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Technical Data:
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N
Formula: C30H23N5O enquiry@selleckchem.com
O
N
Solubility: DMSO N
Purity: 99%
N Tech Support
tech@selleckchem.com
Storage: at -20℃ 2 years N
(chemistry support)
CAS No.: 915019-65-7 Synonyms: NVP-BEZ235 techbio@selleckchem.com
(bio support)
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Biological Activity
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NVP-BEZ235 inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of
these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
inhibitor (mTOR) pathway is often constitutively activated in human tumor cells. [1] For Class I
PI3K family, NVP-BEZ235 biochemical IC50 are 4nM against p110α,75nM against p110β,7nM
against p110σ,5nM against p110γ. Quantification of S473-Akt and T308P-Akt levels by ELISA
revealed that 50% reduction occurred at a compound concentration of 8.0 nmol/L and 30 nmol/L.[3]
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References
[1] Jeffrey A. Engelman et al. Nature Reviews Genetics.2006 August;7:606-619
Return Policy
[2] Sauveur-Michel Maira et al. Mol Cancer Ther.2008 July;7:1851-1863
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PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
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