SYLLABUS: FULL COURSE

1) Transdermal drug delivery system offers the following advantages except:

a) They produce high peak plasma concentration of the drug
b) They produce smooth and nonfluctuating plasma concentration of the drug
c) They minimize interindividual variation in the achieved plasma drug
concentration
d) They avoid hepatic first-pass metabolism of drug

2) In the steroid nucleus, there are:

a) 6 chiral centres with nucleus i.e. 3,8,9,10,11&12
b) 6 chiral centres with nucleus i.e. 5,7,9,10,13&16
c) 7 chiral centres with nucleus i.e. 3,8,9,10,11,12&14
d) 6 chiral centres with nucleus i.e. 5,8,9,10,13&14

3) The no. ‘20’ in ‘Ocusert pilo-20’ refers to the:

a) Rate of release of drug from ocusert
b) Strength of preparation as a percentage
c) Strength of preparation in milligrams
d) Duration of action of ocusert in days

4) Which of the following drugs is most commonly used in prophylaxis of

migraine:
a) Ergotamine c) Sumatriptan
b) Methysergide d) Propranolol

5) Majority of drug cross biological membranes primarily by:

a) Passive diffusion c) Active transport
b) Facilitated diffusion d) Pinocytosis

6) Bragg’s law is given by the equation:

a) 2 =nd sin c) =2d2 sin
b) =2d sin d) n2 =2d sin

7) Which of the following is the source of IR?

a) Hydrogen lamp c) Globar
b) Deuterium discharge lamp d) Hollow cathode lamp

8) Select the correct statement for Micropropogation:

a) Rapid multiplication is possible
b) Genetic uniformity achieved
c) Disease free plant obtained
d) All of above
9) Correct equivalent to -10°C:
a) -10°F c) -18°F
b) +22°F d) +14°F
c) Yearly d) Every 6 months
10) HEPA filter integrity testing done on:
a) Daily b) Monthly
11) Aminocyclase is utilized for
a) N- oxidation of drugs containing hydrazine
b) Resolution of DL-amino acids
c) D-amino acid production
d) Nucleotide production from RNA

12) In the IR spectra the compounds

I) Cyclobutanone II) Cyclopentanone III) Cyclohexanone appear in the
following order of decreasing frequency:
a) I>II>III c) III>II>I
b) II>I>III d) II>III>I

13) ESR is applied to only those substances showing paramagnetism which

is due to the magnetic moment of
a) Neutrons c) Paired electrons
b) Protons d) Unpaired electrons

14) What is the proportion of NaCl required to render a 1.5% solution of a

drug isotonic with blood plasma? Freezing point of 1% w/v solution of
drug is -0.122°C and that of NaCl is -0.576°C.
a) 0.65% c) 0.9%
b) 0.585% d) 0.5%

15) Biotransformation of drugs is primarily directed to:

a) Activate the drug
b) Inactivate the drug
c) Convert lipid soluble drug into non-lipid soluble metabolite
d) Convert non-lipid soluble drug into lipid soluble metabolite

16) Billirubin is not excreted in urine is:

a) Obstructive jaundice c) Hemolytic jaundice
b) Hepatic jaundice d) All of above

17) Chemically furosemide is:

a) 4-chloro-N-pyridyl-5-sulfonyl anthranilic acid
b) 4-fluoro-N-furfuryl-5- sulfonyl anthranilic acid
c) 4-chloro-N-furfuryl-5-sulfonyl anthranilic acid
d) 4-fluoro-N-pyridyl-5-sulfonyl anthranilic acid

18) Which of the following H1 antihistaminic has additional anti 5-HT,

anticholinergic, sedative and appetite stimulating properties:
a) Promethazine c) Cyproheptadine
b) Terfenadine d) hydroxyzine

19) The correct non-ionic surfactant used as a penetration enhancer in the

preparation of mucoadhesives is:
a) Oleic acid c) Glycerol
b) Tween-80 d) Propylene glycol
a) Methysergide c) Ketanserine
d) Ondansetron
20) Theb) Cyproheptadine
5-HT antagonist has antihypertensive property is:
21) In NMR maximum response is observed when
a) Radiofrequency is greater than precessional frequency of nuclei
b) Radiofrequency is less than precessional frequency of nuclei
c) Radiofrequency is equal to precessional frequency of nuclei
d) Both a & b

22) 152a, it is a propellant used for the preparation of aerosol, which is

a) Di-fluoroethane c) Di-chloro di-fluoromethane
b) Di-chlorotetra-fluoroethane d) Di-iodohexane

23) Glucuronide conjugation:

a) Converts water soluble compound into a lipid soluble compound,
thereby increasing the potency.
b) Converts an uncharged species into a charged species, increasing the
shelf life of the compound.
c) Adds an ionic hydrophilic moiety, facilitating its urinary elimination.
d) Adds a bulky substituent to convert it into an active compound.

24) Furosemide act by inhibiting the following in the renal tubular cell:
a) Na+-K+-2Cl- c) Na+-H+ antiporter
cotransporter d) Na+-K+ ATPase
b) Na+ Cl- symporter

25) Heamoglobin S (sickle cell anaemia) is a result of:

a) Transverse mutation c) Nonsense mutation
b) Transition mutation d) Frameshift mutation

26) Nujol is actually a

a) Fixed oil c) Hydrogenated oil
b) Volatile oil d) Mineral oil

27) Which of the following substances used to measure GFR?

a) Inulin c) Cr-EDTA
b) Insulin d) Both A & C

28) The drug employed for anti H.pylori therapy include the following except:
a) ciprofloxacin c) tinidazole
b) clarithromycin d) amoxicillin

29) Chitosan is a:
a) Natural hormone c) Synthetic peptide
b) Natural polysaccharide d) Natural phospholipid

30) The serum enzyme used to evaluate pancreatic function is;

a) Alkaline phosphatase c) Aspartate transaminase
b) Amylase d) LDH
 31) Vd of fluoxetine is 4000 liter & plasma concentration is 1 ng/ml.
Amount of drug in body is?
a) 40 mg c) 0.04 mg
b) 0.4 mg d) 4 mg

32) Select the diuretic that can cause gynaecomastia, hirsutism and
menstrual disturbance as a side effect on long term use:
a) Amiloride c) Metolazone
b) Spironolactone d) Acetazolamide

33) The most important therapeutic indication of acetazolamide is:

a) Congestive heart failure c) Cirrhosis of liver
b) Renal insufficiency d) Glaucoma

34) Kaiser is the unit for:

a) Wave number c) Wave length
b) Frequency d) All of above

35) Teflon is chemically:

a) Polythene tetra fluro ethylene c) Polytetra fluro ethylene
b) Polytetra fluro ethene d) Tetra fluro ethylene

36) In order to prepare a novel drug delivery system from release erythrocyte,
the erytyhrocytes for the purpose of loading the drug are placed in :
a) Hypertonic solution c) Isotonic solution
b) Hypotonic solution d) Both A & B

37) The third edition of INDIAN PHARMACOPOEIA was published in:

a) 1966 c) 1985
b) 1955 d) 1996

38) The following serotonergic receptor function primarily as an autoreceptor

on neurons:
a) 5-HT1A c) 5-HT3
b) 5-HT2A d) 5-HT4

39) Compressed gases that are used as propellants for aerosols are:
a) CO2 c) Nitrous oxide
b) Nitrogen d) All

40) Vehicle for Parenteral preparation which possess antioxidant activity as

well:
a) Ethanol c) Sesame oil
b) Olive oil d) Cotton seed oil

41) The following drug is an inhibitor of gastric mucosal proton pump:

a) carbenoxolone sodium c) famotidine
b) sucralfate d) lansoprazole

42) Neutral thioaliphatic amino acids found in protein is:

a) Cystiene b) Leucine
 c) Valine d) Glycine

43) Liposome are used as carriers for drugs and macromolecules in

pharmaceutical formulations. they are:
a) Phospholipids dispersed gently in aqueous medium to obtain
multilamellar vesicles.
b) Hydrophilic or lipophilic polymer matrix with a drug reservoir.
c) A shallow compartment moulded from a drug impermeable system and
rate controlling polymeric membrane.
d) Microporous membrane made from ethylene / vinyl acetate polymer.

44) What is the formula for preparing primary emulsion by using almond oil.
Oil: Gum: Water ratio?
a) 2: 1:2 c) 4:1:2
b) 3: 1:2 d) 1:4:2

45) Which type of drug is ideal candidate for sustain release dosage form:
a) Having shorter half life c) Having high protein binding
b) Having low solubility d) All of the above

46) Nuclear magnetic moment is not shown by:

a) 13C c) 16O
b) 1H d) 15N

47) One of the following antihypertensive has a similar structure as that of

diuretic agent Chlorthiazide:
a) Guanethidine c) Minoxidil
b) Diazoxide d) Propranolol

48) Following is the example of INTELIGENT POLYMER:

a) Lutrol c) Poloxamer
b) Xanthan gum d) Dendrimer

49) What types of radio activity is most often used in Radio pharmaceuticals?
a) -rays b) a-rays c) ß-rays d) X-rays

50) First 2 hours dissolution of controlled release formulation should be

carried out in which dissolution medium?
a) 0.1 N HCL, PH 0.1 c) 0.1 N HCL, PH 2.4
b) 0.1 N HCL, PH 1.2 d) 0.4 N HCL, PH 4.1

51) Water Attack test is performed on which type of glass?

a) Type-I c) Type-III
b) Type-II d) Type-IV

52) Which of the following is alter native to DOP test for checking installation
of filter(HEPA)?
a) Liq. Paraffin c) EDTA
b) Alcohol d) All of above
 53) Choose correct statement for LAL test:
a) It only detects Gm –ve bacteria
b) It is semiquantitative test
c) It is based on gelling/coagulation/clotting of LAL in presence of
endotoxin
d) All of above

54) Which of the following method uses HIGH VOLTAGE CURRENT to

improve drug delivery through skin?
a) Sonophoresis c) Magnetophoresis
b) Iontophoresis d) Electroporation

55) Which of the following is the equation of second order half life?
a) t 1/2= C/2K c) t 1/2=1/CK
b) t 1/2=0.693/K d) t 1/2=1/(2CK)

56) In NMR, Reference standard used are:

A. Trimethyl silane for aqueous solution
B. Dimethyl-2-silapentane-5-sulphonate for organic compound
C. Tetramethyl silane for organic compound
D. Dimethyl-2-silapentane for aqueous solution
a) A,B b) C,D c) A,D d) B,C

57) Which of the following drug is neither bronchodilator nor anti-

inflammatory, but has antihistaminic and mast cell stabilizing activity:
a) Na cromoglycate c) Beclomethasone
b) Ketotifen d) Mepyramine

58) Which of the following drugs inhibits theophylline metabolism and raises
its plasma concentration:
a) phenytoin c) ofloxacin
b) ciprofloxacin d) rifampicin

59) The long form of WIPO is:

a) World Intellectual Patent Office
b) World Intellectual Property Organisation
c) World International Patent Office
d) World Intellectual Property Office

60) Which vibrational change occur at lower frequency in IR?

a) Bending vibration c) Stretching or bending vibration
b) Stretching vibration d) None of these

61) Quenching is common due to following except:

a) Concentration c) Oxygen
b) Collision d) Fluorescent indicator

62) In Biopharmaceutical classification CLASS-II drugs with

a) Low solubilit y & high permeability
b) high solubility & low permeability
c) Low solubilit y & low permeability
 d) high solubility & high permeability

63) 1,4-Dioxan gives how many signals(peaks) in NMR?

a) 1 b) 2 c) 3 d) 4

64) Gouche confirmation having coupling constant value:

a) 5-12 c) 2-4
b) 10-20 d) 20-40

65) Select fastest acting inhaled bronchodilator:

a) Atropine methonitrate c) Salbutamol
b) Ipratropium bromide d) Salmeterol

66) Select solvent used in NMR:

a) Trifluro acetic acid c) DMSO
b) Carbon tetra chloride d) All of above

67) Gastro-retentive system mainly for the:

a) Having shorter half-life
b) Having poor solubility
c) Having max. absorption in gastric
d) Having degradation in stomach

68) Which of the following statement is wrong for TMS?

a) Produces single peak at d=10
b) It is inert
c) It is volatile & can be easily distilled off & used again
d) Used to prevent a reference against which other peaks are measures.

69) If codon is CGU then Anticodon is:

a) GCC b) GCA c) CGG d) None

70) Isomer of C4H8 produces four diff. signals in NMR ?

a) CH2=CHCH2CH3 c) (CH3)2-C=CH2
b) CH3-CH=CH-CH3 d) Cyclobutane

71) Complete the series 1,9,17,33,49,73,….?

a) 99 b) 97 c) 101 d) 91

72) Cyano groups is identified by IR absorption band at:

a) 1000-1500 c) 2000-2500
b) 1500-2000 d) 3000-3500

73) Action of bradykinin include the following except:

a) Fall in blood pressure c) Increase in capillary permeability
b) Cardiac depression d) bronchoconstriction

74) Serum sample of patient shows elevated levels of -glutamyl transferase.

The patient could be suffering from:
a) Kidney disorder c) Liver disease
b) Parkinson disease d) Myocardial function
75) In NMR, Unit of Applied magnetic field is:
a) Webber c) Gauss
b) Tesla d) All of above

76) Identify the odd statement about ß-oxidation:

a) Characterized by removal of single carbon from the carboxyl and of
the molecule
b) Not utilizes co-enzyme A intermediates
c) Generates high energy phosphate
d) None of above

77) What is meaning of ‘RS’ as per IP?

a) Relative solubility c) Reference standard
b) Relative saturation d) Relative substance

78) All of the following hormonal drugs possess a steroidal nucleus except:
a) Ethinyl estradiol c) Fluoxy mestrone
b) Prednisolone d) Levo-thyronine

79) Proton NMR of PROPANE consist of:

a) A triplet & a singlet c) A singlet, a Doublet & a triplet
b) A doublet & a septet d) Two triplet & a septet

80) The drug that can directly release histamine from mast cells without
involving antigen-antibody reaction is:
a) Aspirin c) Morphine
b) Procaine d) Sulfadiazine

81) If two amide bonds are presents so the peptide will be

a) Dipeptide c) Tetra peptide
b) Tripeptide d) Pentapeptide

82) In IR spectrum, the functional group region is from:

a) 4000 cm-1 to 900cm-1 c) 1400 cm-1 to 900 cm-1
b) 4000 cm-1 to 1400cm-1 d) 4000 cm-1 to 660 cm-1

83) Select odd figure from the following:

a) c)

b) d)

84) A,B,C,D represents 2,5,3,4 and I,N,O,X represents 1,6,9,0

then I,B,C,X represents what?
a) 1,2,3,4 b) 2,4,5,6 c) 1,5,3,0 d) 1,0,2,6

85) What is solubility (in g/100ml) of -Cyclodextrin at 25°C?

a) 14.5 c) 23.5
b) 18.5 d) 30.5
 a) M isshell
86) What to K shell
ALCON & POLYQUAD used in Ophthalmic? c) L shell to M shell
b)
a) L shell to K shell
Preservative d) M shell to L shell
c) Antioxidant
b) Solubility enhancer d) All of above
99) Meter dose Aerosol can be manufactured by:
a) Pressure
87) Which of the filling
following is enzyme inhibitors? c) Cold filling
b) Gelation
a) Grape fruit juice d)
c) Both
Mango A& C
juice
100) Alkanization
b) Apple juice of urine hastens the excretion of: d) All of above
a) Weakly basic drugs c) Strong electrolytes
b) Weakly
88) Proteomics is acidic drugs
the study of: d) Nonpolar drugs
a) Proteins c) RNA
b) DNA d) All of above

89) What happens in BFS technology(or BFS machine) that is used in

parenterals?
a) Container formation c) Sealing
b) Filling d) All of above

90) Potassium sparing diuretic should not be coadministered with:

a) Furosemide c) Captopril
b) Hydrochlorothiazide d) Verapamil

91) In Ophthalmic suspension having particle size less than:

a) 1 nm c) 10 micron
b) 10 nm d) 100 micron

92) Phosphorescence and fluorescence involves what?

a) Absorption spectro. c) Both A & B
b) Emission spectro. d) None of this

93) X:Y =2:3 & Z:X =1:2 then value of Y is?

a) 1 c) 3
b) 2 d) 4
94) Infrared spectra can be obtained for:
a) liquid c) gases
b) solid d) all of above

95) Micropropogation of the plant is carried out through:

a) cross fertilization c) plant tissue culture
b) seed germination d) grafting

96) Sustain release dosage form follows which order:

a) First order c) Zero order
b) Pseudofirst order d) Both A & B

97) In clinical study of drug is done by four phases. In phase-I study of drug is
done on:
a) Few human healthy c) In animals
volunteers d) None of above
b) Many no. of patients

98) X-ray spectral lines Ka doublet arises from transition of electrons from: