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elevated. In current usage, the word "hypertension"[1] without a qualifier normally refers to arterial hypertension. [2] Hypertension can be classified either essential (primary) or secondary. Essential hypertension indicates that no specific medical cause can be found to explain a patient's condition. Secondary hypertension indicates that the high blood pressure is a result of (i.e., secondary to) another condition, such as kidney disease or tumours (pheochromocytoma and paraganglioma). Persistent hypertension is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure. Even moderate elevation of arterial blood pressure leads to shortened life expectancy. At severely high pressures, defined as mean arterial pressures 50% or more above average, a person can expect to live no more than a few years unless appropriately treated.[3] In individuals older than 50 years, hypertension is considered to be present when a person's systolic blood pressure is consistently 140 mm Hg or greater. Beginning at a systolic pressure of 115 and diastolic pressure of 75 (commonly written as 115/75 mm Hg), cardiovascular disease (CVD) risk doubles for each increment of 20/10 mmHg.[4] Prehypertension is defined as blood pressure from 120/80 mm Hg to 139/89 mm Hg. Prehypertension is not a disease category; rather, it is a designation chosen to identify individuals at high risk of developing hypertension.[4] The Mayo Clinic specifies blood pressure is "normal if it's below 120/80".[5] Patients with blood pressures over 130/80 mm Hg along with Type 1 or Type 2 diabetes, or kidney disease require further treatment.[4] Resistant hypertension is defined as the failure to reduce BP to the appropriate level after taking a three-drug regimen.[4] The American Heart Association released guidelines for treating resistant hypertension.[6]
1.9 Secondary hypertension 1.9.1 Renal hypertension 1.9.2 Adrenal hypertension 1.9.3 Cushing's syndrome 1.9.4 Genetic 1.9.5 Coarctation of the aorta 1.9.6 Drugs 1.9.7 Rebound hypertension o 1.10 Pregnancy o 1.11 Children and adolescents 2 Pathophysiology 3 Diagnosis o 3.1 Measuring blood pressure o 3.2 Distinguishing primary vs. secondary hypertension o 3.3 Investigations commonly performed in newly diagnosed hypertension 4 Prevention 5 Drug-free Treatment of Hypertension o 5.1 Lifestyle modification (nonpharmacologic treatment) o 5.2 Investigational Implantable Device Treatment for Resistant Hypertension 6 Drug Treatment of Hypertension o 6.1 Choice of initial medication o 6.2 Advice in the United Kingdom o 6.3 Advice in the United States 7 Prognosis o 7.1 Complications 8 Epidemiology 9 History 10 See also 11 References 12 External links o 12.1 Major studies
[edit] Causes
Although no specific medical cause can be determined in essential hypertension, it often has several contributing factors. These include obesity[7], salt sensitivity, renin homeostasis, insulin resistance, genetics, and age.
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[edit] Obesity
The risk of hypertension is 5 times higher in the obese as compared to those of normal weight and up to two-thirds of cases can be attributed to excess weight. More than 85% of cases occur in those with a BMI>25.[7]
1 Causes o 1.1 Obesity o 1.2 Sodium sensitivity o 1.3 Role of renin o 1.4 Insulin resistance o 1.5 Sleep apnea o 1.6 Genetics o 1.7 Age o 1.8 Liquorice
increasing amounts of salt in a person's bloodstream causes cells to release water (due to osmotic pressure) to equilibrate concentration gradient of salt between the cells and the bloodstream; increasing the pressure on the blood vessel walls.
Hypertension is one of the most common complex disorders, with genetic heritability averaging 30%.[citation needed] Data supporting this view emerge from animal studies as well as in population studies in humans. Most of these studies support the concept that the inheritance is probably multifactorial or that a number of different genetic defects each have an elevated blood pressure as one of their phenotypic expressions. More than 50 genes have been examined in association studies with hypertension, and the number is constantly growing.
[edit] Age
Over time, the number of collagen fibers in artery and arteriole walls increases, making blood vessels stiffer. With the reduced elasticity comes a smaller cross-sectional area in systole, and so a raised mean arterial blood pressure.
[edit] Liquorice
Consumption of liquorice (which can be of potent strength in liquorice candy) can lead to a surge in blood pressure[11]. People with hypertension or history of cardio-vascular disease should avoid liquorice raising their blood pressure to risky levels. Frequently, if liquorice is the cause of the high blood pressure, a low blood level of potassium will also be present. Liquorice extracts are present in many medicines (for example cough syrups, throat lozenges and peptic ulcer treatments).
[edit] Genetics
Hypertension is a feature of a variety of adrenal cortical abnormalities. In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension. [edit] Cushing's syndrome
Medications commonly associated with rebound hypertension include centrally-acting antihypertensive agents, such as clonidine and betablockers.
[edit] Pregnancy
Main article: Hypertension of pregnancy Both adrenal glands can overproduce the hormone cortisol or it can arise in a benign or malignant tumor. Hypertension results from the interplay of several pathophysiological mechanisms regulating plasma volume, peripheral vascular resistance and cardiac output, all of which may be increased. More than 80% of patients with Cushing's syndrome have hypertension. In patients with pheochromocytoma increased secretion of catecholamines such as epinephrine and norepinephrine by a tumor (most often located in the adrenal medulla) causes excessive stimulation of adrenergic receptors, which results in peripheral vasoconstriction and cardiac stimulation. This diagnosis is confirmed by demonstrating increased urinary excretion of epinephrine and norepinephrine and/or their metabolites (vanillylmandelic acid). [edit] Genetic Hypertension can be caused by mutations in single genes, inherited on a mendelian basis.[12] [edit] Coarctation of the aorta The congenital abnormality aortic coarctation can result in hypertension. [edit] Drugs Certain medications, especially NSAIDs (Motrin/Ibuprofen) and steroids can cause hypertension. Licorice (Glycyrrhiza glabra) inhibits the 11-hydroxysteroid hydrogenase enzyme (catalyzes the reaction of cortisol to cortison) which allows cortisol to stimulate the Mineralocorticoid Receptor (MR) which will lead to effects similar to hyperaldosteronism, which itself is a cause of hypertension.[13] [edit] Rebound hypertension High blood pressure that is associated with the sudden withdrawal of various antihypertensive medications. The increases in blood pressure may result in blood pressures greater than when the medication was initiated. Depending on the severity of the increase in blood pressure, rebound hypertension may result in a hypertensive emergency. Rebound hypertension is avoided by gradually reducing the dose (also known as "dose tapering"), thereby giving the body enough time to adjust to reduction in dose. Although few women of childbearing age have high blood pressure, up to 10% develop hypertension of pregnancy. While generally benign, it may herald three complications of pregnancy: pre-eclampsia, HELLP syndrome and eclampsia. Follow-up and control with medication is therefore often necessary.
[edit] Pathophysiology
Most of the secondary mechanisms associated with hypertension are generally fully understood, and are outlined at secondary hypertension. However, those associated with essential (primary) hypertension are far less understood. What is known is that cardiac output is raised early in the disease course, with total peripheral resistance (TPR) normal; over time cardiac output drops to normal levels but TPR is increased. Three theories have been proposed to explain this:
Inability of the kidneys to excrete sodium, resulting in natriuretic factors such as Atrial Natriuretic Factor being secreted to promote salt excretion with the side-effect of raising total peripheral resistance. An overactive renin / angiotensin system leads to vasoconstriction and retention of sodium and water. The increase in blood volume leads to hypertension. An overactive sympathetic nervous system, leading to increased stress responses.
It is also known that hypertension is highly heritable and polygenic (caused by more than one gene) and a few candidate genes have been postulated in the etiology of this condition.[15][16][17]
measured in each arm, and the higher pressure arm preferred for subsequent measurements. BP varies with time of day, as may the effectiveness of treatment, and archetypes used to record the data should include the time taken. Analysis of this is rare at present. Automated machines are commonly used and reduce the variability in manually collected readings [19] . Routine measurements done in medical offices of patients with known hypertension may incorrectly diagnose 20% of patients with uncontrolled hypertension [20] Home blood pressure monitoring can provide a measurement of a person's blood pressure at different times throughout the day and in different environments, such as at home and at work. Home monitoring may assist in the diagnosis of high or low blood pressure. It may also be used to monitor the effects of medication or lifestyle changes taken to lower or regulate blood pressure levels. Home monitoring of blood pressure can also assist in the diagnosis of white coat hypertension. The American Heart Association[21] states, "You may have what's called 'white coat hypertension'; that means your blood pressure goes up when you're at the doctor's office. Monitoring at home will help you measure your true blood pressure and can provide your doctor with a log of blood pressure measurements over time. This is helpful in diagnosing and preventing potential health problems." Some home blood pressure monitoring devices also make use of blood pressure charting software.[22] These charting methods provide printouts for the patient's physician and reminders to take a blood pressure reading. However, a simple and cheap way is simply to manually record values with pen and paper, which can then be inspected by a doctor. Systolic hypertension is defined as an elevated systolic blood pressure. If systolic blood pressure is elevated with a normal diastolic blood pressure, it is called isolated systolic hypertension. Systolic hypertension may be due to reduced compliance of the aorta with increasing age[23].
[edit] Diagnosis
[edit] Measuring blood pressure
Main article: Blood pressure Diagnosis of hypertension is generally on the basis of a persistently high blood pressure. Usually this requires three separate measurements at least one week apart. Exceptionally, if the elevation is extreme, or end-organ damage is present then the diagnosis may be applied and treatment commenced immediately. Obtaining reliable blood pressure measurements relies on following several rules and understanding the many factors that influence blood pressure reading[18]. For instance, measurements in control of hypertension should be at least 1 hour after caffeine, 30 minutes after smoking or strenuous exercise and without any stress. Cuff size is also important. The bladder should encircle and cover two-thirds of the length of the (upper) arm. The patient should be sitting upright in a chair with both feet flat on the floor for a minimum of five minutes prior to taking a reading. The patient should not be on any adrenergic stimulants, such as those found in many cold medications. When taking manual measurements, the person taking the measurement should be careful to inflate the cuff suitably above anticipated systolic pressure. The person should inflate the cuff to 200 mmHg and then slowly release the air while palpating the radial pulse. After one minute, the cuff should be reinflated to 30 mmHg higher than the pressure at which the radial pulse was no longer palpable. A stethoscope should be placed lightly over the brachial artery. The cuff should be at the level of the heart and the cuff should be deflated at a rate of 2 to 3 mmHg/s. Systolic pressure is the pressure reading at the onset of the sounds described by Korotkoff (Phase one). Diastolic pressure is then recorded as the pressure at which the sounds disappear (K5) or sometimes the K4 point, where the sound is abruptly muffled. Two measurements should be made at least 5 minutes apart, and, if there is a discrepancy of more than 5 mmHg, a third reading should be done. The readings should then be averaged. An initial measurement should include both arms. In elderly patients who particularly when treated may show orthostatic hypotension, measuring lying sitting and standing BP may be useful. The BP should at some time have been
Over 91% of adult hypertension has no clear cause and is therefore called essential/primary hypertension. Often, it is part of the metabolic "syndrome X" in
patients with insulin resistance: it occurs in combination with diabetes mellitus (type 2), combined hyperlipidemia and central obesity. Secondary hypertension is more common in preadolescent children, with most cases caused by renal disease. Primary or essential hypertension is more common in adolescents and has multiple risk factors, including obesity and a family history of hypertension. [24]
genetics, race, age and gender are outside the realm of change. Modifiable factors include diet, weight-loss, exercise and stress management. Low-sodium and low-fat diets can reduce cardiovascular risks and keep arteries clear of plaque and blood volume at normal levels. Losing even 10% of body weight can have fantastic benefits towards health, including reversal or prevention of HTN, dropping systolic pressures several points. Exercise maintains a healthy heart, thus healthy cardiac contractions and functions. The heart is a muscle too, working out the cardiac muscles makes the heart beat more efficiently, thus pumping blood around the body more effectively. Stressors can negatively affect blood pressure by activating the sympathetic nervous system, thus fight or flight responses which increase heartrate and blood pressure. Chronic stress can lead to regular and frequent activation of the system and repeated high blood pressure. Effective management of stress can reduce this particular risk.
Creatinine (renal function) - to identify both underlying renal disease as a cause of hypertension and conversely hypertension causing onset of kidney damage. Also a baseline for later monitoring the possible side-effects of certain antihypertensive drugs. Electrolytes (sodium, potassium) Glucose - to identify diabetes mellitus Cholesterol
Testing of urine samples for proteinuria again to pick up underlying kidney disease or evidence of hypertensive renal damage. Electrocardiogram (EKG/ECG) - for evidence of the heart being under strain from working against a high blood pressure. Also may show resulting thickening of the heart muscle (left ventricular hypertrophy) or of the occurrence of previous silent cardiac disease (either subtle electrical conduction disruption or even a myocardial infarction). Chest X-ray - again for signs of cardiac enlargement or evidence of cardiac failure.
[edit] Prevention
Please help improve this section by expanding it. Further information might be found on the talk page. (September 2008) Prevention of hypertension only goes as far as the cause; one can adjust lifestyle related causes but
Weight reduction and regular aerobic exercise (e.g., jogging) are recommended as the first steps in treating mild to moderate hypertension. Regular mild exercise improves blood flow and helps to reduce resting heart rate and blood pressure. These steps are highly effective in reducing blood pressure, although drug therapy is still necessary for many patients with moderate or severe hypertension to bring their blood pressure down to a safe level. Reducing dietary sugar intake Reducing sodium (salt) in the diet may be effective: it decreases blood pressure in about 33 percent of people (see above). Many people choose to use a salt substitute to reduce their salt intake. Additional dietary changes beneficial to reducing blood pressure includes the DASH diet (dietary approaches to stop hypertension), which is rich in fruits and vegetables and low fat or fat-free dairy foods. This diet is shown effective based on research sponsored by the US National
Institutes of Health.[citation needed] In addition, an increase in daily calcium intake has the benefit of increasing dietary potassium, which theoretically can offset the effect of sodium and act on the kidney to decrease blood pressure. This has also been shown to be highly effective in reducing blood pressure. Discontinuing tobacco use and alcohol consumption has been shown to lower blood pressure. The exact mechanisms are not fully understood, but blood pressure (especially systolic) always transiently increases following alcohol and/or nicotine consumption. Besides, abstention from cigarette smoking is important for people with hypertension because it reduces the risk of many dangerous outcomes of hypertension, such as stroke and heart attack. Note that coffee drinking (caffeine ingestion) also increases blood pressure transiently, but does not produce chronic hypertension. Reducing stress, for example with relaxation therapy, such as meditation and other mindbody relaxation techniques, by reducing environmental stress such as high sound levels and over-illumination can be an additional method of ameliorating hypertension. Jacobson's Progressive Muscle Relaxation and biofeedback are also used,[25] particularly, device-guided paced breathing,[26][27] although meta-analysis suggests it is not effective unless combined with other relaxation techniques.[28]
Activation Therapy may be approved by the FDA and made commercially available as early as 2010.
ACE inhibitors such as creatine captopril, enalapril, fosinopril (Monopril), lisinopril (Zestril), quinapril, ramipril (Altace) Angiotensin II receptor antagonists: eg, telmisartan (Micardis, Pritor), irbesartan (Avapro), losartan (Cozaar), valsartan (Diovan), candesartan (Amias) Alpha blockers such as prazosin, or terazosin. Doxazosin has been shown to increase risk of heart failure, and to be less effective than a simple diuretic[31], so is not recommended. Beta blockers such as atenolol, labetalol, metoprolol (Lopressor, Toprol-XL), propranolol. Calcium channel blockers such as nifedipine (Adalat)[32] amlodipine (Norvasc), diltiazem, verapamil Direct renin inhibitors such as aliskiren (Tekturna) Diuretics: eg, bendroflumethiazide, chlortalidone, hydrochlorothiazide (also called HCTZ)
Combination products (which usually contain HCTZ and one other drug)
Choice of initial medication Unless the blood pressure is severely elevated, consensus guidelines call for medically-supervised lifestyle changes and observation before recommending initiation of drug therapy. All drug treatments have side effects, and while the evidence of benefit at higher blood pressures is overwhelming, drug trials to lower moderatelyelevated blood pressure have failed to reduce overall death rates. If lifestyle changes are ineffective or the presenting blood pressure is critical, then drug therapy is initiated, often requiring more than one agent to effective lower hypertension. Which type of many medications should be used initially for hypertension has been the subject of several large studies and various national guidelines. The ALLHAT study showed better costeffectiveness and slightly better outcomes for the thiazide diuretic chlortalidone compared with a calcium channel blocker and an ACE inhibitor in a 33,357-member ethnically mixed study group.[33] The 1993 consensus recommendation for use of thiazide diuretics as initial treatment stems in part from the ALLHAT study results, which concluded in 2002 that "Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive. They should be preferred for firststep antihypertensive therapy."[33] A subsequent smaller study (ANBP2) did not show the slight advantages in thiazide diuretic outcomes observed in the ALLHAT study, and actually showed slightly better outcomes for ACE-inhibitors in older white male patients.[34] Thiazide diuretics are effective, recommended as the best first-line drug for hypertension by many experts, and much more affordable than other therapies, yet they are not prescribed as often as some newer drugs. Arguably, this is partly because they are off-patent, less profitable, and thus rarely promoted by the drug industry.[35] The consensus recommendations of thiazide diuretics as first-line therapy for hypertension stand against a the backdrop that all blood pressure treatments have side-effects. Potentially serious side effects of the thiazide diuretics include hypercholesterinemia, and impaired glucose tolerance with consequent increased risk of developing Diabetes mellitus type 2. The thiazide diuretics also deplete circulating potassium unless combined with a potassium-sparing diuretic or supplemental potassium. On this basis, the consensus recommendations to prefer use of
thiazides as first line treatment for essential hypertension have been repeatedly and strongly questioned.[36][37][38] However as the Merck Manual of Geriatrics notes, "thiazide-type diuretics are especially safe and effective in the elderly."[39]
Prognosis
It is based upon several factors including genetics, dietary habits, and overall lifestyle choices. If an individual conscious of their condition takes the necessary preventative measures to lower their blood pressure, they are more likely to have a much better outcome than someone who does not.
Complications
While elevated blood pressure alone is not an illness, it often requires treatment due to its shortand long-term effects on many organs. The risk is increased for:
Cerebrovascular accident (CVAs or strokes) Myocardial infarction (heart attack) Hypertensive cardiomyopathy (heart failure due to chronically high blood pressure) Hypertensive retinopathy - damage to the retina Hypertensive nephropathy - chronic renal failure due to chronically high blood pressure Hypertensive encephalopathy - confusion, headache , convulsion due to vasogenic edema in brain due to high blood pressure.
Epidemiology
The level of blood pressure regarded as deleterious has been revised down during years of epidemiological studies. A widely quoted and important series of such studies is the Framingham Heart Study carried out in an American town: Framingham, Massachusetts. The results from Framingham and of similar work in Busselton, Western Australia have been widely applied. To the
extent that people are similar this seems reasonable, but there are known to be genetic variations in the most effective drugs for particular sub-populations. Recently (2004), the Framingham figures have been found to overestimate risks for the UK population considerably. The reasons are unclear. Nevertheless the Framingham work has been an important element of UK health policy.
Symptoms include:
Headache Seizure Chest pain Shortness of breath Swelling or edema (fluid buildup in the tissues)
History
Sushruta (6th century BCE) explained hypertension in a manner which matches the modern symptoms of the disease.[42]
Hypertensive Urgency
When blood pressure spikes, but there is no damage to the body's organs as a result and blood pressure can be brought down safely within a few hours with blood pressure medication this is referred to as hypertensive urgency.
Regular monitoring of blood pressure. Eye exam to look for swelling and bleeding. Blood and urine testing.
What's the Treatment for Hypertensive Emergency and Associated Organ Damage?
The first goal is to bring down the blood pressure as quickly as possible with intravenous (IV) blood pressure medications to prevent further organ damage. Whatever organ damage that has occurred is treated with therapies specific to the organ that is damaged. Reviewed by the doctors at The Cleveland Clinic Heart Center.
Hypertensive Emergency
When organ damage occurs as a result of severely elevated high blood pressure, this is considered a hypertensive emergency. When this occurs, blood pressure must be reduced immediately to prevent organ damage. This is done in an intensive care unit of a hospital. Organ damage associated with hypertensive emergency may include:
Changes in mental status such as confusion or coma (encephalopathy). Bleeding into the brain (stroke). Heart failure. Chest pain (angina). Fluid in the lungs (pulmonary edema). Heart attack. Aneurysm (Bulging blood vessel). Eclampsia (occurs during pregnancy).
Fortunately, hypertensive emergency is rare. When it does occur, it is often when hypertension goes untreated or if the patient does not take his or her medication.