DRUG # 1

Drug Classification Mechanism of Indication Contraindication Adverse Effects Nursing

Action responsibilities
Generic Therapeutic Inhibits RNA Acitve Hypersentivity to CNS: ataxia, Before:
Name: Classification: synthesis by tuberculosis with rifampin , product confusion, Assess for lung
Rifampin Antituberculars blocking RNA other agents. components or to drowsiness, fatigue, sounds and character
transcription in Elimination og any rifamycin: headache, weakness and amount of
Brand susceptible meningococcal contaminant therapy Derm: sputum periodically
Name: organisms. carriers. Prevent with unboosted or Rash, pruritus and during therapy.
Rifadin, of disease ritonavir-boosted flushing
rifactane Functional caused by saquinavir, EENT: Instruct patient to
classifications: Haemophilus atazanavir, darunavir Red discoloration of take drug on an
Route/ Dose Pregnancy influenza type B or tipranavir. tears, conjunctivitis, empty stomach 1 hr
ADULTS: Category C in close visual disturbances before or 2 hrs after
PO, IV: contacts.Synegy GI: meals.
600mg/day with other Abdominal pain,
or 10 antmicrobial diarrhea, flatulence, During:
mg/kg/day agents for heartburn, nausea Do not confuse
single dose, S.aureus and vomiting, rifampin with
may also infections increae enzymes, rifabutin
given twice pseudomembranou Administer
weekly s colitis, sore mouth medication to the
PO, IV and tongue right patient in right
CHILDREN: Hematologic: dose and timing
10- Hemolytic anemia,
20mg/kg/day thrombocytopenia, After:
single dose leucopenia, -Advise patient to
or divided q decreased report any usualities
12 hrs for hemoglobin. Like flu-like
2days( not MS: symtopms
exceed Muscle weakness, -Observe adverse
600mg/ day. arthralgia, myalgia reaction and notify
physician
DRUG # 2

Drug Classification Mechanism of Indication Contraindication Adverse Effects Nursing

Action responsibilities
Generic Name: Therapeutic Converted to Pyrazinamide is Pyrazinamide is General: Fever,  Before:
Pyrazinamide Classification: pyrazinoic acid in indicated for the contraindicated porphyria and d -Assess medical
Antitubercular susceptible strains initial treatment of in persons: with ysuria have history
Brand Name: s agent of Mycobacterium active tubercuIosis severe hepatic rarely been -Perform
Tebrazid which lowers the mycobacterial studies
in adults and damage; who reported. Gout
Pregnanct PH of the -Assess serum uric
children when have shown
Route/ Dose: Category C environment acid concentration
present in combined with hypersensitivity GI: . Gl
ADULT: macrophages and other antitubercu- to it; with acute disturbances During :
15 TO inflamed tissue. lous agents. The gout. including nause -Maybe given
30MG/KG PO Together with current a, vomiting concurrently with
rifampicinnprovide recommendation and anorexia ha isoniazide
s greatest of the CDC for ve also been -evaluate hepatic
CHILDREN sterilizing action drug-susceptible Reported. and liver function
15 to 30 mg/kg with reduction in disease is to use a -provide patien the
PO relapse rate. six-month regimen  Hematologic right drugs.
Reduces tubular and -instruct that
for initial
secretion of uric Lymphatic: Thr pyrazinamide
treatment
acid mayintere with
of active ombocytopenia 
ketone
tuberculosis, and measurements
consisting of sideroblastic an After:
isoniazid, rifampin emia with -Advise patient to
and pyrazinamide erythroid hyper take medication as
given for 2 plasia, directed.
months, followed vacuolation of -Instruct to notify
by isoniazid and erythrocytes health professionals
rifampin for 4 and increased if adverse reactions
months. serum iron occur.
concentration
have occurred
rarely with this
drug. Adverse
effects on blood
clotting
mechanisms
have also been
rarely reported.

Other: Mild art
hralgia and mya
lgia have been
reported
frequently.
Hypersensitivity
reactions
including
rashes, urticaria
, and pruritis
have been
reported.
Fever, acne, ph
otosensitivity,
porphyria,
dysuria
and interstitial 
nephritis have
been reported
rarely.
DRUG # 3

Drug Classification Mechanism of Indication Contraindication Adverse Effects Nursing

Action responsibilities
Generic Name: Therapeutic Inhibits First line therapy Isoniazid is Common: Before:
Isoniazid classification: mycobacterial cell of active contraindicated in Peripheral Assess for
Antitubercular wall synthesis and tuberculosis, in patients who neuropathy. myobacterial
Brand name: agent interferes with combination with develop severe Uncommon: studies
Tubizid metabolism. other agents. hypersensitivity Memory Assess for hepatic
Pregnancy Prevention of reactions, impairment, optic function
category C tuberculosis including drug neuritis and Instruct not to
Dosing : 10 patients exposed -induced atrophy, toxic drink alcohol
mg/kg/day PO for to active disease. hepatitis; previous encephalopathy, during therapy
the entire course Functional isoniazid- convulsions, and During:
of treatment. Classification: associated hepatic toxic psychosis. -Administer with
Max: 300 mg/day MAOI injury; severe Elevated serum food or antacid if
adverse reactions transaminase GI irritations occur
to isoniazid such (SGOT SGPT), -advise patient
as drug fever, jaundice, that medication
chills, arthritis; hyperbilirubinemia may cause
and acute liver , nausea, vomiting, discomfort at
disease of any epigastric distress, injection site.
etiology thrombocytopenia, -Massage site
agranulocytosis, after
sideroblastic, administration
hemolytic, or and rotate the
aplastic anemia, injection site
and eosinophilia, After:
systemic Lupus -Instruct patient
Erythematosus, to report adverse
fever, reactions
lymphadenopathy, -advise follow up,
skin eruptions, check unsualities
 vasculitis.
DRUG # 4

Nursing
Drug Classification Mechanism of Indication Contraindication Adverse Effects responsibilitie
Action s
Generic Therapeutic Ethambutol, an In combination Hypersensitivity. Significant: Optic neuritis, Advise
name: classification: antimycobacteria with other Optic and visual disturbances (e.g. patient to
Ethambuto Antitubercula l, is bacteriostatic antitubercular retrobulbar colour blindness and
take this
l r agent against s: For neuritis. Inability irreversible blindness).
susceptible prophylaxis to report visual Blood and lymphatic medicine
Brand Pregnancy bacteria. It and primary disturbances (e.g. system with food.
Name: category C appears to inhibit treatment of unconscious). disorders: Thrombocytopen
Myambuto synthesis of Tuberculosis ia, eosinophilia, leucopenia, Advise
l bacterial neutropenia. patient that
metabolites Gastrointestinal
this drug
thereby, disorders: Nausea,
inhibiting cellular vomiting, abdominal pain, may cause
metabolism and gastrointestinal upset. visual
multiplication General disorders and disturbances
administration site , if affected,
conditions: Malaise, fever. warn
Hepatobiliary
patients not
disorders: Jaundice.
Immune system to drive or
disorders: Hypersensitivity operate
reactions, erythema machinery.
multiforme.
Investigations: Hyperuricae
mia.
Metabolism and nutrition
disorders: Anorexia.
Musculoskeletal and
connective tissue
disorders: Acute gout.
Nervous system
disorders: Headache,
dizziness, peripheral
neuropathy.
Psychiatric
disorders: Confusion,
disorientation,
hallucinations.
Respiratory, thoracic and
mediastinal
disorders: Pulmonaryinfiltr
ates.
Skin and subcutaneous
tissue disorders: Dermatitis,
erythema multiforme,
pruritus.
Potentially
Fatal: Hepatotoxicity
DRUG # 5

Nursing
Drug Classification Mechanism of Indication Contraindication Adverse Effects responsibilities
Action
Generic name: Aminoglycosides Streptomycin Tularaemia Hypersensitivity Neurotoxic BEFORE:
Streptomycin / Anti-TB Agents inhibits to streptomycin reactions (e.g.
bacterial Bacterial and other vestibular and Promote rest
Brand Name: protein endocarditis aminoglycosides. cochlear function
Streptoz synthesis by Tuberculosis disturbance, Educate patient
binding directly Plague opticnerve to adhere to the
Dosage to the 30S Bacteraemia, dysfunction, medication
: ribosomal Brucellosis, peripheral neuritis, therapy.
TB Adult 15 subunits Meningitis, arachnoiditis, DURING:
mg/kg daily; causing faulty Pneumonia, encephalopathy); Add 4.2 mL, 3.2
25-30 mg/kg peptide Urinary tract paraesthesia of mL, or 1.8 mL of
twice wkly; 25- sequence to infections face, rash, fever, sterile water for
30 mg/kg thrice form in the angioneurotic injection to
wkly. Children protein chain. oedema, prepare a
20-40 mg/kg eosinophilia; solution
daily, max: 1 g; exfoliative containing
25-30 mg/kg dermatitis, approx 200 mg,
twice wkly, azotemia, 250 mg, or 400
max: 1.5 g; 25- leucopenia, mg, respectively,
30 mg/kg thrice thrombocytopenia, of streptomycin
wkly, max: 1.5 pancytopenia, per mL.
g. haemolyticanaemia,
muscular weakness, Advise patient
amblyopia. that drug may
Potentially Fatal: have tinnitus and
Resp paralysis from autotoxicity as a
neuromuscular side effect
blockade, hence,monitoring
Clostridium difficile- renal and
associated auditory function
diarrhoea, is important
anaphylaxis; rarely, AFTER:
nephrotoxicity. Watch for
adverse reaction
Advise patient to
report
accordingly
DRUG # 6

Nursing
Drug Classificati Mechanism of Indicatio Contraindication Adverse Effects responsibilities
on Action n
Generic Anti- Inhibit cell respiratory Contraindicated CNS: Prior toadministration,
name: infective wall tract or skin in patientshypersen Neurotoxicity:drowsiness, skintest is to be done
Ampicilli bactericida synthesisdur and skin- sitive to drug unsteady gait,weakness, todetermine signsand
n l ing structure or other penicillin clumsiness,  symptoms
bacterialmul infection andcephalosporins paresthesias, of hypersensitivity.
tiplication tremors,convulsions,
Brand peripheralneuritis. Monitor seizureswhen
name: giving highdoses.
ampicillin Vestibular:
Trihydrat dizziness,ataxia. Do not miss a
e doseunless ordered
GI: byphysician.
Nausea,
vomiting,hepatotoxicity Instruct mother
toreport signs
Metabolic: andsymptoms of
Hypokalemia,hymagnese super in
mia.

Skin:
Skin rash,
urticaria, pruritus,
redness.

Urogenital:
Oliguria,urinary
frequency,hematuria,
tubular
necrosis,azotemia.

Other: Superinfection
DRUG # 7

Nursing
Drug Classification Mechanism of Indication Contraindication Adverse Effects responsibilities
Action
Generic Name: By competing Indicated for Fatigue ● Monitor signs of
increased hepatitis
Entecavir with the natural treatment of CHB Headache
blood acidity (jaundice, fatigue,
substrate with evidence of Dizziness
due to high anorexia,
deoxyguanosine active viral Nausea
levels of lactic pruritus) during
Brand name: triphosphate, replication and Diarrhea
acid and for several
Baraclude entecavir either evidence of Dyspepsia
months following
functionally persistent Vomiting discontinuation of
enlarged
inhibits all three elevations in Somnolence therapy.
fatty liver
activities of the serum Insomnia Exacerbations
HBV polymerase aminotransferase may occur when
abnormal
(reverse s (ALT or AST) or therapy is
liver function
transcriptase, histologically Comprehensive discontinued.
tests
rt): (1) base active disease structured data
priming, (2) Nucleoside on known drug ● May cause
moderate to lactic acidosis and
reverse inhibitor adverse effects
severe kidney severe
transcription of treatment-naïve with statistical
impairment hepatomegaly
the negative with prevalence.
with steatosis.
strand from the compensated liver drug MedDRA and Monitor patient
pregenomic disease (adults resistance to ICD10 ids are for signs (qserum
messenger RNA, and adolescents anti-retroviral provided for lactate levels,
and (3) synthesis ≥16 yr): 0.5 mg PO thera adverse effect elevated liver
of the positive qDay conditions and enzymes, liver
strand of HBV Lamivudine- symptoms. enlargement on
DNA. Upon refractory or palpation).
activation by known lamivudine Suspend therapy
kinases, the drug or telbivudine if clinical
can be resistance
incorporated substitutions
into the DNA (adults and
which has the adolescents ≥16
ultimate effect yr): 1 mg PO qDay
of inhibiting the
HBV polymerase
activity.
DRUG # 8

Nursing
Drug Classification Mechanism of Indication Contraindication Adverse Effects responsibilities
Action
Generic Tenofovir Tenofovir  depression
 osteomalacia
name: Nucleoside works in the belongs to a
 or softening of  pain
Tenofovir reverse same way for class of drugs
bones
transcriptase both HIV called nucleoside  back pain
 low amount of
inhibitors infection and reverse
phosphate in the  diarrhea
Brand (NRTIs). chronic transcriptase
blood
name: hepatitis B inhibitors
 increased blood  headache
Viread virus (NRTIs). It’s also
acidity due to
infections. It a hepatitis B  trouble
high levels of
blocks the virus reverse sleeping
lactic acid
effectiveness transcriptase
 Fanconi  nausea or
of reverse inhibitor (RTI). A
syndrome
transcriptase, class of drugs is vomiting
 a condition of
an enzyme a group of
the kidneys  rash
required for medications that
resulting in
each virus to work in a similar
excessive
make copies way. These
urination
of itself. drugs are often
 thirst and
Blocking used to treat
vomiting
reverse similar
 acute kidney
transcriptase conditions.
failure
can reduce
 decreased
the amount of
the virus in
calcification or
your blood.
density of bone
 broken bone
due to disease
or illness
 chronic kidney
disease stage 3B
(moderate)
 chronic kidney
disease stage 4
(severe)
 chronic kidney
disease stage 5
(failure)
DRUG #9
DRUG # 10
DRUG # 7