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Product Information Novel Life Science Reagents

for Cell Signaling Research

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» Proteasome
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Technical Data:
Orders
M.Wt: 384.24
+1-713-922-4115
Formula: C19H25BN4O4 O OH enquiry@selleckchem.com
H
Solubility: DMSO N N B
N OH Tech Support
Purity: 99% H
O
N tech@selleckchem.com
Storage: at -20℃ 2 years
(chemistry support)
CAS No.: 179324-69-7 Synonyms: Velcade, MG-341, PS-341 techbio@selleckchem.com
(bio support)

Web
Biological Activity
www.selleckchem.com
Targeted elimination of damaged or unwanted proteins via the ubiquitin-proteasome pathway is
fundamental to the control of many essential cell functions, including cell-cycle progression, gene
transcription, and apoptosis.[1] The dipeptide boronic acid inhibitor bortezomib effectively inhibits
proteasome activity (Ki-0.6 nM) but has little affinity for other proteases (e.g., for chymotrypsin,
Ki=320 nM, and for thrombin, Ki=13,000 nM).[2] The level of apoptosis was 80% to 90% in cells
treated with bortezomib plus SN-38, vs. 10% with either agent alone. [3]
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References
[1] Julian Adams et al. Cancer Investigation. 2004,22(2):304-311
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Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the info@selleckchem.com or
recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115
storage temperature,most are recommended stored at -20℃. Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number,
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and
your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt.
recommendations on the product data sheet.

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