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DRUG STUDY

every 8 hours ANST (-) PHARMACOLOGIC CLASS: second-generation


cephalosporin

DRUG NAME: Cefuroxime


Cefuroxime 750 mg IV
THERAPEUTIC CLASS: antibiotic

ACTION INDICATION SIDE EFFECTS NURSING CONSIDERATIONS

Second-generation cephalosporin > Serious lower respiratory tract > diarrhea >Before giving drug, ask patient if he is
that inhibits cell-wall synthesis, infection, UTI, skin or skin-structure allergic to penicillins or
promoting osmotic instability; usually infections, bone or joint infection, >nausea cephalosporins.
bactericidal. septicemia, meningitis, and
gonorrhea >Obtain specimen for culture and
sensitivity tests before giving first dose.
> Perioperative prevention Therapy may begin while awaiting
results.
> Bacterial exacerbations of chronic For I.M. use, inject deep into a large
bronchitis or secondary bacterial muscle, such as the gluteus maximus
infection of acute bronchitis or the side of the thigh.

> Acute bacterial maxillary sinusitis >Absorption of oral drug is enhanced


by food.
> Pharyngitis and tonsillitis
>Tablets may be crushed, if absolutely
> Otitis media necessary, for patients who can't
swallow tablets. Tablets may be
> Uncomplicated skin and skin dissolved in small amounts of apple,
structure infection orange, or grape juice or chocolate
milk. However, the drug has a bitter
> Uncomplicated UTI taste that is difficult to mask, even with
food.
> Uncomplicated gonorrhea
>Tablets and suspension aren't
> Early Lyme disease bioequivalent and can't be substituted
milligram-for-milligram.
> Impetigo
CONTRAINDICATIONS ADVERSE EFFECTS >Monitor patient for signs and
symptoms of superinfection.
>Contraindicated in patients CV: phlebitis, thrombophlebitis.
hypersensitive to drug or other
cephalosporins. GI: pseudomembranous colitis, nausea,
anorexia, vomiting, diarrhea.
>Use cautiously in patients
hypersensitive to penicillin because of Hematologic: transient neutropenia,
possibility of cross-sensitivity with eosinophilia, hemolytic anemia,
other beta-lactam antibiotics. thrombocytopenia.

>Use cautiously in breast-feeding Skin: maculopapular and erythematous


women and in patients with history of rashes, urticaria, pain, induration,
colitis or renal insufficiency. sterile abscesses, temperature elevation,
tissue sloughing at I.M. injection site.

Other: hypersensitivity reactions, serum


sickness, anaphylaxis.

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