Product Information Novel Life Science Reagents

for Cell Signaling Research

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S1010 BIBF1120 (877)796-6397
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» VEGFR-PDGFR
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Technical Data:
Orders
M.Wt:
O
539.62 N N
N +1-713-922-4115
Formula: C31H33N5O4 enquiry@selleckchem.com
Solubility: DMSO NH

Purity: 99% Tech Support

O
O N tech@selleckchem.com
Storage: at -20℃ 2 years O
H
(chemistry support)
CAS No.: 928326-83-4 Synonyms: Vargatef techbio@selleckchem.com
(bio support)

Web
Biological Activity
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Extensive biochemical testing revealed a distinctive, narrow range of kinases that are inhibited
by BIBF 1120 at pharmacologically relevant concentrations.The targeted kinases include all three
VEGFRsubtypes (IC50=13–34 nmol/L), PDGFRa and PDGFRh (IC50=59 and 65 nmol/L),and
FGFRtypes 1, 2, and 3 (IC50=69, 37, and 108 nmol/L,respectively). BIBF 1120 inhibits
mitogenactivated protein kinase and Akt signaling pathways in three cell types contributing
to angiogenesis, endothelial cells, pericytes, and smooth muscle cells, resulting in inhibition
Selleck Overnight Delivery Service
of cell proliferation (EC50=10–80 nmol/L) and apoptosis. [2]

References

[1] Oriol Casanovas et al. Cancer Cell. 2005 October 1;8(4):299-309 Return Policy
[2] Frank Hilberg et al. Cancer Res. 2008 June 15; 68(12): 4774-4782 Please inspect packages immediately upon

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