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Formula: C19H25BN4O4 O OH enquiry@selleckchem.com
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CAS No.: 179324-69-7 Synonyms: Velcade, MG-341, PS-341 techbio@selleckchem.com
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Targeted elimination of damaged or unwanted proteins via the ubiquitin-proteasome pathway is
fundamental to the control of many essential cell functions, including cell-cycle progression, gene
transcription, and apoptosis.[1] The dipeptide boronic acid inhibitor bortezomib effectively inhibits
proteasome activity (Ki-0.6 nM) but has little affinity for other proteases (e.g., for chymotrypsin,
Ki=320 nM, and for thrombin, Ki=13,000 nM).[2] The level of apoptosis was 80% to 90% in cells
treated with bortezomib plus SN-38, vs. 10% with either agent alone. [3]
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References
[1] Julian Adams et al. Cancer Investigation. 2004,22(2):304-311
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