Product Information

S1212 Bendamustine Hydrochloride

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 394.72 C16H21Cl2N3O2.HCl DMSO 99% at -20 2 years 3543-75-7
Cl N Cl O OH N N HCl

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Synonyms: Ribomustin,

Treanda, SDX-105

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Biological Activity
Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and lymphomas. It is also being studied for the treatment of sarcoma.[1] Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.[2] This agent inhibited SU-DHL-1 cell proliferation with IC50 at 50 m. [3]

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References
[1] http://en.wikipedia.org/wiki/Bendamustine [2] http://www.cancer.gov/drugdictionary/?CdrID=350251 [3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317

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MSDS & CoA

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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