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Product Information

S1200 Decitabine
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 228.21 C8H12N4O4 DMSO 99% at -20 2 years 2353-33-5

Novel Life Science Reagents


for Cell Signaling Research

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Synonyms: Dacogen,

5-aza-2'-deoxycytidine

(chemistry support)

techbio@selleckchem.com
(bio support)

Biological Activity
Decitabine(NSC 127716, Dacogen, DAC) is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines.[1] Decitabine(NSC 127716, Dacogen, DAC) was demonstrated to have a wide range of anti-metabolic activities when tested against cultured cancer cells and to be an effective chemotherapeutic agent for acute myelogenous leukemia. However, because of 5-azacytidine's general toxicity, other nucleoside analogs were favored as therapeutics. 5-azacytidine was incorporated into DNA and that, when present in DNA, it inhibited DNA methylation, led to widespread use of 5-azacytidine and Decitabine(NSC 127716, Dacogen, DAC) to demonstrate the correlation between loss of methylation in specific gene regions and activation of the associated genes. [2]

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References
[1] Caraglia M et al. Ann Oncol. 1994 Mar;5(3):269-76. [2] Christman JK. Oncogene. 2002 Aug 12;21(35):5483-95.

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA


Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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