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Carlos J Lozada, MD, Director of Rheumatology Fellowship Program, Professor, Department of Medicine, Division of
Rheumatology and Immunology, University of Miami Miller School of Medicine
Eli Steigelfest, MD, Consulting Staff, Department of Rheumatology, The Consultant Group, PC
Updated: May 5, 2010
Introduction
Background
Osteoarthritis (OA) is the most common articular disease worldwide, affecting over 20 million individuals in the
United States alone. Its high prevalence entails significant costs to society. Direct costs of osteoarthritis include
clinician visits, medications, and surgical intervention. Indirect costs include such items as time lost from work.
Costs associated with osteoarthritis can be particularly significant for elderly persons, who face potential loss of
independence and who may need help with daily living activities. As the populations of developed nations age
over the next few decades, the need for better understanding of osteoarthritis and for improved therapeutic
alternatives will continue to grow.
Pathophysiology
Traditionally, osteoarthritis has been considered a disease of articular cartilage. The current concept holds that
osteoarthritis involves the entire joint organ, including the subchondral bone and synovium.
Osteoarthritis has always been classified as a noninflammatory arthritis; however, increasing evidence has
shown that inflammation occurs as cytokines and metalloproteinases are released into the joint. Therefore, the
term degenerative joint disease is no longer appropriate when referring to osteoarthritis.
Osteoarthritis predominantly involves the weight-bearing joints, including the knees, hips, cervical and
lumbosacral spine, and feet. Other commonly affected joints include the distal interphalangeal (DIP) and
proximal interphalangeal (PIP) joints of the hands.
Cartilage is grossly affected. Focal ulcerations eventually lead to cartilage loss and eburnation. Subchondral
bone formation also occurs, with development of bony osteophytes.
Frequency
United States
Osteoarthritis affects over 20 million individuals in the United States. Based on the radiologic definition of
osteoarthritis, more than half of adults older than 65 years are affected.
International
Osteoarthritis is the most common articular disease. Estimates vary among different populations.
Mortality/Morbidity
The disease progression of osteoarthritis is characteristically slow, occurring over several years or
decades.
Pain is usually the initial and principal source of morbidity in osteoarthritis. The patient can become
progressively less active, leading to morbidities related to decreasing physical activity (including
potential weight gain).
Race
The prevalence of osteoarthritis differs among different ethnic groups. Knee osteoarthritis appears to be more
common in African American women than in other groups.
Sex
The likelihood of developing osteoarthritis increases with age. The disease is equally common among
men and women aged 45-55 years. After age 55 years, the disease becomes more common in
women.
DIP and PIP joint involvement that results in Heberden and Bouchard nodes is more common in
women.
Age
Osteoarthritis can be defined epidemiologically (ie, using radiographic criteria) or clinically (eg,
radiography findings plus clinical symptoms). Based on radiographic criteria, osteoarthritis occurs in
30% of affected individuals aged 45-65 years and in more than 80% by their eighth decade of life,
although most are asymptomatic.
Clinical
History
Pain
o Pain is the main reason persons with osteoarthritis (OA) seek medical attention.
o Initially, symptomatic patients incur pain during activity, which can be relieved by rest and may
respond to simple analgesics.
o Morning joint stiffness usually lasts for less than 30 minutes.
o Stiffness during rest (gelling) may develop.
o Joints may become unstable as the osteoarthritis progresses; therefore, the pain may become
more prominent (even during rest) and may not respond to medications.
Physical
Differential Diagnoses
Rhinosporidiosis
Rheumatoid arthritis predominately affects the wrists and the metacarpophalangeal (MCP) and PIP joints.
Rheumatoid arthritis rarely, if ever, involves the DIP joints or lumbosacral spine. Rheumatoid arthritis is
associated with prominent prolonged (>1 h) morning stiffness. Radiographic findings of rheumatoid arthritis
include bone erosion (eg, periarticular osteopenia, marginal erosions of bone) rather than formation. Laboratory
findings that further differentiate rheumatoid arthritis include systemic inflammation, positive rheumatoid factor
results, joint fluid with polymorphonuclear cell predominance, and a substantially elevated WBC count.
Clinical history and characteristic radiographic findings can be used to differentiate spondyloarthropathy from
sacroiliac and lumbosacral spine involvement.
Secondary osteoarthritis must be considered in individuals with chondrocalcinosis, joint trauma, metabolic bone
disorders, hypermobility syndromes, and neuropathic diseases.
Workup
Laboratory Studies
Imaging Studies
Radiography
o Conduct imaging studies of the affected joint.
o The presence of osteophytes (ie, spurs at the joint margins) is the most characteristic findings.
o Other findings in osteoarthritis include asymmetric joint-space narrowing, subchondral
sclerosis, and subchondral cyst formation.
o Roentgenographic findings are often poor predictors of the degree of symptomatology in a
particular patient.
Procedures
Arthrocentesis of the affected joint can help exclude inflammatory arthritis, infection, and/or crystal arthropathy.
Histologic Findings
Histologically, the earliest changes occur in the cartilage. Proteoglycan staining is diminished, and, eventually,
irregularity of the articular surface with clefts and erosions occurs.
Treatment
Medical Care
Nonpharmacologic interventions are the cornerstones of osteoarthritis (OA) therapy and include patient
education, temperature modalities, weight loss,[1 ]exercise, physical therapy, occupational therapy, and joint
unloading in certain joints (eg, knee, hip).
Surgical Care
Joint lavage: Closed-needle joint lavage may benefit a small subgroup of patients with osteoarthritis.
However, a 2010 meta-analysis of randomized controlled trials of joint lavage for knee osteoarthritis
suggests that, at 3 months, joint lavage alone does not significantly relieve pain or improve function. In
addition, the combination of joint lavage and intra-articular steroids injection is no more effective than
lavage alone. In their review of 6 trials including 855 patients, Avouac et al found that the pooled effect
size (ES) of joint lavage versus placebo was not significant for pain intensity (ES = 0.17 [-0.37, 0.71])
or physical function (ES = -0.15 [-0.34, 0.04]). Likewise, the pooled ES of joint lavage combined with
steroid injection versus joint lavage alone was not significant for pain intensity (ES = -0.82 [-2.47,
0.82]) or physical function (ES = 0.09 [-0.28, 0.45]). [4 ]
Arthroscopy: Arthroscopy may help patients with osteoarthritis of the knee that in whom imaging
reveals specific structural damage (eg, for repairing meniscal tears, removing fragments of torn
menisci that are producing symptoms). Overall, arthroscopy is not recommended for nonspecific
"cleaning of the knee" in osteoarthritis.
Osteotomy
o Consider this procedure in patients with a malaligned hip or knee joint.
o The procedure is usually recommended in younger patients with osteoarthritis.
o Osteotomy can lessen the pain, although it can lead to more challenging surgery later if the
patient requires arthroplasty.
Arthroplasty
o Perform this procedure if all other modalities are ineffective and osteotomy is not viable or if a
patient cannot perform his or her daily activities despite maximal therapy.
o This procedure alleviates pain and may improve function. Approximately 8-15 years of viability
are expected from the joint replacement in the absence of complications.
Consultations
Diet
A diet to achieve some degree of weight loss may be beneficial.
Activity
Osteoarthritis may severely hinder the patient's ability to work or even to perform daily living activities,
depending on the joints involved and the degree of involvement.
Medication
The goals of pharmacotherapy are to reduce morbidity and to prevent complications. Pay careful attention to a
particular pharmacologic regimen's adverse-event profile.
Analgesic agents
Pain control is essential in the management of osteoarthritis (OA). The goals of treatment include pain
alleviation and improvement of functional status. Currently, disease/structure-modifying intervention has been
proven
Initial trial warranted in patients with mild-to-moderate symptoms from osteoarthritis who fail to get sufficient
relief with nonpharmacologic measures. DOC for patients with documented hypersensitivity to aspirin or
NSAIDs, history of upper GI disease, or on anticoagulants.
Dosing
Adult
Pediatric
Interactions
Rifampin may reduce analgesic effects; coadministration with barbiturates, carbamazepine, hydantoins, and
isoniazid may increase hepatotoxicity
Contraindications
Documented hypersensitivity
Precautions
Pregnancy
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Precautions
Hepatotoxicity can occur with various dose levels in persons with chronic alcoholism; severe or recurrent pain
or high or continued fever may indicate a serious illness; contained in many OTC products, and combined use
with these products may result in cumulative doses exceeding recommended maximum dose/d
In more inflammatory presentations of osteoarthritis, such as knee involvement with effusion, these agents may
be used as first-line pharmacologic therapy.
Use the lowest effective dose or intermittent therapy if symptoms are intermittent.
Patients at high risk for GI toxicity may consider adding misoprostol or a proton pump inhibitor to the regimen or
substituting a COX-2–specific inhibitor for the NSAID.
Relieves pain and inflammation. Widely available. Relatively inexpensive as a generic drug.
Dosing
Adult
400 mg PO tid prn; not to exceed 2400 mg/d
Pediatric
Interactions
May decrease effects of loop diuretics; coadministration of anticoagulants may increase PT (monitor and watch
for signs of bleeding); may increase serum lithium levels and risk of methotrexate toxicity; probenecid may
increase toxicity of NSAIDs
Contraindications
Documented hypersensitivity to ibuprofen, other NSAIDs, or aspirin; avoid in peptic ulcer disease, recent GI
bleeding or perforation, renal insufficiency, and high risk of bleeding
Precautions
Pregnancy
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Precautions
Caution in congestive heart failure, hypertension, decreased renal and hepatic function, anticoagulation
abnormalities, or during anticoagulant therapy; adjust dose in renal insufficiency
Black Box Warning
NSAIDs may increase risk of serious cardiovascular thrombotic events, MI, and stroke, which can be fatal;
NSAIDs also increase risk of serious adverse GI effects, including stomach or intestinal bleeding, ulceration,
and perforation, which can be fatal; elderly patients are at greater risk for serious GI events
Meloxicam (Mobic)
To some extent, more selective for COX-2 receptors, compared to traditional NSAIDs. Decreases activity of
cyclooxygenase, which in turn inhibits prostaglandin synthesis. These effects decrease formation of
inflammatory mediators.
Dosing
Adult
Pediatric
Not established
Interactions
Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may
increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and
beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking
anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity;
phenytoin levels may be increased when administered concurrently
Contraindications
Precautions
Pregnancy
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits
outweigh risk to fetus
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Precautions
Acute renal insufficiency, hyperkalemia, hyponatremia, interstitial nephritis, and renal papillary necrosis may
occur; increases risk of acute renal failure in patients with preexisting renal disease or compromised renal
perfusion; reversible leukopenia may occur, (discontinue if there is persistent leukopenia, granulocytopenia, or
thrombocytopenia)
Black Box Warning
NSAIDs may increase risk of serious cardiovascular thrombotic events, MI, and stroke, which can be fatal;
NSAIDs also increase risk of serious adverse GI effects, including stomach or intestinal bleeding, ulceration,
and perforation, which can be fatal; elderly patients are at greater risk for serious GI events
Naproxen component is indicated for relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and
ankylosing spondylitis. Naproxen is an NSAID that inhibits inflammatory reactions and pain by decreasing
activity of cyclo-oxygenase, which is responsible for prostaglandin synthesis.
Esomeprazole component is indicated to decrease risk of gastric ulcers in patients at risk of developing NSAID-
associated gastric ulcers. Esomeprazole is the S-isomer of omeprazole, a proton pump inhibitor. Inhibits gastric
acid secretion by inhibiting H+/K+-ATPase enzyme system at secretory surface of gastric parietal cells.
Dosing
Adult
Pediatric
Interactions
Concomitant use of NSAIDs may reduce antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers;
NSAIDs increase lithium plasma levels; concomitant use with methotrexate may increase methotrexate toxicity;
concomitant use with warfarin may result in increased risk of bleeding complications (monitor INR and
prothrombin time); esomeprazole inhibits gastric acid secretion and may interfere with absorption of drugs for
which gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts, digoxin, atazanavir,
nelfinavir); esomeprazole inhibits CYP2C19 and therefore may alter serum levels/activity of CYP2C19
substrates; esomeprazole is extensively metabolized by CYP2C19 and CYP3A4
Contraindications
Documented hypersensitivity; NSAIDs are contraindicated for perioperative pain in the setting of coronary
artery bypass graft surgery (increased risk of MI and stroke); NSAIDs are contraindicated during late pregnancy
(risk of premature closure of ductus arteriosus)
Precautions
Pregnancy
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits
outweigh risk to fetus
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Precautions
COX-2 inhibitors
Although increased cost can be a negative factor, the incidence of costly and potentially fatal GI bleeds is less
in nonaspirin users receiving COX-2 inhibitors than with traditional NSAIDs.
Celecoxib (Celebrex)
Dosing
Adult
100 mg PO bid or 200 mg PO qd
Pediatric
Interactions
Coadministration with fluconazole may cause increase in celecoxib plasma concentrations because of inhibition
of celecoxib metabolism; coadministration of celecoxib with rifampin may decrease celecoxib plasma
concentrations
Contraindications
Precautions
Pregnancy
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits
outweigh risk to fetus
Precautions
Avoid in late pregnancy to avoid closure of ductus arteriosus; may cause fluid retention and peripheral edema;
caution in compromised cardiac function, hypertension, conditions predisposing to fluid retention, presence of
existing controlled infections, severe heart failure and hyponatremia because may deteriorate circulatory
hemodynamics; NSAIDs may mask usual signs of infection; evaluate symptoms suggesting liver dysfunction or
in abnormal liver lab results; adjust dose in renal insufficiency
NSAID labeling carries a warning about increased risk of hypertension, stroke, and cardiovascular events,
including myocardial infarction
Follow-up
Deterrence/Prevention
Overweight patients who have early signs of osteoarthritis (OA) or who are at high risk should be
encouraged to lose weight.
Recommend quadriceps-strengthening exercises in patients with osteoarthritis of the knees, except in
those with pronounced valgus or varus deformity at the knees.
Prognosis
The prognosis of osteoarthritis depends on joints involved and severity. No proven disease/structure-modifying
drugs for osteoarthritis currently exist; thus, the medication-based regimen is directed at symptom relief.
Patient Education
Educate the patient on the natural history of and management options for osteoarthritis. Explain the
differences between osteoarthritis and other more rapidly progressive arthritides such as rheumatoid
arthritis.
For excellent patient education resources, visit eMedicine's Arthritis Center. Also, see eMedicine's
patient education article Osteoarthritis.
Miscellaneous
Medicolegal Pitfalls
The risk of medications used to treat osteoarthritis (OA) include, but are not limited to, GI toxicities and
potential cardiac toxicities of NSAIDs and potential complications of arthrocentesis. Discuss these risks
with the patient.
Complete a procedure note in the patient's chart for each arthrocentesis.
References
1. Felson DT, Zhang Y, Anthony JM, et al. Weight loss reduces the risk for symptomatic knee
osteoarthritis in women. The Framingham Study. Ann Intern Med. Apr 1 1992;116(7):535-9. [Medline].
3. McCarthy GM, McCarty DJ. Effect of topical capsaicin in the therapy of painful osteoarthritis of the
hands. J Rheumatol. Apr 1992;19(4):604-7. [Medline].
4. [Best Evidence] Avouac J, Vicaut E, Bardin T, Richette P. Efficacy of joint lavage in knee osteoarthritis:
meta-analysis of randomized controlled studies. Rheumatology (Oxford). Feb 2010;49(2):334-40.
[Medline].
5. Altman R, Alarcon G, Appelrouth D, et al. The American College of Rheumatology criteria for the
classification and reporting of osteoarthritis of the hand. Arthritis Rheum. Nov 1990;33(11):1601-10.
[Medline].
6. Altman R, Alarcon G, Appelrouth D, et al. The American College of Rheumatology criteria for the
classification and reporting of osteoarthritis of the hip. Arthritis Rheum. May 1991;34(5):505-14.
[Medline].
7. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of
osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria
Committee of the American Rheumatism Association. Arthritis Rheum. Aug 1986;29(8):1039-49.
[Medline].
8. Altman RD, Dean D. Pain in osteoarthritis. Introduction and overview. Semin Arthritis Rheum. May
1989;18(4 Suppl 2):1-3. [Medline].
9. Altman RD, Lozada CJ. Clinical features of osteoarthritis. In: Hochberg, Silman, Smolen, Weinblatt,
and Weismann, eds. Practical Rheumatology. 2004:503-10.
10. Bernstein J, Quach T. A perspective on the study of Moseley et al: questioning the value of
arthroscopic knee surgery for osteoarthritis. Cleve Clin J Med. May 2003;70(5):401, 405-6, 408-10.
[Medline].
11. Bradley JD, Brandt KD, Katz BP, et al. Comparison of an antiinflammatory dose of ibuprofen, an
analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the
knee. N Engl J Med. Jul 11 1991;325(2):87-91. [Medline].
12. Brand RA, Crowninshield RD. The effect of cane use on hip contact force. Clin Orthop Relat Res. Mar-
Apr 1980;(147):181-4. [Medline].
13. Buckwalter JA, Lohmander S. Operative treatment of osteoarthrosis. Current practice and future
development. J Bone Joint Surg Am. Sep 1994;76(9):1405-18. [Medline].
14. Chang RW, Falconer J, Stulberg SD. A randomized, controlled trial of arthroscopic surgery versus
closed- needle joint lavage for patients with osteoarthritis of the knee. Arthritis Rheum. Mar
1993;36(3):289-96. [Medline].
15. Felson DT. Epidemiology of hip and knee osteoarthritis. Epidemiol Rev. 1988;10:1-28. [Medline].
16. [Guideline] Hochberg MC, Altman RD, Brandt KD, et al. Guidelines for the medical management of
osteoarthritis. Part I. Osteoarthritis of the hip.American College of Rheumatology. Arthritis Rheum. Nov
1995;38(11):1535-40. [Medline].
17. Hogenmiller MS, Lozada CJ. An update on osteoarthritis therapeutics. Curr Opin Rheumatol. May
2006;18(3):256-60. [Medline].
18. Kirkley A, Birmingham TB, Litchfield RB, Giffin JR, Willits KR, Wong CJ, et al. A randomized trial of
arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. Sep 11 2008;359(11):1097-107.
[Medline].
19. Lozada CJ. Management of osteoarthritis. In: Harris, Budd, Firestein, et al, eds. Kelley's Textbook of
Rheumatology. 7th ed. 2005:1528-40.
20. Pelletier JP, Martel-Pelletier J, Howell DS. Etiopathogenesis of Osteoarthritis. In: Arthritis and Allied
Conditions. 13th ed. 1997:1969-84.
21. Puett DW, Griffin MR. Published trials of nonmedicinal and noninvasive therapies for hip and knee
osteoarthritis. Ann Intern Med. Jul 15 1994;121(2):133-40. [Medline].
22. Roberts J, Burch TA. Osteoarthritis prevalence in adults by age, sex, race, and geographic area. Vital
Health Stat 11. Jun 1966;1-27. [Medline].
23. [Guideline] Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. OARSI
recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based,
expert consensus guidelines. Osteoarthritis Cartilage. Feb 2008;16(2):137-62. [Medline].
Keywords
osteoarthritis, osteoarthrosis, OA, knee osteoarthritis, hip osteoarthritis, spinal osteoarthritis, foot osteoarthritis,
secondary osteoarthritis, secondary OA, knee OA, hip OA, spinal OA, foot OA, osteophytes, joint pain, back
pain, noninflammatory arthritis, degenerative joint disease, articular disease, articular cartilage disease, bony
osteophytes
Author
Carlos J Lozada, MD, Director of Rheumatology Fellowship Program, Professor, Department of Medicine,
Division of Rheumatology and Immunology, University of Miami Miller School of Medicine
Carlos J Lozada, MD is a member of the following medical societies: American College of Physicians and
American College of Rheumatology
Disclosure: Pfizer Honoraria Speaking and teaching
Coauthor(s)
Eli Steigelfest, MD, Consulting Staff, Department of Rheumatology, The Consultant Group, PC
Disclosure: Nothing to disclose.
Medical Editor
John Varga, MD, Professor, Department of Internal Medicine, Division of Rheumatology, Northwestern
University
John Varga, MD is a member of the following medical societies: American College of Physicians, American
College of Rheumatology, Central Society for Clinical Research, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.
Pharmacy Editor
Managing Editor
Elliot Goldberg, MD, Dean of the Western Pennsylvania Clinical Campus, Professor, Department of Medicine,
Temple University School of Medicine
Elliot Goldberg, MD is a member of the following medical societies: Alpha Omega Alpha, American College of
Physicians, and American College of Rheumatology
Disclosure: Nothing to disclose.
CME Editor
Alex J Mechaber, MD, FACP, Associate Dean for Undergraduate Medical Education, Associate Professor of
Medicine, University of Miami Miller School of Medicine
Alex J Mechaber, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American
College of Physicians-American Society of Internal Medicine, and Society of General Internal Medicine
Disclosure: Nothing to disclose.
Chief Editor
Herbert S Diamond, MD, Professor of Medicine, Temple University School of Medicine; Chairman Emeritus,
Department of Internal Medicine, Western Pennsylvania Hospital
Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College
of Physicians, American College of Rheumatology, American Medical Association, and Phi Beta Kappa
Disclosure: ACP PEER Honoraria Independent contractor; Stock ownership in multiple Pharmaceutical
companies Ownership interest Other
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