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Development of a Clinical Practice Guideline

First received
Blackwell xxxx xx,Inc
Publishing xxxx; Revision received xxxx xx, xxxx; Accepted for publication xxxx xx, xxxx.

for Testing Nasogastric Tube Placement

Sue Peter and Fenella Gill

PURPOSE. A Perth metropolitan hospital group Sue Peter, SRN, RSCN, MSc, is Nursing Director,
Ambulatory Care, Princess Margaret Hospital for
standardized changes to nasogastric tube Children, Child & Adolescent Health Service, Subiaco,
Perth, WA, Australia; and Fenella Gill, RN, BN,
placement, including removal of the “whoosh Paediatric Certificate, MN, Graduate Certificate in
Tertiary Teaching, is Paediatric Intensive Care Nurse
test” and litmus paper, and introduction of Educator and Co-ordinator, PIC Specialty Master of
Clinical Nursing, Princess Margaret Hospital for Children,
pH testing. Child & Adolescent Health Service, Subiaco, Perth, WA,
and School of Nursing & Midwifery, Faculty Health
DESIGN AND METHODS. Two audits were Science, Curtin University of Technology, Bentley, WA,
Australia.
conducted: bedside data collection at a pediatric

hospital and a point-prevalence audit across seven N asogastric tubes (NGTs) are placed in hundreds of
thousands of hospitalized patients every year, and they are
hospitals. an integral part of the management of many medical and
surgical conditions. They are often inserted for the therapeutic
RESULTS. Aspirate was obtained for 97% of all purpose of administering feeds and/or medications. Con-
firming correct placement avoids complications and, in
particular, avoids the introduction of enteral feeds and
tests and pH was ≤ 5.5 for 84%, validating the medication into the lungs.
Many tubes are inserted without incident; however, there
practice changes. However, patients on is a risk that the tube may be misplaced during insertion
or that it may migrate from the stomach at a later stage. The
continuous feeds and/or receiving acid-inhibiting reported tube-placement error rate varies considerably. Metheny
and Meert (2004) and Weinberg and Skewes (2006) reported
medications had multiple pH testing fails. error rates of between 0.3% and 20%, whereas Ellett, Maahs,
and Forsee (1998) reported error rates up to 43% in children.
PRACTICE IMPLICATIONS. Nasogastric tube In addition to endotracheal intubation, risk factors associ-
ated with a higher incidence of enteral tube misplacement in
placement continues to present a challenge for children include younger age, decreased level of conscious-
ness, abdominal distension, vomiting, and orogastric tubes
(Ellett et al., 1998). Although adverse outcomes related to
those high-risk patients on continuous feeds
misplaced NGT are infrequent, when they do occur the results
can be catastrophic, and recent literature has questioned the
and/or receiving acid-inhibiting medications. reliability of traditional bedside testing methods.
In 2005, a coroner’s findings in the United Kingdom high-
Search terms: Children, nasogastric tube lighted 11 deaths over a 2-year period directly related to
misplaced feeding tubes, prompting the UK National Health
testing, pH aspirate Service (NHS) National Patient Safety Agency (2005a) to
produce a National Safety Alert recommending specific
guidelines on the safe testing of NGTs. In response to this alert,
First received August 30, 2007; Revision received December 6, it was deemed timely to review the current clinical guideline
2007; Accepted for publication January 11, 2008. for NGT testing at Princess Margaret Hospital for Children

© (2008), The Authors 3


Journal Compilation © (2008), Wiley Periodicals, Inc.
Development of a Clinical Practice Guideline for Testing Nasogastric Tube Placement

(PMH) to ensure a safe and practical clinical guideline that (Colagiovanni, 1999; Metheny, 1994; Tait, 2001). There is a
incorporated best evidence, particularly as the existing need to be able to differentiate between gastric contents that
guideline was based on traditional bedside testing methods. may have a pH between 1 and 5 (Huffman, Jarczyk, O’Brien,
Pieper, & Bayne, 2004), small bowel or bronchial secretions
Clinical Practice Guideline Development that may have a pH > 6 (Ellett, 2005), and esophageal
secretions that may have a pH between 6 and 7; although
The purpose of clinical practice guidelines (CPGs) is to esophageal pH can yield an acidic pH in the presence of acid
provide practitioners with guidance in specific areas of reflux from the stomach. It is advocated that this method
healthcare practice. CPGs are designed to improve the replace testing the acidity/alkalinity of aspirate using litmus
quality of health care, reduce practice variation, and reduce paper, which is not adequately sensitive to distinguish
unnecessary, harmful, or ineffective interventions, at an between gastric and bronchial secretions (National Patient
acceptable cost (Graham, Beardall, Carter, Tetroe, & Davies, Safety Agency, 2005b).
2003; National Health & Medical Research Council, 1999). In the absence of NGT aspirates, nurses have tradi-
It was recognized that introduction of a comprehensive tionally utilized the “whoosh test,” whereby air is insufflated
CPG would require the time of appropriately skilled and through the feeding tube while auscultating the epigastrium.
experienced people to develop and implement (Feder, The efficacy of this method is highly questionable. Although
Eccles, Grol, Griffiths, & Grimshaw, 1999; Shekelle, Woolf, there is no evidence that the auscultatory method is effective
Eccles, & Grimshaw, 1999). A working party was estab- in ruling out respiratory placement, there have been multiple
lished, comprised of senior clinical nurses and research anecdotal reports of its ineffectiveness leading to disastrous
nurses (ensuring both research-evidence appraising knowl- results (Chang, Melnick, Bedger, & Bleyaert, 1982; Creel &
edge and clinical expertise), to consider the relevance of Winkler, 2007; Dobranowski, Fitzgerald, Baxter, & Woods,
the evidence and translate it into a form that could be 1992; Hand, Kemster, Levy, Rogol, & Spirn, 1984; Hendry
implemented into practice (Gerrish et al., 2007; Shekelle et al., 1986; McWey, Curry, Schabel, & Reines, 1988;
et al.; Steinberg & Luce, 2005). Metheny, Aud, & Ignatavicius, 1998; Metheny & Stewart,
2002; National Patient Safety Agency, 2005a). Additionally,
Literature Review the whoosh test cannot determine where the tube is posi-
tioned in the gastrointestinal tract. Observing for bubbling at
A review and critical analysis of the literature was the proximal end of the tube is also an unreliable method
undertaken to identify current best practice in a manner that because the stomach also contains air and could falsely
ensured the application of evidence to practice was clear indicate respiratory placement (Metheny, McSweeney, Wehrle,
(Hewitt-Taylor, 2003; National Health and Medical & Wiersema, 1990).
Research Council, 1999). In addition, none of the following methods can be relied
upon to determine distal NGT tip position. However, they
Chest X-ray for Checking NGT Placement can be used as additional information when undertaking a
risk assessment, balancing the need to feed with the risks of
The gold standard test for confirming the position of an a malpositioned NGT. When undertaking serial observations
NGT is an X-ray that visualizes the whole length of the tube, and assessments, the strength of single indicators is increased
although there have been multiple reports of X-rays being if one or more other indicators are present (Metheny et al.,
misinterpreted by physicians not trained in radiology 2005). Observing for signs of respiratory distress, such as
(Hendry, Akyurekli, McIntyre, Quarrington, & Keon, 1986; choking or cyanosis, can be ineffective in detecting a malpo-
Scheiner, Noto, & McCarten, 2002). sitioned tube, especially in unconscious or debilitated
Although there is no sure nonradiographic method to patients (Metheny et al., 1990; Rassias, Ball, & Corwin, 1998;
differentiate respiratory, esophageal, gastric, and small bowel Schorlemmer & Battaglini, 1984). Small bore tubes may
placement of NGT tubes, X-ray confirmation is not a suitable cause few or no symptoms when incorrectly positioned,
method to check NGT placement or position for every patient particularly in high-risk patients such as those who are
prior to every feed or administration of medication. Therefore, unconscious, intubated, lack a gag or swallow reflex, or are
it is necessary to use the most accurate bedside methods. uncooperative during the procedure. Although the absence of
symptoms cannot be relied upon to exclude a malpositioned
Bedside Checking Methods for Checking NGT tube, the presence of respiratory symptoms would certainly
Placement suggest an increased risk of misplacement.
There have been significant difficulties reported in
The most reliable bedside method available to confirm distinguishing respiratory secretions from gastric secretions
NGT placement is the measurement of pH of NGT aspirates withdrawn from the NGT (Hand et al., 1984; Metheny &

4 JSPN Vol. 14, No. 1, January 2009


Meert, 2004; Torrington & Bowman, 1981). However, aspirate Australasia via the Women and Children’s Hospitals Aus-
appearance can help to distinguish between an NGT being tralasia organization (Women’s and Children’s Hospitals
positioned in the small bowel rather than the stomach Australasia, 2006). A total of 10 pediatric sites participated
because aspirates may be bile stained when mixed with in a survey of NGT practices, finding that 5 had introduced
intestinal secretion rather than curdled white when mixed pH indicator strips to replace litmus paper. Various pH
with gastric juice. It has been noted that although the deter- cut-off points were being utilized for testing aspirates,
mination of color is subjective, accuracy can improve with ranging from pH 4 to 6, with a number of hospitals varying
training (Metheny & Meert). Observing for changes in the cut-off point according to the use of acid-inhibiting
gastric residual volume can also help distinguish between medications. The whoosh test was no longer endorsed in
the NGT being positioned in the small bowel rather than 6 sites, and indications for X-rays varied from “no aspirate
the stomach because gastric volumes will be larger than obtained” to “doctor initiated.”
intestinal volumes (Metheny & Meert). In addition, when the Consultation with a number of adult hospitals in the
tube has migrated into the esophagus, the aspirate volume Perth metropolitan area highlighted differences in hospital
has been found to decrease (Metheny et al., 2005). NGT management policies. A number of hospitals had
Determining if the external length of the tube has moved away from the traditional bedside testing methods
changed since the time of the confirmatory X-ray cannot while others were continuing traditional NGT practices. This
be relied upon to ascertain internal NGT distal tip position. communication led to the establishment of a metropolitan-
Marking the tube as it exits from the nares or mouth serves wide hospital-nursing working party to achieve consensus
as an indication of whether the tube has been partially in the standardization of evidence-based changes to NGT
removed but does not reflect the distal tip position. How- policies across hospital sites, to enable benchmarking, and to
ever, there are no risks involved with marking the tube, and undertake a multisite evaluation.
it may help to alert caregivers to detect a change in tube
position (Metheny & Meert, 2004; Metheny et al., 2005). Implementation and Dissemination of the CPG

Alternative Bedside Testing Methods In April 2006, the NGT CPG was introduced at PMH. The
whoosh test was no longer endorsed; litmus testing of gastric
Alternative bedside testing methods include the use aspirates was replaced with pH testing; and a risk assess-
of pH probes, capnography, and measurement of aspirate ment was developed to guide decision-making in balancing
bilirubin, trypsin, and/or pepsin. However, each of these the potential risks with the need to feed (see Figure 1).
methods has limitations and drawbacks. Clinical utilization
of pH probes has been restricted to testing between gastric Potential Barriers to Implementing the CPG
and esophageal placement rather than respiratory place-
ment. Capnography measurement indicates respiratory The PMH working party planned the process for
placement of the NGT; however, this would not occur if implementation of the CPG to incorporate a number of
either a tube positioned in the tracheobronchial tree was dissemination strategies aimed at medical personnel, nursing
not perfectly patent or if the eyelet holes were at the level of staff, and parents of children with NGTs. The active
the cuff of the endotracheal tube or tracheostomy tube. implementation measures included the identification of
Measurement of bilirubin, trypsin, and/or pepsin relies on potential barriers to the adoption of the new guideline
obtaining an aspirate and is not currently commercially (Graham et al., 2003). During the consultation period,
available because more research is needed before this concerns about the impact of the proposed changes
method can be used in practice (Huffman et al., 2004). expressed by many of the nursing staff were:

Establishing Reliability of the CPG • The new guidelines would lead to an increase in the
number of X-rays undertaken and repassing of NGTs.
In the absence of good evidence and considering the • Aspirates for patients on continuous feeds or acid-
limitations of available NGT bedside methods, it was inhibiting medications would be > pH 5.5.
essential for us to address the reliability of the NGT CPG • Decision-making would be difficult in the absence
before implementation. This was partly established by of aspirates.
considering whether a second group would arrive at the
same recommendations after reviewing the same evidence Evaluation Process
(Goolsby, 2003). The UK NHS Patient Safety Agency was
consulted, and a national benchmarking process was To address the concerns raised and ensure a positive
initiated with other children’s hospitals/departments in effect on organizational change, a comprehensive evaluation

JSPN Vol. 14, No. 1, January 2009 5


Development of a Clinical Practice Guideline for Testing Nasogastric Tube Placement

Figure 1. Risk Assessment

process was initiated (Graham et al., 2003; Ring, Malcolm, Evaluation Methods
Coull, Murphy-Black, & Watterson, 2005). A key principle of
CPG development is that the implementation and impact The PMH audit was conducted over a 1-month period.
should be evaluated (Feder et al., 1999; National Health Data were collected by bedside nurses for all patients with
and Medical Research Council, 1999; Ring et al.). A an NGT in situ for each NGT testing procedure, using an
review was planned encompassing two separate clinical adapted NHS Patient Safety audit tool (National Patient
audits: an audit at PMH to address the specific clinical issues Safety Agency, 2005b). In addition, a metrowide 1-day point-
identified and a metrowide hospital point-prevalence audit prevalence audit was conducted across seven metropolitan
to evaluate the impact on nursing practice and identify hospitals. The nurses identified to collect the data from
further educational needs, ensuring linkage between the data each hospital first attended briefing sessions to promote
collected and key points of the CPG (Feder et al.; Gerrish & interrater reliability. Bedside nurses were then interviewed
Clayton, 2004; Mersel, Mor-Yosef, & Shapira, 2005). using a semistructured questionnaire, and documentation

6 JSPN Vol. 14, No. 1, January 2009


was reviewed for all patients with an NGT in situ (Metcalf, intestine. However, there have been other rare and isolated
2006). situations in the literature where fluid aspirated from a
pocket of empyema in the lung had a pH of 5.
Results Indicator strips for pH also must have the appropriate pH
range for sufficient sensitivity, and pH strips with a broad
PMH Audit Results pH range are advocated (Metheny & Meert, 2004). However,
a trial of various pH indicator strips at PMH found color
Concern: The new guidelines would lead to an increase changes of the indicator strips with wide pH values that
in the number of X-rays undertaken and repassing of were difficult to distinguish between. The pH indicator
NGTs. While no sure nonradiographic methods exist to strips with a pH range of 4 to 7 provided more distinctive,
differentiate between respiratory, gastric, esophageal, and observable color changes, thus allowing more accurate
small bowel placement of blindly inserted feeding tubes interpretation of pH levels that are relevant to NGT
(Metheny & Meert, 2004), minimizing the number of radio- placement.
graphs taken to assure correct tube placement is important, Most enteral formulas have a pH close to 6.6, causing
especially in young children, to avoid exposure to the risks the pH of gastric contents to be increased in enterally fed
associated with radiation. During the 1-month PMH audit, a patients. Patients who are receiving continuous feeds may
total of 1,527 NGT tests were undertaken for 52 patients. have a pH > 5.5, although testing can be performed when
Seven X-rays were undertaken on 6 children. Selective use of feeds have been withheld (Khair, 2005). Ellett et al. (2005)
X-rays was observed because only those children who had found that there was a statistically nonsignificant difference
more than one occasion of pH > 5.5 were X-rayed, with in pH between bolus-fed and continuously fed children, and
the exception of one infant who was frequently “gagging” whether or not the child was receiving an acid-inhibiting
where X-ray confirmed the NGT had knotted. If results medication did not significantly affect the pH of aspirate,
from the bedside tests do not confirm correct positioning, although this study reported an inadequate sample size.
the tube can be removed and reinserted; in this way X-rays For the purpose of the data results, pH ≤ 5.5 is reported
can be kept to a minimum. This recommendation was as pH pass, and pH > 5.5 is reported as pH fail. For the
evident in practice because 22 patients had 39 NGTs 1,527 tests, 84% were pH pass. Of the 52 patients, 21 had pH
repassed (range 1–5). pass for all testing, 13 had pH fail on one occasion, and 18 (9
Concern: Aspirates for patients on continuous feeds or pediatric intensive care unit patients) had 2 or more pH fails
acid-inhibiting medications would be > pH 5.5. Nasogastric (range 2–42). Importantly, the PMH audit data identified
aspirates ≤ pH 5.5 will indicate correct placement of NGTs that children receiving continuous feeds more often had > 2
in most patients (adults, children, infants, and neonates), pH fails (61%) than the children who were receiving bolus
including those receiving acid-inhibiting medication feeds (35%). A similar trend was found with those children
(Metheny, 1994). Ellett, Croffie, Cohen, and Perkins receiving acid-inhibiting medications, where 39% had
(2005) found that using the following algorithm—(a) if pH > 2 pH fails compared to 24% receiving bolus feeds. Seven
was ≤ 5, the correct placement in the stomach could be patients who had more frequently recurring pH fails (range
assumed, and (b) if pH > 5 or no aspirate, an X-ray should 7–42) were on both continual feeds and acid-inhibiting
determine tube placement—would result in 92% of children medications. Figure 2 further illustrates these findings.
eventually having correct placement in the stomach. There Concern: Decision-making would be difficult in the
are limitations to using this beside testing method because absence of aspirates. In the situation where no fluid
measuring the pH of withdrawn fluid is only helpful in dif- aspirate is obtained from the NGT, alternative methods such
ferentiating between respiratory and gastric placement when as the whoosh test had traditionally been implemented.
gastric pH is low (Griffiths, Thompson, Chau, & Fernandez, Determining the position of the NGT by auscultation of air
2006; Metheny & Meert, 2004). When gastric pH is ≥ 6, using (whoosh test) into the stomach is an unreliable method of
pH to predict tube placement is of no benefit. Further- checking NGT position. The injection of air into the tracheo-
more, pH of a feeding tube cannot identify if it is in the bronchial tree or into the pleural space can produce a
esophagus. Continuous feedings negate the usefulness of the sound indistinguishable from that produced by injecting
pH method in many situations, which needs to be taken into air into the gastrointestinal tract (Colagiovanni, 1999;
consideration when undertaking a risk assessment. A pH of Metheny et al., 1990; Weinberg & Skewes, 2006). While the
≤ 5.5 was incorporated into the NGT guideline to indicate stomach is never completely empty, it is not always possible
gastric placement, because according to Metheny and to initially obtain an NGT aspirate. The following steps were
Meert, no pulmonary aspirate has been reported < pH 6; incorporated into the CPG to assist nursing staff to obtain an
therefore, ≤ pH 5.5 will exclude 100% of pulmonary place- aspirate: turning the patient onto his or her side, advancing
ments and more than 93.9% of placements in the small the tube to make sure the exit port enters a pool of fluid, and

JSPN Vol. 14, No. 1, January 2009 7


Development of a Clinical Practice Guideline for Testing Nasogastric Tube Placement

Figure 2. Princess Margaret Hospital for Children Audit in the small percentage of nurses at PMH who indicated X-ray
pH Levels Results. pH Pass Percentage (n = 34), (11%) as a testing method in comparison to the adult nurses
and pH Fail Percentage (n = 18) (61%) (Metcalf, 2006).
Eight nurses reported the whoosh test, four reported blue
litmus paper, and two reported the bubble test as recom-
mended alternative methods at their hospitals. Sixty-one
percent of nurses reported the correct, recommended pH
level; 3% did not know; and the remainder varied between
pH 4 to 6. Ninety-three percent of nurses reported checking
NGTs prior to all bolus feeds, 91% prior to medication delivery,
and 90% a minimum of once per day or once per shift for
continuous feeds. However, only a small percentage of nurses,
9% and 6%, respectively, reported checking following
vomiting or coughing episodes (Metcalf, 2006).
Documentation. Seventy-nine patients with an NGT
in situ were identified across the metropolitan hospitals
(23 at PMH). There was incomplete documentary evidence for
approximately 50% of patients for placement and testing of
the NGTs, and data collection was hindered by the absence of
a standardized NGT chart at any of the participating hospitals
(Metcalf, 2006).
There were obvious discrepancies between the knowl-
edge of the nursing staff found during the interviews and
review of the actual documentation. For example, 74% of
nurses indicated the method used to check placement,
yet only 51% of the notes reviewed showed this informa-
injecting air to dislodge the NGT exit port from the gastric tion was documented (Metcalf, 2006).
mucosa (Khair, 2005; Metheny & Meert, 2004).
Metheny et al. (2005) reported obtaining sufficient aspirate Discussion
for testing in 74.2% of 2,754 tests from gastric tubes in
critically ill adults. In the PMH audit, aspirate was obtained In view of the potential catastrophic outcomes that may
for 97% of all tests, thus not supporting staff concerns of occur as a result of a misplaced NGT and the limitations
anticipated high rates of failure to aspirate. These results inherent in the currently available bedside testing methods,
correlate with similar findings of an audit conducted by the it was important to adopt an evidenced-based approach to
NHS Patient Safety Agency across three adult intensive care the introduction of a revised NGT CPG. This incorporated a
units; a 92% success rate of obtaining aspirates was reported. literature review, consultation with clinical experts, establish-
The success in obtaining aspirate for 97% of all tests in the ment of a multisite hospital working party, benchmarking
PMH audit indicated the clinical effectiveness of these steps, activities, implementation of a comprehensive dissemination
although due to incomplete data it was impossible to identify program, and an evaluation process.
which step achieved an aspirate. The steps are illustrated in Data collected during the PMH clinical audit did not
Figure 3. support the concerns expressed by staff of anticipated
high percentages of patients with pH > 5.5 or no aspirate
Metrowide Audit Results obtained with subsequent interruptions to feeding and
increased X-ray exposure. The findings of the PMH audit,
Nurse Interviews. One hundred and four nursing staff however, do need to be interpreted with caution because
across seven hospitals within the Perth metropolitan area this was a clinical audit process and not a research study.
undertook voluntary nursing interviews (18 employed at The nature of the audit, in that many different staff entered
PMH). Ninety-three percent of the nurses (100% at PMH) data across various wards and departments, led to incom-
correctly indicated the use of pH indicator strips to test plete data inputting and a lack of standardized data entries.
stomach aspirate as their hospital’s recommended method Subsequently, this limited data analysis to determine the
to check NGT placement, and 61% indicated X-ray as an most effective actions to take in the absence of aspirates. The
alternative method to pH testing. The recommendation data results yielded a high success rate in obtaining aspirates,
that children are not subjected to routine X-ray was reflected indicating clinical effectiveness of the recommended

8 JSPN Vol. 14, No. 1, January 2009


Figure 3. Confirming the Correct Position of Nasogastric Feeding Tubes in Infants and Children (For Infants Less Than
4 Weeks, Refer to Neonatal Policy)

JSPN Vol. 14, No. 1, January 2009 9


Development of a Clinical Practice Guideline for Testing Nasogastric Tube Placement

steps to take. Further study is required to determine which How Do I Apply This Information to
of the steps were most successful, whether as a single step or Nursing Practice?
in combination, to obtain aspirate.
The children receiving continuous feeds were more likely It is now recommended that pH testing replace the litmus
to have more than one pH fail, as were the children on paper test, and the whoosh test is no longer advocated for
acid-inhibiting medications. When these two factors were confirming NGT placement. It is not always appropriate to
combined, a trend was observed where consistently recurring conduct an X-ray for each occasion where bedside testing
pH fails were evident. Thus, it is not surprising that this methods fail. Our evaluation demonstrated that if initially
group of children received additional X-rays and were nil nasogastric aspirate is obtained, the use of a flow chart of
more likely to have multiple NGT replacements. These interventions will enable aspirate to be obtained and facil-
factors need to be taken into account when undertaking a itate pH testing. The group of patients who will continue to
risk assessment for this “high-risk” group, and further pose a challenge to using pH testing are those on contin-
research is required to identify if this is a subset of children uous feeds and/or receiving acid-inhibiting medications. In
that requires a variation to the current NGT CPG. addition, a comprehensive individual risk assessment of the
Caution is also required before generalizing the results of patient, using a standardized tool, is mandatory to guide
the metrowide audit in view of the limited number of decision-making by the multidisciplinary team.
patients included together with the small number of nursing
staff interviewed. There was an obvious deficit observed Author contact: fenella.gill@health.wa.gov.au and
between knowledge reported by the nursing staff in the sue.peter@health.wa.gov.au, with a copy to the Editor:
interviews compared with the documented evidence. Tradi- roxie.foster@UCDenver.edu
tionally, nurses have not necessarily documented all aspects
of their practice related to NGT management, evident in the
absence of a specific chart to document NGT placement and References
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