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DR . Ahmed Zaki Abdullah Al‐
DR . Ahmed Zaki Abdullah Al‐Ani
Professor of Medicine
The Hashemite Kingdom Of Jordan
Lecture One
Introduction to Pathophysiology
Levels of Organization
Levels of Organization
• Chemical
Ch i l
• Cellular
• Tissue
• Organs
• System Level
System Level
• Organismic
Level
Principles of Human Anatomy and Physiology, 11e 3
LEVELS OF ORGANIZATION
LEVELS OF ORGANIZATION
• The human body consists of several levels of structural
organization
• The chemical level
– atoms, the smallest units of matter that participate in
, p p
chemical reactions, and molecules, two or more atoms
joined together.
• Cells
C ll
– the basic structural and functional units of an organism.
• Tissues
Ti
– groups of similarly specialized cells and the substances
surrounding them that usually arise from a common origin
surrounding them that usually arise from a common origin
and perform certain special functions.
Principles of Human Anatomy
4
and Physiology, 11e
LEVELS OF ORGANIZATION
LEVELS OF ORGANIZATION
• Tissues
– ggroups of similarly specialized cells and the substances
p y p
surrounding them that usually arise from a common origin
and perform certain special functions.
• Organs
O
– structures of definite form that are composed of two or
more different tissues and have specific functions
more different tissues and have specific functions.
• Systems
– related organs that have a common function.
related organs that have a common function
• The human organism
– a collection of structurally and functionally integrated
ll ti f t t ll d f ti ll i t t d
systems; any living individual.
Principles of Human Anatomy
5
and Physiology, 11e
LEVELS OF ORGANIZATION
LEVELS OF ORGANIZATION
• The systems of the human body are the
i t
integumentary, skeletal, muscular, nervous,
t k l t l l
, , y p
endocrine, cardiovascular, lymphatic, ,
respiratory, urinary, digestive, and
reproductive
Principles of Human Anatomy
6
and Physiology, 11e
LEVELS OF ORGANIZATION
LEVELS OF ORGANIZATION
• The human body consists of several levels of structural
organization
• The chemical level
– atoms, the smallest units of matter that participate in
, p p
chemical reactions, and molecules, two or more atoms
joined together.
• Cells
C ll
– the basic structural and functional units of an organism.
• Tissues
Ti
– groups of similarly specialized cells and the substances
surrounding them that usually arise from a common origin
surrounding them that usually arise from a common origin
and perform certain special functions.
Principles of Human Anatomy
7
and Physiology, 11e
Health and Disease
Disease ‐ Deviation from normal (physical, mental and social).
Homeostasis‐ Stable internal environment (BP, temp, fluids, electrolytes) values are
represented in ranges that can be adjusted for additional factors like
age and activity level.
T
Terms used in Pathophysiology
d i P th h i l
Pathophysiology ‐ study of functional or physiological changes in the body
g p , g g
resulting from disease process, both gross changes and
cellular changes.
Pathology ‐ lab study of cell and tissue changes associated with disease
Biopsy ‐ Surgical specimens.
Surgical specimens
Diagnosis ‐ Identification of a disease through the evaluation of signs
and symptoms, lab tests and other tools.
Etiology ‐ The causative factors of a disease (congenital, genetic,
The causative factors of a disease (congenital genetic
microorganisms, metabolic dysfunction, burns, nutritional
deficiency).
Idiopathic ‐ Cause unknown.
Cause unknown
Iatrogenic ‐Caused by an error in treatment or procedure bladder
infections after a cath insertion, bone marrow damage from
prescription of a drug
i ti f d
Predisposing factors -Tendencies that promote development of a
disease in an individual.
-Indicates high risk, not certain development
-Age, gender, diet, occupational exposure, genetic
1 .Initial ‐ Alteration in the metabolic reaction leading to loss of function
p g / g
‐ Leads to morphological/structural changes that lead to cell
death by rupture.
2.Lysis ‐ Dissolution‐releasing lysosomal enzymes which leads
to inflammation which leads to the damaging of nearby cells.
i fl i hi h l d h d i f b ll
‐Necrosis ‐ dead cells liquefy under the presence of certain cell enzymes.
Infarction ‐ an area of dead cells resulting from lack of oxygen.
‐Infarction an area of dead cells resulting from lack of oxygen.
‐Gangrene ‐ an area of necrotic tissue that has been invaded by bacteria.
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