MODIFIABLE NON-MODIFIABLE

Lifestyle Age
Exposure to organism Genetics

Leptospira

Discharged urine of an infected animal

Penetration through skin breaks

or intact mucus membranes
Goes into the bloodstream

Low or absent antibody titer Intermediate antibody titer

Multiplication (Leptospirema) Mild/Shortened Leptospirema

Thrombocytopenia Mild clinical signs

Renal failure Jaundice Coagulopathy Fever Headache Body pain

Ineffective tissue perfusion Impaired skin integrity Renal failure

Increased body temperature Acute pain

Antibody titer Increases

Renal Colonization Eliminates organism from kidneys