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I. Adrenergics/ Sympathomimetics
• mimic effects of NE by stimulating SNS.
increase HR bronchodilation
Increase cardiac contraction vasodilation (skeletal muscle)
increase cardiac conduction relaxation of uterus
lipolylis relaxation of GIT & decrease GI secretions
relaxation fo urinary bladder
increase blood sugar
B. Inactivation of NE:
1. reuptake of NE back into the neuron.
2. enzymatic degradation - MAO & COMT
3. diffusion away from transmitter
synthetic catecholamine
• dobutamine
Epinephrine
Alpha 2 adrenergics
• clonidine
• methyldopa
phenylephrine
Isoproterenol
Indications : tx of congestive heart failure, asthma
MOA: beta adrenergic, increases heart rate & contractility & bronchodilation
Direct Acting
Indirect acting
MOA: blocks alpha & beta receptors in SNS causing decrease BP without
reflex tachycardia & decrease renin
MOA: blocks alpha 1, producing vasodilation & decrease BP & decrease contraction of
prostate
propanolol
MOA: blocks beta 1 & 2 adrenergic receptors, causes decrease HR & BP as well
as bronchoconstriction & uterine contraction
Alpha blockers (ie prazosin) & beta blockers (ie propanolol, metoprolol, pindolol)
• may cause impotence or decrease in libido