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Predisposing -Geographical area tropical islands in the Pacific (Philippines) and Asia Precipitating -Environmental conditions (open spaces with water pots, and plants) -Immunocompromise -Mosquito carrying dengue virus -Soldier -Sweaty skin
Infects cell and generate cellular response Initiates immune response (stimulates release of cytokines)
Cytokines destroys cell membrane and cell wall (viral antigens found in monocytes)
Dengue infection
Fever
anorexia
hemorrhagic manifestations
thrombocytopenia
Leakage of plasma
Bleeding
(Dehydration) hypovolemia
shock
hypotension
(GI bleeding)
Anoxia
(Acidosis)
Intravascular
clot DEATH
Coagulation
defect