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Product Information

S1105 LY 294002
PI3K

Novel Life Science Reagents


for Cell Signaling Research

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+1-713-796-9816

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 307.34 C19H17NO3 DMSO 99% at -20 2 years 154447-36-6
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Biological Activity
LY 294002 has been shown to be a potent inhibitor of PI 3-kinase activity, acting as a competitive inhibitor for ATP binding site of the enzyme. LY 294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells, the IC50 was observed about 10 M, a concentration higher than, but compatible with, the one (1.4 M) reported for in vitro inhibition of PI 3-kinase activity. [1] LY 294002 is also an inhibitor of casein kinase II. Application of LY 294002 causes a substantial acceleration of MEPP frequency (150 M) at the frog neuromuscular junction, through a mechanism that is independent of intraterminal calcium. LY 294002 causes the release of MEPPs through a perturbation of synaptotagmin function. [2]

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References
[1] Fabrice Casagrande et al. FEBS Letters. 1998 February 6;422(3):385-390 [2] Searl TJ et al. Purinergic Signal. 2005 Dec;1(4):389-94 [3] Zarzyska J, Motyl T. J Physiol Pharmacol. 2005 Jun;56(3):181-93

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA


Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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