Summary of Peer-Reviewed Science on Protandim

Published studies available at Pubmed.gov – search Protandim

1. University of Colorado (2006)

● Protandim completely eliminates the age-related increase in cell aging factors, oxidative stress.
● Reduces oxidative stress by a minimum of 40 percent - to the progressive aging rate of a 20 year old.
● Significantly increases activity of SOD (34%) and CAT (54%) - antioxidant enzymes - substantially increasing
the body’s own antioxidant defenses.

2. University of Colorado, (2008)

● Protandim increases glutathione by 300% - an essential Antioxidant, Blood Booster & Cell Detoxifier
● Allows for the regenesis of other antioxidants like Vitamins C and E.
● Plays a critical role in liver detoxification
● Involved in tissue repair within the body
● Plays a fundamental role in entire immune system
● Impacts neurodegenerative disorders like Parkinson’s, MS, Alzheimer’s

3. Louisiana State University (2009)

● Reduced tumor incidence by 33% and tumor multiplicity by 57%.
● Increased expression of antioxidant and anti-inflammatory enzymes.
● “…Protandim may serve as a practical and potent approach for cancer prevention.”

4. Virginia Commonwealth University (2009)

● Protandim protects the heart:

● Prevented the formation of scar tissue in the heart by expressing anti-fibrotic genes.
● Prevented capillary loss in the heart muscle; prevented death of heart cells.
● Osteopontin levels reduced by more than 50%, a fibrosis-promoting factor linked to heart failure.
● Heart output was preserved and cardiac fibrosis prevented.

5. Harvard Medical School, Massachusetts General Hospital, University of Colorado (2010)

● 48% decrease in plasma TBARS, a marker of lipid peroxidation and oxidative stress.
● 57% decrease in plasma Osteopontin, a fibrosis-promoting factor linked to heart failure.
● 35% increase in beneficial, protective plasma PON1 activity, a protective antioxidant enzyme.

6. Louisiana State University (2010)

● Protandim's ability to modulate relationship between superoxide dismutase and tumor suppressor p53 believed
responsible for reduction of skin cancers.
● Protandim's ability to increase production of the body's Nrf2-regulated protective genes, sometimes referred to
as "survival genes".

Contact: Jason & Brooke Northrup

415.223.3965
www.SlowYourAging.info
7. The Ohio State University (2010))

● Protandim’s prevents the proliferation of cells that causes re-blockage of vessels following coronary artery bypass
surgery, stenting, and carotid enarterectomy.
● Reduced Intimal Proliferation to the level seen in a normal healthy saphenous vein.
PROTANDIM
A Promise of Protection

Developed after forty years of research, Protandim is a true scientific breakthrough in age-
related diseases. Protandim is a one-a-day, all natural supplement that activates our body’s
internal defenses - our survival genes - to do what they were created to do, which is protect our
cells from damage and disease.
Over time and around the age of 20, our genes, like the keys of a piano, get out of tune and no
longer function at their peak performance. Aging and disease result from this disharmony.
Protandim activates NRF-2, the master tuner within our cells, and brings our genes back to
the perfect harmony and powerful function of our youth.
Independent research by Harvard, VCU, LSU and others, have validated this ability and
measured Protandim’s impact in tuning over 500 survival genes and what that means for our
health and our battle against age-related diseases, including cancer, heart disease. Additional
studies are being conducted on osteoarthritis, diabetes, HIV/AIDS, periodontal disease, asthma,
reduced injury recovery rates, neurodegenerative diseases like Parkinson’s and Alzheimer’s and
many others.
Published peer-reviewed research demonstrates Protandim’s ability to tune the following genes:
● Antioxidant - reduced oxidative stress/cellular aging by over 40%
● Glutathione – increased by 300% - antioxidant, blood booster, cell detoxifier
● Anti-inflammatory genes increased – reducing inflammation
● Anti-fibrotic genes increased – reducing scarring of the heart
● P-53increased - a tumor suppressor gene
● Osteopontin - reduced by 57%. – osteopontin has been directly linked to a wide variety of
cancers, autoimmune diseases, and osteoporosis.
● FABP-4 – reduced by 85% - associated with multiple pro-inflammatory responses
● FABP -5 - reduced by 66% - lowers likelihood of calcified arteries
● Akr1B10 increased - promotes cell survival

Protandim provides a remarkable promise of protection from all kinds of age-related diseases,
unleashing the power within, which is both safe and our powerful and proven first line of
defense.
Contact: Jason & Brooke Northrup
415.223.3965
www.SlowYourAging.info
*Protandim is not intended to diagnose, treat, cure or prevent any disease.

Contact: Jason & Brooke Northrup

415.223.3965
www.SlowYourAging.info