17591_Brochure.

qxd 11/1/06 10:46 AM Page 2

The cobas e 411 analyzer offers...

Accurate Results
• ECL technology delivers excellent low-end sensitivity and
broad dynamic ranges

Quality Results
• Assay-specific QC confidence intervals to determine
calibration
• Improved tracking capabilities for QC patient samples and
calibrator materials
• Disposable tips and cups reduce the potential for carryover

Standardization
• Uniform reagent carriers, applications, analytical
technologies, and software interface with cobas® analyzers

Control
• Improve your labs’ financial performance, enhance efficiency,
and make a difference for the doctors and patients who rely
on the critical information to make vital decisions about
healthcare, every day.

cobas e 411 analyzer

Confidence in every result .
 cobas e 411 analyzer –
Technical Specifications
System Fully automated, multi-channel immunoas- QC Methods Individual QC and cumulative QC
say analyzer for random access processing
of ECL based immuno assays (Elecsys® Up to 100 controls pre-programmable
system format)
Preventive QC after calibration of the
System Components Self contained bench top analyzer compris- stand-by cobas e packs
ing an analytical unit and a customized
user interface Rerun/Reflex Function Manual rerun
Sample Throughput Up to 86 samples per hour Electrical Requirements Power requirements:
230 Volts AC
Test Throughput 86 results per hour (steady state mode, 110 Volts AC
(theoretical max) only 18 min assays) 1,000 kVA (disk), 1,250 kVA (rack)
Number of Channels 18 channels (reagent slots) for maximum Frequency:
of 18 different chemistries 50 Hz or 60 Hz +/- 0.5 %
Programmable N/A, programming-by-loading (PBT) Water/Waste Water: Bacteria free, deionised water
Parameters concept, application data are transferred Requirements supply, resistance of < 10 µS/cm
without operator intervention from the 2D
barcode of the reagent pack (RP) into the Water consumption:
instrument database Liquid waste: Onboard waste container
(4 liter), direct drain optional
Sample Material Serum/plasma, urine, others
Regulatory and Safety GS, CE, UL, c-UL, EN/IEC 61010-2-101,
Sample Input/Output Disk: 30 positions for samples, Requirements CB certificate
calibrators and controls
Operating Conditions Ambient temperature: 18 to 32º C
Rack: 15 racks with 5 samples each
(= 75 samples in/out) Ambient humidity: 20 to 80%
(RH, without
STAT port: STAT samples are processed condensation)
with priority
Heat Output: 2,879 kJ/hr
Sample Volume 10 – 50 µl (analyzer unit)
Sample Dilution Onboard, user definable, 1 or 2 step, Noise Output: 60 dBA (stand-by),
max 1:400 63 dBA (operation
avg.)
Sample Clot Detection Available (pressure sensor)
Physical Dimensions Width (disk/rack): 120 cm / 170 cm
Sample Barcode Types Code 128 47.2 in / 67 in
Codabar (NW 7)
Interleaved 2 of 5 Depth (disk/rack): 73 cm / 95 cm
Code 39 28.7 in / 37.4 in
Control Unit Panel PC Height: 80 cm / 31.4 in
(closed top cover)
System Interfaces RS 232 serial interface, bi-directional 109 cm / 43 in
(opened top cover)
Sample Data Base 2,000 results (samples and QC)
Weight Disk: 180 kg / 397 lbs
Calibrator/QC Input Elecsys® system specific barcoded CalSet
vials on disk or racks Rack: 250 kg / 551 lbs
Calibration Methods Lot calibration (L-cal)
Reagent Pack (RP) calibration (R-Cal)
Microsoft is a trademark of Microsoft Corporation.
Pentium is a trademark of Intel Corporation.
COBAS, COBAS E, ELECSYS and LIFE NEEDS ANSWERS are trademarks of Roche.
Roche Diagnostics
9115 Hague Road
Indianapolis, IN 46256
http://us.labsystems.roche.com
©2006 Roche Diagnostics. All rights reserved. 491_29744_1006
— 100 / 200 test packs
operator request
— Automatic sample dilution upon
reaction vessel
— Disposable AssayCup utilized as
self-sealing lids that increase onboard stability. sample pipetting
Closed for protection against environmental elements, the cobas e packs have — Disposable AssayTip for carry-over free
common to other Roche systems, reducing storage and inventory requirements. level detection (capacitance)
The cobas e packs are ready-to-use, eliminating hands-on time, and are — Clot detection (pressure sensor) and liquid
greater convenience controlled at 20°C
— 18 channels (reagent slots), temperature
Unique no-prep reagent concept delivers
— Throughput: up to 86 tests per hour
— ECL technology
cobas e 411 Analyzer
and HCG–33% faster than other systems.
Results in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,
STAT turnaround time
— Pentium processor
— Color LCD touch-screen
based user-interface
— Microsoft® Windows® XP
Control Unit
easy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.
The user interface provides specimen control and data management from an
cobas e 411 analyzer user interface
and reagent data
for manual entry of application
— Up to 8 weeks stability — 2-D barcodes eliminate the need
— Automatic calibration notification calibration time
— Automatic bottle changeover preparation and minimizes of samples
Chemiluminescence (CL)
inventory, eliminates reagent — Provides efficient routing
Roche Diagnostics Electrochemiluminescence (ECL) — Automatic reagent registration
providing accurate results the first time. — Unique package design reduces without adapters
— Random reagent placement onboard stability — Liquid level detection — Accommodates multiple tube sizes — Programmable for customization
reactions, ECL technology virtually eliminates unnecessary repeats and reruns,
measuring range — Temperature controlled — Ready-to-use; 60-day mean — Clot detection — Results in real time
concentrations of analyte. By precisely controlling electrically-initiated Chemiluminescence with other Roche systems
ranges. The measuring cell uses an amplified signal to detect ultra-low — 18 reagent channels — 100-200 tests per e pack — Disposable assay tips — Universal, color-coded, compatible — Reduced complexity
immunoassays, delivers excellent low-end sensitivity and broad dynamic compartment reagents process sample rack interface
Electrochemiluminescence (ECL), a sophisticated technology used in Roche measuring range
Roche ECL reagent e pack sample 5-position operator
ECL technology for accurate results the first time ECL extended measuring range
cobas e 411 analyzer
Page 1 10:46 AM 11/1/06 17591_Brochure.qxd
 cobas e 411 analyzer –
Technical Specifications
System Fully automated, multi-channel immunoas- QC Methods Individual QC and cumulative QC
say analyzer for random access processing
of ECL based immuno assays (Elecsys® Up to 100 controls pre-programmable
system format)
Preventive QC after calibration of the
System Components Self contained bench top analyzer compris- stand-by cobas e packs
ing an analytical unit and a customized
user interface Rerun/Reflex Function Manual rerun
Sample Throughput Up to 86 samples per hour Electrical Requirements Power requirements:
230 Volts AC
Test Throughput 86 results per hour (steady state mode, 110 Volts AC
(theoretical max) only 18 min assays) 1,000 kVA (disk), 1,250 kVA (rack)
Number of Channels 18 channels (reagent slots) for maximum Frequency:
of 18 different chemistries 50 Hz or 60 Hz +/- 0.5 %
Programmable N/A, programming-by-loading (PBT) Water/Waste Water: Bacteria free, deionised water
Parameters concept, application data are transferred Requirements supply, resistance of < 10 µS/cm
without operator intervention from the 2D
barcode of the reagent pack (RP) into the Water consumption:
instrument database Liquid waste: Onboard waste container
(4 liter), direct drain optional
Sample Material Serum/plasma, urine, others
Regulatory and Safety GS, CE, UL, c-UL, EN/IEC 61010-2-101,
Sample Input/Output Disk: 30 positions for samples, Requirements CB certificate
calibrators and controls
Operating Conditions Ambient temperature: 18 to 32º C
Rack: 15 racks with 5 samples each
(= 75 samples in/out) Ambient humidity: 20 to 80%
(RH, without
STAT port: STAT samples are processed condensation)
with priority
Heat Output: 2,879 kJ/hr
Sample Volume 10 – 50 µl (analyzer unit)
Sample Dilution Onboard, user definable, 1 or 2 step, Noise Output: 60 dBA (stand-by),
max 1:400 63 dBA (operation
avg.)
Sample Clot Detection Available (pressure sensor)
Physical Dimensions Width (disk/rack): 120 cm / 170 cm
Sample Barcode Types Code 128 47.2 in / 67 in
Codabar (NW 7)
Interleaved 2 of 5 Depth (disk/rack): 73 cm / 95 cm
Code 39 28.7 in / 37.4 in
Control Unit Panel PC Height: 80 cm / 31.4 in
(closed top cover)
System Interfaces RS 232 serial interface, bi-directional 109 cm / 43 in
(opened top cover)
Sample Data Base 2,000 results (samples and QC)
Weight Disk: 180 kg / 397 lbs
Calibrator/QC Input Elecsys® system specific barcoded CalSet
vials on disk or racks Rack: 250 kg / 551 lbs
Calibration Methods Lot calibration (L-cal)
Reagent Pack (RP) calibration (R-Cal)
Microsoft is a trademark of Microsoft Corporation.
Pentium is a trademark of Intel Corporation.
COBAS, COBAS E, ELECSYS and LIFE NEEDS ANSWERS are trademarks of Roche.
Roche Diagnostics
9115 Hague Road
Indianapolis, IN 46256
http://us.labsystems.roche.com
©2006 Roche Diagnostics. All rights reserved. 491_29744_1006
— 100 / 200 test packs
operator request
— Automatic sample dilution upon
reaction vessel
— Disposable AssayCup utilized as
self-sealing lids that increase onboard stability. sample pipetting
Closed for protection against environmental elements, the cobas e packs have — Disposable AssayTip for carry-over free
common to other Roche systems, reducing storage and inventory requirements. level detection (capacitance)
The cobas e packs are ready-to-use, eliminating hands-on time, and are — Clot detection (pressure sensor) and liquid
greater convenience controlled at 20°C
— 18 channels (reagent slots), temperature
Unique no-prep reagent concept delivers
— Throughput: up to 86 tests per hour
— ECL technology
cobas e 411 Analyzer
and HCG–33% faster than other systems.
Results in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,
STAT turnaround time
— Pentium processor
— Color LCD touch-screen
based user-interface
— Microsoft® Windows® XP
Control Unit
easy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.
The user interface provides specimen control and data management from an
cobas e 411 analyzer user interface
and reagent data
for manual entry of application
— Up to 8 weeks stability — 2-D barcodes eliminate the need
— Automatic calibration notification calibration time
— Automatic bottle changeover preparation and minimizes of samples
Chemiluminescence (CL)
inventory, eliminates reagent — Provides efficient routing
Roche Diagnostics Electrochemiluminescence (ECL) — Automatic reagent registration
providing accurate results the first time. — Unique package design reduces without adapters
— Random reagent placement onboard stability — Liquid level detection — Accommodates multiple tube sizes — Programmable for customization
reactions, ECL technology virtually eliminates unnecessary repeats and reruns,
measuring range — Temperature controlled — Ready-to-use; 60-day mean — Clot detection — Results in real time
concentrations of analyte. By precisely controlling electrically-initiated Chemiluminescence with other Roche systems
ranges. The measuring cell uses an amplified signal to detect ultra-low — 18 reagent channels — 100-200 tests per e pack — Disposable assay tips — Universal, color-coded, compatible — Reduced complexity
immunoassays, delivers excellent low-end sensitivity and broad dynamic compartment reagents process sample rack interface
Electrochemiluminescence (ECL), a sophisticated technology used in Roche measuring range
Roche ECL reagent e pack sample 5-position operator
ECL technology for accurate results the first time ECL extended measuring range
cobas e 411 analyzer
Page 1 10:46 AM 11/1/06 17591_Brochure.qxd
 cobas e 411 analyzer –
Technical Specifications
System Fully automated, multi-channel immunoas- QC Methods Individual QC and cumulative QC
say analyzer for random access processing
of ECL based immuno assays (Elecsys® Up to 100 controls pre-programmable
system format)
Preventive QC after calibration of the
System Components Self contained bench top analyzer compris- stand-by cobas e packs
ing an analytical unit and a customized
user interface Rerun/Reflex Function Manual rerun
Sample Throughput Up to 86 samples per hour Electrical Requirements Power requirements:
230 Volts AC
Test Throughput 86 results per hour (steady state mode, 110 Volts AC
(theoretical max) only 18 min assays) 1,000 kVA (disk), 1,250 kVA (rack)
Number of Channels 18 channels (reagent slots) for maximum Frequency:
of 18 different chemistries 50 Hz or 60 Hz +/- 0.5 %
Programmable N/A, programming-by-loading (PBT) Water/Waste Water: Bacteria free, deionised water
Parameters concept, application data are transferred Requirements supply, resistance of < 10 µS/cm
without operator intervention from the 2D
barcode of the reagent pack (RP) into the Water consumption:
instrument database Liquid waste: Onboard waste container
(4 liter), direct drain optional
Sample Material Serum/plasma, urine, others
Regulatory and Safety GS, CE, UL, c-UL, EN/IEC 61010-2-101,
Sample Input/Output Disk: 30 positions for samples, Requirements CB certificate
calibrators and controls
Operating Conditions Ambient temperature: 18 to 32º C
Rack: 15 racks with 5 samples each
(= 75 samples in/out) Ambient humidity: 20 to 80%
(RH, without
STAT port: STAT samples are processed condensation)
with priority
Heat Output: 2,879 kJ/hr
Sample Volume 10 – 50 µl (analyzer unit)
Sample Dilution Onboard, user definable, 1 or 2 step, Noise Output: 60 dBA (stand-by),
max 1:400 63 dBA (operation
avg.)
Sample Clot Detection Available (pressure sensor)
Physical Dimensions Width (disk/rack): 120 cm / 170 cm
Sample Barcode Types Code 128 47.2 in / 67 in
Codabar (NW 7)
Interleaved 2 of 5 Depth (disk/rack): 73 cm / 95 cm
Code 39 28.7 in / 37.4 in
Control Unit Panel PC Height: 80 cm / 31.4 in
(closed top cover)
System Interfaces RS 232 serial interface, bi-directional 109 cm / 43 in
(opened top cover)
Sample Data Base 2,000 results (samples and QC)
Weight Disk: 180 kg / 397 lbs
Calibrator/QC Input Elecsys® system specific barcoded CalSet
vials on disk or racks Rack: 250 kg / 551 lbs
Calibration Methods Lot calibration (L-cal)
Reagent Pack (RP) calibration (R-Cal)
Microsoft is a trademark of Microsoft Corporation.
Pentium is a trademark of Intel Corporation.
COBAS, COBAS E, ELECSYS and LIFE NEEDS ANSWERS are trademarks of Roche.
Roche Diagnostics
9115 Hague Road
Indianapolis, IN 46256
http://us.labsystems.roche.com
©2006 Roche Diagnostics. All rights reserved. 491_29744_1006
— 100 / 200 test packs
operator request
— Automatic sample dilution upon
reaction vessel
— Disposable AssayCup utilized as
self-sealing lids that increase onboard stability. sample pipetting
Closed for protection against environmental elements, the cobas e packs have — Disposable AssayTip for carry-over free
common to other Roche systems, reducing storage and inventory requirements. level detection (capacitance)
The cobas e packs are ready-to-use, eliminating hands-on time, and are — Clot detection (pressure sensor) and liquid
greater convenience controlled at 20°C
— 18 channels (reagent slots), temperature
Unique no-prep reagent concept delivers
— Throughput: up to 86 tests per hour
— ECL technology
cobas e 411 Analyzer
and HCG–33% faster than other systems.
Results in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,
STAT turnaround time
— Pentium processor
— Color LCD touch-screen
based user-interface
— Microsoft® Windows® XP
Control Unit
easy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.
The user interface provides specimen control and data management from an
cobas e 411 analyzer user interface
and reagent data
for manual entry of application
— Up to 8 weeks stability — 2-D barcodes eliminate the need
— Automatic calibration notification calibration time
— Automatic bottle changeover preparation and minimizes of samples
Chemiluminescence (CL)
inventory, eliminates reagent — Provides efficient routing
Roche Diagnostics Electrochemiluminescence (ECL) — Automatic reagent registration
providing accurate results the first time. — Unique package design reduces without adapters
— Random reagent placement onboard stability — Liquid level detection — Accommodates multiple tube sizes — Programmable for customization
reactions, ECL technology virtually eliminates unnecessary repeats and reruns,
measuring range — Temperature controlled — Ready-to-use; 60-day mean — Clot detection — Results in real time
concentrations of analyte. By precisely controlling electrically-initiated Chemiluminescence with other Roche systems
ranges. The measuring cell uses an amplified signal to detect ultra-low — 18 reagent channels — 100-200 tests per e pack — Disposable assay tips — Universal, color-coded, compatible — Reduced complexity
immunoassays, delivers excellent low-end sensitivity and broad dynamic compartment reagents process sample rack interface
Electrochemiluminescence (ECL), a sophisticated technology used in Roche measuring range
Roche ECL reagent e pack sample 5-position operator
ECL technology for accurate results the first time ECL extended measuring range
cobas e 411 analyzer
Page 1 10:46 AM 11/1/06 17591_Brochure.qxd
17591_Brochure.qxd 11/1/06 10:46 AM Page 2

The cobas e 411 analyzer offers...

Accurate Results
• ECL technology delivers excellent low-end sensitivity and
broad dynamic ranges

Quality Results
• Assay-specific QC confidence intervals to determine
calibration
• Improved tracking capabilities for QC patient samples and
calibrator materials
• Disposable tips and cups reduce the potential for carryover

Standardization
• Uniform reagent carriers, applications, analytical
technologies, and software interface with cobas® analyzers

Control
• Improve your labs’ financial performance, enhance efficiency,
and make a difference for the doctors and patients who rely
on the critical information to make vital decisions about
healthcare, every day.

cobas e 411 analyzer

Confidence in every result .
 cobas e 411 analyzer –
Technical Specifications

System Fully automated, multi-channel immunoas- QC Methods Individual QC and cumulative QC

say analyzer for random access processing
of ECL based immuno assays (Elecsys® Up to 100 controls pre-programmable
system format)
Preventive QC after calibration of the
System Components Self contained bench top analyzer compris- stand-by cobas e packs
ing an analytical unit and a customized
user interface Rerun/Reflex Function Manual rerun

Sample Throughput Up to 86 samples per hour Electrical Requirements Power requirements:

230 Volts AC
Test Throughput 86 results per hour (steady state mode, 110 Volts AC
(theoretical max) only 18 min assays) 1,000 kVA (disk), 1,250 kVA (rack)
Number of Channels 18 channels (reagent slots) for maximum Frequency:
of 18 different chemistries 50 Hz or 60 Hz +/- 0.5 %
Programmable N/A, programming-by-loading (PBT) Water/Waste Water: Bacteria free, deionised water
Parameters concept, application data are transferred Requirements supply, resistance of < 10 µS/cm
without operator intervention from the 2D
barcode of the reagent pack (RP) into the Water consumption:
instrument database Liquid waste: Onboard waste container
(4 liter), direct drain optional
Sample Material Serum/plasma, urine, others
Regulatory and Safety GS, CE, UL, c-UL, EN/IEC 61010-2-101,
Sample Input/Output Disk: 30 positions for samples, Requirements CB certificate
calibrators and controls
Operating Conditions Ambient temperature: 18 to 32º C
Rack: 15 racks with 5 samples each
(= 75 samples in/out) Ambient humidity: 20 to 80%
(RH, without
STAT port: STAT samples are processed condensation)
with priority
Heat Output: 2,879 kJ/hr
Sample Volume 10 – 50 µl (analyzer unit)
Sample Dilution Onboard, user definable, 1 or 2 step, Noise Output: 60 dBA (stand-by),
max 1:400 63 dBA (operation
avg.)
Sample Clot Detection Available (pressure sensor)
Physical Dimensions Width (disk/rack): 120 cm / 170 cm
Sample Barcode Types Code 128 47.2 in / 67 in
Codabar (NW 7)
Interleaved 2 of 5 Depth (disk/rack): 73 cm / 95 cm
Code 39 28.7 in / 37.4 in
Control Unit Panel PC Height: 80 cm / 31.4 in
(closed top cover)
System Interfaces RS 232 serial interface, bi-directional 109 cm / 43 in
(opened top cover)
Sample Data Base 2,000 results (samples and QC)
Weight Disk: 180 kg / 397 lbs
Calibrator/QC Input Elecsys® system specific barcoded CalSet
vials on disk or racks Rack: 250 kg / 551 lbs
Calibration Methods Lot calibration (L-cal)
Reagent Pack (RP) calibration (R-Cal)

Microsoft is a trademark of Microsoft Corporation.

Pentium is a trademark of Intel Corporation.
COBAS, COBAS E, ELECSYS and LIFE NEEDS ANSWERS are trademarks of Roche.

Roche Diagnostics
9115 Hague Road
Indianapolis, IN 46256
http://us.labsystems.roche.com

©2006 Roche Diagnostics. All rights reserved. 491_29744_1006

— 100 / 200 test packs

operator request
— Automatic sample dilution upon
reaction vessel
— Disposable AssayCup utilized as
self-sealing lids that increase onboard stability. sample pipetting
Closed for protection against environmental elements, the cobas e packs have — Disposable AssayTip for carry-over free
common to other Roche systems, reducing storage and inventory requirements. level detection (capacitance)
The cobas e packs are ready-to-use, eliminating hands-on time, and are — Clot detection (pressure sensor) and liquid
greater convenience controlled at 20°C
— 18 channels (reagent slots), temperature
Unique no-prep reagent concept delivers
— Throughput: up to 86 tests per hour
— ECL technology
cobas e 411 Analyzer

and HCG–33% faster than other systems.

Results in 9 minutes for critical tests such as Troponin T, CK-MB, Myoglobin,
STAT turnaround time
— Pentium processor
— Color LCD touch-screen
based user-interface
— Microsoft® Windows® XP
Control Unit

easy-to-navigate, Microsoft® Widows® XP based LCD touch-screen.

The user interface provides specimen control and data management from an
cobas e 411 analyzer user interface

and reagent data

for manual entry of application
— Up to 8 weeks stability — 2-D barcodes eliminate the need
— Automatic calibration notification calibration time
— Automatic bottle changeover preparation and minimizes of samples
Chemiluminescence (CL)
inventory, eliminates reagent — Provides efficient routing
Roche Diagnostics Electrochemiluminescence (ECL) — Automatic reagent registration — Unique package design reduces
providing accurate results the first time. without adapters
— Random reagent placement onboard stability — Liquid level detection — Accommodates multiple tube sizes — Programmable for customization
reactions, ECL technology virtually eliminates unnecessary repeats and reruns,
concentrations of analyte. By precisely controlling electrically-initiated measuring range — Temperature controlled — Ready-to-use; 60-day mean — Clot detection with other Roche systems — Results in real time
Chemiluminescence
ranges. The measuring cell uses an amplified signal to detect ultra-low — 18 reagent channels — 100-200 tests per e pack — Disposable assay tips — Universal, color-coded, compatible — Reduced complexity
immunoassays, delivers excellent low-end sensitivity and broad dynamic compartment reagents process sample rack interface
Electrochemiluminescence (ECL), a sophisticated technology used in Roche measuring range
Roche ECL reagent e pack sample 5-position operator
ECL technology for accurate results the first time ECL extended measuring range

cobas e 411 analyzer

Page 1 10:46 AM 11/1/06 17591_Brochure.qxd