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S E N S I E N T'M

The Complete FilmCoating System


Spectrablend" film coating system is the answer to your film coat-

This unique process agglomerates particles,resulting in a dust-free and free-flowingphysicalform Pre-hydration,another key property of Spectrablend", is invaluable in reducing preparation time. Spectrablend" is offered in both clear and colored formats. An alternative option is to pigment Spectrablend'. clear using a color dispersion.

ing problems. Sensient's patented process is proven to be faster and easier to use than competitive products. Spectrablend'" is the

complete film coating system - a prehydrated combination of polymer, plasticizer and pigment It offers the user substantial benefits when compared to other products of this type.

SPECTRABLEND'M CLEAR

Polymer + Plasticizer + Water

SpectrablendTM advantages
When comparing Spectrablend'" bined features of Spectrablend'. versatility of Spectrablend" to alternatives, Spectrablend" was shown to be the superior product in all properties studied. The comresult in easy handling and reduced processing time, thereby improving efficiency and reducing cost The

allows the use of a wide range of plasticizers, film formers and natural or synthetic colors. This offers flexibility

to meet specific customer requirements.

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Agglomerated particles
Dry granule

Free flowing Non-dusting


Rapid Hydration Microbial Stability

Lot-to-Lot Consistency

Reduced Processing Time Easy Handling


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SpectrablendTM Powder Properties


Particle SizeDistribution
The particlesize of Spectrablend'"is greaterwhen comparedto competition. hisnon-dusting T natureof Spectrablend'"esults an r in increased easeof handling.

Rapid Hydration
Spectrablend'"can be rapidlydispersed water. This resultsin in reducedprocessing times,therebyincreasing efficiency.

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Spectrablend'. Competitor Spectrablend'"

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HPMC

A 200gm powder sample was screened sequentially via Roto-Tap Automatic sieve for 10 minutes.

A 50gm powder sample was mixed at 700RPMin 450gm water. At time intervals indicated, a 10gm sample was drawn, filtered using no. 1 Wratten filler and evaporated to dryness ayer 3 hours at 1100 Cto determine percent solids.

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Tablet Coating Parameters


Spectrablend'M dispersionsretypicallymadeat 12-15%solids(w/w) a Tablets aretypicallycoatedto a 0.5-3%weightgain Typical tomizing pressure a air ranges from40-50PSI Typical ir velocityranges a 200-400 cu.ft./min. Inletair temperature istypically60-750C Exhaust ir temperature a istypically35-500C Typical anspeedis 6-20RPM p

(These typical coating parametersand are subjectto equipmentefficiency,tablet type and shape.) are

DispersionPreparation
1. Pourwater into suitable vessel
2. Createvortex in water 3. PourSpectrablend intovortex 4. Reducespeedand mix for 30 minutes or untillump-free 5. Dispersionis now ready for use.

The Complete Film Coating System


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Coating Properties
Moisture Vapor Transmission
Spectrablend'"films are lesspermeable water vaporthan the to
competition. hishelps protectthe activedrugfromdegradation. T to

Film Strength and Elongation


Spectrablend'"ilmsaresignificantly f stronger with greaterelasticity when compared the competition. to
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Spect"blend"

Competitor
Films

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Spectrablend"

Competitor

Filmsof the resultant dispersions were cast on glass, dried and tested for moistu re vapor transmission over a saturated NaClsolution.

using a Texture Technologies'

texture

analyzer

Accelerated Aging
Spectrablend'"films are morestablethan the competitionwhen challenged y hightemperature b andhighhumidity

Disintegration Time
The ability of Spectrablend'"to disintegrate faster increaseshe t efficiency drugdelivery. of

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Spect"blend"

Competitor

Spectrablend"

Competitor

Tablets exposed to 400 C and 7S% relative humidity

Disintegration test via USP(701).Bath temperature 370(. Simulated gastric fluid at pH 1.2.

Light Stability
Spectrablend'" films are more resistanto degradationby visible t lightthanthe competition. hishelps increase shelf-life the T to the of coatedtablet.

Tablet Appearance
Spectrablend'" producs consistentlyieldexcellentilm coatings. y f

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ICH light stability performed on tablets positioned 13" from a 2400 lux light source for 7 days. 4

Tablet on left represents a poorly adhered film coating. The tablet on the right, coated with Spectrablend, represents a well-coated tablet.

email: sensient-pharma@sensient-tech.com

Technical Support
Sensienr"Pharmaceutical echnologies perates ustomer ervice T o c s
and R&Dlaboratoriestaffedby highlyexperienced s technicaleams t that canadviseon application formulation,new productdevelopmentandgloballegislativeequirements. r Ourskilled technicians re a availableto assistn solvingwhatevercoatingand colorproblems i youmayencounter. Asthe leading globalmanufacturer high-purity, of regulated synthetic and naturalcolors,we havemuchto offer.Our technical ervice s isconfidential ndwe welcomeinquiries a from our customers.

World leader in colors and film formers


Sensienr" hasbeenthe world leaderin colorsfor over90 years.We havetakenour basiccolorknowledge andgrown into a leadingtablet
of markets. elyon us R coatingmanufacturero officesall overthe world, Sensienr" hasa broadknowledge the globalpharmaceutical With to find suitablecolorsandcoatings salveyourtabletcoatingneeds. to

Additional Products offered by SensienfM Pharmaceutical echnologies: T

Spectracol
Synthetic Oyes, akes L andPigments NaturalColors

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Spectracel - Hypromellose (HPMC)


SpectracylTM - AcrylicPolymers Colordispersions Additionalfilm coatingsystems

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The Complete Film Coating System

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