Inline Attachment Follows: Agaricus Blazei Murrill (Hime-matsutake) is a newly discovered species of

mushroom that is gathering the attention of many sci.

 Agaricus Max
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JAPANESE NAME : HIME-MATSUTAKE
SCIENTIFIC NAME : AGARICUS BLAZEI MURRILL
Agaricus Blazei Murrill (Hime-matsutake) is a newly discovered species of mushroom that
is attracting the attention of many scientists in the world now. Artificial cultivation of this
Brazilian mushroom was achieved for the first time in the world by Iwaide Fungology
Institute (founder: Dr. Inosuke Iwaide, a professor at Tokyo University and Mie
University) after many trials and errors. This mushroom was presented by professors
Hitoshi Ito, Keishiro Shimura and Sensuke Naruse of mushroom research group at Mie
University medical school as a highlight at the "the 39th General Meeting of Japanese
Cancer Academy" in 1980.

• Agaricus Blazei Murrill is a carcinostatic food that improves the immunity

function of human body

Through the joint research by Mie University medical school, Kobe University faculty of
agriculture and Iwade Fungology Institute, it was announced at various academic meeting
that Agaricus Blazei Murrill (Iwaide's 101 strains) has anticancer effect against implanted
solid cancer, ascites cancer and cancer induced by carcinogenic chemicals on test animals
and various other medical effects including inhibition of hepatopathy induced by carbon
quadrichloride, decholesterolization, reduction of serum lipid, activation of the third
component in complement system and interferon induction. It was also found out through
recent study that it activates helper-T lymphocyte, controls immunity system, activates
macrophage, activates the function of cell membrane skin system and accelerates
enterokinesia against gallbladder cancer. Furthermore, it has been proven that it has
antiallergy effect and accelerates cardiac movement.
1. The surprising anticancer effect of Agaricus Blazei Murrill
When carcinoma cells called "Sarcoma 180" is transplanted to subcutis of 5 - 6 week old
mice, the carcinoma cells proliferate into a big tumor (cancer) and most of such mice will
die within 4-5 weeks.
After transplanting carcinoma cells and making sure that they are settled, certain solutions
containing physiological saline and polysaccharides of various fungi including Agaricus
Blazei Murrill were administered to the mice daily for 10 days, starting from 24 hours after
transplanting. The size of cancer and proliferation impediment rate was periodically
monitored and compared to control group of mice, to which only physiological saline was
administered. Observation was continued for 60 days with different fungus used for the
solution, and anticancer effect of each mushroom was determined by comparing the
number of mice from which the cancer completely disappeared. From the result shown in
"Table 1: Complete Disappearance of Cancer", Agaricus Blazei Murrill has demonstrated
eminent anticancer activity with its complete disappearance rate of 87.5% and cancer
impediment rate of 93.6% through administration of 10mg of polysaccharide per 1kg of
mouse body weight.
2. Discovery of anticancer active components of Agaricus Blazei Murrill
Six kinds of high polymer polysaccharides have been found as carcinostatic active
components of Agaricus Blazei Murrill (see Table 2). FIII-2-b (complex of b-(1-6)郉-
glycan and protein) and RNA (nucleic acid) complex showed a remarkable anticancer
activity. These substances were confirmed as anticancer active components obtained from
the mushroom.
3. Carcinostatic polysaccharides obtained from cultured mycelium and filtrate of
Agaricus Blazei Murrill
Many kinds of carcinostatic polysaccharides (Polysaccharides are also referred to as