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thought), particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known astypical antipsychotics, was discovered in the 1950s. Most of the drugs in the second generation, known as atypical antipsychotics, have been developed more recently, although the first atypical antipsychotic, clozapine, was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's dopamine pathways, but antipsychotic drugs encompass a wide range of receptor targets. A number of harmful and undesired (adverse) effects have been observed, including lowered life expectancy, weight gain, decrease in brain volume, enlarged breasts and milk discharge in men and women (hyperprolactinaemia), lowered white blood cell count (agranulocytosis), involuntaryrepetitive body movements (tardive dyskinesia), diabetes, an inability to sit still or remain motionless (akathisia), sexual dysfunction, a return of psychosis requiring increasing the dosage due to cells producing more neurochemicals to compensate for the drugs (tardive psychosis), and a potential for permanent chemical dependence leading to psychosis much worse than before treatment began, if the drug dosage is ever lowered or stopped (tardive dysphrenia).
[citation needed]
Temporary withdrawal symptoms including insomnia, agitation, psychosis, and motor disorders may occur during dosage reduction of antipsychotics, and can be mistaken for a return of the underlying condition.
[2][3]
The development of new antipsychotics with fewer of these adverse effects and with greater relative effectiveness as compared to existing antipsychotics (efficacy), is an ongoing field of research.
Haldol
Pronunciation: HAL-oh-PER-i-dol Generic Name: Haloperidol Brand Name: Haldol Haldol is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Haldol is not approved to treat mental problems caused by dementia.
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you are allergic to any ingredient in Haldol you are in a coma, have Parkinson disease, or have severe central nervous system depression (eg, severe drowsiness, slow or shallow breathing) you have severely low levels of certain white blood cells (neutrophils) you are taking astemizole, dofetilide, dronedarone, nilotinib, propafenone, sodium oxybate (GHB), terfenadine, or tetrabenazine Contact your doctor or health care provider right away if any of these apply to you.
if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have the blood disease porphyria, low white blood cell levels, electrolyte problems (eg, low blood magnesium, low blood potassium), or high or low blood pressure if you have a history of dementia, Alzheimer disease, seizures, an abnormal electroencephalogram (EEG), thyroid problems, neuroleptic malignant syndrome (NMS), or low white blood cell levels caused by a medicine if you have heart problems or irregular heartbeat (eg, QT prolongation, long QT syndrome), or if a member of your family has a history of these conditions if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary), or if you are at risk of breast cancer if you are dehydrated, drink alcohol, or if you are regularly exposed to extreme heat Some MEDICINES MAY INTERACT with Haldol. Tell your health care provider if you are taking any other medicines, especially any of the following:
Antiarrhythmics (eg, amiodarone, disopyramide, dofetilide, dronedarone, flecainide, procainamide, quinidine, propafenone, sotalol), antipsychotics (eg, iloperidone, paliperidone, ziprasidone), arsenic, astemizole, bepridil, chloroquine, cisapride, dolasetron, domperidone, droperidol, halofantrine, ketolides (eg, telithromycin), kinase inhibitors (eg, lapatinib, nilotinib), macrolides (eg, erythromycin), maprotiline, methadone, phenothiazines (eg, thioridazine), pimozide, quinolone antibiotics (eg, levofloxacin, moxifloxacin), terfenadine, or tetrabenazine because the risk of serious heart-related side effects may be increased Lithium because the risk of unexpected toxic effects, including weakness, severe tiredness, confusion, or unusual muscle movements, may be increased Tramadol because the risk of seizures may be increased Anticholinergics (eg, benztropine) or carbamazepine because they may increase the risk of Haldol's side effects or decrease Haldol's effectiveness Azole antifungals (eg, itraconazole) because they may increase the risk of Haldol's side effects Rifampin because it may decrease Haldol's effectiveness Anticoagulants (eg, warfarin), narcotic pain medicines, or sodium oxybate (GHB) because their actions and the risk of their side effects may be increased by Haldol This may not be a complete list of all interactions that may occur. Ask your health care provider if Haldol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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Haldol is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Haldol at home, a health care provider will teach you how to use it. Be sure you understand how to use Haldol. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Do not use Haldol if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. If you miss a dose of Haldol, use it as soon as possible. Use the remaining doses for the day at evenly spaced intervals. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Haldol.
Haldol may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Haldol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do NOT drink alcohol while you are using Haldol. Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Haldol; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Do NOT use more than the recommended dose without checking with your doctor. Haldol may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Haldol. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Tell your doctor or dentist that you take Haldol before you receive any medical or dental care, emergency care, or surgery. NMS is a possibly fatal syndrome that can be caused by Haldol. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Some patients who take Haldol may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Haldol in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Haldol. Diabetes patients - Haldol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Haldol may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Haldol may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms. Haldol may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Lab tests, including complete blood cell counts, may be performed while you use Haldol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Haldol with caution in the ELDERLY; they may be more sensitive to its effects, especially uncontrolled muscle movements. Haldol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Haldol while you are pregnant. Using Haldol during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Haldol is found in breast milk. Do not breast-feed while taking Haldol.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; restlessness; stomach upset; trouble sleeping. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; confusion; dark urine; decreased sexual ability; decreased urination; dehydration; difficulty speaking or swallowing; drooling; enlarged breasts; excessive or unusual sweating; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mental or mood changes (eg, abnormal thinking, agitation, anxiety, depression); missed menstrual period or other menstrual changes; nipple discharge; prolonged, painful erection; rigid or stiff muscles; seizures; severe or persistent dizziness, headache, or vomiting; shuffling walk; uncontrolled muscle movements (eg, of the arms, legs, tongue, jaw, cheeks; tremors; twitching); yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA. See also: Haldol side effects (in more detail)
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If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; muscle rigidity, tremor, or weakness; rapid or irregular pulse; slow or shallow breathing; unusual drowsiness or deep sleep; very dry mouth. Proper storage of Haldol: Store Haldol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Haldol out of the reach of children and away from pets.
General information:
If you have any questions about Haldol, please talk with your doctor, pharmacist, or other health care provider. Haldol is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information is a summary only. It does not contain all information about Haldol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Compazine
Pronunciation: pro-klor-PURR-uh-zeen Generic Name: Prochlorperazine Brand Name: Generic only. No brands available.
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you are allergic to any ingredient in Compazine or similar medicines you are taking large amounts of central nervous system depressants (eg, alcohol, barbiturates, narcotics) you are taking astemizole, cisapride, or terfenadine you have severe central nervous system depression Contact your doctor or health care provider right away if any of these apply to you.
Treatments for depression are getting better everyday and there are things you can start doing right away.
if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart disease, central nervous system depression, blood problems, liver problems, low blood pressure, increased pressure in the eye, neuroleptic malignant syndrome, tardive dyskinesia, bone marrow problems, unusual muscle movements, Parkinson disease, a predisposition to glaucoma, Reye syndrome, prostate problems, or seizures, or you have alcoholism Some MEDICINES MAY INTERACT with Compazine. Tell your health care provider if you are taking any other medicines, especially any of the following:
Anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine) or lithium because they may decrease Compazine's effectiveness Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), general anesthetics (eg, thiopental), haloperidol, methyldopa, or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as seizures, may be increased ACE inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), astemizole, cisapride, dofetilide, haloperidol, hydantoins (eg, phenytoin), methyldopa, metrizamide, naltrexone, polypeptide antibiotics (eg, actinomycin), serotonin receptor antagonist antiemetics (eg, ondansetron), terfenadine, tramadol, trazodone, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Compazine Bromocriptine, guanethidine, levodopa, or pergolide because their effectiveness may be decreased by Compazine Lithium because unexpected toxic effects may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Compazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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Compazine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Compazine at home, a health care provider will teach you how to use it. Be sure you understand how to use Compazine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Do not use Compazine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. If you miss a dose of Compazine, contact your doctor for instructions. Ask your health care provider any questions you may have about how to use Compazine.
Compazine may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Compazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Compazine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Compazine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Tell your doctor or dentist that you take Compazine before you receive any medical or dental care, emergency care, or surgery. Compazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Compazine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Avoid exposure to extreme heat while taking Compazine.
Patients who will be having spinal cord surgery should stop using Compazine at least 48 hours before surgery. Do not use Compazine for at least 24 hours after surgery and do not use it to control nausea and vomiting that has occurred before or after surgery. Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Compazine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Use Compazine with caution in the ELDERLY; they may be more sensitive to its effects. Compazine should not be used in CHILDREN who are having surgery, who are younger than 2 years old, or who weigh less than 20 pounds; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Compazine while you are pregnant. Compazine is found in breast milk. If you are or will be breast-feeding while you use Compazine, check with your doctor. Discuss any possible risks to your baby.
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If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching. Proper storage of Compazine: Store Compazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Compazine, as well as syringes and needles, out of the reach of children and away from pets.
General information:
If you have any questions about Compazine, please talk with your doctor, pharmacist, or other health care provider. Compazine is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information is a summary only. It does not contain all information about Compazine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Thorazine
Pronunciation: klor-PRO-mah-zeen Generic Name: Chlorpromazine Brand Name: Thorazine
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Treating certain types of emotional, behavioral, or mental conditions. In addition, it may be used to control nausea, vomiting, or continuous hiccups, treat the blood disease porphyria, or to help to treat tetanus. It may also be used for other conditions as determined by your doctor. Thorazine is a phenothiazine. The exact way Thorazine works is not known.
you are allergic to any ingredient in Thorazine you have severe CNS depression (drowsiness leading to unconsciousness or coma) you are also taking cisapride, dofetilide, an H1 antagonist (eg, astemizole, terfenadine), 1A and 1C antiarrhythmics (eg, quinidine, flecainide), metrizamide, pimozide, a quinolone (eg, sparfloxacin), or ziprasidone Contact your doctor or health care provider right away if any of these apply to you.
if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart, lung, liver, or kidney problems; or a history of breast cancer if you have seizures, blood disease, low blood pressure, glaucoma, an enlarged prostate, or difficulty urinating if you have Parkinson disease, Reye syndrome, or alcoholism, or drink more than 3 alcoholcontaining drinks per day Some MEDICINES MAY INTERACT with Thorazine. Tell your health care provider if you are taking any other medicines, especially any of the following:
Anticholinergics (eg, benztropine) because they may decrease Thorazine's effectiveness Metrizamide because side effects, such as increased risk of seizures, may occur Arsenic, beta-adrenergic blockers (eg, propranolol), cisapride, dofetilide, droperidol, H1antagonists (eg, astemizole), haloperidol, IA and IC antiarrhythmics (eg, quinidine, flecainide), macrolide antibiotics (eg, azithromycin), ketolides (eg, telithromycin), meperidine, pimozide, quinolones (eg, sparfloxacin), streptogramins (eg, quinupristin), tricyclic antidepressants (eg, amitriptyline), or ziprasidone because side effects, such as rapid or
irregular heartbeat, low blood pressure, difficult or slow breathing, or drowsiness leading to coma, may occur Guanethidine, levodopa, pergolide, or warfarin because their effectiveness may be decreased by Thorazine Beta-blockers (eg, propranolol), epinephrine, or hydantoins (eg, phenytoin), because their actions and the risk of their side effects may be increased by Thorazine This may not be a complete list of all interactions that may occur. Ask your health care provider if Thorazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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Thorazine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Thorazine at home, a health care provider will teach you how to use it. Be sure you understand how to use Thorazine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Do not use Thorazine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. Thorazine may irritate skin. Avoid contact with skin or clothing. Wear rubber gloves while using Thorazine. Do not suddenly stop taking Thorazine. Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. If you miss a dose of Thorazine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Ask your health care provider any questions you may have about how to use Thorazine.
Thorazine may cause drowsiness, dizziness, blurred vision, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Thorazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Thorazine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Tell your doctor or dentist that you take Thorazine before you receive any medical or dental care, emergency care, or surgery. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Thorazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Thorazine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Some patients who take Thorazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Thorazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Thorazine. Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Thorazine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Use Thorazine with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood pressure and nerve-muscle reactions. Thorazine should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Thorazine while you are pregnant. Thorazine is found in breast milk. Do not breast-feed while using Thorazine.
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If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching. Proper storage of Thorazine: Store Thorazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Thorazine out of the reach of children and away from pets.
General information:
If you have any questions about Thorazine, please talk with your doctor, pharmacist, or other health care provider. Thorazine is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information is a summary only. It does not contain all information about Thorazine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider. Generic Name: fluphenazine (oral) (floo FEN a zeen) Brand Names: Permitil
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What is fluphenazine?
Fluphenazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-ohTHYE-a-zeens). It works by changing the actions of chemicals in your brain. Fluphenazine is used to treat psychotic disorders such as schizophrenia. Fluphenazine may also be used for other purposes not listed in this medication guide.
a history of seizures; Parkinson's disease; liver or kidney disease; severe asthma, emphysema, or other breathing problem; past or present breast cancer; adrenal gland tumor (pheochromocytoma); enlarged prostate or urination problems; low levels of calcium in your blood (hypocalcemia); glaucoma; or if you have ever had a serious side effect while using fluphenazine or any other phenothiazine. Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking fluphenazine. It is not known whether fluphenazine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Fluphenazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.
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doctor about how to avoid withdrawal symptoms when you stop using fluphenazine. Store fluphenazine at room temperature away from moisture, heat, and light. Do not allow liquid medicine to freeze. See also: Prolixin dosage (in more detail)
dizziness, drowsiness, anxiety; breast swelling or discharge; sleep problems (insomnia), strange dreams; blurred vision, headache; changes in your menstrual periods; impotence, trouble having an orgasm; weight gain, swelling in your hands or feet; dry mouth or a stuffy nose; constipation; or mild itching or skin rash. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088 . See also: Prolixin side effects (in more detail)
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atropine (Sal-Tropine, Atreza); lithium (Eskalith, Lithobid); an antibiotic; birth control pills or hormone replacement estrogens; blood pressure medication; a blood thinner such as warfarin (Coumadin); certain asthma medications or bronchodilators; incontinence medications; insulin or diabetes medications you take by mouth; medication for nausea, vomiting, or motion sickness; medications to treat or prevent malaria; medications used for general anesthesia; medicines used to prevent organ transplant rejection; numbing medicine such as lidocaine or Novocain; a stimulant or ADHD medication; ulcer or irritable bowel medications; or
medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma). This list is not complete and there are many other medicines that can interact with fluphenazine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. Generic Name: iloperidone (EYE loe PER i done) Brand Names: Fanapt
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What is Fanapt?
Fanapt (iloperidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain. Fanapt is used to treat schizophrenia. Fanapt may also be used for other purposes not listed in this medication guide.
Avoid drinking alcohol. It can increase some of the side effects of Fanapt. Stop using this medicine and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, restless muscle movements in your face or neck, tremor (uncontrolled shaking), trouble swallowing, or feeling like you might pass out. If you have stopped taking Fanapt for any reason, talk with your doctor before you start taking it again. You may need to restart the medication at a lower dose.
kidney or liver disease; a personal or family history of Long QT syndrome; seizures or epilepsy; heart disease, high blood pressure, heart rhythm problems; history of low white blood cell (WBC) counts; a history of heart attack or stroke; an electrolyte imbalance, such as low potassium or magnesium levels in your blood; a history of breast cancer; diabetes (Fanapt may raise your blood sugar); trouble swallowing; or a history of suicidal thoughts. FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Fanapt, do not stop taking it without your doctor's advice. It is not known whether iloperidone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking Fanapt. Older adults may be more likely to have side effects from this medicine. See also: Fanapt pregnancy and breastfeeding warnings (in more detail)
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your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of Fanapt. See also: Fanapt and alcohol (in more detail)
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very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out; twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; tremor (uncontrolled shaking); trouble swallowing; seizure (convulsions); urinating less than usual or not at all; fever, chills, body aches, flu symptoms; white patches or sores inside your mouth or in your lips; feeling like you might pass out; or penis erection that is painful or lasts 4 hours or longer. Less serious Fanapt side effects may include:
dizziness, drowsiness, tired feeling; dry mouth, stuffy nose, sore throat; nausea, diarrhea, upset stomach; joint pain; breast swelling or discharge; changes in menstrual periods; blurred vision; weight gain; or mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 . See also: Fanapt side effects (in more detail)
arsenic trioxide (Trisenox); droperidol (Inapsine); an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), ketoconazole (Nizoral), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), rifampin (Rifadin, Rimactane, Rifater); an antidepressant such as amitriptylline (Elavil, Vanatrip), clomipramine (Anafranil), desipramine (Norpramin), fluoxetine (Prozac, Sarafem), or paroxetine (Paxil); anti-malaria medications such as chloroquine (Arelan), mefloquine (Lariam), or halofantrine (Halfan); heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quinidex, Quin-Release Quin-G), or sotalol (Betapace); medicine to prevent or treat nausea and vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran); other medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon); migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose). This list is not complete and other drugs may interact with Fanapt. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doc Generic Name: perphenazine (per FEN a zeen) Brand Names: Trilafon
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Trilafon
Perphenazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-ohTHYE-a-zeens). It works by changing the actions of chemicals in your brain. Perphenazine is used to treat psychotic disorders such as schizophrenia. It is also used to control severe nausea and vomiting. Perphenazine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Trilafon (perphenazine)?
Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Perphenazine is not for use in psychotic conditions related to dementia. Perphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Do not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to perphenazine or other phenothiazines. Before you take perphenazine, tell your doctor if you have severe depression, heart disease or high blood pressure, liver or kidney disease, severe asthma or breathing problems, history of seizures, Parkinson's disease, past or present breast cancer, adrenal gland tumor, enlarged prostate or urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had serious side effects while using chlorpromazine or similar medicines. Before taking perphenazine, tell your doctor about all other medications you use.
What should I discuss with my healthcare provider before taking Trilafon (perphenazine)?
Perphenazine is not for use in psychotic conditions related to dementia. Perphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder (such as low platelets or low red or white blood cell counts), or if you are also using large amounts of alcohol or medicines that make you sleepy. You also should not use this medication if you are allergic to perphenazine or other phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil), prochlorperazine (Compazine, Compro), promethazine (Adgan, Pentazine, Phenergan), thioridazine (Mellaril), or trifluoperazine (Stelazine). If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take perphenazine, tell your doctor if you have:
severe or untreated depression; heart disease or high blood pressure; liver or kidney disease; severe asthma, emphysema, or other breathing problem; a history of seizures; Parkinson's disease;
past or present breast cancer; adrenal gland tumor (pheochromocytoma); enlarged prostate or urination problems; low levels of calcium in your blood (hypocalcemia); glaucoma; or if you have ever had a serious side effect while using perphenazine or another phenothiazine. Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking perphenazine. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking perphenazine, do not stop taking it without your doctor's advice. Perphenazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.
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dizziness, drowsiness, anxiety; blurred vision, headache; sleep problems (insomnia), strange dreams; constipation; dry mouth or stuffy nose; breast swelling or discharge; changes in your menstrual periods; weight gain, swelling in your hands or feet; impotence, trouble having an orgasm; or mild itching or skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088 . See also: Trilafon side effects (in more detail)
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atropine (Atreza, Sal-Tropine); lithium (Eskalith, Lithobid); gefitinib (Iressa), imatinib (Gleevec), or nilotinib (Tasigna); an antibiotic; birth control pills or hormone replacement estrogens; blood pressure medication; a blood thinner such as warfarin (Coumadin, Jantoven); certain asthma medications or bronchodilators; heart rhythm medication; HIV or AIDS medications; incontinence medications; insulin or diabetes medications you take by mouth; medication for nausea, vomiting, or motion sickness; medications to treat or prevent malaria; medications used for general anesthesia; medicines used to prevent organ transplant rejection; numbing medicine such as lidocaine or Novocain; a stimulant or ADHD medication; ulcer or irritable bowel medications; or medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma). This list is not complete and there are many other medicines that can interact with perphenazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
Navane
Pronunciation: THYE-oh-THIX-een Generic Name: Thiothixene Brand Name: Navane Navane is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Navane is not approved to treat mental problems caused by dementia.
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you are allergic to any ingredient in Navane you have blood disorders or bone marrow problems, or severe circulation problems (eg, circulatory collapse) you have severe drowsiness you are taking tramadol Contact your doctor or health care provider right away if any of these apply to you.
if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines (including phenothiazines), foods, or other substances
if you have a history of seizures, brain damage, brain tumors, breast cancer, blood disorders, lupus, liver problems, intestinal blockage, eye or vision problems (eg, glaucoma), dementia, Alzheimer disease, alcohol abuse, or depression if you have heart or blood vessel problems, Parkinson disease, or high or low blood pressure if you are regularly exposed to extreme heat if you have a history of alcohol abuse or if you drink more than 3 alcohol-containing drinks per day if you will be having a myelogram Some MEDICINES MAY INTERACT with Navane. Tell your health care provider if you are taking any other medicines, especially any of the following:
Medicines that may lower blood pressure because the risk of severe low blood pressure may occur Anticholinergics (eg, benztropine), antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), opiates (eg, codeine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Navane's side effects Carbamazepine because it may decrease Navane's effectiveness This may not be a complete list of all interactions that may occur. Ask your health care provider if Navane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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Take Navane by mouth with or without food. If you miss a dose of Navane, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Navane.
Navane may cause drowsiness, dizziness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Navane with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Navane; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Navane may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Navane may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Navane may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Navane. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Navane. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Some patients who take Navane may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Navane in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Navane. Tell your doctor or dentist that you take Navane before you receive any medical or dental care, emergency care, or surgery. Lab tests, including liver and kidney function and complete blood cell counts, may be performed while you use Navane. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Navane may cause false results in some pregnancy tests. Check with your doctor if you have any questions or concerns. Make sure your doctor and laboratory personnel know you are using Navane. Use Navane with caution in the ELDERLY; they may be more sensitive to its effects. Navane is not recommended for use in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Navane while you are pregnant. Using Navane during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. It is not known if Navane is found in breast milk. If you are or will be breast-feeding while you use Navane, check with your doctor. Discuss any possible risks to your baby.
Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; blurred vision or other vision changes; changes in breasts; changes in menstrual period; changes in sexual function; chest pain; confusion; difficulty speaking; difficulty swallowing; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; inability to move the eyes; inability to urinate; involuntary movements of the tongue, face, mouth, or jaw; lip smacking or puckering; mask-like face; mental confusion; muscle spasms of the face, neck, or back; numbness of the arms and legs; prolonged or painful erection; puffing of cheeks; restlessness; seizures; severe stomach pain; shuffling walk or stiff arms or legs; swelling of the arms or legs; tension in the leg; tightness in the throat or jaw; tremors of the hands; twitching or twisting movements; unusual or excessive sweating; weakness of the arms or legs; yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA. See also: Navane side effects (in more detail)
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If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; fast or irregular heartbeat; muscle spasms or stiffness; restlessness; seizures; tremors; twitching. Proper storage of Navane: Store Navane at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Navane out of the reach of children and away from pets.
General information:
If you have any questions about Navane, please talk with your doctor, pharmacist, or other health care provider.
Navane is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information is a summary only. It does not contain all information about Navane. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Pentothal
Pronunciation: thye-oh-PEN-tol Generic Name: Thiopental Brand Name: Pentothal
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Causing drowsiness or sleep before surgery or certain medical procedures. It is also used to stop seizures. It may also be used for other conditions as determined by your doctor. Pentothal is a barbiturate. It works by depressing the central nervous system, causing mild sedation or sleep, depending on the dose.
you are allergic to any ingredient in Pentothal you have the blood disease porphyria you are taking sodium oxybate (GHB) Contact your doctor or health care provider right away if any of these apply to you.
if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, lung or respiratory tract disease, heart problems, low blood pressure, adrenal gland problems (eg, Addison disease), asthma, myasthenia gravis, thyroid problems, or increased pressure in the brain if you have a history of substance abuse or dependence, depression, or suicidal thoughts or behavior Some MEDICINES MAY INTERACT with Pentothal. Tell your health care provider if you are taking any other medicines, especially any of the following:
Monoamine oxidase (MAO) inhibitors (eg, phenelzine), probenecid, or sodium oxybate (GHB) because side effects may be increased Aminophylline, beta-blockers (eg, atenolol), clozapine, corticosteroids (eg, prednisone), doxycycline, estrogens (eg, micronized estradiol), griseofulvin, metronidazole, narcotic pain medicine (eg, codeine), oral contraceptives (birth control pills), phenytoin, quinidine, theophylline, valproic acid, or zimelidine because their effectiveness may be reduced by Pentothal This may not be a complete list of all interactions that may occur. Ask your health care provider if Pentothal may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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Pentothal is usually administered as an injection at your doctor's office, hospital, or clinic. If Pentothal contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal. If you miss a dose of Pentothal, contact your doctor immediately. Ask your health care provider any questions you may have about how to use Pentothal.
Pentothal causes drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pentothal. Using Pentothal alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Pentothal. Pentothal will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. Pentothal may decrease the effectiveness of your birth control pill. To prevent pregnancy, be sure to use an additional form of birth control while using Pentothal. Use Pentothal with caution in the ELDERLY because they may be more sensitive to its effects, especially drowsiness, depression, or confusion. PREGNANCY and BREAST-FEEDING: Pentothal has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Pentothal during pregnancy. Pentothal is excreted in breast milk. If you are or will be breast-feeding while you are using Pentothal, check with your doctor or pharmacist to discuss the risks to your baby. When used for longer than a few weeks or at high doses, some people develop a need to continue taking Pentothal. This is known as DEPENDENCE or addiction.
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If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Proper storage of Pentothal: Pentothal is usually handled and stored by a health care provider. If you are using Pentothal at home, store Pentothal as directed by your pharmacist or health care provider.
General information:
If you have any questions about Pentothal, please talk with your doctor, pharmacist, or other health care provider. Pentothal is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information is a summary only. It does not contain all information about Pentothal. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Moban
Pronunciation: moe-LIN-done Generic Name: Molindone Brand Name: Moban Moban is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Moban is not approved to treat mental problems caused by dementia.
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you are allergic to any ingredient in Moban you have severe central nervous system depression (eg, severe drowsiness), are in a coma, or have been sedated you are taking sodium oxybate (GHB) Contact your doctor or health care provider right away if any of these apply to you.
if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of seizures, heart problems (eg, heart failure, slow or irregular heartbeat), abnormal electrocardiogram (ECG), heart attack, stroke, blood vessel problems, high or low blood pressure, or low white blood cell levels if you have a history of liver problems, stomach or bowel problems (eg, narrowing, blockage), neuroleptic malignant syndrome (NMS), suicidal thoughts or attempts, or alcohol abuse or dependence if you have Alzheimer disease, dementia, Parkinson disease, glaucoma, enlarged prostate, or urinary problems if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk for breast cancer if you are dehydrated, drink alcohol, or will be exposed to very high temperatures Some MEDICINES MAY INTERACT with Moban. Tell your health care provider if you are taking any other medicines, especially any of the following:
Barbiturates (eg, phenobarbital), narcotics (eg, codeine), or sodium oxybate (GHB) because the risk of side effects, such as severe drowsiness, may be increased Tramadol because the risk of seizures may be increased Hydantoins (eg, phenytoin) or tetracyclines (eg, doxycycline) because their effectiveness may be decreased by Moban This may not be a complete list of all interactions that may occur. Ask your health care provider if Moban may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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Take Moban by mouth with or without food. Taking Moban at the same time each day will help you remember to take it. Take Moban on a regular schedule to get the most benefit from it. Continue to take Moban even if you feel well. Do not miss any doses. If you miss a dose of Moban, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Moban.
Moban may cause drowsiness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Moban with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Moban; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Do NOT take more than the recommended dose without checking with your doctor. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Neuroleptic malignant syndrome is a possibly fatal syndrome that can be caused by Moban. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
Some patients who take Moban may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Moban in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Moban. Moban may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms. Moban may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Moban may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Lab tests, including complete blood cell counts, may be performed while you use Moban. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Moban with caution in the ELDERLY; they may be more sensitive to its effects, especially involuntary muscle movements. Moban should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Moban while you are pregnant. It is not known if Moban is found in breast milk. If you are or will be breast-feeding while you use Moban, check with your doctor. Discuss any possible risks to your baby.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA. See also: Moban side effects (in more detail)
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If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include involuntary, uncontrolled muscle movements; loss of consciousness; severe or persistent drowsiness. Proper storage of Moban: Store Moban at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Moban out of the reach of children and away from pets.
General information:
If you have any questions about Moban, please talk with your doctor, pharmacist, or other health care provider. Moban is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information is a summary only. It does not contain all information about Moban. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider. Drugs A to Z Pill Identifier Interactions Checker News & Alerts
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Permitil
Generic Name: fluphenazine (floo FEN a zeen) Brand Names: Permitil
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What is the most important information I should know about Permitil (fluphenazine)?
Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. Fluphenazine is not for use in psychotic conditions related to dementia. Fluphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use fluphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to fluphenazine or other phenothiazines. Before you take fluphenazine, tell your doctor if you have heart disease or high blood pressure, a history of seizures, Parkinson's disease, liver or kidney disease, severe asthma or breathing problem, past or present breast cancer, adrenal gland tumor, enlarged prostate, urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had a serious side effect while using fluphenazine or similar medicines. Before taking fluphenazine, tell your doctor about all other medications you use.
What should I discuss with my healthcare provider before taking Permitil (fluphenazine)?
Fluphenazine is not for use in psychotic conditions related to dementia. Fluphenazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use fluphenazine if you have liver disease, brain damage, bone marrow depression, or a blood cell disorder (such as low platelets or low red or white blood cell counts), or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to fluphenazine or other phenothiazines such as chlorpromazine (Thorazine), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Adgan, Pentazine, Phenergan), thioridazine (Mellaril), or trifluoperazine (Stelazine). To make sure you can safely take fluphenazine, tell your doctor if you have any of these other conditions:
heart disease or high blood pressure; a history of seizures or brain injury; Parkinson's disease; liver or kidney disease; severe asthma, emphysema, or other breathing problem; past or present breast cancer;
adrenal gland tumor (pheochromocytoma); enlarged prostate or urination problems; low levels of calcium in your blood (hypocalcemia); glaucoma; or if you have ever had a serious side effect while using fluphenazine or any other phenothiazine. Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking fluphenazine. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking fluphenazine, do not stop taking it without your doctor's advice. Fluphenazine can pass into breast milk and may harm a nursing baby. You should breast-feed while taking fluphenazine. Older adults may be more likely to have side effects from this medicine.
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Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
headache, dizziness, drowsiness; feeling anxious or restless; strange dreams; nausea, constipation, loss of appetite; mild skin rash; dry mouth, stuffy nose; increased sweating or urination; breast swelling or discharge; changes in your menstrual periods; impotence, trouble having an orgasm; or weight gain, swelling in your hands or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 . See also: Permitil side effects (in more detail)
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atropine (Sal-Tropine, Atreza); lithium (Eskalith, Lithobid); an antibiotic; birth control pills or hormone replacement estrogens; blood pressure medication; a blood thinner such as warfarin (Coumadin, Jantoven); certain asthma medications or bronchodilators; incontinence medications; insulin or diabetes medications you take by mouth; medication for nausea, vomiting, or motion sickness; medications to treat or prevent malaria; medicines used to prevent organ transplant rejection; a stimulant or ADHD medication; ulcer or irritable bowel medications; or medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma). This list is not complete and there are many other drugs that can interact with fluphenazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you
Seroquel
Generic Name: quetiapine (kwe TYE a peen) Brand Names: SEROquel, SEROquel XR
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What is Seroquel?
Seroquel (quetiapine) is an antipsychotic medicine. It works by changing the actions of chemicals in the brain. Seroquel is used to treat schizophrenia in adults and children who are at least 13 years old. It is also used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old. Seroquel is also used together with antidepressant medications to treat major depressive disorder in adults. Extended-release quetiapine (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old. Seroquel may also be used for purposes not listed in this medication guide.
Treatments for depression are getting better everyday and there are things you can start doing right away.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
liver or kidney disease; heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke; a history of low white blood cell (WBC) counts; a thyroid disorder; seizures or epilepsy; cataracts; high cholesterol or triglycerides; a personal or family history of diabetes; or trouble swallowing. You may have thoughts about suicide when you first start taking an antidepressant such as Seroquel, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed. Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using Seroquel. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Seroquel, do not stop taking it without your doctor's advice. Quetiapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Seroquel. See also: Seroquel pregnancy and breastfeeding warnings (in more detail) Do not give Seroquel to a child without a doctor's advice. Extended-release Seroquel XR is for use only in adults and should not be given to anyone younger than 18 years old.
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Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke. Avoid drinking alcohol. It can increase certain side effects of Seroquel. See also: Seroquel and alcohol (in more detail)
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very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors; feeling like you might pass out; jerky muscle movements you cannot control, trouble swallowing, problems with speech; tremors, or restless muscle movements in your eyes, tongue, jaw, neck, arms, or legs; mask-like appearance of the face, trouble swallowing, problems with speech; blurred vision, eye pain, or seeing halos around lights; increased thirst and urination, excessive hunger, fruity breath odor, weakness, nausea and vomiting; or fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips. Less serious Seroquel side effects may include:
dizziness, drowsiness, tired feeling; dry mouth, sore throat; stomach pain, upset stomach, nausea, vomiting, constipation; breast swelling or discharge; missed menstrual periods; or increased appetite, weight gain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 . See also: Seroquel side effects (in more detail)
a medication to treat high blood pressure or a heart condition; medications to treat Parkinson's disease; steroids (prednisone and others); an antibiotic or antifungal medication such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), ketoconazole (Nizoral), rifampin (Rifadin, Rimactane, Rifater), and others; anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam); heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), and others; medications to treat HIV or AIDS; migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig); narcotic medication such as methadone (Methadose, Diskets, Dolophine); seizure medication such as carbamazepine (Carbatrol, Tegretol), divalproex (Depakote), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin), or valproic acid (Depakene, Stavzor); or other antidepressant or medicines to treat psychiatric disorders, such as amitriptylline (Elavil, Vanatrip, Limbitrol), clozapine (FazaClo, Clozaril), fluoxetine (Prozac, Sarafem, Symbyax), haloperidol (Haldol), risperidone (Risperdal), thioridazine (Mellaril), and others. This list is not complete and other drugs may interact with Seroquel. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Clozaril
Generic Name: clozapine (KLOE za peen) Brand names: Clozaril, FazaClo, Clopine, Clozapine Synthon, Denzapine, Zaponex
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What is Clozaril?
Clozaril (clozapine) is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Clozaril is used to treat severe schizophrenia. It is also used to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders. Clozaril is usually given after other medications have been tried without successful treatment of symptoms. Clozaril may also be used for other purposes not listed in this medication guide.
untreated or uncontrolled epilepsy; a bone marrow disorder; paralytic ileus or intestinal blockage; a history of infection caused by taking clozapine; or if you are also using drugs that weaken your immune system (such as cancer medicine or steroids).
To make sure you can safely take Clozaril, tell your doctor if you have any of these other conditions:
heart disease, heart rhythm disorder, high blood pressure; history of heart attack or stroke; epilepsy or other seizure disorder; lung disease; liver or kidney disease; diabetes; a history of bone marrow or blood cell disorders; an enlarged prostate or urination problems; glaucoma; or if you smoke. FDA pregnancy category B. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Clozaril, do not stop taking it without your doctor's advice. Clozapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking Clozaril. See also: Clozaril pregnancy and breastfeeding warnings (in more detail)
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days in a row, call your doctor before you start taking it again. If you need surgery, tell the surgeon ahead of time that you are using Clozaril. Store Clozaril at room temperature away from moisture and heat. See also: Clozaril dosage (in more detail)
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mouth and throat ulcers; cough, sore throat; rapid heart rate; or rapid and shallow breathing. Stop using Clozaril and call your doctor at once if you have any of these serious side effects:
seizure (black-out or convulsions); skin rash, bruising, severe tingling, numbness, pain, muscle weakness; fast or pounding heartbeats, chest pain, unusual tiredness, trouble breathing; feeling short of breath (even at night or with mild exertion), swelling in your hands or feet; feeling like you might pass out; slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); high blood sugar (increased thirst, extreme hunger, fruity breath odor, increased urination, drowsiness); very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors; twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or nausea, vomiting, loss of appetite, and jaundice (yellowing of your skin or eyes). Less serious Clozaril side effects may include:
constipation; dry mouth, blurred vision; drooling, especially at night; increased sweating; drowsiness, dizziness, spinning sensation; or sleep problems. This is not a complete list of Clozaril side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 . See also: Clozaril side effects (in more detail)
Maintenance dose: If the first dose is well- tolerated, dosages may then be titrated in daily increments of 25 mg to 50 mg for approximately two weeks until a daily dose of 300 to 450 mg is achieved. If, after the initial titration, a larger dose is necessary a slower increase in dose, not to exceed a 100 mg increment once or twice a week, may be initiated. Cautious titration and a divided dosage schedule may minimize the risks of hypotension, seizure, and sedation in the patient. However, sedation following daytime doses may necessitate administration of most or all of the daily dose at bedtime. Maximum Clozaril dose: 900 mg per day.
any other antipsychotic medication; bosentan (Tracleer); cimetidine (Tagamet); dexamethasone (Decadron, Hexadrol); lithium (Eskalith, Lithobid); St. John's wort; armodafanil (Nuvigil) or modafanil (Progivil); atropine (Donnatal, and others), belladonna, clidinium (Quarzan), dicyclomine (Bentyl), scopolamine (Transderm-Scop); an antibiotic such as ciprofloxacin (Cipro) erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin); an antidepressant such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), or sertraline (Zoloft); diazepam (Valium) or similar medicines such as alprazolam (Xanax), clonazepam (Klonopin), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), and others; heart rhythm medications such as propafenone (Rythmol), flecaininde (Tambocor), or quinidine (Quin-G); HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra); phenothiazines such as chlorpromazine (Thorazine), promethazine (Pentazine, Phenergan, Anergan, Antinaus), and others; or seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenobarbital (Solfoton), phenytoin (Dilantin), or primidone (Mysoline). This list is not complete and there are many other drugs that can interact with Clozaril. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Clozaril Side Effects (in more detail) Clozaril Dosage Clozaril Use in Pregnancy & Breastfeeding Drug Images Clozaril Drug Interactions
Clozaril Support Group 4 Reviews for Clozaril - Add your own review/rating Clozaril MedFacts Consumer Leaflet (Wolters Kluwer) Clozaril Advanced Consumer (Micromedex) - Includes Dosage Information Clozaril Prescribing Information (FDA) Clozapine Prescribing Information (FDA) Clozapine Monograph (AHFS DI) Clozapine Professional Patient Advice (Wolters Kluwer) FazaClo Prescribing Information (FDA) FazaClo Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
Your pharmacist can provide more information about Clozaril. Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.