Академический Документы
Профессиональный Документы
Культура Документы
2011
Estimating the overall significance of deterioration with permutation analysis of point-wise linear regression
North American Perimetry Society Meeting 2011
Pointwise linear regression analysis for detection of visual field progression with absolute versus corrected threshold sensitivities
Manassakorn A et al.
2006
< -1.0
0.01
yes
no
Reliability
7.3y / -
Artes PH et al.
2005
< -1.0
0.05
yes
no
range
range
9y / 6m
At least 5 VF
Pointwise linear regression for evaluation of visual field outcomes and comparison with the Nouri-Mahdavi K et al. advanced glaucoma intervention study methods
2005
< -1.0
0.01
yes
no
1 or 2
At least 3y / 6m
Pointwise linear progression criteria and the detection of visual field change in a glaucoma trial.
Wilkins MR et al.
2006
< -1.0
0.01
yes
no
Anywhere. 2 or 3 cluster hemifield. 2 1, 2, 3, cluster GHT. 2 PNFB 4 or 5 cluster. 2 ONH derived cluster.
16m / 3-4m
At least 6 VF
Examination of Different Pointwise Linear Regression Methods for Determining Visual Field Progression
Gardiner SK et al.
< -1.0
0.01
no
no
Frequency of testing for detecting visual field progression Early detection of visual field progression in glaucoma: a comparison of PROGRESSOR and STATPAC 2 Visual field progression: comparison of HumphreyStatpac2 and pointwise linear regression analysis
Gardiner SK et al.
2002
< -1.0
0.01
no
no
Any y non-edge points (for edge points < -2.0 dB/y) non-edge points (for edge points < -2.0 dB/y)
Viswanathan AC et al.
1997
< -1.0
0.01
no
no
Reliability
/ 4m
MacNaught AI et al.
1996
< -1.0
0.01
no
no
5.6y / 4.2m
Properties
Many strategies with many criteria...not simple!
Aims
Develop a method to infer a simple, single, overall statistical significance of the observed pattern of sensitivity deterioration from PLR Show that significance level of this method produces an equivalent false positive level Compare hit t and specificity to other PLR C hit-rate d ifi it t th criteria for progression
Methodology
Perform PLR Combine p-values Permute test sequence Permutation of PLR: PoPLR!
Significance: Permutation
Permute sequence of VF tests and calculate test statistics under re-ordering
1 2 3 4 5 6 7 8
S
7 3 8 1 5 4 6 2
Sp
Significance: Permutation
Distribution of permuted test statistics (Sp)
Significance: Permutation
Distribution of permuted test statistics (Sp)
Se ensitivity
Specificity
H Hit Rat te
At Fixed Specificity Hit Rate Hi R A > Hit Rate B Hi R Sensitivity A > Sensitivity B
Specificity
Data
Median Baseline MD (dB) Baseline Age (years) -3.0 67 IQR -6.3, -1.2 59, 75
5 exams
8 exams
Final exam
5 exams
5 exams
8 exams
Final exam
Conclusions
PoPLR provides a single, simple, overall estimate of statistical significance for visual field progression Specificity is accurate in population and in individual I di id li d t each patients own data h ti t d t Individualised to Adaptable
Bal
Paul
Alexandre Reis
Marcelo Nicolela
Paul Rafuse
Ray LeBlanc y