Techno-Economic Feasibility Report on Manufacturing of Tablet Dosage Form

Thesis Submitted To

Dr. BABASAHEB AMBEDKAR MARATHWADA UNIVERSITY

In the partial fulfillment of requirement for the award of degree of MASTER OF TECHNOLOGY In [DRUGS AND PHARMACEUTICALS] By Mr. DULAL MAHAVIR MOHATO Under the guidance of Dr. P. S. WAKTE Reader

ISO 9001-2008 Certified

DEPARTMENT OF CHEMICAL TECHNOLOGY, Dr. BABASAHEB AMBEDKAR MARATHWADA UNIVERSITY, AURANGABAD-431004. 2011

Dr. Babasaheb Ambedkar Marathwada University, Aurangabad

NAAC Accredited B+

Department of Chemical Technology

ISO 9001:2008 Certified Faculty of Engineering & Technology University Campus, Aurangabad.

CERTIFICATE

This is to certify that the thesis entitled Techno-Economic Feasibility Report on Manufacturing of Tablet Dosage Form by Mr. DULAL MAHAVIR MOHATO, was satisfactorily carried out under my overall supervision and guidance at the Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad in the partial fulfillment of the requirement for the Master of Technology (Chemical) [Drugs & Pharmaceuticals].

Place: Aurangabad Date:

Dr. P. S. Wakte (Reader)

Dr. Babasaheb Ambedkar Marathwada University, Aurangabad

NAAC Accredited B+

Department of Chemical Technology

ISO 9001:2008 Certified Faculty of Engineering & Technology University Campus, Aurangabad.

CERTIFICATE

This is to certify that the thesis entitled Techno-Economic Feasibility Report on Manufacturing of Tablet Dosage Form is a bonafide work of Mr. DULAL MAHAVIR MOHATO submitted to the Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad in the partial fulfillment of the requirement for the Master of Technology (Chemical) [Drugs & Pharmaceuticals].

Place: Aurangabad Date:

Dr. Devanand B. Shinde Professor and Head

Dr. Babasaheb Ambedkar Marathwada University, Aurangabad

NAAC Accredited B+

Department of Chemical Technology

ISO 9001:2008 Certified Faculty of Engineering & Technology University Campus, Aurangabad.

CANDIDATES DECLARATION

I submit this thesis entitled Techno-Economic Feasibility Report on Manufacturing of Tablet Dosage Form in partial fulfillment for the Master of Technology (Chemical) [Drugs & Pharmaceuticals] to Dr. Babasaheb Ambedkar Marathwada University, Aurangabad. I hereby declare that the project or part thereof has not been previously submitted by me.

Place: Aurangabad. Date:

Mr. DULAL M. MOHATO

ACKNOWLEDGEMENT
I take this opportunity with much pleasure to thank all the people who have helped me through the course of my journey towards producing this thesis. I express my deep sense of gratitude and thanks to Dr. D. B. Shinde, Professor & Head, Department of Chemical Technology, who allowed me to use all the facilities of the department and for arranging Industrial visit at M/s Wockhardt Biotech Limited, Aurangabad. He also supported me like a pillar for constant inspiration. It is a great pleasure and moment of satisfaction for me to express deep sense of gratitude towards Dr. P. S. Wakte, Reader, Department of Chemical Technology, and my project guide for his continuous encouragement and guidance in making my project successful. My sincere thanks to Mr. Vinay Lomte, Associate Professor, Department of Chemical Technology for guidance and arranging Industrial visit at M/s Wockhardt Biotech Limited, Aurangabad. I would like to express my heart-felt thanks to my colleagues Mr. A. L. Kharat, Mr. C. R. Gadekar, Mr. M. D. Deoraye and my Senior Mr. R. R. Ratha, Mr. S. P. Deshmukh for their assistance, criticisms, useful insights, encouragement and compassion. I gratefully acknowledge M/s Wockhardt Limited, Aurangabad for giving permission to visit different Departments in the premises. Finally, this thesis would not have been possible without the confidence, endurance and support of my family. My family has always been a source of inspiration and encouragement. I wish to thank my parents, Shri M. R. Mohato and Smt. R. Devi, whose love, teachings and support have brought me this far.

DULAL M. MOHATO

CONTENTS
Sr. No 1. Introduction Tablet Selected Pharmacotherapy Division Selected drugs for manufacturing Drug information Commercial and Pharmaceutical Importance 2. 3. 4. Objectives Market Survey Technology Development Manufacturing formula List of raw materials List of equipments and machinery Suppliers of raw materials 5. Technical Aspects Plant location Building and facilities Various departments Layout design 6. 7. 8. Economic Aspects Conclusion References 58 60 67 82 115 131 132 42 51 52 53 4 9 12 12 21 25 26 Name of chapter Page No.