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PATHOPHYSIOLOGY

Predisposing -Geographical area tropical islands in the Pacific (Philippines) and Asia Precipitating -Environmental conditions (open spaces with water pots, and plants) -Immunocompromise -Mosquito carrying dengue virus -Soldier -Sweaty skin

Bite of a virus carrying aedes mosquito

Redness & itchiness in the area

Mosquito injects fluid to victim s skin Virus enters blood stream

Infects cell and generate cellular response Initiates immune response (stimulates release of cytokines)

Cytokines destroys cell membrane and cell wall (viral antigens found in monocytes)

Dengue infection

Fever

anorexia

hemorrhagic manifestations

hepatomegaly Increased vascular permeability Positive tourniquet test

thrombocytopenia

Hemoconcentration hypoproteinemia Pleural effusion

Leakage of plasma

Bleeding

(Dehydration) hypovolemia

shock

hypotension

(GI bleeding)

Anoxia

(Acidosis)
Intravascular

clot DEATH
Coagulation

defect

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