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Objective:
To familiarize students with basic principles of radiation physics and
modern physics used in radiotherapy.
IAEA
International Atomic Energy Agency
1.1. Introduction
1.2. Atomic and nuclear structure
1.3. Electron interactions
1.4. Photon interactions
IAEA Review of Radiation Oncology Physics: A Handbook for Teachers and Students - 1.(2/194)
1
1.1 INTRODUCTION
1.1.1 Fundamental physical constants
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1.1 INTRODUCTION
1.1.2 Derived physical constants
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2
1.1 INTRODUCTION
1.1.2 Derived physical constants
Bohr radius:
c 4 o (c)2
ao = = = 0.529 Å
mec 2 e 2 mec 2
Rydberg energy:
2
1 e 2 mec
2
1
ER = mec 2 2 = = 13.61 eV
2 2 4 o (c)2
Rydberg constant:
ER m c 2 2
R = = e = 109 737 cm1
2 c 4 c
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1.1 INTRODUCTION
1.1.3 Physical quantities and units
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3
1.1 INTRODUCTION
1.1.3 Physical quantities and units
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1.1 INTRODUCTION
1.1.3 Physical quantities and units
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4
1.1 INTRODUCTION
1.1.4 Classification of forces in nature
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1.1 INTRODUCTION
1.1.5 Classification of fundamental particles
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1.1 INTRODUCTION
1.1.6 Classification of radiation
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1.1 INTRODUCTION
1.1.6 Classification of radiation
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6
1.1 INTRODUCTION
1.1.7 Classification of ionizing photon radiation
Characteristic x ray
Results from electronic transitions between atomic shells.
Bremsstrahlung
Results mainly from electron-nucleus Coulomb interactions.
Gamma ray
Results from nuclear transitions.
Annihilation quantum (annihilation radiation)
Results from positron-electron annihilation.
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1.1 INTRODUCTION
1.1.8 Einstein’s relativistic mass, energy, and momentum
mo mo
Mass: m( ) = = = mo
2
1 2
1
c
1
where = and =
c 1 2
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1.1 INTRODUCTION
1.1.8 Einstein’s relativistic mass, energy, and momentum
mo mo =
m( ) = = = mo c
2
1 2
1
c
m( ) 1 1 =
1
= = = 1 2
mo
2
1 2
1
c
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1.1 INTRODUCTION
1.1.8 Einstein’s relativistic mass, energy, and momentum
1
Momentum: p= E 2 Eo2
c
=
1
with = and
c 1 2
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1.1 INTRODUCTION
1.1.9 Radiation quantities and units
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Atomic number Z
Number of protons and number of electrons in an atom.
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.1 Basic definitions for atomic structure
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A
Z=
1.98 + 0.0155A2/3
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.1 Basic definitions for atomic structure
For example:
• 1 gram-atom of cobalt-60 is 60 g of cobalt-60.
• 1 gram-atom of radium-226 is 226 g of radium-226.
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For example:
• 1 gram-mole of water is 18 g of water.
• 1 gram-mole of carbon dioxide is 44 g of carbon dioxide.
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.1 Basic definition for atomic structure
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.1 Basic definitions for atomic structure
For example:
• Cobalt-60 nucleus with Z = 27 protons and N = 33 neutrons is
identified as 60
27
Co .
• Radium-226 nucleus with Z = 88 protons and N = 138 neutrons is
identified as 226
88
Ra .
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.1 Basic definitions for atomic structure
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.2 Rutherford’s model of the atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.2 Rutherford’s model of the atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.2 Rutherford’s model of the atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.2 Rutherford’s model of the atom
2ZNe 2 2ZNe 2
EK = D N =
4 o D N 4 o EK
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.2 Rutherford’s model of the atom
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2
d Ruth D N 1
=
4 sin ( / 2)
4
d
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
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h = Ei E f
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
n 137 n n
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IAEA Review of Radiation Oncology Physics: A Handbook for Teachers and Students - 1.2.3 Slide 8 (46/194)
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
Energy levels En of
orbital electron shells in
a one-electron Bohr
atom are:
2
Z
En = ER
n
2
Z
= 13.6 eV
n
ER = Rydberg energy
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c n 137 n n
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.3 Bohr’s model of the hydrogen atom
1 1 1
k= = R Z 2 2 2
nf ni
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.4 Multi-electron atoms
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Atomic radius
In general For the K shell For the outer shell
2 2
rn = ao
n
r (K shell) = r1 = ao
n router shell nao
Zeff Z 2
Binding energy
In general For the K shell For outer shell
2
Zeff
En = ER E (K shell) = E1 = ER (Z 2)2 Eouter shell ER
n2
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.4 Multi-electron atom
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.5 Nuclear structure
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EB = Zmpc 2 + (A Z)mnc 2 Mc 2
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.5 Nuclear structure
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.6 Nuclear reactions
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.7 Radioactivity
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.7 Radioactivity
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.7 Radioactivity
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.7 Radioactivity
• Exponential decay
of the activity
• Concept of half life
• Concept of mean life
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The decay constant P and the half life (t1/2 )P are related
as follows:
ln 2
P =
(t1/2 )P
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.7 Radioactivity
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ND (t) = NP (0)
P
D P
t
{
t
e P e D }
Activity of the daughter nuclei is:
A D (t) =
D P
{
NP (0)P D Pt
e
t
e D = A P (0)
D
}
D P
t t
e P e D = { }
= A P (0)
1
{
t t
e P e D = A P (t)
D
D P
} ( )t
1 e D P , { }
1 P
D
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.7 Radioactivity
At t = tmax
the parent and daughter
activities are equal and
the daughter activity
reaches its maximum:
dAD
=0
dt t =tmax
and D
ln
P
tmax =
D P
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.8 Activation of nuclides
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.8 Activation of nuclides
{
AD (t) = NP (0) 1 e t = Asat 1 e t
D
} { D
}
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
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{
Q = M (P) M (D) + m c 2 }
M(P), M(D), and m are the nuclear rest masses of the
parent, daughter and emitted particles.
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
A
Z
P A4
Z2
D + 42 He
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
A
Z
P A4
Z2
D + 42 He
226
88
Ra 222
86
Rn +
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
p n + e+ + e
A
Z
P A
Z-1
D + e+ + e
13
7
N 136 C + e+ + e
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n p + e + e A
Z
P A
Z+1
D + e + e
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
n p + e + e
A
Z
P A
Z+1
D + e + e
60
27
Co 60
28
Ni + e + e
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p + e = n + e A
Z P + e = A
Z-1 D + e
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
p + e = n + e
A
Z
P + e = A
Z+1
D + e
7
4
Be + e = 73 Li + e
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
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n p + e + e
A
Z
P A
Z+1
D + e + e
137
55
Cs 137
56
Ba + e + e
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1.2 ATOMIC AND NUCLEAR STRUCTURE
1.2.9 Modes of radioactive decay
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1.3 ELECTRON INTERACTIONS
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1.3 ELECTRON INTERACTIONS
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1.3 ELECTRON INTERACTIONS
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1.3 ELECTRON INTERACTIONS
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1.3 ELECTRON INTERACTIONS
1.3.2 Electron-nucleus interaction
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1.3 ELECTRON INTERACTIONS
1.3.2 Electron-nucleus interactions
sin2
(1 cos )5
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1.3 ELECTRON INTERACTIONS
1.3.3 Stopping power
S 1 dEK
= in MeV cm2 / g
tot
dx
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1.3 ELECTRON INTERACTIONS
1.3.3 Stopping power
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The rate of energy loss per gram and per cm2 is called the
mass stopping power and it is a sum of two components:
• Mass collision stopping power
• Mass radiation stopping power
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1.3 ELECTRON INTERACTIONS
1.3.3 Stopping power
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Bremsstrahlung production
through radiative losses is more
efficient for higher energy
electrons and higher atomic
number absorbers
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1.3 ELECTRON INTERACTIONS
1.3.3 Stopping power
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1.3 ELECTRON INTERACTIONS
1.3.3 Stopping power
R = (EK ) dEK
0
tot
(S/ )rad
EK
1
Y=
EK (S/)
0
dEK
tot
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1.4 PHOTON INTERACTIONS
1.4.1 Types of indirectly ionizing photon irradiations
Bremsstrahlung
Results mainly from electron-nucleus Coulomb interactions
Gamma ray
Results from nuclear transitions
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1.4 PHOTON INTERACTIONS
1.4.1 Types of indirectly ionizing photon irradiations
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1.4 PHOTON INTERACTIONS
1.4.1 Types of indirectly ionizing photon irradiations
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• The resulting scattered photon has a lower energy than the incident photon
and the energy excess is transferred to a light charged particle (electron).
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1.4 PHOTON INTERACTIONS
1.4.1 Types of indirectly ionizing photon irradiations
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
I (0)
I
= μdx or
0
I (x) = I (0)e 0
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or
I(x) / I(0) = e μ x
For x = HVL
I(x)
= 0.5
I(0)
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
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ln 2 1 ln10
μ= = =
x1/ 2 x x1/10
or
ln 2
x1/2 = (ln 2)x = x 0.3x1/10
ln10 1/10
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
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Basic relationships:
μ = μm = n a μ = n Z e μ
Na N N
n = = a = A
V m A
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
IAEA Review of Radiation Oncology Physics: A Handbook for Teachers and Students - 1.4.2 Slide 10 (137/194)
E tr
Energy transfer coefficient μtr = μ
h
with Etr the average energy transferred from the primary photon
with energy h to kinetic energy of charged particles (e- and e+).
Eab
Energy absorption coefficient μab = μ
h
with Eab the average energy absorbed in the volume of interest in the
absorbing medium.
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
E ab = E tr E rad
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1.4 PHOTON INTERACTIONS
1.4.2 Photon beam attenuation
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μ = μi
i
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1.4 PHOTON INTERACTIONS
1.4.3 Types of photon interactions with absorber
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1.4 PHOTON INTERACTIONS
1.4.3 Types of photon interactions with absorber
Thomson scattering e Th a Th Th
Rayleigh scattering -
a R R
Compton scattering e c a c C
Photoelectric effect - a
Pair production - a pp p
Triplet production
e tp a tp t
Photodisintegration - a pn pn
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1.4 PHOTON INTERACTIONS
1.4.3 Types of photon interactions with absorber
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1.4 PHOTON INTERACTIONS
1.4.4 Photoelectric effect
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1.4 PHOTON INTERACTIONS
1.4.4 Photoelectric effect
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• Mass attenuation
coefficient m for
photoelectric effect is
proportional to Z 3 /(h )3.
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1.4 PHOTON INTERACTIONS
1.4.4 Photoelectric effect
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1.4 PHOTON INTERACTIONS
1.4.4 Photoelectric effect
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1.4 PHOTON INTERACTIONS
1.4.4 Photoelectric effect
PKK EB (K)
f = 1
h
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1.4 PHOTON INTERACTIONS
1.4.5 Coherent (Rayleigh) scattering
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1.4 PHOTON INTERACTIONS
1.4.6 Compton scattering
Conservation of energy
h + me c 2 = h + me c 2 + EK
p = p cos + pe cos
Compton expressions:
= c (1 cos )
h
c = = 0.24 Å
mec
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1.4 PHOTON INTERACTIONS
1.4.6 Compton scattering
cot = (1+ ) tan
2
h
=
me c 2
IAEA Review of Radiation Oncology Physics: A Handbook for Teachers and Students - 1.4.6 Slide 4 (163/194)
1
h ' = h
1+ (1 cos )
h
=
me c 2
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1.4 PHOTON INTERACTIONS
1.4.6 Compton scattering
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1.4 PHOTON INTERACTIONS
1.4.6 Compton scattering
Maximum and mean energy transfer from the photon with energy h
to Compton (recoil) electron (“Compton Graph #1”).
Mean energy transfer fraction for Compton effect fc
EK (1 cos )
=
h 1+ (1 cos )
h
=
me c 2
(EK )max 2
=
h 1+ 2
EK
fc =
h
IAEA Review of Radiation Oncology Physics: A Handbook for Teachers and Students - 1.4.6 Slide 8 (167/194)
( e c )tr = e c fc
EK
fc =
h
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1.4 PHOTON INTERACTIONS
1.4.7 Pair production
In pair production
• The photon disappears.
• An electron-positron pair with a combined kinetic energy equal to
h 2me c 2 is produced in the nuclear Coulomb field.
• The threshold energy for pair production is:
m c 2
h thr = 2mec 2 1+ e 2 2mec 2
M Ac
me electron mass
MA mass of nucleus
me c 2 = 0.511 MeV
IAEA Review of Radiation Oncology Physics: A Handbook for Teachers and Students - 1.4.7 Slide 1 (169/194)
In triplet production:
• The photon disappears.
• An electron-positron pair is produced in the Coulomb field of an
orbital electron, and a triplet (two electrons and one positron)
leave the site of interaction.
• The threshold energy for triplet production is: h thr = 4me c 2
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1.4 PHOTON INTERACTIONS
1.4.7 Pair production
Atomic cross sections for pair production and for triplet production
• Atomic cross sections for pair
production and triplet
production equal zero for
photon energies below the
threshold energy.
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1.4 PHOTON INTERACTIONS
1.4.7 Pair production
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1.4 PHOTON INTERACTIONS
1.4.7 Pair production
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2mec 2
f = 1
h
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1.4 PHOTON INTERACTIONS
1.4.7 Pair production
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1.4 PHOTON INTERACTIONS
1.4.9 Contribution to attenuation coefficients
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1.4 PHOTON INTERACTIONS
1.4.9 Contribution to attenuation coefficients
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In general,
• Photoelectric effect predominates at low photon energies.
• Compton effect predominates at intermediate photon energies.
• Pair production predominates at high photon energies.
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1.4 PHOTON INTERACTIONS
1.4.10 Relative predominance of individual effects
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1.4 PHOTON INTERACTIONS
1.4.11 Effects following photon interactions
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1.4 PHOTON INTERACTIONS
1.4.12 Summary of photon interactions
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1.4 PHOTON INTERACTIONS
1.4.13 Example of photon attenuation
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1.4 PHOTON INTERACTIONS
1.4.13 Example of photon attenuation
μab
(EK )tr = 1.13 MeV = 0.0236 cm2 /g
μtr
(EK )ab = 1.04 MeV = 0.0256 cm2 /g
Radiation fraction:
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1.4 PHOTON INTERACTIONS
1.4.14 Production of vacancies in atomic shells
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