the problem considered.
Another example, foreign body airway obstruction was considered. (Section

V). It Is shown how to apply expected outcome loss (Section II) to evaluate
various treatments for the differential diagnosis of foreign body airway
obstruction.
FILE
9. SIGNATURE OF PRINCIPAL INVESTIGATOR/ TYPED OR PRINTED NAME DATE

PfVOJECT DIRECTOR / )/
£Jtc*lttC 4- h h.cJC
NSF Form98A (10-76)
r
;%Computers
In Medicine'
Topic of Talk
Edward A. Patrick, a'
professor of electrical engi
neering at Purdue Univer
sity who holds an M.D.
from Indiana University,
School of Medicine, will
discuss "Computers in
Medicine" at 7:30 p.m.
Tuesday at the St. Eliza
beth Hospital Continuing
Education Center.
His presentation is spon
sored by the Lafayette
Medical Education Founda
tion. . . .
Computer Used In Fight

Against Breast Cancer
STAR PUROUE-tAFAYETIE 1UKEAU
and a medical doctor himself,
West Lafayette, Ind. — A said information will be pn>-
Purdue University professor vided to advise surgeons on the
has announced creation of a best treatment for breast can-,
research facility applying new cer in a particular patient.
computer techniques to breast A data bank containing the
cancer patient information. medical history of breast can--
Edward A. Patrick, profes cer patients and other materi
sor of electrical engineering al used in efficient treatment i
of breast cancer victims will
be created. At least one of
the research facilities is to be.
located in Indiana.
, Careful scientific exploration
■ of the computerized data will
be required for proper treat
ment of a victim.
But, Dr. Patrick pointed
out, "with these probabilities
of survival available as a
service to surgeons, they will!
be able to determine the best
way to manage the health
care of that particular pa
tient."
*..He said there has been no
such material available In
computers which could esti
mate the probability of suc
cess in treating breast cancer
problems.
Plans Data Center
T>« Nlwi P\rtin.UfiT«fll drill —
wine proo:em.
WEST LAFAYETTE, Ind.—A Pur Dr. Patrick said an article in a recent
due University professor's proposal to iss-je of the Journal of the American .M?::c2!
create a computerized data bank to help Aisociauon in which two surreor.- prsser.ei
surgeons increase the probability of suc arguments in behalf of radical or.1! lim;:oi
cess in treating breast cancer patients masteciomy showed ckariy "how their data
is being hailed by tlio scientific commu bases are so different."
nity in this country. In the radical surgery, the si-:in. the sub
cutaneous tissue ar.d the muscivs of the
I
The proposal was advanced last month at
chest are removed a.ong with the iy.T.ph
an engineering seminar at Massachusetts In
nodes in the armpit area. A Mrrued. or
stitute" of Tec.-.o.iT/ by Dr. Edward A". Pat tirtin! rr.nstsctorr.y. usuaiiv rr.ear^ Ti".'j\~.~y
rick, who ;? both a rr.eiical doctor and a the tumor ar.d a ctria.r. i~-'jit.'. ci '.j::z
professor of electrical engineering at Purcue.
around it, hut the skin. ;: it is r.o: csneeroas,
Since his presentation in Bostcn Nov. 22, ar.d the chest muscles ar.ci r.cces are leit.
the pre£'i?:vjs Scior.ro M2?a::r.e has accept Hc**h 2*"i'^ro3^h<i* ^*5p b'* p*ro i a/i v.**n r3c^«
ed an article on his ?r«rv>5?i :or publication tion treatment o; the ly.T.t.*! r.c ies. o.: tr.:«
in an upcomir.z i'vje. Andes are not ac »5 a C'C-"**'*v^r^'sl 2*"^^* b-31"**-?* *'"* ••■fl's**
cepted by Science ur.ie-s the subject matter mer.ts dimmish the to-iys lyT.rhjiic produc
is considered to be of significant scientific tion of agents to ward off ir.iecu^n.
Importance. Dr. Patrick said to this p'ir.t ::.* ,'n-js of
A reviewer of the article for Science ex the National Iw.itute of :!•?•. :'i r.ss b«n
pressed the opinion that the proposal v.es.% more toward letting ir.c.vicual c.i.-.^r .tr.:-':s
computer techniques to breast cancer data obtain ar.d compile treatment data.
amounts to a "new modality to treatment of "There has been little effort at or:3r.izx;
disease." it in a logical, stien:.tic way."" hs adieJ.
As outlined by Dr. Patrick, the data bank,
Dr. Patrick has t«n a rropor.ent cf this
actually a research program, could provide
for a number o: yesrs. He is now rostin? the
information for jurieons on the best treat
NIH ar.d fcur.daf.on waters for f.r.ar.c:al s-j>
ment for breast car.ccr in a particular per
port to estaoLst sucn a data r.ro\.e«.r.<
son.
cen-.er in the s'ote. -•j.-.-.api here or 2; t-e
'•\Vh3t v.e are irr.rr.<xi:a'.eiy concerned lî-ra rr.iver«ity Mc^xaf Cer.tc-r a: I:.-:.i>
with is the efficacy of treatment." Dr. Pat -P--/.5.
rick said. "Since breast cancer is s-::b a "V.> are rationally prf-babiy the ^?t fcr
serl:us problem. :t is e;ser.::3i thv. a scien £r:lyzir.r tr.is k--.d 0; cau." Dr. :_•.-.;..
tific approach be used for org-'irji..".; patient
iv.i of the Purcue people avstliblv trj.-.c:-
ca:a end evaluatm.: :;e ciicv.t.2 cf L.ife.-e.r. t:l:e the ta?k.
treatments — ra :;cj1. limited, moc-ticd-limit-
The '.enter would approach cane*: from
ed lymphectomy, chemotherapy or a combi
the standpoint of C3ta proves-;r.z sr.-i :a-.;ern
nation of these."
recojnition. He said it would li no way
Dr. Patrick said in determining the treat conflict with the university cancer researt^
ment cf a patient, a surzeon uses the pa
committee's pro^-sai to the Net;;.-;; Cir.cer
tient's pas: medical history, family hi-tory,
!r.-rit-te to er::.lili a z.:\i::<i: ci-;e: r;-
si^ns, s>r.p;or..s ar.d laboratory u<!i. He
search csr.tcr .iere.'
listed 13 of these criteria that could go into
Dr. Patrick said data on I'/.) zv.-ir.-j H
the data bar.k a'.or.g with the history of
"i I.I*. :•'■: JrM CiT.'rT I< >r:"Z '"" '-Ti-:
r«.-5-sur,:ery or ?•: j.yj.-pry a.-.i the cju^ of
cea'.h it i'"5 r"-.'.:3"'. cm r.ct sur.v. i.
cit;-:::-r.t trea:.T.:r.^ zr.i d.::or:r.: pztle.-.;

profiles could be de'.errriir.sd. Ultimately, he
added, a treatment could ce selected to give "V.'e are Swnlr.g w;:h breast career. c«
the highest probability cf survival for a par- cnuie i: u probably the most i!ifvj::sr.i :ror>
• ticular patient proiile. the woman's Standpoint." Dr. Pa*.-"ksaid.
"With these probabilities of sunival avail He said a sficor.d effort mi:!;: be aur.;i
able as a service to sureesr-s. they will be at telon cancer, which has a r.:gli;r.::-;i:..e
able to determine the best way to manage a.r.ong men.
the health care of that particular patient. Dr. Patrick said the cro-s->eci for NIH
There is noc any one procedure currently grant support for the research 3r:«3rs :occ.
programmed in a computer which can esti but it has yet to be determined whether
mate the required probability distributions seeking NIH support for the actual center
for breast cancer problems," Dr. Patrick would be the best way to p.-ocee-i.
said. He said Purdue r.O'.v hxs t.te <.::y.~::$'-
The different surgical tecLniq-jes — radi capacity to col'.e;: ar.c p::cc:s ;..r .-.:=. :-
cal and rr.ccified-rad:ca! — used in treating thai the capacity would prcba':';.- hivj-j-:
the breast cancer of tne wives of President erJareed when the service fur.c■_';.-. — ::'/•".:•
Gerald Ford azd Vice President Nelson Rock ing physicians and surgeons with prooaouiij
efeller confirm the ranae of Surgical thinking data — was bes"un.
ikdia:;a heivscup
2575 E. 55 PL SOITt F
tKDIAXA 4Q28
JEFFERSOHVILLE
EVENING NEWS
D. 16,073
MAR 2 0 1575
HURSDAY, MARCH 20, 1975 THE EVENING NEWS, JEFFERSONVILLE, INDIAN,
Astronauts' Pump Could Lead To Heart-Lung Machine For Heart Patient^

WARKKN K. LKAKV weeks instead of hours. Heart-lung machines are de and
BOSTON (AP) — Patients Th«* pump developed for the vices that take over for organs pro fcssoVof oToc trT
Apollo program has proved In in pumping and adding oxygen the blood flow. prodScei
having open-heart surge* or ing at Purdue University.
suffering with severe Iic;»m at initial tests to be 10 times less to blood.The machines take the turbulence tad has extn .
i ne pumjrwas-usedin the precise valves that don't
tack sometimes have to depend destructive to blood than the workload off the heart, but de backpack of astronauts* suits to
upon heart-lung machines to best pumps now used in heart* struction of blood components pump cooling water," said blood cells as other valve
keep their bodies going while lung machines, the researchers is a principal reason that exist Armstrong, the first man to
the heart is repaired. said Wednesday. ing mnchncs can only be used walk on the moon. "We were
But because such machines Speaking at a news confer for a few hours.
interested in seeing how it
damage the blood and con ence at the annual meeting of The i"u!ti-discipline team pumped blood."
sequently tax the body, most the Association for the Ad working o» the new pump in Patrick said red cells are de
patients can use them for or*ly vancement of Medical In cludes Dr.Hcnry J. Heimlich, stroyed by hitting the walls and
a few hours even though they strumentation held here, the re director oi surgery at Jewish Joints of the pump or shearing
may need the assistance for searchers said clinical use of each other in the turbulent
longer periods. . the pump was years In the fu Armstrong former astronaut blood flow. Armstrong said his
Researchers sara pump used ture. Dut they said the alumi and aerospec engineering pro-
to cool astronauts on the moon num device, small enough to be
could lead to a heart-lung ma held in the palm of a hand,
chine that sustains people for showed great promise.
:J THE NEWS RECORD. FRIDAY. APRIL 4, 1975
UC researchers perfect NASA artifici?

ByPAULLIDSKY
Using NASA moonflight
technology, a four-man
disciplinary research team, i
two UC faculty members, is perfee-
ting a new pumping system that may ; '■ V
;*
^ ^
:-|1
— lead to improved heart-lung
machines
hearts
The
Armstrong
engineering
Hcimli
"• Jewish
professor of clcctricial engineering at *>;. ' *'\ > ,
Purdue University, and George .\ % •• ,';r; * ""■
Ricvcschl, UC Vice President for: -.. >
special projects. . , .
The pump is called an Apollo
Double Diaphragm Pump (ADDP),' -,V
and is similar to one worn. by'( V(%
astronauts to circulate fluids for/
^ temperature control in their spaceL^
suits. -
The ADDP, stated the icarn, isr:,
superior to- existing; heart lung . ' t> :
machine pumps because it is relative-- ;
ly small, lightweight (13 ounces), has-' - \.;
a high blood flow rate and operates! ■' .'
on a 16-volt battery, making'it easily! ., l . \
transportable. , * \
Existing h«irl-lung machines can';;.-
"* only be used for several hours; .
'} beca use t he pu mp dCst roys red blood j .;.
| cells (RBQ vital lo life, said!-;. •
The Apollo Double Diaphragm Pump which was perfected by UC faculty members using .
Using a standard test designed to moon flight technological gains. .
determine RBCdestruction, the team These results suggest the possibili- critical ill nesses like heart attacks and pump without generating heat an*i
pp
circulated fresh canine blood pneumonia, reported thus raising the temperature of the
machines
times better results in not harming

-l
is its efficiency, which allows it to will include "modifying it with cihtt
RBC than existing pumps.
heart pump
materials to make it more compatible * t
with blood." said Ricvcschl.
As a further improvement, the
team plans to place disposable tubing
in the pump for the blood to pass
through, thereby producing even less
RBC damage, explained llicmhcru
Disposable tubing would also
make it possible for many people to
use the same pump by changing the
parts which come in contacts with the
patient's blood. ARMSTRONG
The ultimate advancement in the
research will be to miniaturize the
ADDP, which is a "step towards im
maneuver," to save the lives of food
choking victims, and the.Hcimhcn
plantation," said Neimlich. He
stressed, however, that implantation
chest drainage valve which was used
in Vietnam.
or the pump is a long way off. •
Patrick has the distinction of not
• Armstrong, best known for his
only having a Ph.D. in electrical
walk on the moon, holds a masters
engineering, hut, also an. M.U.
degree in aerospace engineering, and
honorary doctorate degrees in degree. ' ,
He is now working on a national
engineering, law and science.
computer program which would
As the Deputy Associate Ad
select the proper surgical procedure
ministrator for Aeronautics, at
on an individual basis for the ireat-.
NASA, Armstrong was responsible
ment of breast cancer. ; •
for the coordination and manage
Ricvcschl developed the drug
ment of overall NASA research and
Bcnadryl, the first antihisuminc.
technology related to aeronautics.
Funding for worX on the ADDP is
Hcimltch is widely-known for the
* being provided by.thc Corbctt houn-
, procedure he devised for replacement
dation..;.-...
\ of .the esophagus, "the Hcimlich
>
Whes
Deve
ST. CLAIRSVILLE - A
Wheeling man, married to a
; /v former St. Clairsville woman, is
a member d a research lean
working en the adaptation of a
pump used in suits worn by
astronauts on the moon to extra-
corporal heart lung systems as
well as implantab'.e artificial

heart-lung de\ices.
Dr. Edward Patrick, a
Purdue University prcfe*scr of
electrical engineering «ho also
holds a medical degree' from
Indiana University school of
Medicine, a native of Wheeling,
worked with Neil A. Armstro.-.g,
a graduate of Purdue and the
Tins IS a pump being dtveloptd by a four- to allow a b>pass of the beart for pertodi first man to walk on the moon,
m«D team, which Includts Or. Kdward much longer than cow available wlih Dr. Henry J. HeimHch, M.D.,
Pitrlck, a Whtcllog nativ* and now a present heart-lun? devices. Dr. Patrick Is director' of sunrery at Je-.^sh
prolMsor at Purdue fnlversity, and Nell married to a former St. Clalrsvllle Hospital, Cincinnati, and
A. ArrostroDg, former astronaut, designed resident, Patricia Roy Patrick. George Rieveschl, vice
presid;r.t -of special project
and Department of Environ
mental Engineering, University
of Cincinnati.
Dr. Patrick is the husband of

the former Patricia P.oy who
grew up in St. Clairsville. Her
mother, Mrs. Virginia Roy, and
her aunt, Mrs. Agnes Sch-
wartibach, presently live at 121
Park Drive. St. Clairsville.
Another aunt ar.d uncle. Mr.
.and Mrs. J. F. Belfield, live in
Martins Ferry.
The team presented a paper

on their work last week at the
meeting of the American
Association of Medical
Instrumentation in Boston.
They held that a limitation for
existing heart-lung machines is
that they can be used safely for
only hours as continuous use of
the pump destroys red blood
cells which are filled by organs
such as the kidney, causing
Injury to the organ.
The team presented findings
indicating their "Apollo Double
Diaphragm Pump" is less
destructive to red blood cells by
many times than any exisiting
pump now used in heart-lung
machines.
> we*
iple will find their own way. incinnati's Largest Daily I
yff: '■:.*■• NEIL ARMSTRONG

v.. n -«| V . . ....
L.^S2rJ
DR. HENRY J. HEDOJCH
na
Vi<
Cot
mo
-Shot in
rtOT
ysed
app
cor
Cor
the
one
anru
"be
•iv'»", BY BOB WOMAOC pump bow otd in heart-Jung ma^ the •
chines. - ; S. ^
A Cincinnati research team has "When modrfied ._ it can be ex- govt
used Moon-flight technology to adapt a pected to function even better," says divi:
tiny space-suit pump for temporary the team's report. Nanj
use as an artificial heart. *
- THE PUMP DESIGNED for the BirJ-
• The team included Neil A. Arm
Apollo space program, the report'" ar.d
strong, the first man to walk on the
says, has qualities that are desirable in Jr
Moon; Dr. Henry J. Heirr.Kch. director for an artificial heart-lurs system, in
of surgery at Jewish Hospital; George An I
cluding low weicht. small sue, high - siege
.Rieveschl, vice president of special
efficiency and high reliability.
" projects at the University of Cincin
roun<
nati; and Edward A. Patrick, profes The group tested the ADDP by
sor of electrical engineering at Purdue pumping fresh dog blood through it,
.University. .... then checking red blood cells with • T
microscopes. <£ c*nt
'Armstrong" the former astronaut, >^s from
fa a professor of aerospace engineer- The results of their experiments^ fr°m
.ing at the University of Cincinnati. show that the destruction of red blood vvn.'st (
cells "is less than that reported for
•' • The newly adapted pump is "many any other pump." " ,
times less destructive" to red blood
cells than any existing pump now used • The ADDP was selected by the Na
in heart-lung machines.".a scon-to-be- tional Aeronautics and Space Adminis
published paper by the research team tration h>r the Apollo procram be
said. .: ;■;,"■/'.' cause of •>« high overall efficiency."
" Existing hârt-lurg marines can including r.« low power consumption
t be used safely only for several hours.- - ■ and low heat generation, also qualities
'oi
important in an artificial heart-lung
i^r^Vnth the new pump, "it is omcelv- ■• system, the researchers coted
THEY FOUND thit the blood
A-6 lomnal and Courier, Hon.. Wot. 25, 1974
oncer research
Purdue News Service patient. In addition. It family history of breast lity of survival for a par
Creation of a research would be possible to spot cancer; patient Immunolo- Couritr ticular patient profile.
facility for applying new unusat incidences of breast gical status; duration of "With these probabilities
computer techniques to cancer in a particular geo disease at diagnosis; Metro report of survival available as a
breast cancer patient data graphic location, he believ patient age; peripheral service to surgeons, they
was revealed Friday in es. white blood count; mam- will be able to determine
Boston by a Purdue Uni "What we are immediat mography; associated Patrick said. "For ex the best way to manage
versity professor. ely concerned with Is the pregnancy or associated ample, one group of pa the health care of that par
Edward A. Patrick, both efficacy of treatment/* Dr. menopause. tients would be those with ticular patient. There is
a medical doctor and a Patrick said. "Since breast The data bank would cancerous lymph nodes as not any one procedure cur
professor of electrical engi cancer is such a serious also Include the history of compared with another rently programmed in a
neering, detailed the first problem. It is essential that prc-surgery or post-surgery group whose lymph nodes computer which can esti
steps toward such a vital a scientific approach be and the cause of death if are cancer-free." mate the required probabi
research program in an af used for organizing patient and laboratory tests. Dr. the patient did not survive. He said the probability. lity distributions for breast
ternoon speech delivered data and evaluating the Patrick listed 13 of these Not all of these features of survival for different cancer problems/* Dr. Pat
before the Medicine in En outcome of different treat that are used by surg(*>ns arc Independent, pointing treatments and different rick stated.
gineering Seminar at Mas ments — radical, limited, before reaching a decision to the need for careful sci patient profiles could be His work in this area is
sachusetts Institute of tymphectomy, chem on the method of treat entific exploration of the being supported by the Na
determined. Ultimately, a
Technology. otherapy or a combination ment: data. Dr. Patrick said. treatment can be selected tional Science Foundation *
As a result of this re of these." Cancer stage, primary "When we compile this to give the highest probabi and the Regcnstricff In- .
search program, advisory In determining the treat tumor size, primary tumor patient information and stitutc, Indianapolis, in Co- |
information could be pro ment of a patient, a surg biopsy, micro or macro store it Into a computer, operation with the Depart- <
vided to surgeons on the eon uses the patient's past mammary tissue cancer population distributions can ment of Community Health •
best treatment for breast medical history, family his cells and internal mam be computed for different Sciences, Indiana Univer
cancer in a particular tory and signs, symptoms mary lymph node biopsy; groups of patients/* Dr. sity School of Medicine.
Upmputer system at Purdue
to aid breast cancer victims
Bu JUDY HORAK lab tests, medical history, the fami Today there is no data on survival rates for various treatments for that
f Staff Writer ly history of breast cancer and oth rates for patients in particular particular cascfrom its data bank.
* Within six months, a computer on er data which will be fed into the stages of the disease receiving par
% the Purdue University campus may computer, he explained. ticular treatments, Patrick said, al Unfortunately, the project won't
; be able to tell a doctor which treat Secondly, the set of procedures though several medical centers be immediately available to all
ment is best for a patient with used on the patient and the length maintain data on their cancer pa breast cancer victims. "The cost of
breast cancer. of survival will be fed into the com tients. (computer) terminals to all points of
Edward A. Patrick, both a medi- puter. Procedures include chem the country would increase the cost
i cal doctor and a professor of electri otherapy (drug therapy), radiation, "We're going to ask three or four of health care," he said. "Just be
cal engineering at Purdue, said tumpectomy (removal of cancerous institutions who have cimcer data to cause we have one (data) bank
( Tuesday that the new computer sys- tissue alone), simple mastectomy make it available to this facility," doesn't mean there's automatically
' tern was the first of its kind in the (the removal of the cancerous Patrick said. The medical center in access all across the county."
country. He first discussed the sys-. breast) and the rndical mastectomy Indianapolis and Memorial Hospital Patrick's research is being funded
• tern last week at a seminar at Mas (removal of the breast and under in New York arc two expected by the National Science Foundation
sachusetts Institute of Technology. lying chest wall muscles). sources of data, he said. and the Regensirieff Institute in In-*
. Patrick was back on the WL Some American physicans present
dianapolis in cooperation with the
campus Tuesday for a press confer ly disagree over which route is best The end result of the project
Deaprtment of Community Health
ence on the project. for patients in particular stages of won't be a handy guide telling doc
Sciences at the Indiana University
"There are other centers in the . the disease. While some doctors al- tors which treatment is best for School of Medicine.
country gathering data on breast • wasy perform a radical mastecomy, which stages of cancer. Patrick's
cancer patients," Patrick said. "But increasing numbers of physicans are computer program is more sophis He noted that there is no funding
this is different in its organization." ' performing the less drastic "simple" ticated than that. "The particular yet for a network of terminals tying
This system will collect 20 pieces operation. The lumpectomy Is patient's profile would have to be local physicans to the data bank.The
m of information about each primarily a European technique, submitted to the computer," he said, •kinks' in the system are pragmatic,
patient—her symptoms, results of Patrick said. which would then derive survival he said.
^&-Sl
Reprinted from
28 February 1975,volume 187,pages 764-765
Pattern Recognition May Resolve Management of Breast Cancer: A standard pattern recognition prob
lem is, given "training samples" for
Limited Mastectomy versus Radical Mastectomy class Cry and "training samples" for
class C,,v> to estimate the respective
probability distributions p(l | CRT) and
p(f | C,,v). This is not an easy task. First,
In the 7 October 1974 issue of the primary lesion; /,0, duration of disease a model for the probability distribution
Journal of the American Medical As at diagnosis; /,,, pre- or postmenopause; must be assumed a priori; or in the
sociation two surgeons debated the /,2, associated pregnancy; /u, antibody language of pattern recognition, a
methods of management of breast can to breast cancer antigen; and ju, tu "family structure" must be assumed for
cer. Crile (/) took the position that mor growth rate. the probability distribution. Patrick
limited mastectomy was the method of The patient's feature vector may be considers such estimation of probability
choice, while Anglem (2) took the posi denoted as distribution in detail (3). There is not
tion that management of breast cancer one currently available computer pro
should be by radical mastectomy. Both f = (/.,/. /••] cedure that can be used to construct
surgeons cited their own studies as well a column vector. Let the joint probabil the required estimated probability den
as those of others to support their re ity distribution of f be p(f | CBT) and sity functions pit | CBT) and pit | CLt).
spective positions. pit I Ci.v) for 'he tw° classes, respec Any procedure assumes some structure
However, the data base structures tively. about the functional form of />, whether
cited by the two surgeons were ap Given a patient with a particular fea it is a multivariate Gaussian assump
parently not the same, and as a result ture vector f, what is the probability of tion at one extreme or a "nonparamet-
it is not possible to compute survival the occurrence of CBt or C|,T? ric" structure at the other extreme (4-
probabilities which are conditioned on To answer this question, we must ask 6). Up to now, analyses of breast can
different assumptions. I now propose a what is the probability of CHt or CLX cer data have been dependent on the
method for organizing the data base and for a patient with breast cancer before formation of one-dimensional or two-
then evaluating the outcome of different we look at f for that patient? These a dimensional probability distributions;
treatments. The method can be applied priori probabilities will be denoted for example, with /, (that is, the cancer
to existing data as well as to data that p{CRy) and pCCLT), respectively. Then, stage) or with the two features /, and /,
may be collected in the future. the probability of CBr or CLT for a pa (that is, histopathology). Probabil
Pattern recognition theory and prac tient after looking at his feature vector, ity distributions might have been con
tice is based on classes, features of these called an a posteriori probability, will structed for /, and /,, with the use of
classes, and the statistical distribution of be denoted p(CRV | f) and piCLy I f) for different values of /a (that is, patient
these features for the respective classes. the two respective classes. For the latter age). Another problem is how to use a
In the problem of breast cancer survi notation, the ! in p{CKy ] f) is used to priori knowledge that two features are
val there are two basic classes (a class mean given: that is, probability of CRv statistically dependent.
will be generally denoted O. given f. Thus, given the number of training
The well-known Bayes theorem re samples /VB for class CRT and the num
C»v = survival for Y yean after
ber of training samples NL for class CLY,
radical mastectomy lates the a posteriori probability to the
Cit = survival for Y years after we can estimate p(f|CKT) and pil\Ct\).
a priori probability as
limited mastectomy Once these are estimated and a priori
Additional classes can be defined in probabilities p(CHV) and p(CL1) speci
terms of other treatments or features. fied, then the a posteriori probabilities
The features of the classes will be p(CHy I f) and p(Ci.t) ' 0 can be cal
inferred from the discussion by the culated for any patient f, where piO is
two surgeons and other studies: lx, can calculated from Eq. 3.
cer stage; /2, patient age; /3, histopa- However, difficulties can be antici
thology: /,, lymph node involvement; /.-„ pated. First, what are the a priori prob
treatment: f3. family history of breast abilities p(CHy) and /KCYv)? Might one
cancer; /;, immunological status; /8, pa assume piCRX) = piCLX) = 1/2? Did
tient's cause of death; /9, location of Crile (/) and Anglem (2) cause a priori
Copyright © 1975 by the American Association for the Advancement of Science
/.i I
probabilities (by implication) to depend P(f I Qv) and p(t | CLY), and agree on
on patient age or cancer stage, when a priori relationships among the fea
properly age and stage are part of the tures in f; (iii) establish a computer
feature vector f and should have their data bank for patient samples and
effect by adding to the dimensionality guidelines for this data to be accessed;
of p(t\Cm) and p(f|C,,v), respec and (iv) agree on values for p(Ciiy)
tively? and p(Cr,v). (v) Thus, estimates will
Many of the studies cited by Crile be obtained for p(l | Cny) and
(/) and Anglem (2) involve different p{t | CLY) for Y (years) = 5, 10, 15
parts of the feature vector f. Thus, one (for example).
study might provide training samples Edward A. Patrick
for one part of p(t \ C) while another Department of Electrical Engineering,
study might provide training samples Purdue University, West Lafayette,
for another part of p(f | C). Indiana 47907, and Indiana University
To conclude, any national effort to School of Medicine, Indianapolis
evaluate future breast cancer data or to
Rcfercneti
reevaluate past breast cancer data
1. G. Crilt. Jr., 1. Am. Med. Atioc. lit. 95. 106
should follow guidelines established by (1974).
a recognized group of experts from 2. T. J. Anjlem, Ibid., pp. 99. 108.
J. E. A. Patrick, Fundamental! o/ Pattern Ktcot-
the surgical community and the pat nltion (Prentice-Hall. Engleuood ClifTt. N.J..
tern recognition-statistician community. 1972).
*■ . L. L. Shtn, F. P. Stclmack, "Introduc
This group of experts should (i) de tion to the theory of mcdicil contultlni «nd
diagnosis," Proceeding* of the 197.1 National
termine a set of features to be included Computer Conference.
in f and the values which these features 5. . IEEE (Inn. Elecir. Electron. Ent.)
Tram. Syit. Man Cybirn. 4, I (1974).
can have; (ii) agree on various a priori
6. L. B. Lulled, New Engl. J Mrd. 114 416
structures to be used in obtaining (1971).
the estimated probability distributions 21 October 1974; revised 1> December 1974
AS
Scmcer research plan remedied

Purdue News Service patient. In addition, It family history of breast lity of survival for a par
Creation of a research would be possible to spot oncer; patient Imuumolo- ticular patient profile.
' facility for applying new unur.al incidences of breast Rieal status; duration of "With these probabilities
computer techniques to cancer in a particular £<*o- disease at diagnosis; Metro report of survival available as a
hvar.i en peer patient data Kraphlc location, he l>cllcv- patient n£e; peripheral service to sure/'ons, they
was revealed Friday in cs. while hhxHl count; mam- will be nbte to determine
Boston by n Purdue Uni "What we nre immediat nio>',rnphy; associated Patrick said. "For ex the best way to manage
versity profesfior. ely concerned with is the prej:nancy or ar.ociatcd ample, one e.nutp of pn- the health c;ue of that par
Hriwan! A. Patrick, both efficacy of treatment/* Or. tienln would 1^ tlitr:e with ticular patient. I here is
a medical doctor and a Patrick said. "Since breast The dnta bank would is lymph no«I<'S as not any one procedure cur-
pnif«-.M»r of electrical ei'/;l- cancer is such a serious incl'i<K» the lilstory of ped with another tcntly programmed in n
neerim:, dvtailed the first pn*>letn. It is er.w n'ir»I that prv*.tity,ny or po^'sur^^ry
r.rottp wlvs'* lyirpfi nodes computer which c;m esti
stop*, toward such a vital a scientific noproach >>? ntui id" <t\iisc of dcntli if nn* n»n»*f r-fre^»/' mate, the reouin •! prohaM-
rese.*ir« h program in an af w^*d for or;Mni7.1np patient and HSorntory tests. Dr. \\w p;jt;.*!i* Okj tv,t Mirvlve.
He s.iid t!u» prolKthlllty. lity dislributlotri U>r l)tr;»-;t
ternoon speech delivered data nnd evaluating ihc Patrick listed 13 of th<*%c Nut nil of these features cancer probl^mr;/* Dr. Pat
of survival for different
b-fo'e tre MtxUrine in Kn- Outcome of different trent- th.it nrc u^rd by »!•£•".*« nre Independent, pointing
treatments and different rick stated.
pr*.t;**rl:tp. Seminar nt Mn»- men ts — rn'Uciil, Mmlted, bcff»H» nmcMrK a il<<l'.t<m tn 0^ n* -.0 for cap'fut vi- His work in tbh ana is
patient profiles could be
snc!*uM-tt5 Institute of 1y:nph'-ctomy, chrm- on lie method of treat rnttMr exploration of the N*inj» supportefI *yy tht? Na
determined. Ultimately, a
TechnolojTy. othempy or a combination ment : dat.i. Dr. Putrtck ^'id. treatment can be selected tional Science I outnlatlon
Ar. n result of this re- of these." Cancer stn^c. primary ••When we compile thin to j$lv© the highest probabi and the Rer.'*n urieff In
scorch pror.ram, advisory In determining the treat tunior »izc, primary tumor pntlent Information and stitute, Indianapolis, in co
Information could be pro ment of a patient, a surg biopsy, micro or macro wore it Into a computer, operation with the Depart
vided to surgeons on the eon uses the patient's past mammary tissue cancer popclntkm distributions can ment of Community Health
best treatment for breast medical history, family his cells and internal mam be computed for different Sciences, Indiana Univer
cancer in a particular tory and signs, symptoms mary lymph node biopsy; groups of patients/' Dr. sity School of Medicine.
I
Computer system bt Purdue
to aid breast cancer victims
; Bu JUDY IIORAK lab tests, medical history, the fami Today there is no data on survival rates for various treatments for that
J Staff Writer ly history of breast cancer and oth rat«*s for patients in particular particular casefrom its data bank.
J Within six months, a computer on er data which will be fed into the star's of the disease receiving par-
J the Purdue University can)pus may computer, he explained. tiriil.ir in-atinents, Patrick s;iid, al- Unfortunately, the project won't
, be able to tell u doctor which treat Secondly, the set of procedures thv-u>*h several medu'at centers be immediately available to all
ment is best for a patient with uv«d *>n the patient mid the length miiiit.iin data on their cancer pa- breast cancer victims. "The cost of
br* ast cancer. of survival v,»ll b«' frd into the com tn1»is. (computer) terminals to all points of •
Hdward A. Patrick, both a medl- puter. Procedures include chem- tin; country would u>crea:.e the cost
. cal doctor and a pr«>fc!^>r of electrl- <»'Fi-T.":ny («lni^ therapy), radtition. •#w*e*r« fyMnp to ask tlirre or four of health core," he said. "Just be-
,cnl enj»ln^!finK at Purdue, fin Id Mifliiiiftrtu wl«» huve ranrer data to cau:e we have on»» (dola) bank J
Tu* -%day tli.-ir the u<*w rc-mputer ays- Janiple m:»;.trciomy make it uv.ubMe to this facility." d'H-sti't me.m UiereN automatically
* tew war* tl»e first of itr; kind m tlw (the removal of the cancerous Patrick Mid. The medical center in acre*-; all across the county."
, country. Ite flr.t discur.vd the sy.'k breast) and the radical mnsttctomy IndMiiapolls and Memorial Hospital Patrick's research is beine, funded
< terti last w*x"k at a seminar At Mas- (remov.il of the Itrtr'ir.t and under in New York arc two expected by the National Science l:oti>u1ution
* srtchusetts Institute of Tcchnolojty. lying chi-M wall muscles). sources of data, he said. and the Re;;«*nMn».ff Institute in In
,t !*atrick was back on the WL Some American physicans present
dianapolis in cooperation with the
campus Tucsdiiy for a press confer- ly disagree over which route Is best The end result of the project Deaprtment of Community Health
* cnre on the project. for patients in particular st»i;ea of won't be a handy £u»de telling doc
Sciences at the Indiana University
1 "There arc other centers In the the disease. While some doctors at- tors which treatment is best for School of Medicine.
' country gathering data on brenst wasy perform a radiail mastecomy, which stages of cancer. Patrick's
cancer puticnts," Patrick said. "But increasing numberr* of physlcons are Computer program is more sophis !U? noted that there Is no funding
this is different in its organization." ' performing the less drastic "simple** ticated than rhat. "The particular yet for a network of terminals tying
This sys,tem will collect 20 pieces operation. The lumpectomy is patient's profile would have to bo local physicans to the data bank.The
,m of information about each primarily a European technique, submitted to the computer," he said, 'kinks' in the system arc pragmatic,
patient—her symptoms, results of Patrick said. which would then derive survival he said.
§r
HHBL*****-9*
BOCHESTEB
SEHTIKEL
D. 4,199
2 5 >974
Purdue data center may be tool

in battle against breast cancer
WEST LAFAYETTE. Ind. (AP) — month at Massachusetts Institute of The data bank would contain
A computerized data center Technology. criteria on a specific patient
developed by a Purdue university '"Since breast cancer is such i eluding past medical history. fa->
physician-engineering professor may serious problem, it is essential that history, signs, symptoms and ivs-j
prove a vital tool in combatting scientific approach be used U of laboratory tests, the p,,-^
breast cancer. organizing paiicntj' data a* educator said. With informal:
evaluating the outcome of differed gathered from the b.ink
The center may help surgeons find treatments," Patrick said. probability of survival .'rr difr^-c-
the method of treating breast cancer Treatments often include rcmo*l treutments and d.f.'ereu w-'»
in individual patients that offers the of one breast, as in the case'f profiles could be deterrr.\-,<>d.
highest chance fnr survival, said Dr. President Ford's wife. Botty. or r#h "With these probabilities of ^l
Edward A. Patrick. breasts, which was i2<>ne for the '"c vivial available as a <ervic»
He outlined operation of the data of Vice President Nelson*. surgeons, they w:il r» af,;^
bank at an engineering seminar last Rockefeller. determine the best way to mana,
•the health care of the patient."
Patrick said the focus of t!
National Institute of Health has her
more toward letting .r.divjdj
cancer centers obtain'and cct--
treatment data. "There h3s ko>-
little effort at organizing it in
logical, scientific way."
0£CUSSifiEOv.-V«]
MEW ALBANY
TRIBUHE
D. 12,003
OEC 2 6 1374
Computers In
ii
i!
Treating Breast Cancers

• WEST LAFAYETTE, Ir.d. in? professor may prove a vital.jeons find the methD-i cf treat-.
■(AP)—A computerized data tool in combatting breast can- inp breast career in individual
■ center developed by a P'jrdue cer. patients that ofscrs the highest
Univtxsity physitian-eronec;-: The center may help sur- chance for survival, said Dr.
'' .-Edward A. Patrick.
i
I He outlined operation cf the ■
|dau bank at an ecsmeen-p '<
■ • • I seminar Jast month at V.i<-
i|Sachuse«s Institute of Tech-
'■oology. * ,-
j. J'Since breast cancer is such.
j» -lerious' problem, it is es;e,-.-
. ■ Jtitl that a scientific approach
be used for orâr.::irs patier.ts
* WaU and ev!ja:i.-.; the cj:-
|come of different treatments."
jPatrick said.
Treatments often include re-
Im'oval of one breast, as in t.vo
:«se of President Fords v.:f;
■ Betty, or both brc£«ts. u-h'th
;was done for the v:fe of Vi-.e
• President Nelson A. Kockefel-
■Jhe'data bank would contain

1J criteria on a specific patient
including past medical history..
:family his tor.', sicr.s. sy.r.p-
■tomi and results cf labora^r.-
[tests, the Purdue ecjeator sa:d.
'.With information fathered frc;r.
I the ban):.- a probability of v.'r-
jvival for different t'eatmer.ts
land different ptv.sr.: profiles
could bs determined.
i ■"With these p:obabi!:;ies of
'survival available a« a str.-cc
.to'surgeons, they will be able \n
•determine the best way to mar,.
age - the health care of the
patient".
'."Patrick said"the focus of the
National.Institute cf K«2!th has
been more toward lettir.g indi
vidual" cancer centers obtain
and.-compile treatment data.
There has been little effort at
organizing it in a-logica], scien
tific-way."
OHe.-ls seeking financial sup
port; to establish a data proc
essing center either here or ar
the .Indiana University • Medici!
Center in Indianapolis.
i "We. are nationally probably
the best for analyzing this kind
ofâtai."
O£CUSSIH£OV.'»»--X|
/.* I
INDIANA HEWSCLIP
JUS t. 55 PL SUITE F
UUS IXOIAfU «
VIHCEHHES
SUM-COMMERCIAL
D. 14,662 S. 15.051
JAN 5 197
PAGE 24 VINCENNES SUN-COMMERCIAL. SUNDAY. JANUARY S
Data-Center May
Be Cancer Too
WEST LAFAYETTE. Ind. information gathered from the
<AP>— A computerized data b3r.k. a probability of survival
center developed by a Pur±u for different teatnvnts ar.d dif-
University physician-t-rsiroer- fercr.t patient profiles could be
ing professor may prove a v;tal determined r
tool in combatting breast "With these probabilities of
career. survival available a* a service to
The center mr»y help surgeons survcorj. they will be able to de-
find the method of tr'-atrg terrrune the best way to manage
breast career in \r.<i»:'A'ii\ pa the health care of the pa
tients thxat offers the highest tient."
chance for survival, said Dr. Ed
Patrick said the focus of the
ward A. Patrick.
National Institute of Health has
He outlined operation of the
been more toward letting indi
data bank at an engineering
vidual cancer centers obtain
seminar last month at Massa
3r.d ccrr.pile trea'rr.T.t data.
chusetts Institute of Techno
-There has been litt'e effort at
logy.
organizing it in a logical, scien
"Since breast cancer is such a
tific way."
serious problem, it is essential
that a scientific ar>^r<y»ch *** He is se.-kirg financial suo-
used for or?2'-:?i-i nr;':>i'".tV cert to <■.:••;'.:•!.•"- .-, .Jyi r?~r-'-is-
"ij'.a and k':z:.S."Z *.<■ "'Jl- .•:.4 center either here or at the
come of different treatments." Indiana University Medical
Patrick said. Center in Indianapolis.
Treatments often include re
"We are nationally probably
moval of one breas:. as in the the best for analyzing this kind
case of President Ford's wfe. of data."
, Betty, or both breasts, which was
. done for the wife of Vice Presi He said. "We are starting with
dent Nelson A. Rockefeller. breast cancer, because it is
; The data bank would contain probably the most important
. ;13 criteria on a specific parent from the woman' iSodpoint." He
'including past medical history. said a second effort might be
family history, signs, symptoms aimed at colon cancer, which
fcnd results of laboratory tests. has a high incidence among
men.
<he Purdue educator said. With
in.Kmwia.Buju
PORTLAND
COMMERCIAL.
REVIEW
D. 4,992
DEC .? ? 137^ L
purer programmed
rfcfdid cancer f rear men TS

* vWEST LAFAYETTE. Ind. rHe outlined operation of the moval of one breast, as in the ' from the bank, a crobabili
! (AP>—A computerized data. data bank at an engineering case of President Ford's wife survival for different tesirr
■ center developed by a Purdue seminar last month at Mas-- Betty, or both breasts, which and different pane.-.t ore
University physician-er.emeer- sachusetts Institute .of Tech- was done for the wife of Vice could be deiermir.ed.
Ing professor may prove a vita! President Nelson A. Rockefel "With these prcsatu:::'.
tool in combatting breast can "Since breast cancer is such ler. • survival available as a <•::
cer." ..." • j- ^ . a serious problem, it is essen- The data bank would contain to sureeor^. they win c; ^
.•'♦The center may help sur tial that a scientific approach 13 criteria on a specific patient determine t.ie êst wav io:
geons find the rr.e:bod of treat be used for oreanizine patients' including past medical history1, ace the health care of
ing breast caccer Li ir.diviajal data and evaiuatir.g the cut- family history, siens. syrr.p- • patient. •
patients that offers the highest come of different treatments." toms and results of laboratory ^ "We are hationaily oroo
J&UKCJc;iâulJaidDr Patrick said.^_ ..' " • -:'.' tests, the Purdue educator saidJ- ihe best for ana!\7uig t\'.s
Edward AT Patrick. '• - • , •Treatments often include re- With information gathered , of data."
INDIANA KEWSCLIP
K7S L W n. SCHE f
IXOIUOKIIS, IND1AKA «G8
MUNCIE PRESS
0. 22,539
DEC 2 6
'Purdue savant's data ban-

could be breast cancer too!
WEST LAFAYETTE, Ind.. Betty, or both breasts, He Is seeking financial sup
(AP)—A computerized data; was done for the wife of Vice1 port to-tsublish a data proc
center developed by a Purdue President Nelson A. RockefeK
essing center either here or at
'.sr.
University physician-engineer-1 the Indiana'.University Medical
ing~profe'ss'or may prove a vital The databank vculd contain. Center in Indianapolis.
ool in combatting breast can-! 13 criteria on a specific patient
ccr.
including past medical history.i "We are nationally probably
family history, sicr.s. symp- the best for analyzing this kind
The center may help rur
;eons find the method of treat-
tc.T.s and results of laboratory of data." ' • '
tests, the Purdue educator said.!
flg breast cancer in ir.cirii'jal' ' He said. "We «re starting
'.V:th information C3ihered from1
patients that offers the lushest *ith breast cancer, because it
•.he bank, a probability of sum
chance for s-jrvnal, said Dr. is probably the most important
vival for dL'ferer.t treatments
Edward A. Patrick. .'rcm t he woman's stanipoir.t."
i:.i different pstiest profiles
He outlined operation of the c?:!d b* delerrrur.ed. He said a second effort rrut'-.t
data bank at an encr.eer.£? be aimed • at colon cancer,
seminar last month at Mas r-Tvival available as a service •Ahkh. has a higa incidence
sachusetts Institute of Tech to s^rreons. they rvjii be abie to:] zg men.
nology. . f determine the b»r. way to man

"Since breast cancer is such age the. health care of the
serious problem, it is essen patient."
tial that a scientific approachi
Patrick said the focus of the
be osed for. organizing oatier.ts'i
data and evaluating " the out National Institute of Health has
more toward letting indi
come .of different treatments.":
vidual cancer centers ootain
Patrick said. j
and compile treatment data.
Treatments often include re-! "There has been little effort at
moval of one breast, as in the it in a logical, scien-
case of President Fcrd"s vL'e, tific -4cV."
Engineer-doctor computerizes
breas t cancer data in ivomen
WEST LAFAYETTE. Ind.-Creation of a blood county: mannography: associated the National Science Foundation and
research facility for app'.yine new computer pregnancy or associated menopause. Regenstrieff Institute. Ir.dunscoiis.
techniques to breast cancer patient data has The data bank would also include the cooperation with the Department
been revealed in Boston by a Purdue history of pre-surgery or post-surgery and Communitv Health Sciences. Irrii
University professor. the cause of death if the patient did not University School of Medicine.
Edward A. Patrick, both a medical doctor- survive Dr. Patrick said. "We are startine -,
and a professor of electrical engineering. Not all of these features are independent, breast cancer because it is orobabivthorr
detailed the first steps towards such a vital pointing to the need for careful scientific important from the woman > vewrn-p.' '"
research program. The announcement came exploration of the data. Dr. Patrick said. said a second effort rniznt be aimed ai cc
during a speech delivered before the ■•When we compile this patient cancer, which has a high incidence am:
Medicine in Engineering Seminar at information and store it into a computer, men.
Massachusetts Institute of Techr.oloev. population distributions can be computed for Treatments often include removal of at
As a result of th;s research program, different erouos o: patients." Dr. Patrick breast, as in the case of Pre>iu\m F.ji
advisory information could be provided to said. "For example, one group of patients wife. Bettv. or both breasts, which wa< d
surgeons on the best treatment for breast would be those with cancerous Ivmph nodes for the wife of Vice President Nelson
cancer in a particular patient In ad-iitir>n it 3< c""r?2rr/d w:>h i".?'.hor crnuo whese Rccke-feUer.
would be possioie to spot unusual inciaences lymph nodes are ca-.eer-free." Patrick said the focus of the Na».:c
of breast cancer in a particular eeoeraphic He <aid the probability of survival for Institute of Health has be*n rr.ore tox
location, he believes. different treatments and different patients letting individual cancer centers obtain
•'Vhat we are immediately concerned with profiles could be determined. Ultimately, a compile treatment date. "There has b
Is the efficacy of treatment." Dr. Patrick treatment can be selected to give the highest little effort at organizing it in a ioeu
said. "Since breast cancer is such a serious probabilitv of survival for a particular scientific wav."
problem, it is essential that a scientific patient profile. He is seeking financial suoDort to e<nb
approach be used for organizing patient data "With these probabilities of survival a data processing center, mrhcr at A
and cvaulating the outcome of a different available as a service to surgeons, thev will Lafavette or at the Indiana l'r.iv»r«
treatments—radical, limned. Ivmcheetomy. be able to rtetormir.e the best wav to mar.ace Medical Center in Ird.ar..*.r°i:< "'ê
chemotherapy or a combination of these." the health care of that particular patient. nationallv probablv the best for ar.ilv?
In determining the treatment of a patient, . There is not any one procedure currently this kind of data." the doctor reveals
ii surgeon uses the patient's past medical programmed in a computer which can While this announcement w^< b'tr? r-i
history, family historv and sier.s. svmptoms estimate the required probability the Associate Pre«s. in a '\v>'■>.--.-:•
and laboratory tests. Dr. Patrick li>ted 13 of distributions for breast cancer problems." story in "News from the W.irld of V.c.l..-:?
these that are used bv sureeons before Dr. Patrick stated. appearing in'a recent issue nf He :•
reaching a decision on the method of His work in this area is being supported by Digest, printed this" "A Oncer-Sen-
treatment: Bra."
Cancer stage, primarv tumor size, The article said:
primarv tumor biocsv. micro or macro A group of women in Tucson. An.' . t
mannary ti><ue cancer ceils and internal soon begin ttsi-wearine cr..»«:-ir-^ :
mammary lymph node biopsv: familv ir.icht be able to detect nr>--' '.:':
history of breast cancer: patient icancerous or benign ■ at their earliest s:a
Immunological status: duration of disease at Special sensors in the bras will rex'ora t:s;
diagnosis; patient age; peripheral white templerature. A warmer-than-usuai s
would call for special examination m <ee:
tumor is present, explains Dr. Mj< L.
Y/A3ASH
B-tone. director cf the ra I',;.'.: :r. ••.'.,-;:
PUili DEALER (cancer! division
the of Universitv
Arizona's Medical Center
0.7.817 Dr. Boone estimates that s-:ch c<".'jct
could save the lives oi trcm L.i..".1 to ■■■■■
women a vear. In ire !«?<'■*. :•••"* '-"' "
t^rcc yeir-. •.'•* /v'ii'.i ;:; ••■.. :■'
periodically—for about 11 '.--u:s •.-.*."v
twice a year. Results for ac&roximatciv
( women without car.cer wul t«* ccrr.c j.

with the data from women known to have :
malignancy.
And just recently, public serv;
announcements started arsear::.! frecjer
on television. The soft-spoken rr.ess32e ur:
women to check for breast car.cer mo-tr
with the simple procedure tj<ir.g oniv t
minutes. For the right method, won
should consult their own physician. '
advertisement suggests.
O£CLASSIfi£Ov.*wsj
n/.-. I
INDIANA NEWSCLIP
1571 I W F1_ SUITE F
lS 1.K2UUU
JEFFER80HVILLE
EVENING HEWS
D. 16,073
To Fteiii Breast Cancer

WEST LAFAYETTE. Ind. be used for organizing patients' profiles could be determined.
(AP)—A computerized data data and evaluating the out- • "With these probabilities of
center developed by a..Purdue come of different treatments." survival ava:!aU!e as a service
University j)hyj:aan-e_ii.;inter- Patnc* sam. to surgeons, they wiil be aoie to -
Ing professor may pro\e a vital Treatments often include re determine the best way toman-
tool in combatting breast can moval of one ortjit. as in the age the health care of the
cer. case of President Ford's wife. patient." •
The center may help sur Betty, or both breasts, which Patrick said the focus of the
geons find the method of treat was ccr.e for the wife of Vice National Institute of Health has
ing breasl cancer in individual President Nelson A. Rockefel been more toward lotting indi
patients that offers Die highest ler. vidual cancer centers obtain
.chance for survival, said Dr. The data bank would contain and compile treatment data..
• 'Edward A. Patrick. 13 criteria on a specific patient "There has been little effort at
. He outlined operation of the including past mru:cal history, organizing it in a logical, scien
data bank at an engineering family history, signs, symp tific way.1
seminar last month at Mas toms and results oi laboratory He is seeking financial sup
sachusetts Institute of Tech tests, the Purdue educator said. port to establish a data proc
nology. With information gathered essing center either here or at
1 "Since breast cancer is such from the bank, a probability of the lQiliaoa.L'nivcrsay.ilcdical
• serious problem, it is essen survival for different treat Center in Indianapoiis.
tial that a scientific approach ments and different patient
I
CDH>- w<
INDIANA HEWSCLIP
1575 I. 55 PL S'JIU t
rMDUSAPCUS.
WABASH
PUi:i DEALER
D. 7,817
MUNCIE STAR DEC 2 6 1974 ■<
D. 30,746 S. 36,128
ata center
2 S '974
may combat
.furtfue Physician breast cancer
Working on Cure ,i WEST LAFAYETTE. Ind. (AP)-A
computerized data center developed by a
PurdueJJnjversity physician-engineering
for Breast Cancer . professor may prove a v.taJ tool in com

batting breast cancer.
The center may help surgeons find the
Treatments often Include «•! method of treating breast cancer in individual
patients that offers the highest chance for
survival, said Dr. Edward A. Patrick.
;f
He outlined operation of the data bank at an
engineering seminar last month at Mas
sachusetts Institute of Technology.
cinm-a « pres.jcnt "Since breast cancer is such a serious
problem, it is essential that a scientific ap
i» Si proach t>? used for or.âruzir..; patients' ia'-a
and evaluating the outcome of different
treatments." Patrick «md.
Frejuiients often mciuie removal of one
breast, as in the case of President Fords
cer to individual patients that wife. Betty, or both breasts, which was acr.e
offers the highest chance lor gathered' for the wife of Vice President Nelson A.
Rockefeller.
r his ^ ^
Tranced
month to'the seteDtilic »nd different
The data bank would contain 13 criteria on a
specific patient including past medical
history, family history, sicr.s. symptoms ar.d
2 results of bbira:;ry tens, the PJ.-'iue
educator sa;d. V»;tn information tav.c.-ed
Technology. these
of from the bank, a probability of survival for
different teatrr.?nts and different patient
crc;:ies coula w cct^rrrii.'ei.
*"'.Vitr *V:JC'? v ii-.'iltties Of survival
L"Z'.-~\" 11- J :•'.".'. '. '."■ y.T-1-'.':. '..:■:'■ '■".-
data and evaluating mo ou.;-b u- ^ con.
bi sbli to ce'.ermi.nc the b-cs; way to manage

come of different weatmenls. .ucu.ar patient , the health care of the patient."
Patrick.says. . .. tenas- ■,.. Patrick said the focus o: the National Ln-
. stitute of Health has been more toward letting
Individual cancer centers cb'-ain and cempiie
treatment data. ••There .-.as been iittie e::"ort
at organizing it in a logical, scientific way."
He is seeking financial support to estaoiish
a data processing center either here or at the
Indiana University Medical Center in In
dianapolis.
• "We are nationally probably the best for
analyzing this kind of data."
He said, "We are starling with breast
cancer, became it Is prrL-ab'.y the rr.cst Im
portant from the woman s view point." He
said a second effort might oe aimed at coiun
cancer, which has a high incidence among
men.
OECUSSFICO1-'. •'>/*"
/C I
|~fU£ CISCHVAII LVQl'iRER
CINCINNATI, QHIQ
D. 194.31?
MAR 2 01375
BOSTON (AP) - A pump used to A. Armstrong, former astronaut and

cool astronauts on the Moon could professor of aerospace engineering at
lead to an artlflcal heart-lung ma the University of Cincinnati: Dr.
chine that sustains people for weeks George Rieveschal of the University
Instead of a few hours like present of Cincinnati; and Dr. Edward A. Pat
mahtnes, researchers said Wednes rick, professor of electrical engineer*
day. ing atJMudue University.
The pump de'veloped for the
"The pump was used In the back-
Apollo Program has proved In pre
pa'ck of astronauts' suits to pump
liminary tests to be 10 times less de
cooling water." said Armstong. the
structive to blood than tne best
first man to walk on the Moon. "We'
pumps now used In heart-lung ma
were Interested In seeing how it
chines, the researchers said. De-
pumped blood."
'slrucllon of blood components Is a
Heart-lung machines are devices'
principal reason patients can be sus
that take over for organs In pumping
tained on existing machines for only
and adding oxygen to blood. They
a few hours.
are usually used to take the work
Speaking at a news conference
load oft the heart during open-heart
during the annual meeting of the
.surgery.
•Association for the Advancement of
A principal drawback called
Medical Instrumentation held here,
hemolysls, or the destruction of red
the researchers said cllnlnal use of
blood cells, causes anemia, excesses
the pump In an Improved heartlung
of certain chemicals tn the blood
machine was years in the future. But
and deposits of blcod cell fragments
Jhey said the aluminum pump, small
In the blood that can Injure such fil
enough to be held in the palm of a
tering organs as kidneys.
hand,showed great promise.
Patrick said red cells are dam- '
The research turn Includes Dr. aged or destroyed by contact with
Henry J.Heimlich. director of surgery pump Joints, bouncing against the
. at Jewish HospiUl la Cincinnati; Neil Interior lining of the device or shear
ing each other In turbulent flow.
ARMSTRONG SAID THE re-

searchers were not sure why their
. pump was less destructive to blood.
They theorized that it could be be-
' cause the pump has no moving parts
In the blood flow, produces little
. turbulence and has.efficient check
' valves that don't pinch blood cells as
other valves do.
Helmllch said the two-chamber
jpac« pump, on loan from the Na
tional Aeronautics and Space
■Administration. (NASA) was 10
times less damaging to ted cells even
•■ though It was tested in Its raw form
Just as It was taken out of the astro
naut backpack.
: "Hopefully we will Improve even
• this performance by refining the de- ,
vice," Heimllch said.
•~*.±. . ■ s :l.^ . l. .:
*** '■
A-
tfrxW-t-Vriif-Vjrih l.-^;.:-.i^..il^^l4.r^,
rr
' Lafayette-West Lafayette, Indiana, Thursday,' March 20.* 1975 Vol. 56-No. 67 20 Cents
IBID
A
.
'''■■> T
X >
•:•>
BOSTON (A'P) - A research Armstrong, the first man to walk ing to Dr. Eidward A. Patrick, pro
learn that Includes former astronaut on the moon and now an aerospace fessor of electrical engineering at >••
Neil A. Armstrong and a Purdue engineering professor at the Univer Purdue.
University professor says a pump sity of Cincinnati, said his group "The pump was used in the back
used to cool astronauts on the moon was not sure why its pump was !ess pack of astronauts* suits to pump
could help develop a heart-lung ma destructive. But the researchers cooling water," said Armstrong.
chine capable of sustaining people pointed out that it has. no moving "We were interested in seeing how
for weeks instead of hours. parts in the blood flow, produces it pumped blood.!* X-
'■• §!
Heart-lung machines damage the liitle turbulence, and has extremely Speaking at a news conference at
blood and consequently tax the precise valves that don't pinch blood the annual meeting of the Associ
^ body. Most patients enn use current cells as other valves do. ation for the Advancement of Medi
models for only a few hours even Heart-lung machines are devices cal Instrumentation, the researchers
th^yy.h they may need assistance for that take over for organs in pump said clinical use of the pump was
longer periods. ing blood and adding oxygen to it. years in the future.'But they said
The researchers said Wednesday They arc used primarily in open- the aluminum device, small enough
■VJ
that a water pump developed for the heart surgery or with patients* suf to be held in the palm of a hand,
Apotlo astronauts' backpacks has fering severe heart attack. showed great promise.
proved in initial tests to be 10 times The machines take the workload Others on the team are Dr. Henry
less destructive \o blood than the off the heart, but nrd cells arc de J. Hcimlich, director of surgery at
best pumps now used in heart-lung stroyed when they hit the walls and Jewish Hospital in Cincinnati, and
joints of the pump or shear each
ASTRONAUTS' PUMP FOR HEART-LUNG MACHI
machines. Modifications could im Dr. George Ricveschl of ihc Univer
prove the performance, they said. other in the turbulent flow, accord- sity of Cincinnati. . • . * . Neil Armstrong and Purdue prof report on rcsc;
INDIANA MEWSCLIP
157J f. SJ PL SUITE F
JMD1AKAPCLIS, INDUJU
GOSHEH
NEWS
D. 11,864
The data bank would contain

0£C 2 6 13/4 13 criteria on a specific patient
Including past medical history.
family history, signs, symp
toms and results of laboratory
Data center . . tests, the Purdue educator said.
«S With information gathered from
May Aid In \ the bank, a probability of sur
vival for different teatments
and different patient profUes
Cancer Fight could be determined.
WEST LAFAYETTE, lnd. ''With these probabilities of
(AP}—A computerized data iurvival available as a service
center developed by a .Purdue Jo surgeons, they wilj be able to
University physiciarwr.ffneeP determine the best way u> man-
ing professor may prove a vital ' *gt the health, care of the
tool in combamng breast can r patient." >
cer. Patrick said the focus of the
The center may help sur \ National Institute of Health has
geons find the method of treat bten more toward lettir.g indi
ing breast cancer in individual vidual cancer centers octain
patients that cffers the n:?hest . and compile treatment data
'chance for survival, sajd Ur. "There has been little effort at
Edward A. Patrick. •organizing it in a logical, scien-
•V He outlined operation of the •ti/ic way."
data bank at an engineering 'He is seeking financial sup-
seminar last month at Mas port to establish a data proc
sachusetts Institute of Tech essing center either here or at
nology.
Uie Indiana University Medical
"Since breast cancer is such CenterDTTnia.-fapoiis.
a serious problem, it is essen "We are natio.-.aUy probably
tial that a scientific approach the best for analyzing this kind
be used for orgar.iiir.g pav.er.ts" of data." . • .
data and evaluating the out • • He said. "We are starting
come of different treatments," with breast car.cer. because it
'.Patrick said. is probably the most important
.'.Treatments often include re from the woman's standpoint.
moval of one breast, as in the He said a second effort might
case of President Ford's wife, be' aimed at colon cancer,
Betty, or both breasts, which "■ •which -has a high incidence
"was done for the wife of Vice among men. ■•_ . . . .- \
President Nelson A. Rockefel
ler.
February 19, 197S
on Sast
Q£]« fhif
'. • LAFAYETTE. Ind. - • survival will also be entered. for patients in particular stages for a computer-assisted consulta
dors may one day use termi- Eventually, this data base may of the disease receiving particu tion system on breast cancer.
s- linked to med.cal data be set up so doctors can key in a lar treatments is scattered and
It is not yet clear whetrwr the
aks to help them decide which description of a patient and get does not uniformly list patient
system's cost would be borne by
atment is best for a patient advice on the probability of her characteristics, Patrick said.
doctors, patients or the govern
th breast cancer. survival for a particular number Patrick has begun his research ment, he mentioned.
)r. Edward A. Patrick, a medi- of years under a particular kind on a Digital Equipment Corp.
I doctor who is aho a proies- of treatment. Patrick said. But. Patrick said this kind of
PDP-11/45 using cancer data
r of electrical engineering at Medical doctors disagree on ser.ice is coming, not just for
from the Indiana University
rdue University, is working to which kind of treatment is best breast cancer but in other arejs
Medical Center. He is also coop
for patients in particular stages of computer-assisted diagnosis
ply pjitern recognition tech- erating with doctors in Cincin
and consulting as weii.
ques to the case histories of of the disease. While some doc nati and Pittsburgh.
east cancer patients which in- tors habitually perform a radical A breast cancer consulting serv
mastectomy (removal of the Eventually, he said, "we would
jde information on the pa- ice would be a good proung
hope to establish a protocol that
:nt$ themselves, what treat- breast and underlying chest wall ground, since it would focus on
will be filled out for any woman
ent they received and how muscles), others prefer the less a narrow subject where every
who is receiving treatment or
ng they survived. drastic simple mastectomy (re doctor could use the sime kind
surgery for breast cancer."
Patrick is collecting dat3 on moval of the breast only) when of information, Patnc* sau.
ich patient's symptoms, results ever they tlunk it is a safe alter While he has received money This makes the problem ci de
f lib tests, medical history. native. for his research effort. Patrick signing the system somewhat le>s
imily hmory of breast cancer, Present data on survival rates said'he did not yet have funding complex, he added.
helher she is in a pre- or post-
icnopausal state and other fac-
jrs.
After this information is en-
ered into the computer system,
he set of procedures used on
he patient and the length of
; Computers
In Medicine'
Topic of Talk
Edward A. Patrick, a'
professor of electrical engi
neering at Purdue Univer
sity who holds an M.D.
from Indiana University
School of Medicine, will
discuss "Computers in
Medicine" at 7:30 p.m.
Tuesday at the St. Eliza
beth Hospital Continuing
Education Center.
His presentation is spon
sored by the Lafayette
Medical Education Founda
tion.
-r- --•••- * *-*
?•
' Computer Used In Fight

Aaainst Breast Cancer
STA* P«»OUH-»FAtITT« and a medical doctor himself,
West Lafayette. Ind. - A said information will be pro-
Purdue University professor vided to advise surgeons on the
best treatment for breast can
has announced creation of a|
cer in a particular patient.
research facility applyir.? new j
computer techniques to breast j A data bank containing the
cancer patient information. medical history of breast can-.
cex patients and other materi
Edward A. Patrick, profes
al used in efficient treatment
sor of electrical engineering
of breast cancer victims will
be created. At least one of
the research facilities is to be
located in Indiana.
•Careful scientific exploration
I of the computerized data will
be required for proper treat
ment of a victim.
But, Dr. Patrick pointed
out, "with these probabilities
of survival available as a
service to surgeons, they will
be able to determine the best
way to manage the health
care of that particular pa
tient.". .- ,
v..He said there has been, na
such material available in
computers wliich could esti
mate the probability of suc
cess In treating breast cancer
problems.
14 DAYTON DAILY NEWS ested la i«iBg bow K pumped
«*"• ' Thursday, Marca ?0,197? '" •' blood."
Speaking at t newi confer
IMed Scientists
ence at ths annual ccwtirg of
the Association for the Ad
vancement of Medjcal Instru-
i ... .:. ... ,v. .'mutation, the rtsearchen
[Hail Space Pump itkf clinical use of the pump

was^years In the foture. Bu:'
they said the aluminum de-
' " Armrtnmj . ^vice, jmall enough to b« held
.a BOSTON —W —A research team which includes In the palm of a band, showed
. •' former astronaut Neil A. Armstrong says a pump used prcfessor of electrical engi great promise.
''to cool astronauts on the moon could heip develop a neering ax Purdue university. OTHERS IN tte team ire
* heart-lung machine capable of sustaining people for Dr. Henry J. Heimlich. direc
S weeks instead of hours. "The pump was used In th«
tor of surgery at Jewish hossi-
£• Heart lung machines dam- rare why its punr? wis less backpack of astronauts' suits til in Cincinnati, and Dr.
*"ag« the blood acd cc.ise- cestrucuve. But tfce research to pump cooling water," said George Rievescfcl of tbe Uni
-<jueotly tax tte bociy. Most ers po:med out that it has no Armstrong. "We were icier- versity oJ-Cinanran.'
* patiena can use c;rr«:t cr.od- moving parts in L-.e b'.ood
\*«U for only a few hours, evea. Hosf, produces littie turbul r
ribough they may c«d assist- ence, irA has extremely pre
^ ance for longer periods. cise vaives that Con't pinch
blood ceils as other vtlvu do.
"\ THE RESEARCHERS said
t:Vedces<lay that a water pump Hurt-lung machines are de-
•. iJrveloped fcr the A:ci;o astro- %-.ces that take over for orsios
^•nautr' backpacks has proved in pvirr.ping biood acd adaong
• la taitial t«u to be 19 times ox>oen to a. They are used
J^less destructive to b:ood thin primarily in opeo-heart fur-' N.C.wOUTCH'fHEILMAN
Vth« best pumps cow used in gery or with panects suffering; oiuulunt
•.heart-hmj michioe*. Modil»- severe heart auack.

.^catiorJ couJd improve the per- ENTERPRISES
THE MACHINES take the
•• tormaAce, they taxi •«>rt)oad Off the heart, but red t. O. BOX }JU OAVION. OHIO 4S4M
* Armstront. the first man to ceils are destroved when îey

(513) 2234328
Tvalk «o the moon and cow an rut the walls and y>\nis of the
• aerospace eng.ceenn? prcles- pump or s.iear eaca otiir in
■?KT U the L'civersiry cl Ciecin- the turcuient flow, according
•'tatl, taid h:» group wxj txx to Dr. Edward A. Patrick,
Moon-Shot Pumo for Heart-Lung Care
NASA Davice a Medical Aid

A (juartet cf enterprising scientists, including formtr
astronaut Neil Armstrcr.?. hive fcjrrd to their "surprise"
that a pump used to circulate water in.space suits Is 10
toes more effective t.Vaa any existxg pump roar u>ed
■ in heart-lung machines.
With to adaptations whatever, the pump proved
strikingly less destructive cf red bloedcclls. a ir.aicr
drawback in present b!»d-ciic-Jlati.-.g ptxss. Further, they
encountered co clotting problems even alter two hours
of use.
They foresee Lv.at the pump may remove a na--or cb»
ttade in the development of both short and long-tern ar-
' tifitial heart-lur.g devices.
In addition :o Armstrong, the team members are Dr.
■ Henry J. Keimllcb, dire: or of surgery at Jewish Hospital,
Cincinnati, Ohio: Dr. Edward A. Patrick, physician and
■ professor of electrical engineering at Purd'j* University
and Indiana Univers.ry Schscl of Msdicire: ar.d Dr. Cccrge
Rieveschel, v;ce^res!dtct for special projects at tie MOON PUMP—A device that is used to cool astro
University of C'ocnnati. nauts on the mcon could be an artificial heart-long
The <J»vicc, known as lie Apollo Doubli Di3phra?rn. was machine that sustains people for wceKS.
developed fcr the 1MJ NASA mooa-shot flights in wnich
Annstrorg tefarr.e the first man to set foot en the tncon. to enter the chamber on ore side while restrictin? it en
It circulated water in the space suits to maintain tem ihe other—ard vice-versa. The actual preisces a slightly
perature control. ' . pulsed blood f.vjw, akin to c functioning heart.
'■ So compact it fits in the palm of the hand, the pump The tcientisti are using an Acclio pump "borm-ed'
by chance u ur..<v.:e;y suited to pumping blood. To an from NASA. Wh?n they first ch:se the p'J^1.? to ex-..;ri
amazing depee, it m:x:cs the shape acd action cf a Luman its blsod-rumpir.2 pctesual. tisy ci sir because it -*as
heart. small, low weight, eifcciest, reliable acd only required
It has r*in chambers and four valves, ar.d the flow a very low amount of power.
areas are separate frcn the "drive" apparatus, that is Protection cf the delicate bleed cells they feel is
an electro-rnazn't system r.oi a n;e motor. achieved by the pump because "there are r.o mov.n pjrts
" —The magnets move a snail oscillating arm that alter in the area of blood flow. Tr.ere is no pitching of-tte cells
nately opens ar.d doses no diaphragms, allowing'blood aad little turbulence to ttJt Dow."
Blood Expert HailsSerumHepafiih Vaccine

.(Continued from Page One) Highly purified extracts cf ■ Semm hepatitis, which is hepatitis. Ombreakj of
the carrier-antigen form, the also rampant amar.g drug
Merck Co., Inc.. a~'major infectious hepatitis are-due
base of the vaccine, waich addicts who transmit it by
pharmaceutical firm. has proved hishly effecriv* to faulry driskia? water, I
sharing ccr.tamtsated
in animals at very lew hypedermrc needies, -is not infected food handlers, and
Dr. Hilleman, who also
developed the mumps vac ccs?s. One shot of the the same as infectious in some cases, shellfish.
cine, announced the ne»- dis vaccine may provide life
covery at a Nitior.il Acad time protection.
emy of Sciences meeting. Among blood do.iers about
He .said the vaccine current- two per thousand are
■ ry is being tested in chim
panzees to define exact dos-.
estir-ated to be serua
hepatitis carriers. Tests cow
required to detect such
Medicare /
age and is being prepared
for human trials. carriers, however, are
A spokesman for t>.e

fecsral: Food and Drug
reliable only for one of the
two, which means the other_
slips by.
Social Security
Administration confirmed By WENDELL COLTIN
In young, healthy people,
that the Merck Institute has
the" disease can be so mild,
been granted appnval for Dr. F. Marott Sicex. pTcfessorof the Biochemistry Dept. i
they scarcely know they
wide-scale tests o! the at Eostcn University, is the re* presidi.-.t of AGE. s^cceec- ,
have it.
vaccine with volunteers. ing Dr. D:nhan Harmon of the University cf Nebraska i
"HOWEVER, patients whj Medical Center Li Onaia. Dr. Harman continues to serve
T« develop the 'vscctee. need blood transfusions are as elective director. '
•ke research drew on earlier alrea-Jy sic"*, weaker.eu,1
discoveries abfiut ihe and highly vulnerable," Dr. • AGE- — the American Agfcg Asxiatioo. Inc.-r- will
. ■ ■ \ ,-■ .
F
,,:,n
:1 ■^ ^
: (
r'V-
X
<*•■■'<
-..-*%^v
*. •■=•-• <
t :■.
Spoce feehnology pump, adapted in heort machine it tmo//cr than mon't hood.
Moon-Suit Pump Next To Heart

BOSTON' 'L'PH - The first said, is small enough to fit in
man on the moon says a bet the palm of the hand and has
ter heart-lung b'.ood pump al twin chambers and four
ready exists, and three other valves, just like the heart.
scientists agree. . The flow areas are separat
Nell Armstrong should ed from the drive apparatus.
know. The pump is used to
Magnets move- a small
circulate vaicr in spj<.e suits,
oscillating arm that alternate'
and it's 10 lirr.es more effec
tive than blood pumps now in ly opens and closes two dia
use. phragms, allowing blood to
Armstrong Hcimlich enter the chamber on or.e side
They say that even with no
adaption t h e pump proved Space for improvement. while restricting it on the
less destructive to red blood other.
George Rieveschel-of the Uni
cells,' a major problem with The device, known as the
versity of Cincinnati — say Apollo Double Diaphragm,
blood-circulating pumps.
The four — Armstrong, Dr. their development may re was announced by the men
Hcmy J. He i ml ich of tê move a major obstacle to the while here for the annual
Jewish Hospital of Cincinnati, development of short and long meeting of the Association for
Dr. Edward Patrick of term heart-lung devices. the Advancement of Medical
Purdue University a n d Dr. The space-suit pump, they Instrumentation.
"oTcussiifeo

Title Pattern Recognition: Applied To Medicine Requested Award Elements

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Title Pattern Recognition: Applied To Medicine Requested Award Elements

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PROPOSAL NO* ^0^118

OOJ CLASS i*LlO

REQUESTED AWARD ELEMENTS: AMOUNT 0 013 88000

OLD NSF PROP NUMBER P<»K0<+95GG0

WEST LAFAYETTE, INDIANA 47907

Central Processing Section

Enclosed, for consideration of support by the National Science

We hereby certify that Purdue Research Foundation-Purdue University

Please refer to the proposal for a description of other research

This proposal is being submitted only to the National Science

Please refer technical questions concerning the proposal to Pro

Favorable consideration of this proposal will be appreciated.

ery truvLy yours,

i. Davis, Associate Director

PATTERN RECOGNITION APPLIED TO MEDICINE

School of Electrical Engineering

NATIONAL SCIENCE FOUNDATION

Division of Sponsored Programs

Purdue Research Foundation

PRINCIPAL INVESTIGATOR: APPROVED:

Edward A. Patrick C. L. Coates, Head

S. M. Marks, Assistant DirecTfor

IESEARCH ON Pattern Recognition Applied to Medicine

PATRICK, Edward A. Purdue University 0018259-00-

3. BRANCH/CAMPUS E18. ADDRESS (City. Stilt, end Zip orCountry)

/.Lafayette % Indiana Rgkfig 47907

1. ADDITIONAL PI/PD 21A. S.S.N. 22. ADDITIONAL PI/PD 22A. S.S.N.

AREAS OF SPECIAL INTEREST (S miy bt itUetii) 32. TYPE OF ACTION (Project)

27. 27A. CODE NEW 4 Q REDUCTION

31. 31A. CODE YES t \ | NO

36. WITHDRAWAL 37. DECLINATION 38. REASON FOR DECLINATION^

□ YES □ NO □ YES □ NO n YES □

60. FY 61. FY 52. FY

54. PROGRAM RATING OF PROPOSAL 55. INTERNATIONAL IMPLICATIONS

a □ >*»TICI>ATION IN INTERNATIONAL PROG

NSF torn 1, Feb. 1970

(ENG-7404118) Caplan ■ 0 9 New 0 1

Patrick. Edward A. Purdue University

I tm\. tiu. wrffft

C. OHcleMni I<LYft.Rtn«wil Op. 17.L*v.ofObcOI((.

Pattern Recognition Applied to Medicine

19. FIELDS OF SCIENCE

20. FIELDS OF APPLICATION

a. HEALTH 0Q2 ,0,3,0. 0, (

PROQRAM DIRECTOR'S PROPOSAL ACTION DATA

NON-AWARD ACTION RECORD

NSF Form 779. Dec. 73

PROJECT N»P ORANT NO.

4AME OP INSTITUTION (NSP OIK ADDRESS OP INSTITUTION fcr.ci.uoi • RANCH/CAMPUt «■ COMPONCHT)

Purdue University West Lafayette, Indiana

PRINCIPAL INVESTIGATOR SOCIAL SECURITY NO. DIVISION (OPPICE) AND DIRECTORATE

Patrick, Edward A. Engineering

Electrical Sciences and Analysis

P4K0495-000 (ENG-7404118) Control and Automation

Pattern Recognition Applied to Medicine

SUMMARY OP PROPOSED WORK (limit TO II PIC

This research is concerned with using pattern recognition to store

ENG-74-04118 10/1/74 $79,600 24 Mos.

INSTRUCTIONS FOR USE

NSF Form 4, Jan. 1970

School of Electrical Engineering

Previous Grant Number GJ1099

■RINCIPAL INVESTIGATOR: APPROVED: