MALINDA SIRUE, BSN4

MODULE 2, Activity 101 Precipitating Factors:

 exposure to radiation
and certain chemicals
General Pathophysiology Of Breast Cancer  having a sibling with
leukemia
Predisposing  HTLV-1 virus
Factors: ETIOLOGY:  genetic abnormalities
Age Unknown  chromosomal
Gender translocations
Race
Family HIstory
Somatic mutations in
the DNA

Activate oncogene/
deactivate tumor-
supppresor gene

Malignant transformation
of lymphoid stem cells

s/sx:
Uncontrolled proliferation bone pain Treatment:
of lymphoblast in the bone joint pain Analgesic
marrow

Diagnostic Treatment:
Test: Lymphoblast replace the  Remission
BM aspiration normal marrow elements Induction Therapy
BM biopsy  Consolidation and
Maintenance
Therapy
 BM Transplantation
 CNS prophylaxis
 Diagnostic Leukopenia Decreased production of s/sx: Treatment:
Test: 9 normal blood cells  presence of  Blood
(↓4.36 x 10 /L)
CBC petechiae transfusion
Decreased production  bruise & bleed  Epoetin and
of normal blood cells easily hemapoetic
 anemia stimulants
Spillage of lymphoblast
s/sx: Infection  fatigue
into the bloodstream
fever, chills  dizziness
seizure  palpitations
 dyspnea

Organ infiltration
If treated: If not treated
Antibiotic
Ig
Leukapheresis
Septicemia

Prevention of Death
complications

Diagnostic CNS
Kidneys Test:
s/sx: Liver / Diagnostic
s/sx: MRI
h/a, weakness, blurred Spleen Test:
 Little/ no UO vision, balance difficulty, Ultrasonography
Renal failure  ↑RR Treatment: leukocyte cells vomiting, lethargy
 Flank pain Intrathecal impairs the
 Restless Extra cells
chemotherapy circulation of
 n/v cause the
CSF s/sx: s/sx:
 legs and liver/spleen
↑ CSF hepatomegal
feet swelling to rupture
leukocytes y
 uremia s/sx:
Diagnostic splenomegaly
 azotemia leukocyte cells cranial nerve palsies elevated ALT
Test:
compresses confusional states bleeding s/sx:
(81 u/L)
Spinal Tap
spinal/ cranial optic neuropathy hypotension
nerves cerebellar dysfunction tachypnea
papilledema Hypovolemic
Progress to coma shock tachychardia
 Physical
Overgrown s/sx: Exam Lymph
thymus shortness of Diagnostic nodes
breath test:
cough Lymph node
suffocation biopsy
Compress Mediastinal
the Superior lymphadenopathy
Vena Cava
s/sx:
lymphadenopathy
Bronchial/tracheal
SVC syndrome obstruction

Treatment: s/sx:
s/sx:  O2 cough, wheezes, Esophageal
 swelling of administration respiratory tract compression
head, neck and  Bronchodilators obstruction
arms
 obstruction of
blood flow Erosion of node
s/sx: into a bronchus/
dysphagia trachea

s/sx: Severe
hemoptysis hypoxia

DEATH