Product Information

S1550 Pimobendan
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 334.37 C19H18N4O2 Unknown 99% at -20 2 years 74150-27-9 Synonyms:

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Biological Activity
Pimobendan(Vetmedin) is a Ca(2+) sensitizer with an IC50 of 26 M and a selective phosphodiesterase III inhibitor with an IC50 of <1 M.[1] The inhibitory effects of pimobendan on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. Pimobendan decreased the catecholamine secretion (IC(50)=29.5 M) elicited by carbachol, an agonist at nicotinic acetylcholine receptors, but not that elicited by veratridine, an activator of voltage-dependent Na(+) channels, or by high K(+), an activator of voltage-dependent Ca(2+) channels. Pimobendan also inhibited carbachol-induced influx of Na(+) (IC(50)=25.9 M) and Ca(2+) (IC(50)=26.0 M), but not veratridine-induced Na(+) influx or high K(+)-induced Ca(2+) influx. [2]

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References
[1] http://en.wikipedia.org/wiki/Pimobendan [2] Toyohira Y et al. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371(2):107-13

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

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