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  • Causes and Effects of Cerebrovascular Disease

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    Terence Valdehueza
    5K просмотров2 страницы
    Cerebrovascular disease is caused by damage to blood vessels in the brain from hypertension. Hypertension damages the inner lining of blood vessels, exposing collagen that causes platelets to aggregate in an attempt to repair, but the repair is not always complete. Major risk factors include age over 48, male gender, hypertension, obesity, and a high-cholesterol diet. Blocked blood vessels can decrease blood flow and oxygen supply to the brain, stimulating mitochondria to produce lactic acid and lowering pH in an acidic, anaerobic environment. This decreases ATP production in neurons, impairing cellular function and death. Infarctions can occur in different areas of the brain, causing various neurological deficits depending on the location.

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    Оригинальное название

    Pathophysiology CVA

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    Cerebrovascular disease is caused by damage to blood vessels in the brain from hypertension. Hypertension damages the inner lining of blood vessels, exposing collagen that causes platelets to aggregate in an attempt to repair, but the repair is not always complete. Major risk factors include age over 48, male gender, hypertension, obesity, and a high-cholesterol diet. Blocked blood vessels can decrease blood flow and oxygen supply to the brain, stimulating mitochondria to produce lactic acid and lowering pH in an acidic, anaerobic environment. This decreases ATP production in neurons, impairing cellular function and death. Infarctions can occur in different areas of the brain, causing various neurological deficits depending on the location.

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    Attribution Non-Commercial (BY-NC)
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    5K просмотров2 страницы

    Causes and Effects of Cerebrovascular Disease

    Загружено:

    Terence Valdehueza
    Cerebrovascular disease is caused by damage to blood vessels in the brain from hypertension. Hypertension damages the inner lining of blood vessels, exposing collagen that causes platelets to aggregate in an attempt to repair, but the repair is not always complete. Major risk factors include age over 48, male gender, hypertension, obesity, and a high-cholesterol diet. Blocked blood vessels can decrease blood flow and oxygen supply to the brain, stimulating mitochondria to produce lactic acid and lowering pH in an acidic, anaerobic environment. This decreases ATP production in neurons, impairing cellular function and death. Infarctions can occur in different areas of the brain, causing various neurological deficits depending on the location.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате DOCX, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    из 2

    PATHOPHYSIOLOGY OF CEREBROVASCULAR DISEASE Definition: Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels supplying

    the brain. Hypertension is the most important cause; it damages the blood vessel lining, endothelium, exposing the underlying collagen where platelets aggregate to initiate a repairing process which is not always complete and perfect.

    PREDISPOSING FACTORS: - Age (48 years old) - Gender (Male)

    PRECIPITATING FACTORS: - Hypertension - Obese (BMI: 33.51) - Increased cholesterol in diet

    Obstruction of blood vessels

    Decreased cerebral blood flow

    Decreased O2 supply Stimulation of mitochondria Production of lactic acid Change in pH level (acidic) Anaerobic environment Decreased production of ATP by neurons Decreased depolarization Increase cellular death

    Infarction

    Medial aspect of one frontal lobe or both

    Lateral hemisphere and deeper structures of frontal, parietal and temporal

    Occipital lobe; anterior and medial portion of temporal lobe, thalamus involvement

    Cerebral penducle; cerebellum and brainstem

    Paralysis of foot/leg; impaired gait; problems in decision making or performing acts voluntarily; slowness of thought; urinary incontinence; cognitive and affective disorders

    Contralateral hemiplegia (face and arm); aphasia; homonymous hemianopsia; altered consciousness; left- right confusion

    Homonymous hemianopsia and other visual defects like color blindness; loss of central vision and visual hallucinations; memory deficits; loss of sensory modalities; spontaneous pain; aphasia

    Oculomotor nerve palsy; visual disturbance such as diplopia; dystaxia; vertigo; dysphagia

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