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  • Featured Product of Selleck - INO-1001 (Purity 99%)

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    Selleck Chem
    30 просмотров1 страница
    Technical Data: M.Wt: 136.15 Formula: C7H8N2O Solubility: DMSO Purity: >99% Storage: at -20℃ 2 years CAS No.: 3544-24-9 Biological Activity of INO-1001: INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties[1,2]. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5] References on INO-1001: [1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60 [2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1) [3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56 [4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23 [5] Szabó G et al. Shock. 2004 May;21(5):426-32

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    Featured Product of Selleck---INO-1001(Purity>99%)

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    Technical Data: M.Wt: 136.15 Formula: C7H8N2O Solubility: DMSO Purity: >99% Storage: at -20℃ 2 years CAS No.: 3544-24-9 Biological Activity of INO-1001: INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties[1,2]. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5] References on INO-1001: [1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60 [2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1) [3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56 [4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23 [5] Szabó G et al. Shock. 2004 May;21(5):426-32

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    30 просмотров1 страница

    Featured Product of Selleck - INO-1001 (Purity 99%)

    Загружено:

    Selleck Chem
    Technical Data: M.Wt: 136.15 Formula: C7H8N2O Solubility: DMSO Purity: >99% Storage: at -20℃ 2 years CAS No.: 3544-24-9 Biological Activity of INO-1001: INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties[1,2]. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5] References on INO-1001: [1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60 [2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1) [3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56 [4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23 [5] Szabó G et al. Shock. 2004 May;21(5):426-32

    Авторское право:

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    Скачайте в формате PDF, TXT или читайте онлайн в Scribd
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    Product Information

    S1132 INO-1001
    PARP

    Novel Life Science Reagents


    for Cell Signaling Research

    Toll Free:
    (877)796-6397
    -- USA and Canada only --

    Fax:
    +1-713-796-9816

    Technical Data:
    M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 136.15 C7H8N2O DMSO 99% at -20 2 years 3544-24-9 NH2 O NH2

    Orders
    +1-713-922-4115 enquiry@selleckchem.com

    Tech Support
    tech@selleckchem.com
    (chemistry support)

    techbio@selleckchem.com
    (bio support)

    Biological Activity
    INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties.[1,2] INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5]

    Web
    www.selleckchem.com

    Selleck Overnight Delivery Service

    References
    [1] [2] [3] [4] [5] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60 Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1) Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56 Tth O et al. Life Sci. 2006 Jun 20;79(4):317-23 Szab G et al. Shock. 2004 May;21(5):426-32

    Return Policy
    Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

    Goods ordered in error can only be accepted

    MSDS & CoA


    Please visit www.selleckchem.com to download MSDS and CoA.

    for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

    Notes
    PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
    Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

    be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

    For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

    Copyright 2010 Selleck chemicals.

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