Storlllzson of blorcsctor

stodlz6onis lhl pl@E. ct 6nd.ini |net dabtc e condt.i \^itchh tot6[, r,svotd ot tlvtng mldooqanl3ms. anabsotdr tt 16 condi a^d, prrcric,lt ontdorlrltchts o. in b .pprcrched tems o! achiovin! a@eprebt6 in an probabllirythdab3.n6 o, vtabte ot oEenisms.rn6 In conbn bior6acrJr ot design, sroritizauontheeapplicslions: has Pr6sre.iliation qlipn.nrs ol lvaintenane stedte ot ope.aung condtuons h rhy, lhb mrnsthat having mued rh6l atl eaD|eolganbms .bsent is ar .e6ssary ro prevent enlly or Mrnja0 infedtnsnicoorgan'sms dudng the onti.e ! i-' peiod planiopeEtion. or
Sieiliz.lion en be adievsd by:

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and dairy,blolochnology phtm.cou cal indusldos olhor b6n6lit3ol a *l! d3sl9n6d and CtP plgnl Inchd6s:opodtot s.l6ty (op66lou 6|0 nol Gqullld L 'nt" lenls to voBsots cl.!n ft6m and potsnt cLlni.g mr|6d.h do not n6d lo bo h.ndlod bv oDto!s),and do\4.lin6 (f .nv) b.teen producl runs / trcduct chdng.owr ls

ls obviolslv dnd ol rhe rechnology CIP(Cleaninsrn-Pla@) SIP(sleili:alon_rn_Place) nutdedil imporrad to many indusl.ies including food dairv beveEge dre In he'llh andpeGonal indusl'ies whlch phamaediel cosmellc biotechnolosy place a hygie^ic oraseplic eftnonmenl in must thepocessing take

lClPl Cleaninq.ln_Place
6uda@s pipes vessels' ol the of ctP tcloanln+lac6) k a melhod cleaning inle,jor up disassemblv to the 1950s' ffiings wilhout and p@5s equipment a$ciated ol manuallv- advenl clP Ms a The 5nd Ere disassembled cleaned dosedsystems sine the of lcquenlIntm.lcleaninq beir prolEsses boon[o indusfi;sthatneoded sFtemswiltrprogmMblo loqic tulli auionated CIP 1e5os, ha;;iwd lt' includs data @ntolle6,rnulip6 bltln; bnks.seNo.s,valvesneaterchangers acquisilion opeBt\td 6vslns clP spiry andspe.i.l9 des-Eoed tozle syslemsslmple manually ' n 6!rrbeloLiidh G;6irlt ' "
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lnd6tries' s or pro'ess in used all ror'cbailt|g in Pli.' andls widelv clP stands u:d rhat r ha3b6ndeEloped.rMii-Equ:Em6or po$ lrdctrvtalllg T etroentbio gainmdimum@d beoftsclP @!B s Etie9 ol m* ln &e fooderd r6m Esse\ andPlpe errpos h to imov lolids.id bededa

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': la1|. panl tor clea'ings Lne consLming where and piD@ss Thtaskof Abmtntlind f al it eniryE @qulted, bemB dangercus lt wee feaslble all ClP allo6 pr@ss denl p.oss runswilhoutthe requlemerlto dismantle btween and lrDewotk b cleaned lo or or entertie quiphontlt @n be 6nied olt with.Lromaled nanlal syslens5ndis a specialv regulations rriable reptable pocssthat meelsthe.l ngenlhygiene and prevalenl lhe lood,ddnkandphamaeutlEl IndGtn6. ln

ot Thonalonry cl6anin9 3rorlti:ing .nd tiqutds in ctp sysrems atrati .crd uoed sr6 or and ba66d !h6clP svdemw t altow accursto do6in9 lhs conconkdtod o, ct6rntno agont, y nonna hto wat.r to grt6a tos.tBngth sotuuor.u torcbEntng lbto proc5s Dtanl ls used htn ptanl ctasn i, nsqssary This sotutionth6n w lho to snd g.nl'e ihesyslem onor lhene{ oroduclion b tun

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BenetilsofCleanlnoln Plac6lclpl
Cloa.lDol. Placehashrny bengitsto lh6 enduser.soineoflrE hain Easons tor ihplementi.gCleanlrOh Pl&o ,|el

operatoB norequied to e.rerplenr .ieanir afe - Salety to en - Dffclll lo ecess a.eas b. ct66ned pFdudrunsis mr,tnised doln lihe bed,n - PEduclion clsts luGtanltatiy Erycting - Cleaning canberduced by creanng conslnplion Educed clearing is as - Water crctes dlsqnedro are system befutyulcma.bd cln -fte deening tholEf@reduchg Ebour cquiernenls Aulornaled .y6tem!.an gtw Euq.shted r6peEbbt6 CIP 6nd quahysssu.sne Fnled snd ctp rr:itraiaroqgins quarny - A,rldnated EFrerslan FoJide ror assuane m.rMd. & nornod behsndrod ope..roE ro Dy :@::us l4irn: or - Uso cleantng mteEts is horoefiocnty conrotred ueing Ctp3ysren s

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i6 clean @mdel6llis lh6nnolrnelio the When dele'oenl l. cycl complelo rheclsanhg

lank thon ls solutlDn nrade{rp ln an oxlsmal lvs|onrlho ln s te i!-.ul.tion 'loenln{l and up lo thoplanllo bs closnedll b rcclrculaled toPp6d as lEquldunlil int6dLrcod

detelsisbulEquG graler & 6vsbn! Jselesswaler clean'ng tnoen4l Ec.rculairon due Fav be unsuil'btd lo do$ @nlsmin'on capUrou ayana,n"ote crromsta'@s ll requied @idjate 6as for th66 tvpes fton one Prcess lo anothor'we @n polenli'l @3t savinssand pav back @frparcdto .n xislingsvstemto demonsrat6

Svsten Desldn
. ' ro, a Cl'lnlns In PbcoststenIs'lh6r"danln! a*'t" t*,* -*ri"ram cal :r EqulEme'rd ch pDcs* vossr' F.cloBrob@nsldsed l"il'fr*:E"
tlrn6 lne lvp cleanrng roquled lhq avsllable the odtsB ves.lsi .!and;d or cl6ening c ' 6 - 6 ' u s6 d --" "ol cleanlns medium .nd wnotlEr rsclo!-d d e t e s n t : *,1 ' " t" deanr'shesdscan De!6roc1ed ''l ih6:'fsilirim;d" vMlhthis Inronna{on lhe fioii;n& &uld
to m'tc$ descdbedsbN Thi. then do$ pumpslo DeseEc{ed oe'ng Lseo The modulosEe 'nd lor the head5and lhe type ol ceaning nalenal 'iiromalan th! lrcm el@ aled be also @nfiguEfon c5n

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ClernlnoIn placesvgtem An erampleof a throo.tenk

tanks,whicha mounbdIn d 6taintos!.toot band,Tho tsnks Thsr6aro threoholding a ala nonnslly bulk@usticiaok,dillr6 doreqontrsn| andtish tvoloftank.Thoopadty acco.ding tho inlriatsystemroqutcmonrs to of 6aolrtankis slculslod d6sc bodabove t. lho casol the burkdeanlnorhuid rankrh6cuftomermayatso6p.city tho tanrr.iza quanrities. cbanlngliquidis nomIy dlivEd a to 6uttoprimundelivery Au|k to point oubide the p@ss ptant and puinpedro rh6 sror.ge tank by ihe connecfion defverywhicr.Heating be Epecitied the but| ctsa.ing tiquidtahkdependjng cn fo. on p.ope.lies or the clean'ngagenr lagging and ctaddingcn atso be ,itrd tor ilr. neroy emcie.cylmprord

I I

The bnlkcleaning liquidaspumpd rhe dereqe.l tank beloreach cteaning b 6yct alon! withwaterlo maksup 3 batct of dele|lent,The deterggntls nom.lty more ofoclivat a higher temperatue. lhi. is rhecasett murd rhe. be pumped lI though a plrr6 he.r ;xchengs io bd t to Ine reqlird temperatlro. Theglriem shoM allo$ tnedere|ged bo lsddtai.d lhirjgh th. hear lo ordEnger udll lt rBach* theoptimum temp.fatue. hetexchdgerhbutdbcdsiqned suir. ' The lo thlempeEtule l. a r6ciutalion6y!tem. dop

'1 otihecteaning deteqenr noftnalyGrared porc"nr"q" is o" , ..,,1:l!ii'.en$h otrhe!"anlns i" (usuauy garer). thenajor8 or cas6 $rs is betw.n , and, , .. lgent b6hgused wilh h
ae pumpshm rn rheaias;; br a . ) " ,,:rr S{.Dah. r,Eqods a) udry a posine drsctraEe ., toalc'Iaid andb) usiig a condudivty tm prcbato Ead rhe;rrensflioi rh6daersc,jt, . * ,_ wih alkatis, acids). 6nducrjvi9p6be iE tored rn m.; . ., I (!hi6ir onlyeffedive nor The --; line, , recidlalion/scsEnge.
. $/hen Ihe dete.gen! eady tor B! the pbces w*el ro b cteaned seteridand . . ls ts will , rne Gysreh run thrcuqha cleanlnootrte. A prB.jn6. w t b6 clnied out tiEt uslng ... srl6. frcn he nnsewaterrank.The deteEentwil lhen b cyded throuohthe loess 6yBlm bero beingetumd to lho dereEont tank A tina,dBe w'[ lhen be ca4iedout by.vorume. ths are vaddusmelhodsot achieving requiEdsir.ngth but tho . rh. , . 1,0% .,

again udngwler hon thedn* waler lank.

c.n eqelcdonl3thl! d6tOonl thonb.6_o!od b{lk cloanirr! on.uslomor Oolondif,g to the thuld b.lns adlod a3 no@ssarv malnloin roquiEdcl.anins d.onclh bv w! or lho h condudivitv Pobo ll mry b. ufldosnabb sohd 63$ lo @s0 pFvtoudymbdlonod Panol $e proesl 6ttl6m dueio crosr contamln.llonll lhl! wo.o do!6rlontIn snothr rh6 c.se tho debrge.l u/ouldb6 dumpodto d.ain alid !s6 ll n F not prsclicallo dirchd!6 lho dsts'!nl to d6in 6Gtn alksli/acldthsn m dn m3lalra 5v{0m to

lsed to cle8n .umberot ves$ls the. lo !'feglard lhe a Is the clP system being lo ve$els/planlnol beingclanedit iB ncessary havea safe valveor sidil'r svslem The doublese.i (bod and bleed)v.lves 6hownh'e a chaftber belweentlvo v'lvD seats.\,!henrhe val is openlhuid w nowthrough\ryhenil is cl6ed the chamb" ihe betw6on !t{o Ne seats has an oPn pan so ihel anv cleaningliquld passing al and thoulh lhe inlel 66iwi[ ddln out ol the chember c.mt eu6o contaminatio. lh6 oulletsideol lhs lve of lhat Anolhrnerhodof ensunng thetbis no @nlamin.tion olher pioess li.es dldng is oleening to ose a seing bendtl platesy.tm wtre d dired connodlonls nad Leding the pocess plantto b clned, Prolimitv ftrln tls CIP &ed .lo lh pipeline !r,ltcaEsnay be usedwftnth slvingbendlo eNu tharrhe cofiect patnb 6elected and befoe vel!sc.n botlend cle.ningdaded

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F.oces3Control'

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"i*' .iY or it",r"cesrhodosisn the ope.aro, "*n pocessbeinscleaned rhe@!lome6 and

lo opEuon The6nt@l or ct ;dn! ini lci iFreos en varvtrcn eimpbmanuel

rvrry rnracaeo crb.orrif!ftuiluct

eii co.ltrclsvste'n v#';ffir;; @uments. 'ti

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theE aB a rietv ol difeen(.PEv dvi6s on dependant . vadet ol taclo6 hduding c'Pilal lvpandsoilrype 6Ptav chaningtime,!ss6l5i2e.

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Fl{d soriv a.ll! Fl,d lpraybalb16 lowcosr, marnronsncd. oporato lotuprEsurd tow They at (2 b.r) bul us. l 9hvolum$ol walor.Ctoanhgrnes,E long8ndra,Eoi6nds ro b,bout2 " 3 mal@s. These ltemshava tixedspreyprirelnanoaE notr6a[ysuir8blo when Ihc w3!l is badly 6oil6d hasmatedet or bakod on.
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'r L:i.ii..,.,r,., ii,ii";n briiiirni'n.iad r-.-erv.s".ra rTnes herd3a6 highgssue unik,hth di@tonatJ6ts ofie.ing deariaqr he3 t.sr nEn6r ep|tar,@sl3 6 invotvedbur tuIy Indexed coveEE; d bng ra.ge usnq tow vorums ol Eter 6nddelergonr compeB.te forthi. sitl

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somoot tho common3pEt patl6m3.vall.bl6. Bqul.6m6nts jn lhe caseol Laq. and indlvidual can of rheve6sel bo rvoidodir nocs$a.y

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Sterilization Place ln lSlP) lntroduction

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Wrn pbe6s equipmeit Eacl'e! comneroiaLkle pllpotion!, lhe sterilEalionot !ni6 by .ltodavinE beomes lmpEdical and 6omemoansol slrilizhg lrre essential in equlpmenl .n! is n6ded.Sudl Installelom,In oder to coftply $dlh.GMP, musl te and dEslgn,Insiarr.tion, opeEliohallyqualilid(oa. lo, and oq and ih GtedlEaton. to proco$ m6t b varidald. hee is a 6honinttDduclion th 6redliz.tlon In Pl.ce so,

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pEceduB. (slP) vaddauon : .- .:r.

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Oetailsof Sterillrrtion In PlacelslPla {ili r, . , I , i , ,r

wil A stedrtruon In Pl.co iP) {ndallEtlon u;ualv.omPd!. oneor more guar ar a roinenroi 'irio d 6inrlil,sat sep"cto' plMssng equipment.
by Piphg' hadesG,@n@cted dqidstaint*s slealor flenbleTeton@lined
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6teampBsure up 1o,sav 20 psi 6'd The indrhtion wll be capableof $lthstandino in temperalu.os lhe l2l' to 125'c Enge Thee sill bea 5uPplv ' ' sledlinng @iEspondins fd ot steao suhable ihe prce<lute,undorP5s!E contol and a "lrapp6d dEin al a _ .* ' 'l( lN Flnl on lh 8yBl.m,.Mlch llrll P,EE@nddeo mu bd mt sleatnTht'le ope{alio.of th. icralbtion *al be enlElled bv 6u1sbhs6l.ly valvesor "DuBld6ks" -

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Docltn qlrtificsllonot a stp instaltalon equ]E contimrton tE! !h. procesc sil plp6 qulpm6nl, md(, and 3toam.upptyoqllpm6ntm..t ploiot 6fclfica(oru ,or mare6ls6ndlor prAsuroandtemporrlue,6isrance.fton on mu{ b6 patdto tio qualily lho5team, ol tvtrich ttboLrsed. uslaflyman6 tho3l6am gor6rat6d This ftat b generator sream abo passa mtdljtt.r in s dodicatod 'cl6a;-sto.m" the may beroe

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o&e. d4ign sspecrsof the equipme,tinlended,or stp wil inctdo e.su,ins that l]lle stean en each a pads ot the equiphdntin conlactwith productand that ah is nol tppd in rheplart dudng6tditt rion.

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Finaly, rempratuF sensors besit\ed musl sfere theywil r6pr6entretiabty slateot the ih6 oquipmodunr/g ste.itiatoncyde. lhe hstattrtimqlafirrcalion a @tkesignedSlp systeheilt involve ot codi;hg lh6prope, insretbtion thepro.oss ot equiprnenr @ftect sld siriilsand@nncrions a[ pipo ror vyD.k, inclLding ensudng plqpr.ondensa!6 inat dEinage ocd/i ThestritirngcydoIs can . thenrur Sblm under pBssu.e p6sd ihrcuOh enur b ihe ,j/hflo hsrr0atio{ llowind rheescapodairthrough propdy p,aced !nA in |hepiplng onn eqrhftent o. Thse

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@ s 8re6!a[y prcte.ld.by staam4sistantb.clenlt tittes.

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coldnsalodt''n T16 oE66tFd rioll{6llo^ cYcllhoJh' |lt ot atr, and nar lh6 '' I atMvt vlcld !t'tl'6 Indl0'lo6

thils on the slam pEssum. hdicatod ismp6slu|d' tnd ithtmum md frs{mufi ' oxpoours me wlll b s6l ll sppropdale lho linal svldenoeol tht v'liditv ol th8 @lturEm6diun lhough th' 3ledlized p|ocati may be acnbv6dbt runnlng .bdE Uon a nulaclo ng pocess66andthonIncuballno la|! nuhber or of !d up ln lmitation th ms gmw{h@uG ot 6smpld3, thoe.ti6 balch to ensoE no bactodal m.1i6 wr"ch pass h any e!.1, ihe regular manlfaclue ot p.oduct balches Po or e.dobnn |eds anr poesslng in the stP pltnt nill @nli'm