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PART IV Drugs used in disorders of coagulation

.001All of the following physiologic reactions are

involved in the control of bleeding EXCEPT :

a) Platelet adhesion reaction

b) Platelet release reaction

c) Activation of the antifibrinolytic system

c

d) Triggering of the coagulation process

.002Which of the following substances is

synthesized within vessel walls and inhibits
thrombogenesis ?

a) Thromboxane A2 (TXA2 )

b) Prostacyclin (PGI2 ) b

c) Prostaglandin ((PGE )

d) None of the above

.003All of the following groups of drugs are for

thrombosis treatment EXCEPT :

a) Anticoagulant drugs

b) Antifibrinolitic drugs

c) Fibrinolitic drugs b

d) Antiplatelet drugs
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.004Pick out the drug belonging to anticoagulants of

direct action :

a) Aspirin indirect action !!!

b) Heparin
b

c) Dicumarol

d) Phenprocoumon

.005Which of the following drugs has low-molecular

weight ?

a) Dicumarol

b) Enoxaparin b

c) Phenprocoumon

d) Heparin

.006Indicate the drug belonging to antagonists of

heparin :

a) Aspirin

b) Dicumarol

c) Dalteparin d

d) Protamine sulfate
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.007Tick the drug used as an oral anticoagulant :

a) Heparin

b) Daltreparin
NOT INcluded
c
c) Dicumarol

d) Enoxaparin

.008All of the following drugs are indirect acting

anticoagulants EXCEPT :

a) Dicumarol

b) Warfarin
c

c) Dalteparin

d) Phenindione

.009Which of the following drugs belongs to

coumarin derivatives?

a) Heparin

b) Enoxaparin

c) Dalteparin d

d) Warfarin
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.010Heparin is effective when administred orally.

This consideration is :

a) True
b
b) False

.011All of these drugs are antiplatelet agents

EXCEPT :

a) Aspirin

b) Urokinase

c) Ticlopidine b

d) Clopidogrel

.012The use of heparin is recommended for

treatment of deep venous thrombosis. This
statement is :

a) True
a
b) False
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.013Mechanism of aspirin action is :

a) Converts inactive plasminogen into active plasmin

b) Inhibits COX and thus thromboxane synthesis

c) Enhances the interaction between antitrombin III

b
and both thrombin and the factors involved in the
intrinsic clotting cascade

d) Inhibits the glycoprotein IIb/IIIa complex

.014Which doses of Aspirin may be more effective

in inhibiting Tromboxane A2 ?

a) Low a

b) High

.015Which of the following drugs is an inhibitor of

platelet glycoprotein IIb/IIIa receptors ?

a) Aspirin

b) Clopidogrel
d

c) Ticlopidine

d) Abciximab

.016Ticlopidine is an inhibitor of ADP-induced

platelet aggregation. It’s :

a) True

b) False
a
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.017Which of the following drugs is fiibrinolytic ?

a) Ticlopidine

b) Streptokinase b

c) Aspirin

d) Warfarin

.018Mechanism of urokinase action is an inhibition

of Thromboxane A2. This statement is :

a) True Not Included

b

b) False

.019Fibrinolytic drugs are used for following

EXCEPT :

a) Central deep venous thrombosis

b) Multiple pulmonary emboli

c) Heart failure c

d) Acute myocardial infarction

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.020Indicate the drug belonging to fibrinoliytic

inhibitors :

a) Aminocapronic acid

b) Ticlopidine
a

c) Streptokinase

d) Vitamin K

.021Aminocapronic acid is a drug of choice for

treatment of :

a) Acute myocardial infarction

b) Bleeding from fibrinolytic therapy b

c) Heart failure

d) Multiple pulmonary emboli

.022Tranexamic acid is an analog of aminocapronic

acid. It’s :

a) True
a
b) False