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Overview
Most new treatments are developed in clinical trials. Clinical trials are studies
that evaluate the effectiveness of new drugs or treatment strategies. The
development of more effective cancer treatments requires that new and innovative
therapies be evaluated with cancer patients. Participation in a clinical trial may
offer access to better treatments and advance the existing knowledge about
treatment of this cancer. Clinical trials are available for most stages of cancer.
Patients who are interested in participating in a clinical trial should discuss
the risks and benefits of clinical trials with their physician. To ensure that you
are receiving the optimal treatment of your cancer, it is important to stay
informed and follow the cancer news in order to learn about new treatments and the
results of clinical trials.
Patients diagnosed with stage IV rectal cancer have been perceived to have few
treatment options. Certain patients, however, can still be cured of their cancer
and others derive meaningful palliative benefit from additional treatment.
Patients with stage IV rectal cancer can be broadly divided into two groups: those
with cancer that is localized to a single site and those with more widespread
cancer.
Treatment of Non-Localized Stage IV Rectal Cancer
While some patients have a single site of cancer that can be treated with curative
intent, the majority of patients with stage IV rectal cancer have unresectable or
widespread cancer. Historically, these patients have been considered incurable and
were offered treatment with chemotherapy for the purpose of prolonging their
duration of survival and alleviating symptoms from progressive cancer.
A newer chemotherapy drug, Camptosar�, has been compared to the best supportive
care available in patients with colorectal cancer that no longer responded to
chemotherapy with 5-fluorouracil. In this direct comparison, patients receiving
Camptosar� treatment were 2.6 times more likely to be alive after one year of
treatment. This clinical study established Camptosar� as a standard treatment for
patients with colorectal cancer that had stopped responding to 5-FU.
More recently, French researchers assigned 387 previously untreated patients with
advanced colon or rectal cancer to receive either A) fluorouracil and calcium
folinate plus Camptosar� or B) fluorouracil and calcium folinate alone. The
results showed a response rate of 49% for patients receiving both Camptosar� and
fluorouracil, compared with 31% for patients receiving fluorouracil alone. The
time it took for the cancer to progress (begin growing again) was also more
delayed in patients receiving the Camptosar� (6.7 versus 4.4 months). The average
survival time was 17.4 months for patients receiving Camptosar� and fluorouracil,
compared with 14.1 months for those receiving fluorouracil alone. The Camptosar�
regimen had more side effects; however, all were manageable and reversible.
Rectal cancer may spread or metastasize to the liver, lung or other locations in
the body. When the site of metastasis is a single organ, such as the liver,
patients may benefit from local treatment directed at that single site of
metastasis.
The most common location of metastasis for patients with rectal cancer is the
liver. Highly selected patients with isolated areas of rectal cancer can be cured
if the primary cancer in the rectum and the isolated area of cancer outside the
rectum can be surgically removed. Several clinical trials have reported that
patients who have isolated areas of rectal cancer in the liver or lungs that is
surgically removed are cured in approximately 25% of circumstances. Surgical
removal of cancer can be accomplished with acceptable side effects in many
community cancer centers, with mortality rates of approximately 2%.
Liver-Directed Therapies
For patients with disease confined to the liver who are not surgical candidates,
several other liver-directed treatments approaches have been developed. The goal
of liver-directed therapies is to inject chemotherapy directly into the blood
supply of the liver, thereby delivering chemotherapy directly to the cancer and/or
to block the flow of blood to the liver to further "starve" the cancer cells by
preventing the necessary blood flow.
Hepatic Artery Infusion: Hepatic artery infusion has been the most widely
evaluated of the liver-directed treatment strategies. The most commonly used
chemotherapeutic agent infused into the hepatic artery is FUdR. A clinical study
in patients with cancer confined to the liver compared hepatic artery infusion
with FUdR to no additional treatment. The study demonstrated that patients treated
with hepatic artery infusion survived on average 13.5 months, compared to 7.5
months for patients who received no additional treatment.
Hepatic Artery Infusion and Systemic Chemotherapy: When rectal cancer has spread
to the liver, it is likely that cancer may exist elsewhere in the body; therefore,
many doctors have advocated giving systemic chemotherapy over hepatic artery
infusion chemotherapy directed exclusively to the cancer cells in the liver.
Several clinical studies have been performed in patients with cancer metastatic to
the liver that compare hepatic artery infusion with FUdR to treatment with
systemic 5-fluorouracil-based chemotherapy. An analysis of all of these trials
together has demonstrated that hepatic artery infusion produces a higher remission
rate than systemic chemotherapy; however, the average overall survival is not
significantly improved. Patients treated with hepatic artery infusion lived on
average 16 months, compared to 12 months for patients treated with systemic 5-
fluorouracil chemotherapy.
One clinical trial has compared the effectiveness of hepatic artery infusion plus
systemic infusion of chemotherapy versus systemic infusion chemotherapy alone.
Physicians randomly allocated 156 patients with colorectal cancer to two groups.
One group received 6 cycles of chemotherapy into the hepatic artery and systemic
chemotherapy, while the other group only received systemic chemotherapy. Two years
following treatment, 86% of patients who received the combination treatment with
HAI and systemic chemotherapy survived, compared to 72% of patients who received
systemic chemotherapy alone. The average survival was 72 months for patients who
received the combined treatment and 59 months for those who received systemic
chemotherapy treatment alone. Only 10% of patients receiving combined treatment
developed a cancer recurrence, compared to 60% of patients receiving the systemic
chemotherapy treatment alone. The combined therapy did not lead to an increased
treatment-related mortality.
In summary, for patients with rectal cancer isolated to the liver who are unable
to undergo surgical removal of the cancer, hepatic artery infusion improves
response rates and prolongs survival when compared to no treatment and may produce
a minor survival advantage compared to patients treated with systemic 5-
fluorouracil chemotherapy. In addition, the combination of HAI plus systemic
chemotherapy appears to offer improved responses compared to HAI or systemic
chemotherapy alone.
Strategies to Improve Treatment
While some progress has been made in the treatment of Stage IV rectal cancer, the
majority of patients still succumb to cancer and better treatment strategies are
clearly needed. Future progress in the treatment of rectal cancer will result from
continued participation in appropriate clinical trials. Currently, there are
several areas of active exploration aimed at improving the treatment of rectal
cancer.
Oral Chemotherapy Agents: Several new chemotherapy agents are being developed that
can be taken orally. The most common are the fluoropyramidines, which may provide
the same or greater benefit as intravenous 5-fluorouracil without requiring
intravenous administration.
Vascular endothelial growth factor (VEGF) plays a crucial role in the progression
of cancer by stimulating the new growth of blood vessels. In essence, VEGF
stimulates the body to provide a blood supply for a newly developing cancer.
Researchers have developed a type of antibody, a recombinant humanized monoclonal
antibody called rhuMAb VEGF, that inhibits the effects of VEGF in the body. This
monoclonal antibody has now been studied in patients with metastatic rectal
cancer.
RhuMAb VEGF and other anti-angiogenesis components are being evaluated alone or in
combination with chemotherapy.
Vaccines: One strategy for stimulating the immune system to attack cancer cells is
the use of vaccines. Cancer cells often display certain small proteins and/or
carbohydrates (antigens) on their surface that are not displayed by healthy cells.
Vaccines are often comprised of these specific antigens, which can be taken
directly from the patient�s cancer cells, other patient�s cells or produced in a
laboratory. If these antigens are injected into the patient, the immune system
recognizes them as �foreign� and will attack the cancer cells displaying the
antigens. Researchers are now evaluating various strategies to enhance the immune
response against the injected antigens, including combining the patient�s own
immune cells with the specific antigens in a laboratory prior to injection.