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GENERIC NAME: cefadroxil TRADE NAME: Duricef MECHANISMS OF ACTION: Interferes with bacterial cell-wall synthesis causing cell to rupture and die CLINICAL USE IN YOUR PATIENT: For prevention of skin infections caused by staphylococci and streptococci due to patients surgical incision. DRUG CATEGORY: First-generation cephalosporin; Anti-infective

DOSAGE AND ROUTE: Usual Dose Range: 1 g/day P.O. or 500 mg P.O. q 12 hours Your Patients Dose: CONTRAINDICATIONS & ADVERSE REACTIONS: Hypersensitivity to cephalosporins or penicillins; chills, fever, superinfection, anaphylaxis CNS: headache, lethargy, paresthesia, syncope, seizures CV: hypotension, palpitations, chest pain, vasodilation EENT: hearing loss GI: nausea, vomiting, diarrhea, cramps, oral candidiasis, pseudomembranous colitis GU: vaginal candidiasis, nephrotoxicity Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression Hepatic: hepatic failure, hepatomegaly Musculoskeletal: arthralgia Respiratory: dyspnea Skin: urticaria, maculopapular or erythematous rash CLIENTS RESPONSE TO MEDICATION: NURSING IMPLICATIONS: Assess baseline CBC and kidney and liver function test results. Monitor for signs and symptoms of superinfection and other serious adverse reactions. Be aware that cross-sensitivity to penicillins may occur. With longterm therapy, obtain monthly Coombs test. REFERENCE: Dwyer Schull, P. (2009). Nursing spectrum drug handbook 2010 (5th ed.). New York: McGraw-Hill Professional. Deglin, J. H., & Vallerand, A. H. (2009). Daviss drug guide for nurses. (11th ed.). Philadelphia: F.A. Davis Company