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Name

:

Dr. R.P.Tripathi

Date of Birth

:

24.12.1956

Designation :

 

Scientist F, Deputy Director

Postal Address :

Medicinal and Process Chemistry Division Central Drug Research Institute, Chattar Manzil Palace

Lucknow-226001 Phone No.(0522) 212411-418 Extn 4462(Office), (0522) 710421(Residence), 09415521539, 09415004443

or

Educational Qualifications: M.Sc. (Gorakhpur University), M.Phil, Ph. D.(Delhi University )

Degree

University

Year

Division

Field

Ph.D.

Delhi University

1985

 

--

Organic Chemistry

M. Phil

Delhi University

1982

A Grade

Organic Chemistry

M.Sc.

Gorakhpur University

1979

I

st

Chemistry

B.Sc.

Gorakhpur University

1977

I

st

Biological Sciences

Positions held:

JRF UGC New Delhi 1981-1983 SRF UGC New Delhi 1983-1985 Research Associate NIH project at CDRI, Lucknow 1985-1987 Scientist B CDRI, Lucknow 1987-1992 Scientist C CDRI, Lucknow 1992-1997 Scientist E1 CDRI, Lucknow 1997-2001 Scientist EII CDRI, Lucknow 2001-2006 Scientist F, CDRI, Lucknow 2006-Till date

Membership of scientific bodies:

Life member Indian Chemical Society Life member Indian medicinal chemists association Life member UP association of advancement of science and technology Life member Society of biological chemists of India Member of Association of Carbohydrate Chemists & Technologists of India Editorial Board Member ARKIVOC Editorial Board Member Trends in Carbohydrate Research Editorial Board member of Medicinal Chemistry An Indian Journal Associate Editor Carbohydrate News Letter Editorial board member International Journal of Drug Design and Delivery Reviewer for a number of International Scientific Journals and books Member of different Selection Committees and Research Boards

Research and training Experience:

27 years research experience in different laboratories of Delhi University and Central Drug Research Institute, Lucknow and abroad. Countries visited: 1. France, INSA Exchange Programme, University of Rennes 1, Rennes, France 2006 Pretoria, South Africa ICS-UNIDO Programme-2010

Projects Handled or in Hand: NIH USA, VW Foundation Germany, DRDO, ICMR, DBT New

Delhi

Research Specialisation:

Organic Chemistry: Oxygen and nitrogen heterocyles, Nucleosides, carbohydrates, asymmetric

synthesis, Combinatorial Chemistry,

Medicinal

Chemistry:

Development

of

antiparasitic

agents(malaria,

filarial,

leishmania,

trypanosome), antivirals, Tuberculosis, diabetes, and antitoxicants

The Group: Ph.D. Students Supervised:

1. Dr. AR Khan (Faculty Integral University, Lucknow)

2. Rahul Tripathi (Joined BARC Mumbai in between as senior scientist in between)

3. Dr. VK Tiwari (BHU Faculty, Chemical Sciences)

4. Dr. RC Mishra (Georgia State University)

5. Dr. Neetu Tewari ( P.G. teacher Govt Girls PG College Dehradun)

6. Dr. Diksha Katiyar (BHU Faculty, MVBHU Chemistry)

7. Dr. Shyam Sunder Verma (Research Scientist- Ranbaxy)

8. Dr. Namrata Dwivedi ((Jwahar Lal Nehru PDF Fellow- NCL Pune)

9. Dr Nisha Saxena ( Faculty, Lovely University, Punjab)

10. Dr. Biswajit Singh (Cadila Pharma)

11. Dr. Jyoti Pandey (IIT Mumbai, Res Associate)

12. Dr. Surendra Singh Bisht (Selected as Scientist at FRI Dehradun and joinig shortly)

13. Miss Nimisha Singh (submitted thesis, working with Prof. Vijayan at IISc Banglore)

14. Mr. Amit Yadav (joined PG Govt College Hardoi, Kanpur University in between)

Present Group Members:

15. Mr. Mridul Mishra (SRF, writing thesis)

16. Mr. V.P. Pandey (SRF)

17. Mr. A. Sharma (SRF)

18. Arya Ajay (SRF)

19. Seerat Fatima (SRF)

20. Namrata Anand (SRF)

21. Munna P. Gupt (JRF)

22. Dr. Sarvesh Pandey (CSIR, Res. Asso.)

23. Mr. Rahul Sharma (Project Assistant)

24. R. Ramkrishnan (JRF)

Technician: 1. Mr. V. K. Maurya (STA)

Short Term/ Long Term Training:

2.

Mr. P. Yakabaram

3. Miss Aparana Pandey

4. Mr. Ankur Srivastava (Torrent Pharmaceutical)

5. Miss Abha Verma

6. Mr. Beni Ram Sahu (Drug Inspector Chattisgarh)

7. Mr. Rajendra Yadav (Pharma Teacher Dehradun)

8. Pranav Gangwar (Zydus cadila Baroda)

9. Pooja Pandey (Zydus cadila Baroda)

10. Miss Priyanka Singh(continiuing) 11.Udai Tripathi (continuing)

Honors and Awards:

1. Best paper award by Indian Pharmacological society of India on “3-Cyano-4-methyl-5-vinyl

pyridine: A potent synthetic hepatoprotective agent. P.K.S. Visen, Binduja Saraswat, G.K. Patnaik,

R.C. Srimal, R.P. Tripathi and D.S. Bhakuni. Indian J. Pharmacol. (1993), 25, 149.”

2. Best Poster award: Carbo-XX held at Lucknow University In Nov 2005

3. Most Cited paper award by Elsevier: Bioorganic & Medicinal Chemistry Most Cited Paper

2003-2006 award to RP Tripathi on Synthesis and bioevaluation of glycosyl ureas as -glucosidase

inhibitors and their effect on Mycobacterium: Neetu Tewari, V.K. Tiwari, R.C. Mishra, R.P.

Tripathi, A.K.Srivastava, R. Ahmad, R. Srivastava and B.S.Srivastava, Bioorg. Med. Chem., 2003,

11, 2911-2922.”

4. INSA Visiting Scientist Fellowship: Visited University Rennes 1, Rennes, France 1.6.06 to

30.6.06

5. “Synthesis and antitubercular activity of 5-benzyl-3-phenyl dihydroisoxazole” Second best poster

award Euro-India First International Conference on Holistic Medicine 21.8.2008. Surendra S. Bisht,

Vivek Parashar Pandey and R. P.Tripathi.

6.

Best poster award: CARBO-XXIII „08held at Bhavnagar University. Poster entitled “Synthesis

of polyfunctional alkenoyl and alkanoyl C-glycosides and their α-glucosidase inhibitory activity”

presented by Surendra S. Bisht.

7. Miss Jyoti Pandey one of my Ph.D. students was selected for DST-DFG '09' award for the

participation in Noble Laureates and students meeting at Lindau, Germany based on her scientific

caliber.

8. Excellence in Carbohydrate Research Award” First eTCR award 2009 by Association of

Crabohydrate Chemists and Technologists of India at Shimla University on 11.11.2010.

1.

8. List of Publications: Total 117

Synthesis

of

dispiro-cycloalkanones,

their

in

Total Citation: 810

Average Citation: 8.27 H Index: 16

silico

screening

and

bioevaluation

as

antituberculosis and mycobacterial NAD + -dependent DNA ligase inhibitors Rama P. Tripathi ,

Jyoti Pandey, Vandana Kukshal, Arya Ajay, Mridul Mishra, Divya Dube, Deepti Chopra, R.

Dwivedi Vinita Chaturvedi and Ravishankar Ramachandran MedChemComm 2011 (In press)

2. A simple and

efficient

one pot

synthesis

of multifunctional 5-aryl-5H-thiazolo[3,2-a]-

pyrimidines Seerat Fatima, Anindra Sharma, Rahul Sharma and R.P. Tripathi Journal of

Heterocyclic Chemistry 2011 (In press)

3. Application of butenonyl-C-glucosides in the synthesis of pyrazolinyl-, aminopyrimidinyl- and

biphenyl methyl- β-D- C-glucopyranosides Seerat Fatima, V. P. Pandey, Rama P Tripathi

Molecular Diversity 2011 (minor revision submitted)

4.

Chemical approaches against tuberculosis therapy in last decade, Rama P. Tripathi, Surendra

Singh Bisht, Arya Ajay, Mridul Mishra, Anindra Sharma, Munna Pd. Gupt Future Medicinal

Chemistry 2011, (Revised Manuscript submitted)

5. Application of click chemistry towards an efficient synthesis of 1,2,3-1H-triazolyl glycohybrids as

enzyme inhibitors, N. Anand, S.K. Pandey and Rama P. Tripathi Carbohydrate Research 2011,

346, 16-25. http://dx.doi.org/10.1016/j.carres.2010.10.017

6. One pot protecting group free synthesis of multifunctional biphenyl methyl-C-β-D-glycosides in

aqueous medium Mridul Mishra, Rahul Sharma, R.P. Tripathi , Tetrahedron 2011,

67, 740-748.

7. Synthesis and bio-evaluation of alkylaminoaryl phenyl cyclopropyl methanones as antitubercular

and antimalarial agents. Arya Ajay, Vandana Singh, Shubhra Singh, Swaroop Pandey, Sarika

Gunjan, Divya Dubey, Sudhir Kumar Sinha, Bhupendra N. Singh, Vinita Chaturvedic, Renu Tripathi,

Ravishankar Ramchandran, Rama P. Tripathi, Bioorganic Medicinal Chemistry 2010,18, 8289-8301

http://dx.doi.org/10.1016/j.bmc.2010.09.071

8. DBU catalysed aldol reaction of D-xylofuranosyl dialdoese with acetophenones: unprecedented

ether cleavage accompanied with formation of dienones P. Gangwar, A. Sharma and R.P. Tripathi

Trends Carbohydr Res. 2010, 2, 42-45.

9. Synthesis And Optimization Of Antitubercular Activities In A Series Of 4-(Aryloxy)Phenyl

Cyclopropyl Methanols Surendra S. Bisht, Namrata Dwivedi, Vinita Chaturvedi, Namrata Anand,

Mridul Misra, Rahul Sharma, Brijesh Kumar, Richa Dwivedi, Shyam Singh, Sudhir Kumar Sinha,

Versha Gupta, P.R. Mishra, Anil K. Dwivedi and Rama P. Tripathi European Journal of Medicinal

Chemistry 2010, 45, 1965-1978 http://dx.doi.org/10.1016/j.ejmech.2010.09.063

10. Search of antimycobacterial activities in hybrid molecules with benzopyran skeleton

Rama P. Tripathi, Surendra Singh Bisht, Vivek Parashar Pandey, Sarvesh K. Pandey,

Shubhra Singh, Sudhir Kumar Sinha, Vinita Chaturvedi Medcicnal Chemistry Research 2010, DOI

10.1007/s00044-010-9402-6

11. Synthesis and anti breast cancer activity of biphenyl based chalcones: Anindra Sharma, Bandana

Chakravarti, Munna Prasad Gupt, Jawed A. Siddiqui, Rituraj Konwar, Rama P. Tripathi Bioorganic

Medicinal Chemistry 2010, 18, 4711-4720

12. Regioselective [3+2] cycloaddition of chalcones with a sugar azide: easy access to 1-(5-deoxy-D-

xylofuranos-5-yl)-4,5-disubstituted-1H-1,2,3-triazoles:

Nimisha

Singh,

S.

Tripathi Carbohydrate Res. 2010, 243, 1641-1648.

K.

Pandey,

Rama

P.

13. Synthesis and Antitubercular Activity of 5-benzyl-3-phenyl dihydroisoxazoles. S. S. Bisht, A.

Ajay, S. K. Sinha, V. Chaturvedi and Rama P. Tripathi International Journal of Drug Design and

Discovery 2010, 1,11-18.

14. Leishmania

donovani:

Oral therapy with glycosyl

1,4-dihydropyridine

analogue

showing

apoptosis like phenotypes targeting pteridine reductase 1 in intracellular amastigotes Jaspreet Kaur ,

Nasib Singh , Biswajit Kumar Singh , Anuradha Dube , Rama Pati Tripathi , Prashant Singh , Neeloo

Singh Experimental Parasitology 2010, 125, 310314

15. Synthesis and molecular docking studies of 1-phenyl-4-glycosyl-dihydropyridines as potent

antileishmanial agents. V. P. Pandey, S. S. Bisht, M. Mishra, A. Kumar,M. I. Siddiqi, Aditya Verma,

Monika Mittal, Shraddha A. Sane, Suman Gupta,Rama P. Tripathi European Journal of Medicinal

Chemistry 2010,45,2381-2388

16. Kaur Jaspreet; Singh Nasib; Singh Biswajit Kumar; Dube Anuradha; Tripathi Rama Pati; Singh

Prashant; Singh Neeloo Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine

analogue

showing

apoptosis

like

phenotypes

targeting

pteridine

reductase

1

in

intracellular

amastigotes.Experimental Parasitology 2010;125(3):310-4

17.

Application of Huisgen (3+2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobnzofuran-2-yl

methyl [1,2,3]-triazoles and their Antitubercular evaluations. Rama P. Tripathi, A. K. Yadav, S. S.

Bisht, V. Chaturvedi, S. K. Sinha European Journal of Med. Chem. 2010, 45, 142-148.

18. „L-Proline catalyzed multicomponent reaction of 3, 4-dihydro-(2H)-pyran,urea/thiourea, and

aldehydes: diastereoselective synthesis of hexahydropyrano pyrimidinones (thiones). J. Pandey, .N.

Anand, Rama P. Tripathi Tetrahedron 2009,65, 9350-9356

19. An orally effective dihydropyrimidone (DHPM) analogue inducesapoptosis-like cell death in

clinical isolates of Leishmania donovani overexpressing pteridine reductase 1. N. Singh , J. Kaur , P.

Kumar , S. Gupta , N. Singh ,A.Ghosal , A. Dutta , Ashutosh Kumar, RamaPati Tripathi ,M. I.

Siddiqi , C. Mandal , A. Dube Parasitology Reseach 2009

20. Synthesis of plurisubstituted furo[3,2-b] pyrans and furo[3,2-b] chromenes from D- glucose VP

Paandey, SS Bisht, RP Tripathi Trends in Carbohydr. Res. 2009, 1, 27-31.

21.

BF3.OEt2

catalaysed

mannosylation

of

phenolics

with

2,3,4,5-di-O-isoprpylidene

D-

mannofurnaos accompanied by selective in situ deketalization Nisha Saxena, Jyoti Pandey, .

Tamarkar, AK Srivastva and RP Tripathi, Trends in Carbohydr. Res. 2009, 1, 29-37

22. Synthetic studies in butenonyl C-glycosides: Preparation of polyfunctional alkanonyl glycosides

and their enzyme inhibitory activity. S. S. Bisht, S. Fatima, A. K. Tamrakar, N. Rahuja, N. Jaiswal,

A. K. Srivastava, Rama P. Tripathi Bioorganic & Medicinal Chemistry Letters 2009, 19, 2699

2703.

23. An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of

aromatic aldehydes and β-keto esters or ketones. Anindra Sharma, Jyoti Pandey, R.P. Tripathi

Tetrahedron letters 2009, 50, 18121816.

24. Solution phase synthesis of a library of carbapeptide analogues based on glycosylamino acid

scaffolds, their in silico screening and antimicrobial evaluation. Jyoti Pandey, Anindra Sharma,

Vinod K. Tiwari, Divya Dube, Ravishankar Ramachandran, Vinita Chaturvedi, Sudhir K. Sinha,

Nripendra N. Mishra, Praveen K. Shukla, Rama P. Tripathi J. Comb. Chem. 2009, 11, 422427.

25. Synthesis and antitubercular screening of imidazole derivatives. V.K. Tiwari, J. Pandey, S.S.

Verma, V. Chaturvedi, S. Sinha, R.P. Tripathi European Journal of Med. Chem. 2009, 44, 3350-

3355.

26. Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

Mridul Misra, Swaroop Kumar Pandey, Vivek Parashar Pandey, Jyoti Pandey, Renu Tripathi, Rama

Pati Tripathi Bioorganic Medicinal Chemistry, 2009, 17, 625-633.

27. L-Ascorbic Acid in organic Synthesis- Tripathi, R.P., Biswajit Singh, S.S. Bisht,; J. Pandey,

CURRENT ORGANIC CHEMISTRY 2009, 13, 99-122.

28. Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents

B.K. Singh , Mridul Mishra , Nisha Saxena , G.P. Yadav , P.R. Maulik ,M.K. Sahoo , R.L. Gaur c,

P.K. Murthy , R.P. Tripathi, European Journal of Medicinal Chemistry 2008, 43, 2717-2723

29. Pharmacokinetics and excretion of the novel anti-tuberculosis compound 1,2 : 5,6-di-O-

isopropylidene-3-O-(phenyl cyclopropyl methanonyl)-alpha-D-glucofuranose (S-001-14) after oral

doses in rats Lal J, Tripathi R.P., Gupta RC, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

2008, 58, 410-418.

30.

Recent Development on catalytic reductive amination and applications Tripathi R. P., Verma S.

S.,

Pandey J., V. K. Tiwari CURRENT ORGANIC CHEMISTRY 2008, 12, 1093-1115.

26.

Leishmania donovani pteridine reductase 1: Biochemical properties and structure- modelling

studies Kumar P, Kumar A, Verma SS, Dwivedi N., Siddiqui, I., Dube , A; Tripathi, R.P. ; Singh,

N.

EXPERIMENTAL PARASITOLOGY 2008, 120, 73-79.

31.

Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation

N Saxena; N Singh; M. Mishra; G. B. Shiva Keshava; P. K. Shukla; Rama Pati Tripathi. JOURNAL

OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2008, 23, 476-482.

32. Synthesis and antitubercular activity of nucleoside analogs based on L-ascorbic acid and bases

Author(s): Tripathi

R.P.,

Dwivedi

N,

RESEARCH 2008, 17, 53-61.

Singh

N,

Mridul

Mishra.

MEDICINAL

CHEMISTRY

33. NAD(+)-dependent DNA ligase (Rv3014c) from M-tuberculosis: Strategies for inhibitor design

Dube D, Kukshal V, Srivastava SK, R.P. Tripathi and R. Ramachandran MEDICINAL CHEMISTRY

RESEARCH 2008, 17, 189-198.

34. Aldol reaction of beta-C-glycosylic ketones: synthesis of C-(E)-cinnamoyl glycosylic compounds

as precursors for new biologically active C-glycosides Bisht SS, Pandey J, Sharma A, Tripathi, R.P.

CARBOHYDRATE RESEARCH 2008, 343, 1399-1406.

35. NAD(+)-dependent DNA ligase: A novel target waiting for the right inhibitor. Dwivedi N, Dube

D, Pandey J, Singh BK, Ramchandran R., Tripathi R.P. MEDICINAL RESEARCH REVIEWS 2008,

28, 545-568.

36. Preparation and

reactions

of sugar

azides

with alkynes: synthesis

of sugar

triazoles

as

antitubercular agents Singh BK, Yadav AK, Kumar B, Gaikwad, A.N.; Sinha, S.K., Chaturvedi V.

and Tripathi R.P. CARBOHYDRATE RESEARCH 2008 , 343, 1153-1162.

37. Evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting molecules

active against multi-drug resistant Mycobacterium tuberculosis.

38. Chaturvedi V, Dwivedi N, Tripathi R.P., Sudhir Sinha JOURNAL OF GENERAL AND

APPLIED MICROBIOLOGY 2007, 53, 333-337.

39. D-Glucosamine, a natural aminosugar as organocatalyst for an ecofriendly direct aldol reaction of

ketones

with

aromatic

aldehydes

in

water.

Singh

N,

Pandey J,

COMMUNICATIONS 2008, 9 743-746.

Tripathi

R.P.

CATALYSIS

40. An efficient chemoselective etherification of phenols in polyfunctional aromatic compounds

Pandey J, Mishra M, Bisht SS, Sharma A. and Tripathi R.P. TETRAHEDRON LETTERS 2008, 49,

695-698

41. One-pot Amberlite IR-120 catalysed synthesis of glycosyl dihydropyridones. Tiwari VK, Tewari

N, Katiyar D, Tripathi R.P. MONATSHEFTE FUR CHEMIE 2007, 138, 1297-1302

42. An elegant and unprecedented approach to 2-methylbenzofurans. Yadav AK, Singh BK, Singh N,

Tripathi R.P. TETRAHEDRON LETTERS 2007, 48, 6628-6632

43. Synthesis

and

biological

evaluation

of

potential

modulators

of

malarial

Glutathione-S-

transferase(s). R. Ahmad, A. K. Srivastava, R. P. Tripathi, S. Batra and R. D. Walter J. Journal of

Enzyme Inhibition and Medicinal Chemistry, June 2007; 22(3): 327342

44. L-Ascorbic acid in organic synthesis: a facile synthesis of 4-(butenolide-5-methylidenyl)-1,4-

dihydropyridines. S. S. Bisht, N. Dwivedi, R. P. Tripathi Tetrahedron Lett., 2007, 48, 1187.

45. Diastereoselective

synthesis

of

glycosylated

prolines

as

alpha-glucosidase

inhibitors

and

organocatalyst in asymmetric aldol reaction. J. Pandey, N. Dwivedi, N. Singh, A. K. Srivastava, A.

Tamarkar and R. P. Tripathi Bioorganic & Med. Chem. Letters, 2007, 17, 1321.

46. An elegant and unprecedented approach to 2-methyl benzofurans. A. K. Yadav, B. K. Singh, N.

Singh, R. P. Tripathi Tetrahedron Lett, 2007, 48, 6628-6632.

47. L-ascorbic

acid

in

organic

synthesis: DBU-catalysed

one-pot

synthesis

of

tetramic

acid

derivatives from 5,6-O-isopropylidene ascorbic acid. B. K. Singh, S. S. Verma, N. Dwivedi, R. P.

Triapthi Tetrahedron Letters, 2006, 47, 2219.

48. DBU assisted expeditious synthesis of glycosyl dienes via glycosylated beta-hydroxy esters. S. S.

Verma, N. Dwivedi, B. K. Singh, R. P. Tripathi Carbohydr. Res, 2006, 341, 1930.

49. Search of antitubercular activities in tetrahydroacridines: Synthesis and biological evaluation. R.

P. Tripathi, S. S. Verma, J. Pandey, K.C. Agarwal, V. Chaturvedi, Y.K. Manju, A. K. Srivastva, A.

Gaikwad, S. Sinha Biorganic & Med.Chem.Lett., 2006, 16, 5144.

50. Recent developments in search of antifilarial agents. R. P. Tripathi, D. Katiyar, N. Dwivedi, B.

K. Singh, J. Pandey Curr.Med. Chem., 2006, 13, 3319.

51. Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines. R.

P. Tripathi, N. Saxena, V. K. Tiwari, S. S. Verma, V. Chaturvedi, Y. K. Manju, A. K. Srivastva, A.

Gaikwad and S. Sinha Biorganic & Med. Chem., 2006, 14, 8186.

52. Asymmetric organocatalysis with glycosyl-beta-amino acids: direct asymmetric aldol reaction of

acetone with aldehydes. N. Dwivedi, S. S. Bisht, R. P. Tripathi Carbohydr. Res., 2006, 341, 2737.

53. An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic

acid. B. K. Singh, S. S. Bisht, R. P. Tripathi Beilstein J. Org. Chem., 2006, Art. No. 24,

54. Fighting Tuberculosis: An old disease with new challenges R. P. Tripathi, N. Tewari, N.

dwivedi, V. K. Tiwari Medicinal Res. Review, 2005, 25, 93.

55. Search of new prototypes for chemotherapy of filariasis: Chemotherapeutic and biochemical

approach. S. Misra-Bhattacharya, P. Bajpai, S. K. Verma, D. Katiyar, N. Tewari, R. P. Tripathi, I.

Bansal, J. K. Saxena. Journal of Parasitology Research, 2005, 95, 383.

56. Synthesis and DNA topoisomerase-II inhibitory activity of unnatural nucleosides. R. C. Mishra,

N. Dwivedi, I. Bansal, J. K. Saxena, R. P. Tripathi Nucleosides, Nucleotides and Nucleic Acids,

2005, 24, 15.

57.

Tetrabutylammonium

Hydrogensulphate

Catalysed

Efficient

Synthesis

of

Glycosyl(aryl)

Dihydropyrimidinones. N. Dwivedi, R. C. Mishra and R. P.Tripathi Lett. Org. Chem., 2005, 2, 450.

58. Synthesis and Antimycobacterial Activities of Glycosylated Amines and Amino Alcohols D.

Katiyar, V. K. Tiwari, N. Tewari, S. S. Verma, S. Sinha, A. Gaikwad, A. K. Srivastava, V.

Chaturvedi, R. Srivastava, B. S. Srivastava, R.P. Tripathi Eur. J. Med. Chem., 2005, 40, 351.

59. Mycobacterium

tuberculosis

NAD+-dependent

DNA

ligase

is

selectively

inhibited

by

glycosylamines compared with human ligase I. S.K. Srivastava, D. Dube, N. Tewari, N. Dwivedi, R.

P. Tripathi, R. Ramchandran Nucleic Acid Research 2005, 33, 7090.

60. NAD+-dependent

adenylation

domain

ligase

(Rv3014c)

and

identification

from

M.tuberculosis

of

novel

inhibitors.

R.Ramachandran J. Biol. Chem., 2005, 280, 30273.

H37Rv: crystal

S.K

Srivastava,

structure

of

the

R.P

Tripathi,

61. Current status of malaria control. R. P. Tripathi, R. C. Mishra, N. Dwivedi, N. Tewari, S. S.

Verma Curr Med Chem., 2005, 12, 2643.

62. An

efficient

synthesis

of

aryloxyphenyl

cyclopropyl

methanones:

a

new

class

of

anti-

mycobacterial agents. N. Dwivedi, N. Tewari, V. K. Tiwari, V. Chaturvedi, Y. K. Manju, A. K.

Srivastava, A. Gaikwad, S. Sinha, R. P. Tripathi Bioorg Med Chem Lett., 2005, 15, 4526-30.

63.

Synthesis and antitubercular activities of bis-glycosylated diamino alcohols. R. P. Tripathi, V.

K.

Tiwari, N. Tewari, D. Katiyar, N. Saxena, S. Sinha, A. Gaikwad, A. K. Srivastava, V. Chaturvedi,

Y.

K. Manju, R. Srivastava, B. S. Srivastava. Bioorg Med Chem., 2005, 13, 5668.

 

64.

Search

for

new

prototypes

for

the

chemotherapy

of

filariasis:

a

chemotherapeutic

and

biochemical approach. P. Bajpai, S. K. Verma, D. Katiyar, N. Tewari, R. P. Tripathi, I. Bansal, J. K.

Saxena, S. Misra-Bhattacharya Parasitol Res., 2005, 95,383.

65. Reductive amination of glycosyl aldoses: Synthesis of N-glycosylated -glycosyl amino alcohols

and their antidiabetic potential. S. S. Verma, R. C. Mishra, A. K. Tamrakar, B. K. Tripathi, A. K.

Srivastava, R. P. Tripathi. J. Carbohydr. Chem., 2004, 23, 493.

66. 4-Methyl-7- (tetradecanoyl)-2H-1-benzopyran-2-one: A novel DNA topoisomerase II inhibitor

with

adulticidal

and

embryo

static

activity

against

sub

periodic

Brugia

malayi.

S.

Misra-

Bhattacharya, D. Katiyar, R. P. Tripathi, J. K. Saxena Parasitology Research, 2004, 92, 177.

67. A versatile synthesis of Dihydropyrimidinone C-nucleosides. R. C. Mishra, D. Katiyar, N.

Tewari, R. P. Tripathi, Nucleosides, Nucleotides and nucleic Acid, 2004, 23, 531.

68. Diastereoselective Synthesis of Galactopyranosyl Amino Esters and their Transformations into

C-nucleosides, D. Katiyar, R. C. Mishra, R. P. Tripathi, Journal of Carbohydrate Chemistry, 2004,

23, 49.

69. Search for new antitubercular agents: SPOS of Glycoconjugates on Sieber Amide resin, R. P.

Tripathi, R. C. Mishra, D. Katiyar, K. K. Srivastava, R. Srivastava, B. S. Srivastava Ind. J. Chem,

2004.

70. Synthesis of Galactopyranosyl Amino Alcohols as a new class of antitubercular and antifungal

agents. N. Tewari, V. K. Tiwari, R. P. Tripathi, A. Gaikwad, S. Sinha, P. K. Shukla, R. Srivastava

and B. S. Srivastava, Bio. Med. Chem.Lett., 2004, 12, 329.

71. An efficient syntheses of -mannosylated phenolics as -glycosidase inhibitors. A. R. Khan, V. K.

Tiwari, A. K. Srivastava, R. P. Tripathi J. Enzyme Inhibition 2004, 19, 107.

72. Potential Inhibitors of DNA topoisomerase-II: ruthenium (II) poly-pyridyl and pyridyl-azine

complexes. M. Chandra, A. N. Sahai, D. S. Pandey, R. P. Tripathi, J. K. Saxena, V.J.M. Reddy, M.

Carmen Peutra, Pedro Valerga J. Organometallic Chemistry 2004, 689, 2256.

73. 1,3 Dipolar Cycloaddition of Glycosyl Nitrile Oxides with Alkenes: Diastereoselective Synthesis

of Glycosyl Isoxazolines. R.C. Mishra, N. Tewari, S. S. Verma and R. P. Tripathi , J. Carbohydr.

Chem. 2004, 23, 353.

74. Phenylene bridged bis -glycosyl ureides as potential antileishmanial agents. N. Tewari, Ramesh,

R. C. Mishra, S. Gupta, R. P. Tripathi, Bioorg. Med. Chem.Lett. 2004, 14, 4055.

75. Tetrabutylammonium Hydrogen Sulphate Catalysed Eco-friendly and Efficient Synthesis of

Glycosyl 1,4-Dihydropyridines. N. Tewari, N. Dwivedi, R. P. Tripathi Tetrahedron Lett., 2004 , 45,

9011.

76. Solid phase synthesis of cyclopropyl phenyl methanones, R. K. Grover, R. C. Mishra, B. Kundu,

R. P.Tripathi R. Roy. Tetrahedron Lett. 2004, 45, 7331.

77. Glutathione synthesis in filarial worms: an attractive target for the design and synthesis of new

antifilarials. K. Arora, R. C. Mishra, R. P. Tripathi, A. K.Srivastava, Rolf D. Walter. Med. Chem

Res., 2004, 13, 687.

78. 7-O-(4-methyl piperazin-acetyl)-4-methyl-2H-1-benzopyran-2-ones: A novel lead compound for

antifilarial activity. R. P. Tripathi, V. K. Tiwari, S. Bhattacharya, K. Srivastava, V. M. L. Srivastava

and K. Murty Acta Tropica, 2003, 87, 215.

79. DBU

Assisted

Cyclorelease

Elimination:

Combinatorial

Synthesis

and

-glutamyl

cystein

synthetase & glutathione-S- transeferase Modulatory Activity of C- nucleoside anlogs. R. C. Mishra,

N. Tewari, K. Arora, R. Ahmad, R. P. Tripathi, V. K. Tiwari, R. D. Walter , A. K. Srivastava Combi

Chem & Highthroughtput Screening, 2003, 6, 37.

80. Synthesis and Antifilarial Evaluation of N1, Nn- Diglycosylated Diaminoalkanes. V. K. Tiwari, N.

Tewari, D. Katiyar, R. P. Tripathi, K. Arora, S. Gupta, A. K Srivastava, M. A. Khan, P. K. Murthy

Bio-Org. & Med. Chem., 2003, 11, 1789.

81. Synthesis and antifilarial evaluation of 7-O-acetamidyl-4-alkyl-2H-1-benzopyran-2-ones. D.

katiyar,

V.

K.Tiwari,

R.

P.Tripathi,

V.

J.

M.

Forsch/Drug Research, 2003, 53, 857.

Reddy,

S.

Bhattacharya,

J.

K.Saxena

Arzn.

82. Synthesis and bioevaluation of glycosyl ureas as -glucosidase inhibitors and their effect on

Mycobacterium. N. Tewari, V. K. Tiwari, R. C. Mishra, R. P. Tripathi, A. K.Srivastava, R. Ahmad,

R.

Srivastava, B. S. Srivastava Bioorg. Med. Chem., 2003, 11, 2911.

83.

Amberlite IR -120 Catalysed Efficient Synthesis of Glycosyl Enaminones and their Application.

N.

Tewari, D. Katiyar, V. K. Tiwari and R. P. Tripathi Tetrahedron Lett., 2003, 44, 6639.

84. Synthesis and Antimycobacterial Activity of 3,5-Disubstituted Thiadiazine thiones. D. Katiyar,

V. K. Tiwari, R. P. Tripathi, A. K. Srivastava, V. Chaturvedi, R. Srivastava and B. S. Srivastava

Bio. Med. Chem., 2003, 11, 4369.

85. Synthesis of Glycosylated β-Amino Hydroxamates as New Class of Antimalarials. R. C.Mishra,

R. Tripathi, D. Katiyar, N. Tewari, D. Singh, and R. P.Tripathi Bio. Med. Chem., 2003, 11, 5363.

86. Combinatorial

and

conventional

synthesis

of

glycohybrid

molecules

as

new

class

of

antitubercular agents V. K. Tiwari, R. P Tripathi, V. Chaturvedi, A. Srivastava, S. Sinha, R.

Srivastava, B. S. Srivastava Medicinal Chem Res., 2003, 12, 394.

87. Synthesis of Glycosylated -amino acids as new class of antitubercular agents. R. P. Tripathi, R.

Tripathi, V. K. Tiwari, Laxmi Bala, S. Sinha, A. Srivastava, R. Srivastava, B. S. Srivastava Eur. J.

Med. Chem., 2002, 37, 773.

88. Unexpected

Isomerisation

of

Double

bond

with

DBU:

A

Convenient

Synthesis

of

Tetrasubstituted -alkylidene tetrahydrofuranoses. V. K. Tiwari, R. P. Tripathi Indian J. Chem, 2002,

41B, 1681.

89. Conjugate Addition of Amines to Sugar Derived Olefinic Ester: Synthesis of Glycosylated

Amino Esters as DNA Topoisomerase II Inhibitors. A. R. Khan, R. P. Tripathi, V. K.Tiwari, R. C.

Mishra, V. J. M. Reddy and J. K. Saxena, J. Carbohydrate Chemistry, 2002, 21, 591.

90. DBU/ TBAB/4A0 Catalysed cyclatic amidation reactions: A highly efficient & convenient

synthesis of C-Nucleosides. N. Tewari, R. C. Mishra, V. K. Tiwari, R. P. Tripathi, Synlett, 2002, 11,

1779.

91. Synthesis and immunomodulatory activities of 2'-hydroxy-3'-N, N-Disubstituted aminopropyl-α-

D-glucofuranoses as immunomodulators. A. R. Khan, R. P. Tripathi, A. P. Bhaduri, R. Sahai, A.

Puri, L. M. Tripathi, V. M .L Srivastava, Eur. J. Med. Chem, 2001, 36, 103.

92. Identification of inhibitors of DNA Topoisomerase-II from a synthetic library of glycoconjugates.

R. P. Tripathi, S. K. Rastogi, B. Kundu,

J.

.K. Saxena, V. J. M. Reddy, S. Srivastava, S. Chandra,

and A.P. Bhaduri Combi. Chem. & Highthroughput Screen., 2001, 4, 237.

93. Study on the loading and reactions of naked sugars on solid phase. R. C. Mishra, R. P. Tripathi

Medicinal Chemistry Research, 2001, 10, 548.

94. Glycosyl amino acid derivatives as inhibitors of yeast DNA topoisomerase. I. P. Jain, Z. K. Khan,

R. P.Tripathi, B. L. Tekwani Abstract of the symposium CTTDDR published in Medicinal

Chemistry Research, 2001, 10, 550.

95. Synthesis and antiviral activity of 3-O-(2'-hydroxy aminopropyl)- α -D-glucofuranoses. N. S.

Rana, P. Gupta, R. P. Tripathi, A. P. Bhaduri Acta Pharmaceutica, 2001, 1, 63.

96. Antifilarial activity of 2H-1-Benzopyran-2-ones (coumarins). R. P. Tripathi, R. Tripathi, S. N.

Singh, A. P. Bhaduri, R. K. Chaterjee and K. Murthy Acta Tropica, 2000, 76, 101.

97. -Cyano ethyl propenoates: a new class of antileishmanial agents. S. Tewari, R. P. Tripathi, A. R.

Khan, S. Gupta, J. C. Katiyar, A. P. Bhaduri Arzen Forsch/ Drug Res., 1999, 49, 144.

98. DNA Topoisomerases of filarial parasites:Effect of antifilarial compounds. U. Pandya, J. K.

Saxena, S. M. Kaul, P. K. Murthy, R. K. Chatterjee, R .P. Tripathi, A. P. Bhaduri, O. P. Shukla

Medical Science Res., 1999, 27, 103.

99. Hepatoprotection

by

3-cyano-5-ethenyl-4-methyl

pyidine

(compound

89/62)

against

experimentally induced liver injury in rats. S. Srivastava, S. C. Tripathi, A. K. Srivastava, D. S.

Bhakuni, R. P. Tripathi and G. K. Patnaik Acta Pharmaceutica, 1997, 47, 117.

100. Cabohydrates in biological recognition. A. R. Khan, R. P. Tripathi, A. P. Bhaduri, Biol.

Memoirs., 1997, 23, 73.

101. Synthesis of 2,3-anhydronucleosides of pyrazolo(3,4-d) pyrimidine as antiviral agents. R.

P.Tripathi, Anil Mishra, Ram Pratap, D. S. Bhakuni Indian J. Chem., 1996, 35B, 441.

102. Asymmetric induction in the epoxidation of 3-and 5-O-allyl glycofuranoses with mCPBA. A.R.

Khan. R. P. Tripathi, A. P. Bhaduri Indian J. Chem. 1996, 35B, 405.

103. Synthesis and spermicidal activities of dithiocarbamates. R. P. Tripathi, A. R. Khan, B. S.

Shetty and A. P. Bhaduri Acta Pharmaceutica, 1996, 46, 169.

104. Effect of 3-O- (aminoalkyl)- -D-gluco (xylo) furanoses on glutathione metabolism of falarial

parasites. A. K. Srivastava, R. P. Tripathi, A. R. Khan, A. P. Bhaduri, S. N. Singh, R. K. Chatterjee

Helminthologia, 1995, 32, 25.

105. Synthesis

and

antiviral

activities

of

3-O-(aminoalkyl)-1,2-O-isopropylidene-α-D-gluco-

(xylo)furanoses, R. P.Tripathi, V. Singh, A. R. Khan , A. P. Bhaduri, G. Saxena, K. Chandra Indian

J Chem., 1995, 34B, 791.

106. Glutathione-S-transferase activity in S. cervi females and effect of new antifailarial compounds.

A. K. Srivastava, R. P. Tripathi, A. R. Khan, A. P. Bhaduri, S. N.Singh, R. K. Chatterjee Indian J.

Parasitology, 1994, 46, 169

107. 3-Cyano-4-methyl-5-vinyl pyridine: A potent synthetic hepatoprotective agent. P.K.S. Visen,

Binduja Saraswat, G. K. Patnaik, R. C. Srimal, R. P. Tripathi, D. S. Bhakuni. Indian J. Pharmacol.,

1993, 25, 149.

108. 3-Cyano-4-methyl-5-vinyl pyridine: A potent synthetic hepatoprotective agent. P.K.S. Visen,

Binduja Saraswat, G. K. Patnaik, R. C. Srimal, R. P. Tripathi, D. S. Bhakuni. Indian J. Pharmacol.,

1993, 25, 149.

109. Synthesis

of

1/2-benzyl-4,6-disubstituted

1H/2H-pyrazolo(3,4-d)-pyrimidines

and

their

antileishmanial activities. A. Mishra, L. M. Ojha, R. P. Tripathi, R. Pratap, D. S. Bhakuni. Indian J.

Heterocyclic Chem., 1991, 1, 51.

110. Studies

in nucleosides: PartXX: Synthesis and antileishmanial activities of 4-oxo-(5H)-

pyrazolo{3,4-d] pyrimidine- & -nucleosides. A. Hasan, R. P. Tripathi, Ram Pratap, D. S. Bhakuni

Indian J. Chem., 1989, 28B, 403.

111.

Studies

in

nucleosides:

PartXIX:

Synthesdis

of

4,6-disubstituted

derivatives

of

1--D-

arabinofuranosylpyrazolo{3,4-d] pyrimidines and their antiviral activities. R. P. Tripathi, Ram

Pratap, D. S. Bhakuni Indian J. Chem., 1987, 26B, 1054.

112. Studies in nucleosides: PartXVII: Synthesis of 4-amino-6-methoxy pyrazolo{3,4-d] pyrimidine

and 4-amino-6-methylthio pyrazolo[3,4-d]pyrimidine ribosides and their antiviral activities. R. P.

Tripathi, A. Hasan, Ram Pratap, D. S. Bhakuni Indian J. Chem., 1987, 26B, 851.

113. A novel synthesis of 4-propyl 2H-1-benzopyran-2-ones. V. K. Ahluwalia, R. P. Singh, R. P.

Tripathi Montash fur chemie, 1984, 115, 765.

114. An efficient synthesis of 4-propylpyranocoumarins. V. K. Ahluwalia, R. P. Singh, R. P.

Tripathi Gazzeta Chimica. Italiana, 1984, 114, 505.

115. An elegant synthesis of 6-butyryl chromans and chromenes. V. K. Ahluwalia, R. P. Singh, R. P.

Tripathi Gazzeta Chimica. Italiana,1984, 114, 359.

116. A facile synthesis of 4-propyl psoralen and angellicine derivatives. V.K. Ahluwalia, R. P.

Tripathi J. Indian Chem Soc., 1984, LXI, 1023.

117. A convenient synthesis of propyl substituted benzofuro coumarins. V. K. Ahluwalia, R. P.

Singh, R. P. Tripathi Heterocycles, 1984, 22, 2783.

List of Patents filed or in process:

1. A process for the synthesis of & - isomers of 6-amino-4-oxo-(5H)- pyrazolo{3,4-d] pyrimidine- &

-nucleosides. Patent in India No. 173563

2. A novel combinatorial library of 3-substituted amino-3-glycosylated propanoates useful as

antifungal and antibacterial agents. Rama Pati Tripathi, Praveen Kumar Shukla, Sudhir Sinha,

Ranjana Srivastava, Kishor Kumar Srivastava, Vinita Chaturvedi, Anil Srivastava, Brahm Shankar

Srivastava. 0716DEL2004 Filing date 4/15/04

3. A process for the preparation of novel combinatorial library of 3-substituted amino-3-glycosylated

propanoates useful as antifungal and antibacterial agents. Rama Pati Tripathi, Bijoy Kundu,

Praveen Kumar

Shukla,

Sudhir

Sinha,

Ranjana

Srivastava,

Kishor

Kumar

Srivastava,

Vinita

Chaturvedi, Anil Srivastava, Brahm Shankar Srivastava. (NF / 315 / 01)

4. A process for the preparation of novel combinatorial library of 3-substituted amino-3-glycosylated

propanamides useful as antifungal and antibacterial agents. Rama Pati Tripathi, Bijoy Kundu,

Praveen Kumar

Shukla,

Sudhir

Sinha,

Ranjana

Srivastava,

Kishor

Kumar

Srivastava,

Vinita

Chaturvedi, Anil Srivastava, Brahm Shankar Srivastava. Patent Appl. No.: 1272DEL2001 Filing

Date: 24/12/2001 Patent No.: 194984 Grant Date: 17/03/2006

5. A novel combinatorial library of 3-substituted amino-3-glycosylated propanamides useful as

antifungal and antibacterial agents. Rama Pati Tripathi, Praveen Kumar Shukla, Sudhir Sinha,

Ranjana Srivastava, Kishor Kumar Srivastava, Vinita Chaturvedi, Anil Srivastava, Brahm Shankar

Srivastava. 1529DEL2004 Filing Date 8/17/04 Patent No.: 196956 Grant Date: 23/06/2006

6. A process for the preparation of novel N1, Nn-diglycosylated diamino alkanes useful as inhibitors

of parasitic enzymes. Rama Pati Tripathi, Vinod Kumar Tiwari, Arvind Kumar Srivastava, Kavita

Arora, Sapana Gupta, K.P. Murthy, R. D. Walter. (INF/PAT/05/2001)

7. A process for the preparation of novel 4-alkyl-7-O-(acetamid-2-yl)-2H-1-benzopyran-2-ones

useful as inhibitors of helminthic and protozoan DNA topoisomerases. Rama Pati Tripathi, Jitendra

Kumar

Saxena,

Onkar

Prasad

Shukla,

Subhash

Chandra,

Puvada

Kalpana

Murthy,

Shailija

Bhattacharya, Kamal Kamboj, Anil Kumar Dwivedi, Ranjeet Kumar Chatterjee, Satyawan Singh,

Vishwa Mohan Lal Srivastava, Anil Kumar Rastogi, Amiya Prasad Bhaduri. 620/DEL/01

8.

N1, Nn-diglycosylated diamino alkanes useful as inhibitors of parasitic enzymes) Rama Pati

Tripathi, Vinod Kumar Tiwari, Arvind Kumar Srivastava, Kavita Arora, Sapana Gupta, P. K.

Murthy, R. D. Walter. (INF/PAT/06/2001)

9. A process for the preparation of novel combinatorial library of N1 glycosylated and N3 -

substituted ureas and thioureas useful as antitubercular agents, Rama Pati Tripathi, Vinod Kumar

Tiwari, Ram Chandra Mishra, Ranjana Srivastava, Sudhir Sriwastava, Vinita Chaturvedi, Kishor

Kumar Srivastava, Brahm Shankar Srivastava 264 DEL2002 Filing Date/ 20.03.2002

10.

Novel

combinatorial

library

of

N1

glycosylated

and

N3 substituted

ureas

Useful

as

antitubercular agents, Rama Pati Tripathi, Vinod Kumar Tiwari, Ram Chandra Mishra, Ranjana

Srivastava,

Sudhir

Sriwastava,

Vinita

Chaturvedi,

Kishor

Kumar

Srivastava,

Brahm

Shankar

Srivastava. 0715DEL2004 4/15/04 Patent Number(s): IN200400715-I1

11. Diglycosylated diaminoalcohol as novel antitubercular agents, Rama Pati Tripathi, Vinod

Kumar Tiwari, Neetu tewari, Ranjana Srivastava, Sudhir Srivastava, Vinita Chaturvedi, Kishor

Kumar Srivastava, Brahm Shankar Srivastava. 999/DEL/30.09.2002.

12. A process for the preparation of diglycosylated diaminoalcohol as antitubercular agents Rama

Pati Tripathi, Vinod Kumar Tiwari, Neetu tewari, Ranjana Srivastava, Sudhir Srivastava, Vinita

Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava (998/DEL/30.09.2002)

13. Novel Galactopyranosylated aminoalcohols useful in chemotherapy of tubercular infections;

Rama Pati Tripathi, Neetu Tewari, Ram Chandra Mishra, Ranjana Srivastava, Sudhir Sinha, Anil

Srivastava, Vinita Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava 1212DEL2004

Filing Date 6/30.2004

14. A process for the preparation of Galactopyranosylated aminoalcohols useful in chemotherapy of

tubercular infections, Rama Pati Tripathi, Neetu tewari, Ram Chandra Mishra, Ranjana Srivastava,

Sudhir Sinha, Anil Srivastava, Vinita Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar

15.

Novel 1,3,5-thiazidine -2-thiones useful in chemotherapy of tubercular infections, Rama Pati

Tripathi, Diksha Katiyar, Ranjana Srivastava, Anil Srivastava, Vinita Chaturvedi, Kishor Kumar

Srivastava, Brahm Shankar Srivastava 1098DEL2004 Filing Date 6/11/2004

16. A process for the preparation of 1,3,5-thiazidine -2-thiones useful in chemotherapy of tubercular

infections, Rama Pati Tripathi, Diksha Katiyar, Ranjana Srivastava, Anil Srivastava, Vinita

Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava, 1098DEL2004 Filing Date

6/11/04

17. Novel Phenyl Cyclopropyl methanones useful as antitubercular agents, Rajesh Grover, R.C.

Mishra, S.S. Verma, R.P. Tripathi, Raja Roy, A.K. Dwivedi, S.Singh, Ranjana Srivastava, Anil

Srivastava, Vinita Chaturvedi, Manju Y. Krishnan , Brahm Shankar Srivastava 0636DEL2004 Filing

Date 3/31/2004

18. A process for the preparation of novel glycosylated aminoalcohols useful in the treatment of

tuberculosis Ramapati Tripathi, Vinod Kumar Tiwari, Neetu Tewari, Diksha Katiyar, Anil Kumar

Dwivedi, Styawan Singh, Anil Gaikwad, Sudhir Sinha, Ranjana Srivastava, Sudhir Srivastava, Vinita

Chaturvedi, Kishor Kumar Srivastava, Brahm Shankar Srivastava 1217DEL/04 30.6.04

19.

Novel Dispiro cyclalkanones

useful as

inhibitors

of NAD+-dependent

DNA

Ligase

and

antitubercular agents Rama Pati Tripathi, Jyoti Pandey, Nimisha Singh, Divya Dube, Vandna

Kukshal,

Shalini

Bhatnagar,

0082DEL2010 Dated 29.01.10

Sudhir

Sinha,

Vinita

Chaturvedi,

Ravishankar

Ramchandran

20. An Antitubercular formulation of 4-alkoxy phenyl cyclopropyl methanes Rama Pati Tripathi,

Prabhat Ranjan Mishra, Girish Kumar Gupta, Surendra Singh Bisht, Jyoti Pandey, Vinita Chaturvedi,

Sudhir Sinha, Versa Gupta and Anil Kumar Dwivedi 0183DEL2010 FILED ON 29.01.10

Chapters in Book: 1. Synthesis and antifilarial evaluation of a few carbohydrate derivatives.

R.P.Tripathi, V.Singh, A.R.Khan, A.P.Bhaduri, S.Bhatnagar and A.K. Srivastava. “Trends in

Carbohydrate Chemistry,” edited by P.L.Soni, Surya International Publication, Dehradune pp 1-4

(1995).

2. Search of new drugs for tuberculosis: Glycosylated -amino acids as new class of antitubercular

agents, Trends in Carbohydrate Chemistry, Vol-8 (in press), and Published by Surya international

publication, Dehradun. Authors: V.K.Tiwari, R. P. Tripathi, R. Tripathi, Laxmi Bala, S. Sinha, A.

Srivastava, R. Srivastava, B.S. Srivastava.

Paper Presented in conference: (Last three years)

1. Identification of inhibitors of DNA Topoisomerase II from a synthetic library of glycopeptides, R.

P. Tripathi, S. K. Rastogi, B. Kundu, J.K. Saxena, S. Srivastava, V.J.M. Reddy, S. Chandra, A. P.

Bhaduri, Fifth IUPAC International Symposium on Bio-Organic Chemistry, ISBOC-5, at National

Chemical Laboratory- Pune, 3rd Jan - 4 th Feb 2001.

2. Unexpected Isomerisation reaction with DBU: An easy access to -alkylidene tetrahydrofuranose,

V. K. Tiwari, R. P. Tripathi, Current Trends in Drug Discovery Research, 11-15 Feb 2001 at CDRI

Lucknow.

3. Antifilarial profile of a novel lead compound: 7-O- (4-methyl piperazin-acetyl)-4-methyl 2H-1-

benzopyran-2-ones, R. P. Tripathi, V. K. Tiwari, S. Bhattacharya, K. Srivastava, V. M. L.

Srivastava and K. Murty, Indian Conference of Parasitology, 1-3 Oct 2001 at Jodhpur.

4. Synthesis of glycosylated amino esters as DNA topoisomerase-II inhibitors A.R.Khan, R. P.

Tripathi, V. K. Tiwari, R. C. Mishra, V. J. M.Reddy and J. K. Saxena, National Biorganic

Symposium 7, GNDU Amritsar 7-9 Nov 2001

5. Depletion

of

intracellular

Glutathione

of Setaria

cervi by Dimethylmaleate,

Phorone

and

Aminoalkane derivatives. S. Gupta,V. K. Tiwari,

R. P. Tripathi, A. K. Sriwastava,

Indian

Conference of Parasitology, 1-3 Oct 2001 at Jodhpur.

6.

Glycosylated -amino acids as new class of antitubercular agents. V. K. Tiwari, R. P. Tripathi, R.

Tripathi, Laxmi Bala, S. Sinha, A. Srivastava, R. Srivastava, B. S. Srivastava, 16th Carbohydrate

Conference,6-7 December at Trivendrum.

7. Conjugate Addition of Hydrazine and Hydroxyl Amines to Sugar derived Olefinic Esters:

Synthesis of glycosylated heterocycles. R. C. Mishra, N. Tewari, R. P. Tripathi, 22-24 Feb Alembic

Ltd Vadodara.

8. Synthesis and bioevaluation of glycosyl ureas as -glucosidase inhibitors and antituberculosis

agents. V. K. Tiwari, N. Tewari, R. C. Mishra, R. P. Tripathi, A .K. Srivastava, R. Ahmad, R. Srivastava

and B. S. Srivastava. International symposium on Drug Discovery and Process Research, Shivaji

University Kolhapur, January 23-25, 2003.

9. A versatile synthesis of dihydropyrimidinone C-Nucleosides. R. C. Mishra, D. Katiyar, N. Tewari,

R. P. Tripathi,

International symposium

University Kolhapur, January 23-25, 2003.

on Drug Discovery and Process Research, Shivaji

10. -glucosidase inhibitory potential of glycosyl ureas. N. Tewari, R. C. Mishra, R. Ahmad, A. K.

Srivastava, and R. P. Tripathi, International conference on Role of Free Radical and antioxidants in

Health and disease, King George Medical University Lucknow, February 10-12, 2003.

11. Glutathione modulatory potential of 4-alkyl-7-O-acetamidyl coumarins in malarial and filarial

parasites, D. Katiyar, K. Arora, R. Ahmad, A. K. Srivastava, and R. P. Tripathi, International

conference on Role of Free Radical and antioxidants in Health and disease, King George Medical

University Lucknow, February 10-12, 2003.

12. Synthesis and antitubercular activity of Novel purines Derivatives of 2,3-O,O-Dialkyl-6-deoxy-L-

ascorbic

acid

and

4,5

didehydro-5,6-dideoxy-L-ascorbic

acid.

N.

Dwivedi,

R.

P.

Tripathi.

XXI

Carbohydrate Conference, Deptt of Chem Delhi University, 26-29 Nov. 2006.

13.

Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in

asymmetric aldol reactions. Jyoti Pandey, Namrata Dwivedi, Nimisha Singh, A. K. Srivastava, A.

Tamarkarb and R. P. Tripathi XXI Carbohydrate Conference, Deptt of Chem Delhi university, 26-29

Nov. 2006

14. Synthesis and Antitubercular Activity of Nucleoside analogs based on purines and L-Ascorbic acid.

N. Singh, N. Dwivedi, M. Misra and R. P. Tripathi. Current trends in drug discovery 17-21 Feb 2007,

C.D.R.I Lucknow.

15.

L-Ascorbic

acid

in

organic

synthesis:An

Ecofriendly

and

facile

synthesis

of

4-vinyl-1,

4-

Dihydroryridine Surendra. S. Bisht Current trends in drug discovery 17-21 Feb 2007, C.D.R.I Lucknow.

16. An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

Biswajit K Singh, 11 th ISCB conference (ISCBC 2007) International Conference on Advances in Drug

Discovery research Feb 24-26 2007. Dr. Babasaheb Ambedkar Marathwada University.

17. Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines Nisha

Saxena, R P, Triapthi 11 th ISCB conference (ISCBC 2007) International Conference on Advances in

Drug Discovery research Feb 24-26 2007. Dr. Babasaheb Ambedkar Marathwada University.

18. The gateway to solution phase synthesis of a library of an artificial glycopeptides: in silico

screening and antimicrobial evaluation Jyoti Pandey, A. Sharma, R. Ramachandran, V. Chaturvedi,

S. Sinha, P. K. Shukla and Rama P. Tripathi* International Conference on Biomedical and Bioorganic

Chemistry Mar 04, 2009 at Delhi University and Jan 22-24, 2009 at Bhavnagar University, Bhavnagar

(Gujarat) India.

19.

Synthesis

of

polyfunctional

alkenoyl

and

alkanoyl

C-glycosides

and

their

α-glucosidase

inhibitory activity.” Surendra Singh Bisht, Anindra Sharma, Arvind K. Srivastva and Rama P.

Tripathi.

Presented

in

CARBO-XXIII

Bhavnagar (Gujarat) India.

conference

Jan

22-24,

2009

at

Bhavnagar

University,

20. Synthesis of glycopeptides based on glycosylaminoacid scaffolds Mridul Misra, Anindra

Sharma, Rama P. Tripathi,

CARBO XXIV, Carbohydrate Conference, Lachoo Memorial

College of Science and technology, Jodhpur, Rajasthan, 7-9 December, 2009.

21. An attempt towards the synthesis of unnatural deoxynucleosides S. K. Pandey, B. K. Singh

and R. P. Tripathi CARBO XXIV, Carbohydrate Conference, Lachoo Memorial College of

Science and technology, Jodhpur, Rajasthan, 7-9 December, 2009.

22. Search of antimycobacterial activities in hybrid molecules with benzopyran skeletons Rama P. Tripathi, Surendra Singh Bisht, Vivek P. Pandey, Sarvesh K. Pandey, Subhra Singh, Vinita Chaturvedi and Sudhir Kumar Sinha 4 th international symposium on Current Trends in Drug Discovery Research (CTDDR-2010), 17 th -21 st February 2010.Central Drug Research Institute, Lucknow, U.P.; India

23. Synthesis of hybrid molecules with charbohydrate aromatic and heterocyle skeletons as

potent antidiabetics Seerat Fatima, Surendra Singh Bisht, Arvind K. Srivastva and Rama P. Tripathi 4 th international symposium on Current Trends in Drug Discovery Research (CTDDR-

2010), 17 th -21 st February 2010, Central Drug Research Institute, Lucknow, U. P.; India. 24.Synthesis and anti breast cancer activity of biphenyl based chalcones Anindra Sharma, Munna

Prasad Gupt, Bandana Chakravarti, Rituraj Konwar, Rama P. Tripathi

Current Trends in Drug Discovery Research (CTDDR-2010),

4 th international symposium on

17 th -21 st February 2010. Central Drug Research

Institute, Lucknow, U.P.; India 25.Synthesis ,molecular modelling and their antitubercular evaluations of benzylidene tetrahydroquinazolines: Nimisha Singh, Richa Dwiwedi, Vinita Chaturvedi, S. Sinha, M.I.Siddiqui and R.P.Tripathi 4 th international symposium on Current Trends in Drug Discovery Research (CTDDR-2010), 17 th -21 st February 2010. Central Drug Research Institute, Lucknow,

U.P.; India

26.Diastereoselective efficient synthesis of hexahydro-4-phenyl-1H-pyrano[2,3-d]pyrimidin- 2(8H)-ones (thiones) via L-Proline/TFA catalyzed Biginelli-type reaction Jyoti Pandey, N. Anand and Rama P. Tripathi 4 th international symposium on Current Trends in Drug Discovery

Research (CTDDR-2010), 17 th -21 st February 2010. Central Drug Research Institute, Lucknow, U.P.; India 27. Synthesis of 1H-(1-cyclopropyl phenyl methyl) and 1-(phenyl-but-3-enyl)-azoles and their antimicrobial Evaluations Namrata Anand, Rahul Sharma, Shubra Singh, Nipendra Mishra, Vinita Chaturvedi, Sudhir Kumar Sinha, P.K. Shukla and R.P. Tripathi

4 th international symposium on Current Trends in Drug Discovery Research (CTDDR-2010),

17 th -21 st February 2010. Central Drug Research Institute, Lucknow, U.P.; India

Invited Lectures:

1. Polysaccharides structure & function- its relevance to medicinal chemists-In TAB Meeting CSIR

Science centre New Delhi 9th July 1991.

2. Carbohydrtes in Drug Design- In modern Trends in chemical research: From laboratory to

Industry, March 5-7 1992, APS University Reewa, M.P.

3. Strategies in the design of antiviral agents: National Seminar organized by Purvanchal academy of

Sciences March 1993, at Neoria Jaunpur.

4. Chemotherapy of filariasis-National Seminar organized by Purvanchal Academy of Sciences

March 1993, at Purvanchal University Jaunpur 1994.

5. Development of drugs against Tuberculosis- Annual Convention Of Chemical Society of DBS

college, Kanpur University, Kanpur December 2002

6. Carbohydrates in Drug Design: National Conference on Chemistry at Interfaces-Trends and

Perspectives, December 19-20, 2003, Sant Longowal Institute of Technology, Longowal, Punjab.

7.

Application of carbohydrates in development of ne chemotherapeutics APS University March

2004 New trends in Chemistry

8. Carbohydrates in Drug design: An attempt to develop new generation of Antimycobacterial

Agents XIX Carbohydrate Conference, Forest Research Institute Dehradun. Uttaranchal 1-3rd

December 2004.

9. Search of New Antimycobacterial Agents. Bundelkhand University Jhansi, Jan 2005.

10. Carbohydrates in Drug Desin against Tuberculosis. XIX Carbohydrate Conference, Chemistry

Department Lucknow University, Lucknow 23-26 Nov 2005 December 2005.

11. Role of sugars in the development of new generation of Antitubercular agents. Chemistry Deptt.

BHU Varanasi 24 March 2006.

10. Tuberculosis: New Drug Development University of Rennes1 FRANCE 13th June 2006.

11. Potential of Simple Sugars in Chemistry and Medicinal Chemistry. BHU, 30th Sept 2006.

12. Explorations in Medicinal Chemistry with Simple Sugars. Delhi University, 27th Nov 2006.

13. GLYCOCONJUGATES: NOVEL INHIBITORS OF M.TUBERCULOSIS NAD+ -DEPENDENT

DNA LIGASE (Rv3014c) BHU Varanasi, 24 TH March 2007

14. Application of Monosaccharides as Chemotherapeutics NIPER Chandigarh India December 2007

15. Our effort to develop new antitubercular agents 1st International Euro-India Conference on

Holistic Medicine 21. 8. 2008 Kottayam, Kerala.

16. Antioxidant Defense System of Parasites: A Tool for Drug Discovery 27 th Feb MMV BHU

Varanasi 2008.

17. Medicinal Chemistry with sugars Bhavnagar University, Bhavnagar (Gujarat) 2009.

18. Application of carbohydrate based chiral ligands for the synthesis of biologically active

compounds of potential application in Defence 04.08.2009. DRDE Gwalior

19. Development of new generation of Antitubercular agents Pretoria South Africa 3.8.2009.

21.

Development of new drugs with sugars Institute of Medical Sciences BHU, Varanasi, 2009

22. Monosachharides of medicinal Importance Delhi University, Delhi 04.03.2009.

23. Developing drugs with sugars LMC Pharmacy and engineering Jodhpur Feb 2010

24. Drug DISCOVERY & Development: Role of Medicinal and PROCESS CHEMISTY 29 TH May

2010 Zydus Cadila Vadodara, Gujrat

25. Application of Carbohydrate Scaffolds in Synthesis of New Generation of Anti-diabetic

Agents Carbo XXV Shimla University Himachal Pradesh 11.11. 2010.