Family Poxviridae

Virus 1. 2. 3. 4. 5.

Variola major Variola minor Cowpox Orf Molluscum contagiosum

Parvoviridae

Parvovirus B19

Hepadnaviridae

Hepatitis B virus

Characteristics - DNA virus - Complex, enveloped - Transmission = direct and sexual contact - Host 1. Man 2. Man 3. Cattle 4. Goat, sheep 5. Man - DNA virus - Icosahedral, no envelope - Single stranded DNA - Transmission 1. Aerosol 2. Transfusion 3. Congenital - DNA virus - Icosahedral, enveloped - Spherical particles - Tubular particles - Dane particles - Transmission Parental Sexual contact Prenatal / perinatal routes

Infection 1. 2. 3. 4. 5.

Smallpox Alastrim Haemorrhagic ulcer Ulcer Chronic, multiple nodules

1. Erythema infectiosum 2. Aplastic crisis, polyarthralgia 3. Hydrops fetalis

Acute / chronic hepatitis B Cirrhosis Liver cancer

Family Herpesviridae 1. 2. 3. 4. 5. 6. 7. 8.

Virus HSV-1 (HHV-1) HSV-2 (HHV-2) VZV (HHV-3) EBV (HHV-4) or Eipstein-Barr virus CMV (HHV-5) HHV-6 HHV-7 KSHV (HHV-8) -

Characteristics DNA virus Icosahedral, enveloped More than 100 types Causes latent infection Transmission 1. Oral, close contact, sexual, congenital 2. Sexual, congenital 3. Aerosol, close contact, congenital 4. Close contact, saliva 5. Close contact, congenital 6. Close contact, aerosol 7. ? 8. ?

Infection 1. Gingivostomatis, herpetic whitlow, dendritic ulcer herpes genitalis encephalitis 2. Herpes genitalis, congenital infection 3. Varicella (chickenpox), zoster (shingles), vaccine available 4. Infectious mononucleosis (tonsil and uvula = swollen with white exudates Soft palate = petechial rash) Burkitts lymphoma (affecting maxilla and eye) Nasopharyngeal carcinoma 5. Hepatitis Hepatosplenomegaly 6. Exanthema subitum 7. ? 8. Kaposi sarcoma (mouth, esophagus, stomach, small intestine)

Family Papovaviridae

Virus 1. Papilloma virus (HPV) 2. Polyoma virus BK virus cystitis JC virus 3. Vacuolating virus

Characteristics DNA virus Icosahedral, no envelope Transmission 1. Close contact, sexual, perinatal 2. Both BK and JC, respiratory (asymptomatic, persistent in kidney)

Infection 1. Warts Epidermodysplasia Verruciformis Condyloma accuminata Genital cancer Laryngeal papilloma 2. BK virus = haemorrhagic (immunodeficient) Slow virus infection JC virus = progressive multifocal leukoencephalopaty Slow virus infection A. Feces B. Aerosol = Acute respiratory disease, pharyngitis Ocular = Acute hemorrhagic cystitis Epidemic keratoconjunctivitis C. Pharyngitis Pneumonia D. Epidemic keratoconjunctivitis E. Acute respiratory disease Pneumonia F. Gastroenteritis

Adenoviridae

Adenovirus (has A,B,C,D,E,F)

DNA virus Icosahedral, no envelope Transmission Generally aerosol and ocular secretion 1. A = fecal-oral 2. B= aerosol and ocular 3. C = aerosol 4. D = ocular 5. E= aerosol 6. F = aerosol and fecal-oral

Family Caliciviridae (Human Calici Virus) Picornaviridae

1. 2. 1. 2. 3. 4. 5. 6. 7.

Virus Norovirus (Norwalk agent) Sappovirus Polio virus Coxsackie A Coxsackie B ECHO virus Enterovirus (68-71) Rhinovirus Hepatitis A

Characteristics RNA virus Icosahedral, no envelope Transmission = fecal-oral RNA virus Icosahedral, no envelope Vector = cockroaches / flies Can occur in CNS, heart, musculoskeletal system, liver Transmission Generally fecal-oral and aerosol 1. Fecal-oral 2. Fecal-oral, conjunctiva 3. Fecal-oral 4. Fecal-oral 5. Fecal-oral,conjunctiva 6. Aerosol, saliva, fomites 7. Fecal-oral

Infection 1. Epidemic gastroenteritis (adult) 2. Epidemic gastroenteritis (child) 1. Poliomyelitis, have vaccines 2. Herpangina (mouth blisters) meningitis haemorrhagic conjunctivitis 3. Pleurodynia Meningitis Myocarditis 4. Meningitis Rashes Respi illness 5. Lower respi illness Epidemic HFMD (Hand, foot, mouth disease) Haemorrhagic conjunctivitis Meningitis 6. Cold Croup (respiratory difficulty and a hoarse, brassy cough Bronchopneumonia 7. Acute hepatitis, have vaccines 1. ??? 2. Fever Arthralgia Encephalitis 3. Acute gastroenteritis, have vaccines

Reoviridae

1. Reovirus 2. Colorado tick fever 3. Rotavirus

RNA virus Icosahedral, no envelope Respiratory Enteric Orphan (REO) Double stranded RNA Transmission 1. Fecal-oral 2. Tick. Man 3. Fecal-oral

Family Coronaviridae

Virus 1. Coronavirus 2. SARS coronavirus

Orthomyxoviridae

1. Influenza A 2. Influenza B 3. Influenza C

Paramyxoviridae 1. 2. 3. 4. 5. Paramyxovirus (HA & NA) Parainfluenza Mumps Morbillivirus (HA) Measles Nipah virus Pneumovirus (no HA or NA) RSV (respi syncytial virus) -

Characteristics RNA virus Complex, no enveloped Transmission 1. Aerosol, contact 2. Aerosol, contact, feces RNA virus Helical, enveloped Has envelope glycoproteins made up of Hemaglutinin Neuraminidase Has antigenic shift and antigenic drift Transmission = Aerosol, droplets contact RNA virus Helical, enveloped Has envelope glycoproteins Hemaglutinin Neuraminidase Transmission 1. Aerosol, close contact 2. Aerosol 3. Aerosol 4. Close contact (pigs) 5. Aerosol

Infection 1. Upper respi tract infection 2. SARS (Severe Acute Respiratory Syndrome) Diarrhea

1. Acute respi disease (pandemics / endemics), have vaccines 2. Acute respi disease (epidemics), have vaccines 3. URTI, no vaccine

1. Respi tract 2. Parotitis (inflammation of parotid glands as in mumps) Orchitis (inflammation of testes) Meningoencephalitis, have vaccine 3. Measles (rashes) SSPE (Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus, have vaccines 4. Bronchiolitis Croup 5. Encephalitis

Family Filoviridae

Virus 1. Marburg virus 2. Ebola virus

Rhabdoviridae

1. Rabies virus

Arenaviridae

1. Lassa virus

Togaviridae

1. EEE / WEE (western equine encephalitis) 2. Chikungunya 3. Rubella

Characteristics RNA virus Tubular shaped and enveloped Transmission = direct contact with blood RNA virus Helical, enveloped Bullet shaped, enveloped Infect all warm-blooded animals Transmission Bite in skin or mucus membrane Inhalation of bat droppings RNA virus Complex, no enveloped Natural host = rodents RNA virus Icosahedral, enveloped Host 1. Bird 2. Monkeys 3. Man Transmission Air-borne Direct contact Transplacental (rubella)

Infection Both cause Haemorrhagic fever Can be fatal Rabies Encephalitis

Haemorrhaic fever Neurologic disease

1. Encephalitis 2. Fever Myositis (muscle fibers and skin are inflamed and damaged, resulting in muscle weakness) Arthritis 3. Rubella (rashes) Congenital rubella syndrome

Family Flaviviridae

1. 2. 3. 4.

Virus Yellow fever Dengue Japanese encephalitis Hepatitis C

Characteristics RNA virus Icosahedral, enveloped Host 1. Monkeys 2. Man 3. Birds 4. Man

Bunyaviridae

1. Hantaan 2. California encephalitis 3. Crimean Congo fever 1. HTLV-1 (Human T-cell Lymphotropic Virus) 2. HTLV-2 3. HIV-1 4. HIV-2

RNA virus Helical, enveloped

Retroviridae

RNA virus Transmission Sexual intercourse From mother to son (vertical transmission Infected blood products

Infection 1. Haemorrhagic fever Hepatitis, has vaccine 2. Fever Arthralgia Rash Haemorrhagic fever 3. Encephalitis (Encephalitis is an inflammation of the brain), has vaccine 4. Hepatitis Cirrhosis HCC (Hepatocellular Carcinoma) 1. Haemorrhagic fever with renal syndrome 2. Encephalitis 3. Haemorrhagic fever 1. Adult T cell leukemia Lymphoma Tropical Spastic paraparesis 2. Hairy cell leukemia (unrestrained proliferation of white blood cells) 3. AIDS 4. AIDS