n-Butyl acetate

GESTIS Substance Database

n-Butyl acetate

IDENTIFICATION

IDENTIFICATION
n-Butyl acetate
Butyl acetate
1-Butylacetate

ZVG No: 13320

CAS No: 123-86-4
EC No: 204-658-1
INDEX No: 607-025-00-1

CHARACTERISATION

SUBSTANCE GROUP CODE

143400 Carboxylic acid esters

STATE OF AGGREGATION
The substance is liquid.

PROPERTIES
colourless
fruity odour

CHEMICAL CHARACTERISATION
Flammable liquid.
Vapours may form explosive mixtures with air when the substance is heated above its

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flash point.
This may already be possible at elevated ambient temperature.
Slightly soluble in water.
Lighter than water.
Medium volatile.
Acute or chronic health hazards result from the substance.
(see: chapter REGULATIONS).

Substance information in Wikipedia

FORMULA

C6H12O2
C6H12O2

Molar mass: 116,16 g/mol

Conversion factor (gaseous phase) at 1013 mbar and 20 °C:
1 ml/m³ = 4,83 mg/m³

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT
Melting point: -77 °C
Reference: 00440

BOILING POINT
Boiling Point: 127 °C
Reference: 00440

DENSITY
DENSITY
Value: 0,88 g/cm³
Temperature: 20 °C
Reference: 00440

RELATIVE VAPOUR DENSITY

Ratio of the density to dry air at the same temperature and pressure

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Value: 4,01
Reference: 00440

RELATIVE DENSITY OF THE VAPOUR-AIR-MIXTURE

Ratio of the density to dry air at 20 °C and standard pressure
Value: 1,04
Reference: 99999

VAPOUR PRESSURE
Vapour pressure: 10,7 hPa
Temperature: 20 °C
Reference: 00106

Vapour pressure: 20,2 hPa

Temperature: 30 °C
Reference: 00446

Vapour pressure: 35,1 hPa

Temperature: 40 °C
Reference: 00446

Vapour pressure: 58,3 hPa

Temperature: 50 °C
Reference: 00446

EVAPORATION NUMBER
The evaporation number is the time required for complete evaporation of a substance,
related to the time required for evaporation of diethyl ether.

Evaporation 11
number:
Reference: 08105

FLASH POINT
Flash point: 27 °C
Closed cup
Reference: 00440

IGNITION TEMPERATURE
Ignition temperature: 390 °C
Temperature class: T2
Reference: 00440

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EXPLOSION DATA
Lower explosion limit:
1,2 vol.%
58 g/m³
Upper explosion limit:
ca. 8,5 vol.%
Lower explosion point:
19,5 °C
Max. exper. safe 1,02 mm
gap (MESG):
Explosion group: IIA
Maximum explosion pressure:
8,6 bar
Reference: 00440

SOLUBILITY IN WATER
Concentration: 4,3 g/l
Temperature: 20 °C
Reference: 00440

PARTITION COEFFICIENT (octanol/water)

log Kow: 1,78
Recommended value of LOG KOW Databank.
Reference: 02070

HAZARDOUS REACTIONS
Hazardous chemical reactions:
Risk of explosion in contact with:
strong oxidizing agents
The substance can react dangerously with:
alkali hydroxide
potassium-tert.-butoxide

TOXICOLOGY / ECOTOXICOLOGY

TOXICOLOGICAL DATA
LD50 oral rat
Value: 10800 mg/kg
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg.
196, 1992.

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LD50 dermal
Species: Rabbit
Value: > 17600 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 7, 1974.

LC50 inhalation rat

Value: 1,85 mg/l/4 h
Inhalation Toxicology. Vol. 9, Pg. 623, 1997.

Reference: 02071

ECOTOXICOLOGICAL DATA

LC50 Fish (96 hours)

Minimum: 18 mg/l
Maximum: 185 mg/l
Median: 81 mg/l
Study number: 4
Reference for median:
Wellens, H. 1982. Comparison of the Sensitivity of Brachydanio rerio and Leuciscus
idus by Testing the Fish Toxicity of Chemicals and Wastewaters.
Z.Wasser-Abwasser-Forsch. 51(2):49-52 (GER) (ENG ABS); Dawson, G.W., A.L.
Jennings, D. Drozdowski, and E. Rider 1977. The Acute Toxicity of 47 Industrial
Chemicals to Fresh and Saltwater Fishes. J.Hazard.Mater. 1(4):303-318 (OECDG Data
File)

Reference: 02072

OCCUPATIONAL HEALTH AND FIRST AID

ROUTES OF EXPOSURE
Main Routes of exposure:
The main intake pathway for n-butyl acetate (B.) proceeds via the respiratory
tract.[07619]

Respiratory tract:
B. has the lowest vapor pressure of all of the isomers of butyl acetate.[07639]
Nevertheless, inhalative exposure in working places nearly exclusively proceeds in the
form of vapors.
The direct inhalation of aerosols of B. is not expected under occupational
conditions.[07748]
When volunteers were experimentally exposed to B. vapors the intake kinetics reached
steady state within 60 minutes. During inhalation of 37 or 103 ppm B., the quantities in
the exhalation air determined after 120 minutes corresponded to retention rates of
about 70 %.[99996]

Skin:

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A permeability coefficient of about 1.6 g/m2 x h was estimated in an experiment on

isolated human skin.
Based on this indication of minor skin penetrability and the low toxicity in animal
experiments, the uptake through the skin is not considered to be significant during
occupational handling.[07619]

Gastrointestinal tract:
Absorption via the gastrointestinal tract was determined in
animal experiments but no quantitative data is available.[00450]
The possibility of effective uptake should be assumed.[99999]

TOXIC EFFECTS
Main toxic effects:
Acute:
Irritation to the eyes and airways,
disturbances to the central nervous system
Chronic:
Irritation to the mucous membranes, changes to the skin[07619]

Acute toxicity:
Information on the irritative effects through B. on the eyes differs.[99983]
Following an accidental exposure to the eye and also in an older experiment on rabbits'
eyes, distinct damage to the cornea ("chemical burns") was observed but this was
reversible within a relatively short time period. By comparison, in several more recent
tests on rabbits, B. was shown to cause only weak or even no irritation to the eyes.
No skin irritating action was found in experiments on rabbits and guinea pigs under
various test conditions. Tests on the tolerability of products containing B. (up to 25 %
B.) to the skin of volunteers did also not provide any hints of significant irritation. No
skin sensitizing action was determinable in several tests on volunteers (maximization
test with formulations containing B.) and in various animal experiments. When applied
dermally in animal experiments, the toxicity was very low (LD50, rabbit: > 17600 mg/kg
bw).
Vapors of B. irritate the eyes and upper airways and (in high concentrations) they
cause damage to the CNS. Data on the onset of irritation are available from various
studies on volunteers which in part had differing results. In an older study on 10 test
persons, the majority of volunteers felt irritation to the throat at 200 ppm and to the eyes
and nose at 300 ppm when exposed for 2 - 5 minutes.
The 300 ppm exposure caused strong irritation to the throat.[07619]
In a more recent experiment 200 ppm caused strong tussive irritation, whereas 103
ppm for 120 minutes was well tolerated.[99996]
By comparison, volunteers exposed to up to 295 ppm for 20 minutes in another new
experiment did not feel significant irritation. In a second experiment, however, exposure
to 147 ppm for 4 h led to irritation to the throat, difficulty in breathing and a nasty odor.
In summary, 100 ppm B. was considered to be tolerable. Irritation to the eyes and nasal
mucous membranes as well as uncomfortable odor perception were the dominant
effects also following short exposure through to 14000 ppm. During occupational
handling of very high concentrations (no details given), depressive effects to the CNS

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like weakness, vertigo and unconsciousness were reported to have occurred. In

standardized inhalative toxicity tests on rats (according to OECD-guideline 403) 4
h-LC50 values were > 4000 ppm. Rats exposed to 1500 - 6000 ppm for 6 h showed
symptoms of CNS depression but they survived.
14050 ppm inhaled for 6 hours was lethal for rats.[07619]
The deceased animals showed moderate inflammatory changes in the respiratory
tract.[07639]
By contrast, 2 tests on rats provided extremely low 4 h-LC50 values of 160 and 390
ppm. The animals showed pronounced damage to the lung (through to necrosis of
alveolar cells and pulmonary edema). The results were attributed to the presence of B.
in the test atmosphere to a large part as an aerosol. However, the results were not
reproduceable.[07619]
For occupational exposure they are considered not to be relevant.[07748]
The IDLH value (immediately dangerous to life or health) for B. (vapor) was estimated
to be 1700 ppm.[07930]
In animal experiments, the acute oral toxicity was very low.[07619]
The average narcotic dose (ND50) for rabbits was 2200 mg/kg bw and the LD50 value
7000 mg/kg bw.[07639]
The LD50 value for rats was between 10700 and 14130 mg/kg bw.[07619]
However, based on the indication of lung injuries due to aerosols (see above), an acute
risk should even be expected for the intake of low doses if aspiration takes
place.[99999]

Chronic toxicity:
Following repeated contact of the liquid with the skin degreasing and slight irritation
were found at the affected areas.
In isolated cases, persons with eczema showed positive reactions to B. in skin tests
(patch tests). However, in view of the negative results of several induction tests (see
"Acute toxicity"), no skin sensitizing potential can be derived. It was generally reported
from occupational experience that workers exposed to B. and other substances
suffered from irritation to the eyes, nose and throat as well as tightness in the
chest.[07619]
Some hints of systemic effects due to high B. concentrations cited in the literature
resulted from studies on exposure to mixtures of solvents and these do not allow
conclusions to be drawn on actions specifically attributable to B.[99983]
In a 14-week study on rats (exposure on 65 days for 6 h each day) which inhaled B. in
concentrations of 500, 1500 or 3000 ppm, only the neurotoxic potential of the ester was
studied. In both of the upper dose groups, signs of hypoactivity, sedation and in part
increased motor activity were found. No damage to the peripheral and central nervous
system was histologically determinable. No neurotoxic effects appeared at 500 ppm
(NOEL for the neurotoxicity).
No further valid studies are available on the long-term systemic effects.
However, the assessments available for the metabolites can also be used for the
estimation of the toxicity of B. Following exposure to 100 ppm of the metabolite
n-butanol, no systemic effects are to be expected. The intake of acetic acid
corresponding to this level of exposure is in the range of the nutritional intake.
Therefore, for working places, irritation to the mucous membranes of the eyes and

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airways (see "Acute toxicity") is estimated to be the critical effect to be used for the
determination of threshold limit values.[07619]

Reproductive toxicity, Mutagenicity, Carcinogenicity:

For classifying the reproductive toxicity and mutagenic and carcinogenic potential see
list in Annex VI of the CLP regulation / TRGS 905 / List of MAK values (see section
REGULATIONS).
(see section REGULATIONS).
Reproductive toxicity:
There is no reason to fear a risk of damage to the developing embryo or foetus when
MAK and BAT values are observed.
Animal experiments available for B. are insufficient because only high concentrations
were tested and found in part to be fetotoxic but not teratogenic. However, these
concentrations were also toxic to the dams.
Taking the data available for the metabolites n-butanol and acetic acid into
consideration, no damage to the developing embryo or fetus is to be assumed following
exposure to 100 ppm B.
Mutagenicity:
No hints of a mutagenic potential have been produced in in-vitro tests available.[07619]
There is a lack of in-vivo tests.
Carcinogenicity:
No data is available.[99983]

Biotransformation and Excretion:

The toxicokinetics of B. has only started to be studied.[99983]
From the distribution coefficients for B. in the blood and tissues it follows that it can be
distributed throughout the wole body - with the highest affinity to the fat tissue.
However, B. is apparently metabolized very quickly.[07619]
The first metabolization step is the hydrolytic split of the ester to form n-butanol and
acetic acid.[00450]
This can already proceed partially on the mucous membranes (confirmed in in-vitro
experiments on the nasal tissue of rats). In one animal experiment, immediate
metabolism was also shown for systemically available B.: 14C-labelled B. applied
intravenously to rats was detectable in the blood only for short time periods (half life:
0.4 min). The content of n-butanol in the blood and brain already reached its maximum
after 2.5 minutes and then also decreased quickly. Slightly later, polar metabolites
(butyraldehyde and probably conjugates of n-butanol as well as intermediates of the
citric acid cycle were found in the blood.[07619]
The determination of B. in the exhalation air as a detection method for exposure is
considered to be more suitable than the quantification of metabolites in the
urine.[07748]

Annotation:
This occupational health information was compiled on 04.02.2004.
It will be updated if necessary.

FIRST AID
Eyes:

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Rinse the affected eye with widely spread lids for 10 minutes under running water whilst
protecting the unimpaired eye.
Arrange medical treatment.
[00330]

Skin:
Remove contaminated clothing while protecting yourself.
Cleanse the affected skin areas thoroughly with soap under running water.
For irritation or extensive contact:
Arrange for medical treatment.
[00330]

Respiratory tract:
Whilst protecting yourself remove the casualty from the hazardous area and take him to
the fresh air.
Lay the casualty down in a quiet place and protect him against hypothermia.
In the case of breathing difficulties have the casualty inhale oxygen.
If the casualty is unconscious but breathing lay him in a stable manner on his side.
If the casualty has stopped breathing give mouth to nose resuscitation. If this is not
possible use mouth to mouth resuscitation. Keep his respiratory tract clear.
For massive exposure always:
Arrange medical treatment.
[07656, 00022]

Swallowing:
Rinse the mouth and spit the fluids out.
Apply charcoal (3 tablespoons as a suspension in a glass of water).
Do not make the casualty vomit.
Arrange medical treatment.
During spontaneous vomiting hold the head of the casualty low with the body in a prone
position in order to avoid aspiration.
[07656, 08013, 00022, 07638]

Information for physicians:

No serious cases of poisoning through n-butyl acetate have been reported to date.
Indications of acute symptoms result form general experience during occupational
handling and from animal experiments.

- Symptoms of acute poisoning:

Eyes: generally slight, rapidly reversible irritation through vapors; irritation, possibly
even damage to the cornea through the liquid
Skin: generally no irritative effects, following prolonged contact possible degreasing and
slight irritation; absorptive-toxic effects less likely
Inhalation: irritation to the nose, throat, trachea;[07619] following high concentrations
systemic effects and (more likely moderate) damage to the deeper airways;[07639]
however, when directly inhaled as liquid aerosol or following aspiration: danger of
serious damage to the lung![07748]
Ingestion: (slight) irritation to the mucous membranes, following high doses
gastrointestinal disturbances and absorptive-toxic effects;[00419] danger of aspiration

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(even following low doses!)[00330]

Absorption: at high doses/concentrations symptoms of CNS depression: headache,
vertigo, weakness, drowsiness -> unconsciousness; danger of respiratory paralysis,
cardiac arrest.[00419]

- Medical advice:
Thoroughly rinse contaminated eyes. Further check by an eye doctor is to be
recommended.
Cleanse contaminated skin with soap and water.[07656] Then, an ointment containing
fat can be applied.[99999]
Following massive inhalation, immediately apply fresh air and then oxygen as soon as
possible.[07656]
In the narcotic and asphyxial state of poisoning, protection of the functions of the
heart/circulatory system and respiratory system is absolute top priority; use measures
of cardiopulmonary cerebral resuscitation as necessary.[08013]
Following direct inhalation of aerosols or if there is suspicion of aspiration,
glucocorticoids and all further prophylactic measures for pulmonary edema are
urgent;[07748] soon also carry out prophylaxis for pneumonia.[00330]
Analogous measures can also become necessary for prolonged or massive inhalation
of vapors.[00419]
Following ingestion, application of rather a lot of charcoal and a salinic laxative is
recommended.
If large amounts of the liquid have been swallowed, consider immediate elimination of
the poison through gastrolavage (always with intubation because of the danger of
aspiration).
Further treatment is analogous to that for a poisoning with alcohol.
Following ingestion or massive inhalation always hospitalize the casualty and in
particular stabilize/check the functions of the heart/circulatory system, the acid-base
balance and the functions of the liver and kidneys (alkaline diuresis under controlled
conditions as necessary).[08013]

Recommendations:
Provide the physician information about the substance/product and treatment already
administered.
It is important to obtain information on any medicaments being used by the casualty
(possible interactions!).[99999]

Annotation:
This first aid information was compiled on 04.02.2004.
It will be updated if necessary.

SAFE HANDLING

TECHNICAL MEASURES - HANDLING

Workplace:
Provision of good ventilation in the working area.

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Use a trap if there is a floor drain.

Washing facility at the workplace required.
When handling excessive amounts of the substance an emergency shower is required.

Equipment:
Use closed apparatus if possible.
If release of the substance cannot be prevented, then it should be suctioned off at the
point of exit.
Consider emission limit values, a purification of waste gases if necessary.
Label containers and pipelines clearly.
Unsuitable materials:
Plastics have to be proven for their resistibility.

Advice on safer handling:

Take care to maintain clean working place.
The substance must not be present at workplaces in quantities above that required for
work to be progressed.
Do not leave container open.
Sufficient ventilation must be guaranteed for refilling, transfer, or open use.
Do not transport with/using compressed air.
Avoid splashing.
Fill only into labelled container.
Avoid any contact when handling the substance.

Cleaning and maintenance:

Only conduct maintenance and other work on or in the vessel or closed spaces after
obtaining written permission.

TECHNICAL MEASURES - STORAGE

Storage:
Do not use any food containers - risk of mistake.
Containers have to be labelled clearly and permanently.
Store in the original container as much as possible.
Use breakable containers only up to 5 litres content.
Keep container tightly closed.
Store in a cool place.
Keep container in a well-ventilated place.
Store smaller vessels in cabinets with collecting tubs.
Substance is sensitive to air, protect from air/oxygen.
The maximum permissible stored quantities are to be found in the Technische Regel für
Gefahrstoffe "Lagerung von Gefahrstoffen in ortsbeweglichen Behältern" (TRGS 510).
Storage is not permissible in hallways, thoroughfare, stairways, public hallways and
corridors, on the roof, in attics, and in workrooms.

Conditions of collocated storage:

Storage class 3 (Flammable liquid substances)
Only substances of the same storage class should be stored together.
Collocated storage with the following substances is prohibited:

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- Pharmaceuticals, foods, and animal feeds including additives.

- Infectious, radioactive und explosive substances.
- Gases.
- Other explosive substances of storage class 4.1A.
- Flammable solid substances or desensitized substances of storage class 4.1B.
- Pyrophoric substances.
- Substances liberating flammable gases in contact with water.
- Strongly oxidizing substances of storage class 5.1A.
- Ammonium nitrate and preparations containing ammonium nitrate.
- Organic peroxides and self reactive substances.
- Non combustible acutely toxic substances of storage class 6.1B.
Under certain conditions the collocated storage with the following sub-stances is
permitted (For more details see TRGS 510):
- Oxidizing substances of storage class 5.1B.
- Noncombustible toxic or chronically acting substances of storage class 6.1D.
- Combustible solids of storage class 11.
The substance should not be stored with substances with which ha-zardous chemical
reactions are possible.

TECHNICAL MEASURES - FIRE AND EXPLOSION PROTECTION

Technical, constructive measures:
Substance is combustible.
Fire fighting equipment must be available.
The possibility of the formation of a hazardous explosive atmosphere must be
evaluated in the risk assessment. Depending on the result of the risk assessment,
measures in accordance with TRGS 722 (prevention of formation), TRGS 723
(prevention of ignition) and TRGS 724 (constructive explosion protection) may be
required.
Take precautionary measures against static discharges.
Earth all parts which can be electrically charged.

Precaution on handling:
Area with fire risk.
At higher temperatures, vapours can be released in such quantities that an explosive
mixture can be formed with air. Areas with higher temperatures are thus to be
considered as at risk of explosion.
This may be the case simply in the presence of elevated ambient temperatures.
Keep at a distance from sources of ignition (e.g. electrical devices, open flames, heat
sources, sparks).
Observe the smoking prohibition!
Absolutely no welding in the working area.
Only work with vessels and lines after these have been thoroughly rinsed.
Work done with fire or open flame should only be carried out with written permission if
the risk of fire or explosion cannot be completely eliminated.
Do not use any tools that cause sparks.
It must be avoided that gases or vapours can escape into other rooms where sources
of ignition are present.

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ORGANISATIONAL MEASURES
Instruction on the hazards and the protective measures using instruction manual (
TRGS 555) are required with signature if just more than one minor hazard was
detected.
Instruction must be provided before employment and then at a minimum of once per
annum thereafter.
An escape and rescue plan must be prepared when the location, scale, and use of the
work-site so demand.
It must be assured that the workplace limit values are being maintained. If the limit
values are exceeded, additional protection measures are necessary.
The measurements must be recorded and kept on file.
Observe the restrictions on juvenile employment as defined in the
"Jugendarbeitsschutzgesetz".
Only employees are permitted to enter the work areas. Signposting to this effect must
be displayed.

PERSONAL PROTECTION
Body protection:
Wear flameproof, antistatic protective clothing.

Respiratory protection:
In an emergency (e.g.: unintentional release of the substance, exceeding the
occupational exposure limit value) respiratory protection must be worn. Consider the
maximum period for wear.
Respiratory protection: Gas filter A, Colour code brown.
Use insulating device for concentrations above the usage limits for filter devices, for
oxygen concentrations below 17% volume, or in circumstances which are unclear.

Eye protection:
Sufficient eye protection should be worn.
Wear glasses with side protection.

Hand protection:
Use protective gloves. The glove material must be sufficiently impermeable and
resistant to the substance. Check the tightness before wear. Gloves should be well
cleaned before being removed, then stored in a well ventilated location. Pay attention to
skin care.
Skin protection cremes do not protect sufficiently against the substance.
The following materials are suitable for protective gloves (Permeation time >= 8 hours):
Glove (multi-layer) - PE/EVAL/PE
(PE=Polyethylene; EVAL=Ethylene-vinyl-alcohol-copolymer)
Following materials are unsuitable for protective gloves because of degradation, severe
swelling or low permeation time:
Natural rubber/Natural latex - NR
Polychloroprene - CR
Nitrile rubber/Nitrile latex - NBR
Butyl rubber - Butyl

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Fluoro carbon rubber - FKM

Polyvinyl chloride - PVC
The times listed are suggested by measurements taken at 22 °C and constant contact.
Temperatures raised by warmed substances, body heat, etc. and a weakening of the
effective layer thickness caused by expansion can lead to a significantly shorter
breakthrough time. In case of doubt contact the gloves' manufacturer. A 1.5-times
increase / decrease in the layer thickness doubles / halves the breakthrough time. This
data only applies to the pure substance. Transferred to mixtures of substances, these
figures should only be taken as an aid to orientation.

Occupational hygiene:
Take heed of usual occupational hygiene measures when handling chemical
substances, espacially wash the skin with soap and water before breaks and at the end
of work and apply fatty skin-care products after washing.
Avoid contact with skin. In case of contact wash skin.
Avoid inhalation of vapour or mist.
Change clothing that has become wet and do not reuse until completely dry.
Increased risk of combustion from wicking.

DISPOSAL CONSIDERATIONS
Hazardous waste according to Waste Catalogue Ordinance (AVV).
If there is no way of recycling it must be disposed of in compliance with the respective
national and local regulations.

Collection of small amounts of substance:

Place in a collection container for halogen-free organic solvents and solutions of
halogen-free organic substances.
Collection vessels must be clearly labelled with a systematic description of their
contents. Store the vessels in a well-ventilated location. Entrust them to the appropriate
authorities for disposal.

ACCIDENTAL RELEASE MEASURES

Shut off all sources of ignition.
Evacuate area. Warn affected surroundings.
Wear respiratory protection, eye protection, hand protection and body protection (see
chapter Personal Protection).
Absorb any spilt liquid with an absorbent (e.g. diatomite, vermiculite, sand) and dispose
of according to regulations.
Use non-sparking tools.
Afterwards ventilate area and wash spill site.

Endangerment of watert:
Low hazard to waters. Inform the responsible authorities when very large quantities get
into water, drainage, sewer, or the ground.

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FIRE FIGHTING MEASURES

Classes of fires:
B liquid or melting substances

Suitable extinguishing media:

Dry extinguishing powder
Carbon dioxide

Instructions:
Cool surrounding containers with water spray.
If possible, take container out of dangerous zone.
Heating causes a rise in pressure, risk of bursting and
explosion.
Shut off sources of ignition.
Beware of backfire.

Special protective equipment:

In the case of a fire hazardous substances can be released.
Carbon monoxide and carbon dioxide
Wear self-contained breathing apparatus.

REGULATIONS

EUROPEAN GHS CLASSIFICATION AND LABELLING

Classification:
Flammable liquids, Category 3; H226
Specific Target Organ Toxicity (single exposure), Category 3; H336

Signal Word: "Warning"

Hazard Statement - H-phrases:

H226: Flammable liquid and vapour.
H336: May cause drowsiness or dizziness.

Supplemental Hazard Statement - EUH-phrases:

EUH066: Repeated exposure may cause skin dryness or cracking.

Precautionary Statement - P-phrases:

P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition
sources. No smoking.

Manufacturer's specification by Merck

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Reference: 01211
State: 2019
Checked: 2020

The substance is listed in appendix VI, table 3 of CLP regulation.

The given classification can deviate from the listed classification, since this
classification is to be complemented concerning missing or divergent danger classes
and categories for the respective substance.

Reference: 99999

GHS-CLASSIFICATION OF MIXTURES
The classification of mixtures containing this substance results from Annex 1 of
Regulation (EC) 1272/2008.

Reference: 07500

WORKPLACE LABELLING ACCORDING TO GERMAN ASR A1.3

Prohibition label:

No open flame; fire, open ignition sources and smoking

prohibited

No admittance for unauthorized persons

Warning label:

Caution - inflammable material

Precept label:

Use safety goggles

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Wear safety gloves

GERMAN WATER HAZARD CLASS

Substance No: 42
WGK 1 - low hazard to waters
Classification according to the announcement of the list of substances hazardous to
water in the Federal Register of 10.08.2017, last update 06.08.2020

TECHNICAL INSTRUCTIONS ON AIR QUALITY CONTROL (TA LUFT)

Chapter 5.2.5 Organic Substances.
The following values, specified as overall carbon, are in all not allowed to be exceeded
in exhaust gas:
Mass flow: 0,50 kg/hr
or
Mass conc.: 50 mg/m³
At old units with an annual mass flow till 1,5 Mg/a, specified as total carbon, the
emissions in exhaust gas are not allowed to exceed 1,5 kg/h.

TRANSPORT REGULATIONS

UN Number: 1123
Shipping name: Butyl acetates
Hazard Identification Number: 30
Class: 3 (Flammable Liquids)
Packing Group: III (low danger)
Danger Label: 3

Classification F1
code:

Tunnel restrictions:
Transports in bulk or in tanks: passage forbidden through tunnels of category D and E.
Other transports: passage forbidden through tunnels of category E.

Reference: 07902

IFA GESTIS-Substance Database 17/24 16.10.2020

n-Butyl acetate

TRGS 900 - GERMAN OCCUPATIONAL EXPOSURE LIMIT VALUES

62 ml/m³
300 mg/m³

Peak limitation: Excursion factor 2

Duration 15 min, mean; 4 times per shift; interval 1 hour
Category I - Substances for which local irritant effects determine the exposure limit
value, also respiratory allegens

There is no reason to fear a risk of damage to the developing embryo or foetus when
AGW and BGW are adhered to.

Source: AGS

EC OCCUPATIONAL EXPOSURE LIMIT VALUES

Directive 2019/1831/EU
Recommended indicative occupational exposure limit value for the European
Union
A national occupational exposure limit value has to be set.
8 hours limit value: 241 mg/m³ (50 ppm)
Short term limit value: 723 mg/m³ (150 ppm)

RECOMMENDATIONS OF MAK-COMMISSION
This data is recommended by scientific experience and is not established law.

100 ml/m³
480 mg/m³

Peak limitation: Excursion factor 2

Duration 15 min, mean; 4 times per shift; interval 1 hour
Category I - Substances for which local irritant effects determine the exposure limit
value, also respiratory allegens

Pregnancy: Group C
There is no reason to fear damage to the embryo or foetus when MAK and BAT values
are observed.

DIRECTIVE 2012/18/EU (Seveso III)

Annex I Part 1 Section: P5a
Flammable liquids Category 2 or 3 (or other liquids with a flash point ≤ 60 °C),
maintained at a temperature above their boiling point
Qualifying quantity for the application of
Lower-tier requirements: 10 t
Upper-tier requirements: 50 t

Annex I Part 1 Section: P5b

IFA GESTIS-Substance Database 18/24 16.10.2020

n-Butyl acetate

Flammable liquids Category 2 or 3 (or other liquids with a flash point ≤ 60 °C), where
particular processing conditions, such as high pressure or high temperature, may
create major-accident hazardsor-accident hazards
Qualifying quantity for the application of
Lower-tier requirements: 50 t
Upper-tier requirements: 200 t

Annex I Part 1 Section: P5c

Flammable liquids, Category 2 or 3 not covered by P5a and P5b
Qualifying quantity for the application of
Lower-tier requirements: 5000 t
Upper-tier requirements: 50000 t

RESTRICTIONS OF USE / BANS OF USE

REACH Regulation (EC) No 1907/2006 Annex XVII
Annex XVII, Point 3
1. The putting into circulation and the utilisation of the substance is not allowed in
decorative objects, games and joke articles.
2. Substances labelled with H304 which can be utilised as fuels in decorative lamps
and are put in circulation in amounts of 15 l or less must not contain a dye and/or a
perfume.
Further information on prohibitions can be taken from the regulation.
Annex XVII, Point 40
Shall not be used, as substance or as mixtures in aerosol dispensers
where these aerosol dispensers are intended for supply to the general
public for entertainment and decorative purposes such as the following:
— metallic glitter intended mainly for decoration,
— artificial snow and frost,
— “whoopee” cushions,
— silly string aerosols,
— imitation excrement,
— horns for parties,
— decorative flakes and foams,
— artificial cobwebs,
— stink bombs.
Further information on prohibitions and exceptions can be taken from the regulation.

Annex XVII to Regulation (EC) No 1907/2006, consolidated version (BAUA) (only in

German)

Consumer Goods Ordinance

Attachment 1 to § 3, Point 5
The substance must not be utilised for the production or treatment of joke articles.

IFA GESTIS-Substance Database 19/24 16.10.2020

n-Butyl acetate

TECHNICAL RULES FOR HAZARDOUS SUBSTANCES

TRGS 201
Einstufung und Kennzeichnung bei Tätigkeiten mit Gefahrstoffen; Ausgabe Februar
2017, zuletzt geändert und ergänzt April 2018

TRGS 400
Gefährdungsbeurteilung für Tätigkeiten mit Gefahrstoffen; Ausgabe Juli 2017

TRGS 555
Betriebsanweisung und Information der Beschäftigten; Ausgabe Februar 2017

TRGS 600
Substitution; Ausgabe Juli 2020

TRGS 402
Ermitteln und Beurteilen der Gefährdungen bei Tätigkeiten mit Gefahrstoffen: Inhalative
Exposition; Ausgabe Januar 2010, zuletzt geändert und ergänzt Oktober 2016

TRGS 401
Gefährdung durch Hautkontakt, Ermittlung - Beurteilung - Maßnahmen; Ausgabe Juni
2008; zuletzt berichtigt März 2011

TRGS 500
Schutzmaßnahmen; Ausgabe September 2019

TRGS 509
Lagern von flüssigen und festen Gefahrstoffen in ortsfesten Behältern sowie Füll- und
Entleerstellen für ortsbewegliche Behälter; Ausgabe September 2014, zuletzt berichtigt,
geändert und ergänzt Oktober 2020

TRGS 510
Lagerung von Gefahrstoffen in ortsbeweglichen Behältern; Ausgabe Januar 2013,
geändert und ergänzt November 2014, berichtigt November 2015

TRGS 800
Brandschutzmaßnahmen; Ausgabe Dezember 2010

TRGS 720
Gefährliche explosionsfähige Gemische - Allgemeines; Ausgabe Juli 2020

TRGS 721
Gefährliche explosionsfähige Gemische - Beurteilung der Explosionsgefährdung;
Ausgabe März 2006, zuletzt berichtigt, geändert und ergänzt Oktober 2020

TRGS 722
Vermeidung oder Einschränkung gefährlicher explosionsfähiger Atmosphäre, Ausgabe
März 2012

TRGS 723

IFA GESTIS-Substance Database 20/24 16.10.2020

n-Butyl acetate

Gefährliche explosionsfähige Gemische - Vermeidung der Entzündung gefährlicher

explosionsfähiger Gemische; Ausgabe Juli 2019, zuletzt berichtigt, geändert und
ergänzt Oktober 2020

TRGS 724
Gefährliche explosionsfähige Gemische - Maßnahmen des konstruktiven
Explosionsschutzes, welche die Auswirkung einer Explosion auf ein unbedenkliches
Maß beschränken, Ausgabe Juli 2019

REGULATIONS OF GERMAN ACCIDENT INSURERS

DGUV Regel 112-190
Benutzung von Atemschutzgeräten, Ausgabe Dezember 2011
http://publikationen.dguv.de/dguv/pdf/10002/r-190.pdf
(in German only)

DGUV Regel 112-195

Benutzung von Schutzhandschuhen, Aktualisierte Nachdruckfassung Oktober 2007
http://publikationen.dguv.de/dguv/pdf/10002/bgr195.pdf
(in German only)

LINKS

Statement concerning the rating as carcinogenic, mutagenic or toxic for reproduction (in
german only, source BAuA)
Statement concerning the Occupational Exposure Limit Value (in german only, source
BAuA)
International Limit Values
OECD Screening Information DataSet (SIDS)
The MAK Collection for Occupational Health and Safety
DGUV Information 213-098: List of substances - lesson in schools (in German only)

REFERENCES

Reference: 00001
IFA: Erfassungs- und Pflegehandbuch der GESTIS-Stoffdatenbank (nicht öffentlich)
Data acquisition and maintenance manual of the GESTIS substance database
(non-public)

Reference: 00022
G. Hommel
"Handbuch der gefährlichen Güter" Loseblattsammlung mit Ergänzungslieferungen
"Handbook of dangerous goods " loose-leaf collection with supplement deliveries
Springer-Verlag, Heidelberg

Reference: 00106

IFA GESTIS-Substance Database 21/24 16.10.2020

n-Butyl acetate

Sorbe "Sicherheitstechnische Kenndaten chemischer Stoffe" ("Safety-related

characteristics of chemical substances"), sicherheitsNet.de, Landsberg, 07/2011

Reference: 00330
U. Welzbacher "Neue Datenblätter für gefährliche Arbeitsstoffe nach
Gefahrstoffverordnung" Loseblattsammlung mit Ergänzungslieferungen, WEKA-Verlag,
Augsburg

Reference: 00419
CHEMINFO - Chemical Profiles Created by CCOHS

Reference: 00440
Datenbank CHEMSAFE, Version 2016.0, DECHEMA-PTB-BAM

Reference: 00446
Datenbank CHEMSAFE, DECHEMA-PTB-BAM. Dampfdruckdaten berechnet aus
Antoine-Konstanten

Reference: 00450
HSDB-Datenbankrecherche 2003

Reference: 01211
GHS-Sicherheitsdatenblatt, Merck
GHS Material Safety Data Sheet, Merck

Reference: 02070
LOG KOW Databank, compiled by Dr. James Sangster, Sangster Research
Laboratories, Montreal, Canada, distributed by Technical Database Services (TDS),
New York

Reference: 02071
Toxicological Data, compiled by the National Institute of Health (NIH), USA, selected
and distributed by Technical Database Services (TDS), New York, 2009

Reference: 02072
Ecotoxicological Data, compiled by the US Environmental Protection Agency (EPA),
selected and distributed by Technical Database Services (TDS), New York, 2009

Reference: 05133
Kühn-Birett-Merkblätter: 133. Ergänzungslieferung; 12/2000

Reference: 05300
TRGS 510 "Lagerung von Gefahrstoffen in ortsbeweglichen Behältern" Ausgabe
Januar 2013, in der Fassung vom 30.11.2015

Reference: 05350
TRGS 900 "Arbeitsplatzgrenzwerte" Ausgabe Januar 2006, zuletzt geändert und
ergänzt Oktober 2020

Reference: 06002

IFA GESTIS-Substance Database 22/24 16.10.2020

n-Butyl acetate

L. Roth, U. Weller
"Gefährliche Chemische Reaktionen" Loseblattsammlung mit Ergänzungslieferungen
"Dangerous chemical reactions" loose-leaf collection with supplement deliveries
ecomed-Verlag

Reference: 07500
Verordnung (EG) Nr. 1272/2008 des Europäischen Parlaments und des Rates vom 16.
Dezember 2008 über die Einstufung, Kennzeichnung und Verpackung von Stoffen und
Gemischen, zur Änderung und Aufhebung der Richtlinien 67/548/EWG und
1999/45/EG und zur Änderung der Verordnung (EG) Nr.1907/2006
(EG-GHS-Verordnung)

Reference: 07580
Bekanntmachung der Liste der wassergefährdenden Stoffe im Bundesanzeiger vom
10.08.2017, zuletzt geändert 06.08.2020

Reference: 07619
DFG: Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten; Verlag
Chemie

Reference: 07635
AUERDATA 98

Reference: 07638
M. Daunderer "Toxikologische Enzyklopädie - Klinische Toxikologie - Giftinformation,
Giftnachweis, Vergiftungstherapie" Loseblatt-Ausgabe, ecomed-Verlagsgesellschaft
mbH, Landsberg

Reference: 07639
J. Konietzko, H. Dupuis (Hrsg.) "Handbuch der Arbeitsmedizin, Arbeitsphysiologie,
Arbeitspathologie, Prävention" Loseblattausgabe, ecomed-Verlagsgesellschaft mbH,
Landsberg ab 1989

Reference: 07656
D. Walsh (Hrsg.) "Chemical Safety Data Sheets; Vol. I Solvents, Vol. II Metalls, Vol. III
Corrosives and Irritants, Vol. IV Toxic Chemicals, Vol.V Flammable Chemicals"
University of Technology, Loughborough 1990

Reference: 07748
American Conference of Governmental Industrial Hygienists "Documentation of the
threshold limit values and biological exposure indices Loseblattsammlung mit
Ergänzungslieferungen

Reference: 07795
H. Geerißen "GloSaDa 2000 Plus - Glove Safety Data"

Reference: 07902
BAM: Datenbank Gefahrgut-Schnellinfo

Reference: 07930

IFA GESTIS-Substance Database 23/24 16.10.2020

n-Butyl acetate

NIOSH IDLHs "Dokumentation for Immediately Dangerous to Life or Health

Concentrations (IDLHs)" U.S. Department of Health and Human Service, Cincinnati Mai
1994

Reference: 08013
Ludewig "Akute Vergiftungen" 9. Auflage, Wissenschaftliche Verlagsgesellschaft,
Stuttgart 1999

Reference: 08105
Brock, Groteklaes, Mischke: Lehrbuch der Lacktechnologie. Vincentz, Hannover 2000,
ISBN 3-87870-569-7, S. 100

Reference: 08112
DFG Deutsche Forschungsgemeinschaft: MAK- und BAT-Werte-Liste 2020,
Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Mitteilung 56;
GMS PUBLISSO

Reference: 99983
Liste arbeitsmedizinisch-toxikologischer Standardwerke (2)
List of standard references regarding occupational health and toxikology (2)

Reference: 99996
Projektgebundene arbeitsmedizinisch-toxikologische Literatur (2)
Project related bibliographical references regarding occupational health and toxikology
(2)

Reference: 99999
Angabe des Bearbeiters
Indication of the editor

This substance datasheet was created with greatest care. Nevertheless no liability irrespective of legal basis can
be accepted.

IFA GESTIS-Substance Database 24/24 16.10.2020