Product Information

S1055 Enzastaurin
PKC

Novel Life Science Reagents

for Cell Signaling Research

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O NH N O N

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 515.61 C32H29N5O2 DMSO 99% at -20 2 years 170364-57-5

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Tech Support
N

tech@selleckchem.com
N

Synonyms: LY317615

(chemistry support)

techbio@selleckchem.com
(bio support)

Biological Activity
Enzastaurin induced marked dose-dependent growth inhibition in all MM cell lines investigated including MM.1S, MM.1R, RPMI 8226 (RPMI), RPMI-Dox40 (Dox40), NCI-H929, KMS-11, OPM-2, and U266.IC50 ranged from 0.6 to 1.6 M.[1] Enzastaurin has a direct effect on human tumor cells, inducing apoptosis and suppressing the proliferation of cultured tumor cells. Enzastaurin treatment also suppresses the phosphorylation of GSK3ser9, ribosomal protein S6S240/244, and AKTThr308.[2] Enz inhibited PKC and radiosensitized HDMEC with an enhancement ratio of 1.31 0.05. Enz combined with RT reduced HDMEC capillary sprouting to a greater extent than either agent alone. Enz prevented radiation-induced GSK3 phosphorylation of serine 9 while having no direct effect on VEGFR phosphorylation. Treatment of xenografts with Enz and radiation produced greater reductions in microvessel density than either treatment alone. The reduction in microvessel density corresponded with increased tumor growth delay. [3]

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Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

References
[1] Klaus Podar et al. Blood.2007 February 15;109(4):1669-1677 [2] Jeremy R. Graff et al. Cancer Res August 15, 2005 65:7462-7469 [3] Spalding AC et al. Translational Oncology.2008,1(4):195-201

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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