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Immunotec Patents

For USA Distribution only


Dear Entrepreneur,

My distinguished colleagues and I have worked, what often seems


a lifetime, to accomplish our goal; To provide you, the Immunotec
Entrepreneur, with a product (documented by these patents)
which allow us all to experience a healthier future.

It is with great pride that I extend my heartiest wishes to you for a


healthy and successful future.

Best Regards,

Dr. Gustavo Bounous


Immunotec Medical Director
Immunotec US PATENT

U.S. Patent 5,230,902

A method of improving the active sys- enhanced resistance of target cells


temic humoral immune response in a against the mutagenic and carcinogenic
mammal as measured by sheep red effect of dimethlylhydrazine.
blood cell injection (SRBC), compris-
ing administering orally to the mammal A method of producing a sustained
an effective amount of undenatured increase of tissue concentration level
whey protein concentrate (WPC) of glutathione in a mammal, which
obtained from bovine, goat, or sheep comprises orally administering to the
milk and containing substantially all mammal an amount of undenatured
the whey protein present in the raw whey protein concentrate obtained
milk, administered as a daily replace- from bovine, goat, or sheep milk and
ment for up to all the protein consumed containing substantially all the whey
by the mammal, wherein the improved protein present in the raw milk as a
active systemic humoral immune daily replacement for up to all the
response is based on the overall amino protein consumed by the mammal,
acid and associated small peptides pat- wherein the sustained increase of the
tern resulting from the contribution of tissue concentration level of glu-
substantially all the WPC protein tathione in the mammal is based on the
components, the daily amount of WPC overall amino acid and associated
not substantially exceeding the daily small peptides pattern resulting from
protein requirement for the mammal. the contribution of substantially all the
WPC protein components, the daily
The method of claim 1, wherein the amount of WPC not substantially
improved active systemic humoral exceeding the daily protein requirement
immune response is associated with for the mammal.

United States Patent Patent Number: 5,230,902


Bounous et al. Date of Patent: July 27, 1993

UNDENATURED WHEY PROTEIN ABSTRACTS


CONCENTRATE TO IMPROVE
ACTIVE SYSTEMIC HUMORAL This invention provides a method of improving the humoral
immune response or increasing the concentration levels of
IMMUNE RESPONSE glutathione in mammals, which comprises administering
orally to a mammal a therapeutically or a prophylactically
Inventors: Gustavo Bounous et al. effective amount of undenatured whey protein concentrate
Montreal, Canada which has a biological activity based on the overall amino
acid and associated small peptides pattern resulting from
Assignee: Immunotec Research the contribution of all its protein components. A method for
Corporation, improving the humoral immune response in mammals also
is disclosed which comprises administering orally to a
Montreal, Canada mammal the combination of a vitamin supplement contain-
ing vitamin B2 in an amount in excess of minimum daily
requirements and an effective amount of undenatured whey
protein concentrate. This invention further provides a
dietary supplement for a mammal which comprises an
effective amount of Vitamin B1, and B2 and a therapeutically
or prophylactically effective amount of whey protein
supplement.
Immunotec US PATENT

U.S. Patent 5,290,571

A method of improving the immune response in


mammals as measured by sheep red blood cells
injection comprising administering orally to the
mammal an undenatured whey protein concentrate
obtained from bovine, goat, or sheep milk containing
substantially all the heat labile whey protein present
in the raw milk, the whey protein being present in an
amount sufficient to provide an amount of from
about 18 g to about 28 g of whey protein per 100 g of
composition, Vitamin B1 in an amount of at least 1.5
mg per 100 grams of composition, the Vitamin B1 and
Vitamin B2 being administered in amounts in excess
of minimum daily requirements.

United States Patent Patent Number: 5,290,571


Bounous et al. Date of Patent: Mar. 1, 1994

BIOLOGICALLY ACTIVE WHEY ABSTRACTS


PROTEIN CONCENTRATE
The present invention is concerned with a whey protein
composition comprising a suitable concentration of whey
Inventors: Gustavo Bounous et al. protein concentrate wherein the whey protein concentrate
Montreal, Canada contains proteins which are present in an essentially unde-
natured state and wherein the biological activity of the whey
Assignee: Immunotec Research protein concentrate is dependent on the overall amino acid
Corporation, and small peptides pattern resulting from the contribution of
Montreal, Canada all its proteins components and a method of producing said
whey protein composition. The invention also relates to
several applications of said composition.

The portion of the term of this patent subsequent to Jul. 27, 2010 has been disclaimed.
Immunotec US PATENT
U.S. Patent 5,451,412

A method of increasing the rate of therapeutically, or a prophylactically


synthesis, rate of replenishment, and effective amount of undenatured
concentration levels of glutathione whey protein concentrate containing
in animal organs, comprising the step substantially all the heat labile whey
of administering to an animal a protein present in milk.

United States Patent Patent Number: 5,451,412


Bounous et al. Date of Patent: Sept. 19, 1995

BIOLOGICALLY ACTIVE ABSTRACTS


UNDENATURED WHEY PROTEIN
CONCENTRATE AS FOOD The present invention is concerned with a whey protein
SUPPLEMENT composition comprising a suitable concentration of whey
protein concentrate wherein the whey protein concentrate
Inventors: Gustavo Bounous et al. contains proteins which are present in an essentially unde-
Montreal, Canada natured state and wherein the biological activity of the whey
protein concentrate is dependent on the overall amino acid
Assignee: Immunotec Research and small peptides pattern resulting from the contribution
Corporation, of all its protein components and a method of producing
Montreal, Canada said whey protein composition. The invention also relates to
several applications of said composition.
The portion of the term of this patent subsequent to Jul. 27, 2010 has been disclaimed.

U.S. Patent 5,456,924

A method of treating HIV-seropositive wherein the substantially undenatured


individuals so as to increase their whey protein concentrate comprises
blood mononuclear cell glutathione substantially all the heat labile whey
concentration and to maintain or protein contained in raw milk, in an
increase body weight which comprises amount effective to increase their
administering to HIV-seropositive blood mononuclear cell glutathione
individuals a substantially undena- concentration and maintain or
tured whey protein concentrate, increase body weight.

United States Patent Patent Number: 5,456,924


Bounous et al. Date of Patent: Oct. 10, 1995

METHOD OF TREATMENT OF ABSTRACTS


HIV-SEROPOSITIVE INDIVIDUALS
WITH DIETARY WHEY PROTEINS Undenatured whey protein concentrate is administered to
HIV-seropositive individuals to elevate their blood mononu-
clear cells, glutathione (GSH) level, body weight and sense
Inventors: Gustavo Bounous et al. of well being. In addition T-helper cells concentration and
Montreal, Canada their T-helper cells/T-suppressor cells ratio are slightly
elevated.
Assignee: Immunotec Research
Corporation,
Montreal, Canada

The portion of the term of this patent subsequent to Jul. 27, 2010 has been disclaimed.
Immunotec CANADIAN PATENT
Canadian Patent 1338682

A dietary supplement for a mammal cysteine thereby raising cell glu-


comprising a substantially undena- tathione content and improving
tured whey protein isolate mixture humoral immune response.
containing the bovine serum albumin,
alpha-lactalbumin and lactoferrin pro- Use of a whey protein composition for
teins, which are cystine rich, said improving the immune response in
bovine serum albumin and lactoferrin mammals, wherein the whey protein
also being rich in glutamyl cysteine, concentrate comprises a substantially
in an amount effective to replenish undenatured whey protein isolate
depleted cellular glutathione and mixture which is cystine rich and rich
enhance the immune response. in glutamyl cysteine, in an amount
effective to replenish depleted cellular
A whey protein concentrate compris- glutathione and enhance the immune
ing cystine to act as a precursor for response.
glutathione synthesis and including
heat labile protein components provid-
ing an amino acid and associated small
peptide pattern adapted significantly
to enhance the bioavailabality of the

Canadian Patent No.: 1338682

BIOLOGICALLY ACTIVE UNDENATURED


WHEY PROTEIN CONCENTRATE AS FOOD
SUPPLEMENT

Inventors: Gustavo Bounous et al.


Montreal, Canada

Assignee: Immunotec Research


Corporation,
Montreal, Canada
Printed in Canada